{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T19:27:46Z","timestamp":1793042866169,"version":"4.5.0"},"reference-count":153,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T00:00:00Z","timestamp":1773273600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animals"],"abstract":"<jats:p>Reproductive efficiency in cattle is critically dependent on embryo quantity and quality, particularly in assisted reproductive technology (ART) programs such as superovulation, embryo transfer, and embryo production. Nutrition is a key determinant of embryo yield through its regulatory effects on metabolic signaling, ovarian function, oocyte competence, and early embryogenesis. This review synthesizes the current evidence describing mechanistic links between nutritional status and embryo production in dairy and beef cattle across both in vivo and in vitro systems. Energy balance, protein supply, micronutrients, and fatty acids influence metabolic hormones including insulin, insulin-like growth factor-1, and leptin, which regulate hypothalamic\u2013pituitary\u2013gonadal axis activity, follicular recruitment, and steroidogenesis. Negative energy balance disrupts endocrine signaling, elevates circulating non-esterified fatty acids, increases oxidative stress, and impairs oocyte mitochondrial function, resulting in reduced embryo yield, compromised blastocyst quality, and diminished cryotolerance. Targeted micronutrients such as selenium, zinc, vitamins A and E, B-complex vitamins, and omega-3 fatty acids enhance antioxidant capacity, membrane integrity, and epigenetic regulation, thereby supporting embryo viability and post-transfer survival. Furthermore, early-life nutrition programs long-term reproductive capacity by influencing ovarian reserve establishment and oocyte epigenetic competence. Strategic nutritional management is therefore essential to optimize ART outcomes and promote sustainable genetic progress in cattle production systems.<\/jats:p>","DOI":"10.3390\/ani16060892","type":"journal-article","created":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T14:46:31Z","timestamp":1773326791000},"page":"892","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Impact of Nutrition on Embryo Production in Cattle: Mechanistic Insights"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1117-7867","authenticated-orcid":false,"given":"Ramanathan","family":"Kasimanickam","sequence":"first","affiliation":[{"name":"College of Veterinary Medicine, Washington State University, Pullman, WA 99164, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2017-8864","authenticated-orcid":false,"given":"Vanmathy","family":"Kasimanickam","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Washington State University, Pullman, WA 99164, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,3,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.anireprosci.2006.08.007","article-title":"The effect of nutritional management of the dairy cow on reproductive efficiency","volume":"96","author":"Roche","year":"2006","journal-title":"Anim. Reprod. Sci."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.anireprosci.2011.05.009","article-title":"The role of nutritional supplementation on the outcome of superovulation in cattle","volume":"126","author":"Velazquez","year":"2011","journal-title":"Anim. Reprod. Sci."},{"key":"ref_3","first-page":"260","article-title":"Influences of nutrition and metabolism on fertility of dairy cows","volume":"9","author":"Bisinotto","year":"2012","journal-title":"Anim. Reprod."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1530\/REP-08-0362","article-title":"The role of IGF1 in the in vivo production of bovine embryos from superovulated donors","volume":"137","author":"Velazquez","year":"2009","journal-title":"Reproduction"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"e14629","DOI":"10.1111\/rda.14629","article-title":"Association between metabolic parameters and embryo production in superovulated dairy cattle","volume":"59","author":"Tirpan","year":"2024","journal-title":"Reprod. Domest. Anim."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.theriogenology.2005.09.020","article-title":"Contribution of the oocyte to embryo quality","volume":"65","author":"Sirard","year":"2006","journal-title":"Theriogenology"},{"key":"ref_7","first-page":"49","article-title":"The ART of studying early embryo development: Progress and challenges in ruminant embryo culture","volume":"86","author":"Lonergan","year":"2016","journal-title":"Theriogenology"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1071\/RD11901","article-title":"Intrafollicular conditions as a major link between maternal metabolism and oocyte quality","volume":"24","author":"Leroy","year":"2012","journal-title":"Reprod. Fertil. Dev."},{"key":"ref_9","first-page":"403","article-title":"Interactions between nutrition and ovarian activity in cattle: Physiological, cellular and molecular mechanisms","volume":"61","author":"Armstrong","year":"2003","journal-title":"Reproduction"},{"key":"ref_10","first-page":"521","article-title":"Metabolic changes in follicular fluid of the dominant follicle in high-yielding dairy cows early postpartum","volume":"127","author":"Leroy","year":"2004","journal-title":"Reproduction"},{"key":"ref_11","first-page":"647","article-title":"Consequences of bovine oocyte maturation, fertilization or early embryo development in vitro versus in vivo: Implications for blastocyst yield and quality","volume":"124","author":"Rizos","year":"2002","journal-title":"Reproduction"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1071\/RD12092","article-title":"Development of bovine embryos derived from reproductive techniques","volume":"25","author":"Alberto","year":"2012","journal-title":"Reprod. Fertil. Dev."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/S0301-6226(03)00112-X","article-title":"Energy balance relationships with follicular development, ovulation and fertility in postpartum dairy cows","volume":"83","author":"Butler","year":"2003","journal-title":"Livest. Prod. Sci."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.anireprosci.2003.10.009","article-title":"Relationship between level of milk production and estrous behavior of lactating dairy cows","volume":"81","author":"Lopez","year":"2004","journal-title":"Anim. Reprod. Sci."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"3351","DOI":"10.1098\/rstb.2009.0184","article-title":"Nutritional effects on oocyte and embryo development in mammals: Implications for reproductive efficiency and environmental sustainability","volume":"364","author":"Ashworth","year":"2009","journal-title":"Philos. Trans. R. Soc. B"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/s40104-022-00818-9","article-title":"Role of functional fatty acids in modulation of reproductive potential in livestock","volume":"14","author":"Zeng","year":"2023","journal-title":"J. Anim. Sci. Biotechnol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1262\/jrd.2012-064","article-title":"Selenium and vitamin E improve the in vitro maturation, fertilization and culture to blastocyst of porcine oocytes","volume":"58","author":"Tareq","year":"2012","journal-title":"J. Reprod. Dev."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Scanes, C.G., and Hill, R.A. (2017). Epigenetics and Developmental Programming in Ruminants: Long-Term Impacts on Growth and Development. Biology of Domestic Animals, CRC Press.","DOI":"10.1201\/9781315152080"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"S1943","DOI":"10.3945\/ajcn.110.000927","article-title":"Developmental programming and epigenetics","volume":"94","author":"Gabory","year":"2011","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Velazquez, M.A. (2023). Nutritional strategies to promote bovine oocyte quality for in vitro embryo production: Do they really work?. Vet. Sci., 10.","DOI":"10.3390\/vetsci10100604"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.theriogenology.2018.11.010","article-title":"Influence of Nutrition, Body Condition, and Metabolic Status on Reproduction in Female Beef Cattle: A Review","volume":"125","author":"Baruselli","year":"2019","journal-title":"Theriogenology"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"5115","DOI":"10.3168\/jds.2017-14064","article-title":"Effects of Nutrition on the Fertility of Lactating Dairy Cattle","volume":"101","author":"Rodney","year":"2018","journal-title":"J. Dairy Sci."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"5601","DOI":"10.3168\/jds.2015-9528","article-title":"Effects of Dietary Fat on Fertility of Dairy Cattle: A Meta-Analysis and Meta-Regression","volume":"98","author":"Rodney","year":"2015","journal-title":"J. Dairy Sci."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"746","DOI":"10.3168\/jds.S0022-0302(89)79168-2","article-title":"Impact of Protein Nutrition on Reproduction in Dairy Cows","volume":"72","author":"Ferguson","year":"1989","journal-title":"J. Dairy Sci."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1186\/s40168-025-02309-1","article-title":"The impact of rumen and hindgut microbiomes on the persistent productivity of long-lived dairy cows","volume":"14","author":"Yang","year":"2026","journal-title":"Microbiome"},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Constantin, N.T., Bercea-Strugariu, C.M., B\u00eer\u021boiu, D., Posastiuc, F.P., Iordache, F., Bilteanu, L., and Serban, A.I. (2023). Predicting pregnancy outcome in dairy cows: The role of IGF-1 and progesterone. Animals, 13.","DOI":"10.3390\/ani13101579"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/s11250-016-1211-6","article-title":"Significance of insulin resistance and oxidative stress in dairy cattle with subclinical ketosis during the transition period","volume":"49","author":"Youssef","year":"2017","journal-title":"Trop. Anim. Health Prod."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.theriogenology.2016.04.039","article-title":"Associations of insulin resistance later in lactation on fertility of dairy cows","volume":"86","author":"Baruselli","year":"2016","journal-title":"Theriogenology"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"skaf330","DOI":"10.1093\/jas\/skaf330","article-title":"Persistence of subacute ruminal acidosis across first and second lactations in dairy cows based on reticular pH metrics and microbiota, and systemic health responses","volume":"103","author":"Biber","year":"2025","journal-title":"J. Anim. Sci."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"R418","DOI":"10.1152\/ajpregu.2001.280.2.R418","article-title":"Effect of water restriction on feeding and metabolism in dairy cows","volume":"280","author":"Senn","year":"2001","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1007\/s00484-020-02038-0","article-title":"Factors influencing water intake in dairy cows: A review","volume":"65","author":"Golher","year":"2021","journal-title":"Int. J. Biometeorol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"3385","DOI":"10.3168\/jds.2007-0926","article-title":"Water intake and dry matter intake changes as a feeding management tool and indicator of health and estrus status in dairy cows","volume":"91","author":"Lukas","year":"2008","journal-title":"J. Dairy Sci."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"15","DOI":"10.11648\/j.ijbc.20251001.12","article-title":"Review on water requirement and utilization in farm animal","volume":"10","author":"Mosneh","year":"2025","journal-title":"Int. J. Bioorg. Chem."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/S0378-4320(00)00076-2","article-title":"Nutritional Interactions with Reproductive Performance in Dairy Cattle","volume":"60\u201361","author":"Butler","year":"2000","journal-title":"Anim. Reprod. Sci."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0749-0720(15)30807-0","article-title":"The Effects of Nutrition on Reproductive Performance of Beef Cattle","volume":"7","author":"Rice","year":"1991","journal-title":"Vet. Clin. N. Am. Food Anim. Pract."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1262\/jrd.51.23","article-title":"The roles of vitamin A for cytoplasmic maturation of bovine oocytes","volume":"51","author":"Ikeda","year":"2005","journal-title":"J. Reprod. Dev."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Chen, Y.H., Chen, Y.M., Tu, P.A., Lee, K.H., Chen, J.Y., and Hsu, J.T. (2023). Effect of Supplementing Vitamin E, Selenium, Copper, Zinc, and Manganese During the Transition Period on Dairy Cow Reproductive Performance and Immune Function. Vet. Sci., 10.","DOI":"10.3390\/vetsci10030225"},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"BenSouf, I., Saidani, M., Maazoun, A., Bejaoui, B., Larbi, M.B., M\u2019Hamdi, N., Aggad, H., Joly, N., Rojas, J., and Morillo, M. (2025). Use of Natural Biomolecules in Animal Feed to Enhance Livestock Reproduction. Int. J. Mol. Sci., 26.","DOI":"10.3390\/ijms26052328"},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Van Emon, M. (2020). Impacts of Bovine Trace Mineral Supplementation on Maternal and Offspring Production and Health. Animals, 10.","DOI":"10.3390\/ani10122404"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"4946","DOI":"10.1093\/jas\/skz351","article-title":"Zinc Supplementation During In Vitro Embryo Culture Increases Inner Cell Mass and Total Cell Numbers in Bovine Blastocysts","volume":"97","author":"McCall","year":"2019","journal-title":"J. Anim. Sci."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"10099","DOI":"10.3168\/jds.2024-25150","article-title":"Invited Review: Limitations to Current Mineral Requirement Systems for Cattle and Potential Improvements","volume":"107","author":"Weiss","year":"2024","journal-title":"J. Dairy Sci."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"106924","DOI":"10.1016\/j.anireprosci.2022.106924","article-title":"Functions of Manganese in Reproduction","volume":"238","author":"Studer","year":"2022","journal-title":"Anim. Reprod. Sci."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"2021","DOI":"10.1071\/AN17057","article-title":"Effect of nano-selenium and nano-zinc particles during in vitro maturation on the developmental competence of bovine oocytes","volume":"58","author":"Helmy","year":"2018","journal-title":"Anim. Prod. Sci."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1530\/REP-08-0375","article-title":"Cellular proliferation and vascularization in ovine fetal ovaries: Effects of undernutrition and selenium in maternal diet","volume":"137","author":"Caton","year":"2009","journal-title":"Reproduction"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1021\/cb200084y","article-title":"Zinc sparks are triggered by fertilization and facilitate cell cycle resumption in mammalian eggs","volume":"6","author":"Kim","year":"2011","journal-title":"ACS Chem. Biol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1016\/j.theriogenology.2010.05.015","article-title":"Effect of increasing zinc sulphate concentration during in vitro maturation of bovine oocytes","volume":"74","author":"Picco","year":"2010","journal-title":"Theriogenology"},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Fabjanowska, J., Kowalczuk Vasilev, E., Klebaniuk, R., Milewski, S., and G\u00fcm\u00fc\u015f, H. (2023). N-3 Polyunsaturated Fatty Acids as a Nutritional Support of the Reproductive and Immune System of Cattle\u2014A Review. Animals, 13.","DOI":"10.3390\/ani13223589"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"4299","DOI":"10.3168\/jds.2024-25409","article-title":"Omega-3 fatty acid supplementation from late pregnancy to early lactation attenuates the endocannabinoid system and immune proteome in preovulatory follicles and endometrium of Holstein dairy cows","volume":"108","author":"Butenko","year":"2025","journal-title":"J. Dairy Sci."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Keane, J.A., and Ealy, A.D. (2024). An overview of reactive oxygen species damage occurring during in vitro bovine oocyte and embryo development and the efficacy of antioxidant use to limit these adverse effects. Animals, 14.","DOI":"10.3390\/ani14020330"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.theriogenology.2022.10.005","article-title":"Optimizing swine in vitro embryo production with growth factor and antioxidant supplementation during oocyte maturation","volume":"194","author":"Currin","year":"2022","journal-title":"Theriogenology"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1002\/mrd.20701","article-title":"Selenium improves the developmental ability and reduces the apoptosis in porcine parthenotes","volume":"74","author":"Uhm","year":"2007","journal-title":"Mol. Reprod. Dev."},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Qazi, I.H., Angel, C., Yang, H., Pan, B., Zoidis, E., Zeng, C.J., Han, H., and Zhou, G.B. (2018). Selenium, selenoproteins, and female reproduction: A review. Molecules, 23.","DOI":"10.3390\/molecules23123053"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1055\/s-0029-1231026","article-title":"Changes in GH\/IGF-1 axis in intrauterine growth retardation: Consequences of fetal programming?","volume":"41","author":"Setia","year":"2009","journal-title":"Horm. Metab. Res."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"R23","DOI":"10.1530\/JOE-21-0087","article-title":"The growth hormone-insulin-like growth factor axis in pregnancy","volume":"251","author":"Kaur","year":"2021","journal-title":"J. Endocrinol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"100540","DOI":"10.1016\/j.animal.2022.100540","article-title":"Effect of dietary protein and energy intake on embryonic survival and gene expression in the uterine endometrium of early pregnant gilts","volume":"16","author":"Zhao","year":"2022","journal-title":"Animal"},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Doppenberg, J. (2010). Functional amino acids in swine nutrition and production. Dynamics in Animal Nutrition, Wageningen Academic Publishers.","DOI":"10.3920\/978-90-8686-706-6"},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Abdelnour, S.A., Abd El-Hack, M.E., Swelum, A.A., Saadeldin, I.M., Noreldin, A.E., Khafaga, A.F., Al-Mutary, M.G., Arif, M., and Hussein, E.O.S. (2019). The usefulness of retinoic acid supplementation during in vitro oocyte maturation for the in vitro embryo production of livestock: A review. Animals, 9.","DOI":"10.3390\/ani9080561"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.theriogenology.2024.03.013","article-title":"Zinc improves the developmental ability of bovine in vitro fertilization embryos through its antioxidative action","volume":"221","author":"Feng","year":"2024","journal-title":"Theriogenology"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"105339","DOI":"10.1016\/j.livsci.2023.105339","article-title":"Embryo yield and quality in superovulated Simmental donor cows following oral supplementation with different sources of omega-3 and omega-6 fatty acids","volume":"277","author":"Garza","year":"2023","journal-title":"Livest. Sci."},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Chen, M., Zheng, Z., Shi, J., and Shao, J. (2021). Insight on polyunsaturated fatty acids in endometrial receptivity. Biomolecules, 12.","DOI":"10.3390\/biom12010036"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1071\/RD11907","article-title":"The role of fatty acids in oocyte and early embryo development","volume":"24","author":"McKeegan","year":"2011","journal-title":"Reprod. Fertil. Dev."},{"key":"ref_62","first-page":"1190","article-title":"Nutritional management of the donor cow","volume":"70","author":"Santos","year":"2008","journal-title":"Theriogenology"},{"key":"ref_63","first-page":"168","article-title":"Effects of energy and protein nutrition in the dam on embryonic development","volume":"11","author":"Wiltbank","year":"2014","journal-title":"Anim. Reprod."},{"key":"ref_64","first-page":"191","article-title":"Effect of organic or inorganic trace mineral supplementation on follicular response, ovulation, and embryo production in superovulated heifers","volume":"100","author":"Lamb","year":"2007","journal-title":"Anim. Reprod. Sci."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1095\/biolreprod.106.058578","article-title":"Impact of dietary fatty acids on oocyte quality and development in lactating dairy cows","volume":"77","author":"Gutierrez","year":"2007","journal-title":"Biol. Reprod."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1038\/s41598-024-81393-z","article-title":"Nicotinamide mononucleotide boosts the development of bovine oocyte by enhancing mitochondrial function and reducing chromosome lagging","volume":"15","author":"Hashimoto","year":"2025","journal-title":"Sci. Rep."},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Wang, S., Liu, M., Di, A., Jiang, X., Wu, J., Zhang, J., Liu, X., Bai, C., Su, G., and Song, L. (2025). NAD+ promotes superovulation of Huaxi cattle through regulation of cumulus cell proliferation and oocyte maturation. Int. J. Mol. Sci., 26.","DOI":"10.3390\/ijms26052276"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1093\/biolre\/ioaf119","article-title":"Alpha-ketoglutarate modulates the reprogramming of mitochondrial and nuclear DNA methylation during the earliest stages of bovine preimplantation embryo development","volume":"113","author":"Ispada","year":"2025","journal-title":"Biol. Reprod."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1111\/j.1439-0531.2007.00960.x","article-title":"Reduced Fertility in High-Yielding Dairy Cows: Are the Oocyte and Embryo in Danger? Part I: The Importance of Negative Energy Balance and Altered Corpus Luteum Function to the Reduction of Oocyte and Embryo Quality in High-Yielding Dairy Cows","volume":"43","author":"Leroy","year":"2008","journal-title":"Reprod. Domest. Anim."},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Serbetci, I., Gonz\u00e1lez-Grajales, L.A., Herrera, C., Ibanescu, I., Tekin, M., Melean, M., Magata, F., Malama, E., Bollwein, H., and Scarlet, D. (2024). Impact of Negative Energy Balance and Postpartum Diseases During the Transition Period on Oocyte Quality and Embryonic Development in Dairy Cows. Front. Vet. Sci., 10.","DOI":"10.3389\/fvets.2023.1328700"},{"key":"ref_71","first-page":"246","article-title":"Negative Energy Balance and Reproduction: A Review","volume":"32","author":"Chandra","year":"2026","journal-title":"Agric. Rev."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"361","DOI":"10.2478\/jvetres-2021-0035","article-title":"Effect of Negative Energy Balance on Plasma Metabolites, Minerals, Hormones, Cytokines and Ovarian Follicular Growth Rate in Holstein Dairy Cows","volume":"65","author":"Song","year":"2021","journal-title":"J. Vet. Res."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.anireprosci.2009.11.009","article-title":"Transvaginal follicular aspiration and embryo development in superstimulated early postpartum beef cows and subsequent fertility after artificial insemination","volume":"119","author":"Aller","year":"2010","journal-title":"Anim. Reprod. Sci."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1111\/j.1439-0531.2007.00961.x","article-title":"Reduced fertility in high-yielding dairy cows: Are the oocyte and embryo in danger? Part II. Mechanisms linking nutrition and reduced oocyte and embryo quality in high-yielding dairy cows","volume":"43","author":"Leroy","year":"2008","journal-title":"Reprod. Domest. Anim."},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Zhou, X., Cao, J., Feng, G., Li, Y., Liu, D., and Liu, G. (2026). Commensal microbiota and reproductive health in livestock: Mechanisms, cross-system crosstalk, and precision strategies. Animals, 16.","DOI":"10.3390\/ani16030371"},{"key":"ref_76","doi-asserted-by":"crossref","unstructured":"Guo, Y., Wang, F., Mao, Y., Kong, W., Wang, J., and Zhang, G. (2023). Influence of parturition on rumen bacteria and SCFAs in Holstein cows based on 16S rRNA sequencing and targeted metabolomics. Animals, 13.","DOI":"10.3390\/ani13050782"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1016\/j.tjnut.2025.02.012","article-title":"Dietary short-chain fatty acids supplementation improves reproductive performance and gut microbiota in gilts","volume":"155","author":"Xu","year":"2025","journal-title":"J. Nutr."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"2345","DOI":"10.1038\/s41598-020-59410-8","article-title":"Metabolism-Associated Genome-Wide Epigenetic Changes in Bovine Oocytes During Early Lactation","volume":"10","author":"Poirier","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"111113","DOI":"10.1016\/j.mce.2020.111113","article-title":"Energy sensors and reproductive hypothalamo\u2013pituitary\u2013ovarian axis (HPO) in female mammals: Role of mTOR, AMPK and SIRT1","volume":"521","author":"Estienne","year":"2021","journal-title":"Mol. Cell. Endocrinol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1071\/RD09161","article-title":"Regulation of folliculogenesis and the determination of ovulation rate in ruminants","volume":"23","author":"Scaramuzzi","year":"2011","journal-title":"Reprod. Fertil. Dev."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1095\/biolreprod.106.055749","article-title":"Effects of metformin on bovine granulosa cell steroidogenesis: Possible involvement of adenosine 5\u2032-monophosphate-activated protein kinase (AMPK)","volume":"76","author":"Tosca","year":"2007","journal-title":"Biol. Reprod."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1530\/REP-09-0351","article-title":"Metformin decreases IGF-1-induced cell proliferation and protein synthesis through AMP-activated protein kinase in cultured bovine granulosa cells","volume":"139","author":"Tosca","year":"2010","journal-title":"Reproduction"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1093\/humrep\/dep420","article-title":"The effect of nutritionally induced hyperlipidaemia on in vitro bovine embryo quality","volume":"25","author":"Leroy","year":"2010","journal-title":"Hum. Reprod."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1093\/biolre\/ioy138","article-title":"DNA methylomes of bovine gametes and in vivo produced preimplantation embryos","volume":"99","author":"Jiang","year":"2018","journal-title":"Biol. Reprod."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"858","DOI":"10.2527\/1996.744858x","article-title":"Plasma and milk urea nitrogen in relation to pregnancy rate in lactating dairy cattle","volume":"74","author":"Butler","year":"1996","journal-title":"J. Anim. Sci."},{"key":"ref_86","doi-asserted-by":"crossref","unstructured":"Krisher, R.L. (2013). Oocyte metabolism and its relationship to developmental competence. Oocyte Physiology and Development in Domestic Animals, Wiley-Blackwell.","DOI":"10.1002\/9781118538074"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1093\/humupd\/dmaa043","article-title":"Metabolic co-dependence of the oocyte and cumulus cells: Essential role in determining oocyte developmental competence","volume":"27","author":"Richani","year":"2021","journal-title":"Hum. Reprod. Update"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/S1090-0233(02)00310-6","article-title":"The role of essential trace elements in embryonic and fetal development in livestock","volume":"166","author":"Hostetler","year":"2003","journal-title":"Vet. J."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1039\/C4MT00228H","article-title":"X-ray fluorescence imaging and other analyses identify selenium and GPX1 as important in female reproductive function","volume":"7","author":"Ceko","year":"2015","journal-title":"Metallomics"},{"key":"ref_90","doi-asserted-by":"crossref","unstructured":"Wang, B., Li, X., Zhou, Z., Zhu, Y., Zuo, Z., and Guo, H. (2026). The role of five key minerals (Cu, Se, Zn, Co, Fe) in reproductive function of female cattle: Current insights and future directions. Vet. Sci., 13.","DOI":"10.3390\/vetsci13020208"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"497","DOI":"10.21451\/1984-3143-AR992","article-title":"Negative energy balance and metabolic stress in relation to oocyte and embryo quality: An update on possible pathways reducing fertility in dairy cows","volume":"14","author":"Leroy","year":"2017","journal-title":"Anim. Reprod."},{"key":"ref_92","doi-asserted-by":"crossref","unstructured":"Wathes, D.C. (2022). Developmental Programming of Fertility in Cattle\u2014Is It a Cause for Concern?. Animals, 12.","DOI":"10.3390\/ani12192654"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"100782","DOI":"10.1016\/j.animal.2023.100782","article-title":"Gestational and Postnatal Nutritional Effects on the Neuroendocrine Control of Puberty in Heifers","volume":"17","author":"Garza","year":"2023","journal-title":"Animal"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"107458","DOI":"10.1016\/j.anireprosci.2024.107458","article-title":"Developmental Programming of the Ovarian Reserve in Livestock","volume":"264","author":"Cushman","year":"2024","journal-title":"Anim. Reprod. Sci."},{"key":"ref_95","doi-asserted-by":"crossref","unstructured":"Moriel, P., Palmer, E.A., Harvey, K.M., and Cooke, R.F. (2021). Improving Beef Progeny Performance Through Developmental Programming. Front. Anim. Sci., 2.","DOI":"10.3389\/fanim.2021.728635"},{"key":"ref_96","doi-asserted-by":"crossref","unstructured":"Noya, A., Casas\u00fas, I., Ferrer, J., and Sanz, A. (2019). Effects of Developmental Programming Caused by Maternal Nutrient Intake on Postnatal Performance of Beef Heifers and Their Calves. Animals, 9.","DOI":"10.3390\/ani9121072"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.mce.2011.11.013","article-title":"Role of the Pre- and Post-Natal Environment in Developmental Programming of Health and Productivity","volume":"354","author":"Reynolds","year":"2012","journal-title":"Mol. Cell. Endocrinol."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1095\/biolreprod.112.107235","article-title":"Maternal undernutrition in cows impairs ovarian and cardiovascular systems in their offspring","volume":"88","author":"Mossa","year":"2013","journal-title":"Biol. Reprod."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1111\/j.1439-0531.2012.02052.x","article-title":"Effects of maternal environment during gestation on ovarian folliculogenesis and consequences for fertility in bovine offspring","volume":"47","author":"Evans","year":"2012","journal-title":"Reprod. Domest. Anim."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"2355","DOI":"10.3168\/jds.2011-4325","article-title":"Low numbers of ovarian follicles \u22653 mm in diameter are associated with low fertility in dairy cows","volume":"95","author":"Mossa","year":"2012","journal-title":"J. Dairy Sci."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1016\/j.theriogenology.2015.06.010","article-title":"Influence of puberty and antral follicle count on calving day in crossbred beef heifers","volume":"84","author":"McNeel","year":"2015","journal-title":"Theriogenology"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"2326","DOI":"10.1017\/S1751731120001159","article-title":"Effects of micronutrient supplementation on performance and epigenetic status in dairy cows","volume":"14","author":"Gasselin","year":"2020","journal-title":"Animal"},{"key":"ref_103","doi-asserted-by":"crossref","unstructured":"W\u00f3jcik, E., K\u0119pka, K., and Skup, M. (2023). Effect of selected micro- and macroelements and vitamins on the genome stability of bovine embryo transfer recipients following in vitro fertilization. Animals, 13.","DOI":"10.3390\/ani13061056"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1095\/biolreprod.108.071670","article-title":"Antral follicle count reliably predicts number of morphologically healthy oocytes and follicles in ovaries of young adult cattle","volume":"79","author":"Ireland","year":"2008","journal-title":"Biol. Reprod."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1071\/AN14470","article-title":"Nutritional programming and the reproductive function of the offspring","volume":"54","author":"Dupont","year":"2014","journal-title":"Anim. Prod. Sci."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.anireprosci.2004.04.003","article-title":"Effects of maternal nutrition on fetal and neonatal reproductive development and function","volume":"82\u201383","author":"Rhind","year":"2004","journal-title":"Anim. Reprod. Sci."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1017\/S1751731114000834","article-title":"Nutritional management to optimize fertility of dairy cows in pasture-based systems","volume":"8","author":"Butler","year":"2014","journal-title":"Animal"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.anireprosci.2004.11.008","article-title":"Effect of dietary protein on embryo recovery rate and quality in superovulated heifers","volume":"87","author":"Mikkola","year":"2005","journal-title":"Anim. Reprod. Sci."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"449","DOI":"10.5187\/jast.2020.62.4.449","article-title":"Nutrient requirements in Hanwoo cows with artificial insemination: Effects on blood metabolites and embryo recovery rate","volume":"62","author":"Kang","year":"2020","journal-title":"J. Anim. Sci. Technol."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.theriogenology.2020.02.006","article-title":"Metabolic biomarkers, body condition, uterine inflammation and response to superovulation in lactating Holstein cows","volume":"146","author":"Kasimanickam","year":"2020","journal-title":"Theriogenology"},{"key":"ref_111","first-page":"65","article-title":"Influence of body condition of dairy cows on the oocyte and embryo quality in vitro","volume":"47","author":"Makarevich","year":"2012","journal-title":"Reprod. Domest. Anim."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1146\/annurev-animal-111523-102249","article-title":"Lipotoxicity and oocyte quality in mammals: Pathogenesis, consequences, and reversibility","volume":"13","author":"Meulders","year":"2025","journal-title":"Annu. Rev. Anim. Biosci."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"8470","DOI":"10.3168\/jds.2022-21919","article-title":"Effects of early lactation body condition loss in dairy cows on serum lipid profiles and on oocyte and cumulus cell transcriptomes","volume":"105","author":"Ruebel","year":"2022","journal-title":"J. Dairy Sci."},{"key":"ref_114","doi-asserted-by":"crossref","unstructured":"Van Hoeck, V., Sturmey, R.G., Bermejo-Alvarez, P., Rizos, D., Gutierrez-Adan, A., Leese, H.J., Bols, P.E., and Leroy, J.L. (2011). Elevated non-esterified fatty acid concentrations during bovine oocyte maturation compromise early embryo physiology. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0023183"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.anireprosci.2014.07.015","article-title":"Reduced oocyte and embryo quality in response to elevated non-esterified fatty acid concentrations: A possible pathway to subfertility?","volume":"149","author":"Bols","year":"2014","journal-title":"Anim. Reprod. Sci."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.theriogenology.2016.04.062","article-title":"The functional role of insulin in fertility and embryonic development\u2014What can we learn from the bovine model?","volume":"86","author":"Laskowski","year":"2016","journal-title":"Theriogenology"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1210\/me.2012-1307","article-title":"IGF-I signaling is essential for FSH stimulation of AKT and steroidogenic genes in granulosa cells","volume":"27","author":"Zhou","year":"2013","journal-title":"Mol. Endocrinol."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.anireprosci.2005.02.009","article-title":"Detrimental effects of high plasma urea nitrogen levels on viability of embryos from lactating dairy cows","volume":"91","author":"Rhoads","year":"2006","journal-title":"Anim. Reprod. Sci."},{"key":"ref_119","doi-asserted-by":"crossref","unstructured":"Shokrollahi, B., Park, M., Jang, G.S., Jin, S., Moon, S.J., Um, K.H., Jang, S.S., and Baek, Y.C. (2025). Maternal overnutrition in beef cattle: Effects on fetal programming, metabolic health, and postnatal outcomes. Biology, 14.","DOI":"10.3390\/biology14060645"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1530\/REP-18-0644","article-title":"Effects of an n-3 polyunsaturated fatty acid-enriched diet on embryo production in dairy cows","volume":"158","author":"Freret","year":"2019","journal-title":"Reproduction"},{"key":"ref_121","doi-asserted-by":"crossref","unstructured":"Kussano, N.R., Franco, M.M., and Dode, M.A.N. (2024). Biochemical profiling of the follicular environment to predict oocyte competence in cattle. PLoS ONE, 19.","DOI":"10.1371\/journal.pone.0298316"},{"key":"ref_122","first-page":"e220090","article-title":"Biochemical alterations in the follicular fluid of bovine peri-ovulatory follicles and association with final oocyte maturation","volume":"4","author":"Alrabiah","year":"2022","journal-title":"Reprod. Fertil."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.theriogenology.2023.05.016","article-title":"The relationship between bovine blastocyst formation in vitro and follicular fluid amino acids","volume":"206","author":"Sanei","year":"2023","journal-title":"Theriogenology"},{"key":"ref_124","doi-asserted-by":"crossref","unstructured":"Su, X., Gao, G., Chen, L., Zhang, L., Liu, G., Bian, C., Su, G., and Yang, L. (2025). Identification of candidate blood biomarkers through metabolomics analysis in bovine superovulation. Front. Vet. Sci., 12.","DOI":"10.3389\/fvets.2025.1552045"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"113863","DOI":"10.1016\/j.celrep.2024.113863","article-title":"Integrated stress response signaling acts as a metabolic sensor in fat tissues to regulate oocyte maturation and ovulation","volume":"43","author":"Grmai","year":"2024","journal-title":"Cell Rep."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.theriogenology.2007.09.008","article-title":"Factors affecting success of embryo collection and transfer in large dairy herds","volume":"69","author":"Chebel","year":"2008","journal-title":"Theriogenology"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1071\/RD09221","article-title":"Factors affecting fertilisation and early embryo quality in single- and superovulated dairy cattle","volume":"22","author":"Sartori","year":"2010","journal-title":"Reprod. Fertil. Dev."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.theriogenology.2005.09.025","article-title":"Modifying oocytes and embryos to improve their cryopreservation","volume":"65","author":"Seidel","year":"2006","journal-title":"Theriogenology"},{"key":"ref_129","first-page":"411","article-title":"Effects of energy balance on follicular development and first ovulation in postpartum dairy cows","volume":"54","author":"Beam","year":"1999","journal-title":"J. Reprod. Fertil. Suppl."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/S0749-0720(15)31125-7","article-title":"Effects of nutrition on reproduction in dairy cows","volume":"3","author":"Weaver","year":"1987","journal-title":"Vet. Clin. Food Anim. Pract."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1111\/j.1439-0531.2008.01147.x","article-title":"Genetic improvement of dairy cow reproductive performance","volume":"43","author":"Berglund","year":"2008","journal-title":"Reprod. Domest. Anim."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.prevetmed.2015.04.011","article-title":"Associations of peripartum markers of stress and inflammation with milk yield and reproductive performance in Holstein dairy cows","volume":"120","author":"Huzzey","year":"2015","journal-title":"Prev. Vet. Med."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"3167","DOI":"10.1007\/s10815-025-03636-w","article-title":"Advances in supplementation strategies for enhancing bovine in vitro embryo production: A review of growth factors and antioxidants","volume":"42","author":"Kereilwe","year":"2025","journal-title":"J. Assist. Reprod. Genet."},{"key":"ref_134","unstructured":"Lopez-Rodriguez, A., Salfer, I.J., Gebremedhn, S., and Webb, R. (2021). Nutritional stress, folliculogenesis, and embryo quality in cattle. Animals, 11."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1016\/S0093-691X(03)00119-5","article-title":"Relationships between transition period diet, metabolic parameters and fertility in lactating dairy cows","volume":"60","author":"Pushpakumara","year":"2003","journal-title":"Theriogenology"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"2775","DOI":"10.3168\/jds.S0022-0302(97)76240-4","article-title":"Estimation of economic values of indices for reproductive performance in dairy herds using computer simulation","volume":"80","author":"Plaizier","year":"1997","journal-title":"J. Dairy Sci."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1016\/j.theriogenology.2010.04.008","article-title":"Economic consequences of reproductive performance in dairy cattle","volume":"74","author":"Inchaisri","year":"2010","journal-title":"Theriogenology"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"100117","DOI":"10.1016\/j.animal.2020.100117","article-title":"Economic analysis of the use of in vitro produced embryos transferred during heat stress under dairy herd constraints","volume":"15","author":"Ferreira","year":"2021","journal-title":"Animal"},{"key":"ref_139","doi-asserted-by":"crossref","unstructured":"Gimeno, I., Berdasco, M., Pato, M.L., Salvetti, P., Carrocera, S., Goyache, F., Garc\u00eda, A., Vicente, F., and G\u00f3mez, E. (2026). Long-term metabolic and developmental effects of in vitro embryo technologies in female cattle. J. Dairy Sci., in press.","DOI":"10.3168\/jds.2025-26902"},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"2555","DOI":"10.1093\/jas\/skz116","article-title":"BOARD INVITED REVIEW: Post-transfer consequences of in vitro-produced embryos in cattle","volume":"97","author":"Ealy","year":"2019","journal-title":"J. Anim. Sci."},{"key":"ref_141","unstructured":"Lamb, G.C., Mercadante, V.R.G., and Fontes, P.L.P. (2016, January 7\u20138). Donor and recipient management to optimize embryo technology success. Proceedings of the Applied Reproductive Strategies in Beef Cattle, Des Moines, IA, USA."},{"key":"ref_142","doi-asserted-by":"crossref","unstructured":"Fernandez-Novo, A., P\u00e9rez-Garnelo, S.S., Villagr\u00e1, A., P\u00e9rez-Villalobos, N., and Astiz, S. (2020). The effect of stress on reproduction and reproductive technologies in beef cattle\u2014A review. Animals, 10.","DOI":"10.3390\/ani10112096"},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1093\/biolre\/ioaa224","article-title":"The effects of assisted reproduction technologies on metabolic health and disease","volume":"104","author":"Heber","year":"2021","journal-title":"Biol. Reprod."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1111\/j.1439-0531.2012.02090.x","article-title":"Mechanisms linking metabolic status and disease with reproductive outcome in the dairy cow","volume":"47","author":"Wathes","year":"2012","journal-title":"Reprod. Domest. Anim."},{"key":"ref_145","first-page":"1","article-title":"Nutritional, technological and managerial parameters for precision feeding to enhance feed nutrient utilization and productivity in different dairy cattle production systems","volume":"11","author":"Makkar","year":"2016","journal-title":"CABI Rev."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"e20230077","DOI":"10.1590\/1984-3143-ar2023-0077","article-title":"Applications of livestock monitoring devices and machine learning algorithms in animal production and reproduction: An overview","volume":"20","author":"Curti","year":"2023","journal-title":"Anim. Reprod."},{"key":"ref_147","doi-asserted-by":"crossref","unstructured":"Naspinska, R., Moreira da Silva, M.H., and Moreira da Silva, F. (2023). Current advances in bovine in vitro maturation and embryo production using different antioxidants: A review. J. Dev. Biol., 11.","DOI":"10.3390\/jdb11030036"},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1111\/rda.12946","article-title":"Effects of supplementation of medium with different antioxidants during in vitro maturation of bovine oocytes on subsequent embryo production","volume":"52","author":"Sovernigo","year":"2017","journal-title":"Reprod. Domest. Anim."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"107186","DOI":"10.1016\/j.anireprosci.2022.107186","article-title":"Mechanisms of action of non-enzymatic antioxidants to control oxidative stress during in vitro follicle growth, oocyte maturation, and embryo development","volume":"249","author":"Silva","year":"2023","journal-title":"Anim. Reprod. Sci."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1186\/s40104-025-01188-8","article-title":"Feeding rumen-protected choline during the periconceptional period programs postnatal phenotype of suckled beef calves","volume":"16","author":"Sagheer","year":"2025","journal-title":"J. Anim. Sci. Biotechnol."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/s43170-022-00080-z","article-title":"Synergistic power of genomic selection, assisted reproductive technologies, and gene editing to drive genetic improvement of cattle","volume":"3","author":"Mueller","year":"2022","journal-title":"CABI Agric. Biosci."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"899","DOI":"10.21451\/1984-3143-AR2018-0017","article-title":"Influences of nutrition and metabolism on reproduction of the female ruminant","volume":"15","author":"Meikle","year":"2018","journal-title":"Anim. Reprod."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"3510","DOI":"10.3168\/jds.2010-3547","article-title":"An evaluation of the effect of altering nutrition and nutritional strategies in early lactation on reproductive performance and estrous behavior of high-yielding Holstein-Friesian dairy cows","volume":"94","author":"Gilmore","year":"2011","journal-title":"J. Dairy Sci."}],"container-title":["Animals"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-2615\/16\/6\/892\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T15:31:31Z","timestamp":1773329491000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-2615\/16\/6\/892"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,12]]},"references-count":153,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2026,3]]}},"alternative-id":["ani16060892"],"URL":"https:\/\/doi.org\/10.3390\/ani16060892","relation":{},"ISSN":["2076-2615"],"issn-type":[{"value":"2076-2615","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,12]]}}}