{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T19:55:12Z","timestamp":1790970912728,"version":"4.1.0"},"reference-count":247,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T00:00:00Z","timestamp":1775865600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animals"],"abstract":"<jats:p>Tail biting is a widespread problem in pig production worldwide and a major cause of reduced welfare in pigs. To prevent this harmful behavior, it is a common practice to optimize husbandry and enrich the environment with organic materials. Fiber-rich materials such as straw, hay, or alfalfa reduce tail biting. These observations were also made for swine inflammation and necrosis syndrome (SINS), which causes acral necrosis and increase the risk for tail biting. A supplementation of the diet with straw and hay significantly reduced systemic inflammation in pigs. Organic materials and feed components play an important role in preventing tail biting and SINS. Gut health in particular is influenced by diet and its components. Different effects of nutritional ingredients could disrupt the balance of the gut microbiota, damage the intestinal barrier and results in leaky gut and systemic inflammation. This inflammatory response can induce SINS and behavioral changes. The aim of this literature review is to summarize current knowledge on the effects of feeding and gut health on the occurrence of tail biting and SINS in pigs and to derive possible measures for prevention.<\/jats:p>","DOI":"10.3390\/ani16081174","type":"journal-article","created":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T07:29:29Z","timestamp":1776065369000},"page":"1174","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Feeding of Undocked Pigs: Effects of Feed Components and Feed Composition"],"prefix":"10.3390","volume":"16","author":[{"given":"Frederik","family":"Loewenstein","sequence":"first","affiliation":[{"name":"LSZ Boxberg, Seeh\u00f6fer Str. 50, 97944 Boxberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Mascher","sequence":"additional","affiliation":[{"name":"Tier\u00e4rzte Team Tiefenbach, Steig\u00e4ckerweg 10, 74564 Crailsheim, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanja","family":"Frey","sequence":"additional","affiliation":[{"name":"Pig Health Service Baden-W\u00fcrttemberg, Schaflandstr. 3\/3, 70736 Fellbach, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-6305-6543","authenticated-orcid":false,"given":"Mirjam","family":"Lechner","sequence":"additional","affiliation":[{"name":"Independent Researcher, Am Wasen 20, 91567 Herrieden, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,4,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.tvjl.2009.08.028","article-title":"Tail-biting: A new perspective","volume":"186","author":"Taylor","year":"2010","journal-title":"Vet. J."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.tvjl.2009.02.021","article-title":"Tail biting induces a strong acute phase response and tail-end inflammation in finishing pigs","volume":"184","author":"Heinonen","year":"2010","journal-title":"Vet. J."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"European Food Safety Authority (EFSA) (2007). Scientific Opinion of the Panel on Animal Health and Welfare on a request from Commission on the risks associated with tail biting in pigs and possible means to reduce the need for tail docking considering the different housing and husbandry systems. EFSA J., 5, 611.","DOI":"10.2903\/j.efsa.2007.611"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"European Food Safety Authority (EFSA) (2014). Scientific Opinion concerning a multifactorial approach on the use of animal and non-animal-based measures to assess the welfare of pigs. EFSA J., 12, 3702.","DOI":"10.2903\/j.efsa.2014.3702"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.applanim.2016.08.004","article-title":"Effects of different enrichment devices on some welfare indicators of post-weaned undocked piglets","volume":"184","author":"Nannoni","year":"2016","journal-title":"Appl. Anim. Behav. Sci."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"21","DOI":"10.7120\/09627286.27.1.021","article-title":"Case control study on environmental, nutritional and management-based risk factors for tail-biting in long-tailed pigs","volume":"27","author":"Kallio","year":"2018","journal-title":"Anim. Welf."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1017\/S1751731114001359","article-title":"Injurious tail biting in pigs: How can it be controlled in existing systems without tail docking?","volume":"8","author":"Arnott","year":"2014","journal-title":"Animal"},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Reiner, G., Kuehling, J., Loewenstein, F., Lechner, M., and Becker, S. (2021). Swine Inflammation and Necrosis Syndrome (SINS). Animals, 11.","DOI":"10.3390\/ani11061670"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/s40813-020-00170-2","article-title":"Swine inflammation and necrosis syndrome is influenced by husbandry and quality of sow in suckling piglets, weaners and fattening pigs","volume":"6","author":"Reiner","year":"2020","journal-title":"Porc. Health Manag."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/j.anscip.2023.08.014","article-title":"13 (P1\u20139). Maternal sow feed and hygiene influence their offspring. 1\u2014Swine inflammatory and necrotic syndrome assessment on pre-weaning piglets","volume":"14","author":"Lemoine","year":"2023","journal-title":"Anim. Sci. Proc."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1016\/j.anscip.2023.08.015","article-title":"14 (P1\u201310). Maternal sow feed and hygiene influence their offspring. 2\u2014Incidence and severity of tail biting, post-weaning","volume":"14","author":"Guillou","year":"2023","journal-title":"Anim. Sci. Proc."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"2007","DOI":"10.1017\/S1751731118003403","article-title":"Prevalence of an inflammation and necrosis syndrome in suckling piglets","volume":"13","author":"Reiner","year":"2019","journal-title":"Animal"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Leite, N.L., Knol, E.F., Nuphaus, S., Tsuruta, S., Vogelzang, R., and Lourenco, D. (2022, January 3\u20138). Swine inflammation and necrosis syndrome (SINS) and its association with biting behavior after weaning. Proceedings of the 12th World Congress on Genetics Applied to Livestock Production, Rotterdam, The Netherlands.","DOI":"10.3920\/978-90-8686-940-4_83"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.applanim.2005.08.021","article-title":"Formalised review of environmental enrichment for pigs in relation to political decision making","volume":"98","author":"Bracke","year":"2006","journal-title":"Appl. Anim. Behav. Sci."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Buijs, S., and Muns, R. (2019). A review of the effects of non-straw enrichment on tail biting in pigs. Animals, 9.","DOI":"10.3390\/ani9100824"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.applanim.2005.10.014","article-title":"Effects of species-relevant environmental enrichment on the behaviour and productivity of finishing pigs","volume":"99","author":"Docking","year":"2006","journal-title":"Appl. Anim. Behav. Sci."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.applanim.2007.02.006","article-title":"The effect of varying lengths of straw bedding on the behaviour of growing pigs","volume":"109","author":"Day","year":"2008","journal-title":"Appl. Anim. Behav. Sci."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.applanim.2018.10.013","article-title":"Implication and impact of straw provision on behaviour, lesions and pen hygiene on commercial farms rearing undocked pigs","volume":"210","author":"Wallgren","year":"2019","journal-title":"Appl. Anim. Behav. Sci."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.livsci.2018.06.010","article-title":"Early intervention with enrichment can prevent tail biting outbreaks in weaner pigs","volume":"214","author":"Lahrmann","year":"2018","journal-title":"Livest. Sci."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.livsci.2016.07.009","article-title":"Influence of raw material on the occurrence of tail-biting in undocked pigs","volume":"191","author":"Veit","year":"2016","journal-title":"Livest. Sci."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.livsci.2018.10.012","article-title":"Grass silage f\u00fcr growing-finishing pigs in addition to straw bedding: Effects on behaviour and gastric health","volume":"218","author":"Holinger","year":"2018","journal-title":"Livest. Sci."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1002\/mrd.23642","article-title":"Reproductive health of the sow during puerperium","volume":"90","author":"Kauffold","year":"2023","journal-title":"Mol. Reprod. Dev."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"e00591-20","DOI":"10.1128\/mSystems.00591-20","article-title":"Consumption of dietary fiber from different sources during pregnancy alters sow gut microbiota and improves performance and reduces inflammation in sows and piglets","volume":"6","author":"Liu","year":"2021","journal-title":"mSystems"},{"key":"ref_24","unstructured":"Zonderland, J.J., Bosma, B., and Hoste, R. (2011). Financi\u00eble Consequenties van Staartbijten bij Varkens, Wageningen UR Livestock Research. Rappaport 543."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1017\/S1751731115002098","article-title":"Why are most EU pigs tail docked? Economic and ethical analysis of four pig housing and management scenarios in the light of EU legislation and animal welfare outcomes","volume":"10","author":"Niemi","year":"2016","journal-title":"Animal"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1053\/tvjl.2001.0605","article-title":"Tail biting in pigs","volume":"162","author":"Simonsen","year":"2001","journal-title":"Vet. J."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/s40813-018-0103-8","article-title":"Phasing out pig tail docking in the EU\u2014Present state, challenges and possibilities","volume":"4","author":"Berg","year":"2018","journal-title":"Porc. Health Manag."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.applanim.2016.08.013","article-title":"Can tail-in-mouth behaviour in weaned piglets be predicted by behaviour and performance?","volume":"184","author":"Munsterhjelm","year":"2016","journal-title":"Appl. Anim. Behav. Sci."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"2609","DOI":"10.1017\/S1751731118000563","article-title":"The effect of docking length on the risk of tail biting, tail-directed behaviour, aggression and activity level of growing pigs kept under commercial conditions","volume":"12","author":"Thodberg","year":"2018","journal-title":"Animal"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"287","DOI":"10.7120\/09627286.25.2.287","article-title":"Behavioural differences between weaner pigs with intact and docked tails","volume":"25","author":"Paoli","year":"2016","journal-title":"Anim. Welf."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.1017\/S1751731117000490","article-title":"More tail lesions among undocked than tail docked pigs in a conventional herd","volume":"11","author":"Lahrmann","year":"2017","journal-title":"Animal"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.applanim.2014.04.001","article-title":"Tail biting behaviour and tail damage in pigs and the relationship with general behaviour: Predicting the inevitable?","volume":"156","author":"Ursinus","year":"2014","journal-title":"Appl. Anim. Behav. Sci."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.applanim.2017.12.006","article-title":"Tail posture predicts tail biting outbreaks at pen level in weaner pigs","volume":"200","author":"Lahrmann","year":"2018","journal-title":"Appl. Anim. Behav. Sci."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.applanim.2009.09.002","article-title":"Tail posture predicts tail damage among weaned piglets","volume":"121","author":"Zonderland","year":"2009","journal-title":"Appl. Anim. Behav. Sci."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.applanim.2018.08.008","article-title":"Early indicators of tail biting outbreaks in pigs","volume":"208","author":"Wedin","year":"2018","journal-title":"Appl. Anim. Behav. Sci."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.applanim.2018.08.016","article-title":"Tail posture as a detector of tail damage and an early detector of tail biting in finishing pigs","volume":"209","author":"Larsen","year":"2018","journal-title":"Appl. Anim. Behav. Sci."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Wallgren, T., Larsen, A., and Gunnarsson, S. (2019). Tail posture as indicator of tail biting in undocked finishing pigs. Animals, 9.","DOI":"10.3390\/ani9010018"},{"key":"ref_38","unstructured":"Steuert, L. (1943). Das Buch Vom Gesunden und Kranken Haustier, Paul Parey Verlag. [11th ed.]."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"2056","DOI":"10.1152\/japplphysiol.01138.2006","article-title":"Free radical-mediated skeletal muscle dysfunction in inflammatory conditions","volume":"102","author":"Supinski","year":"2007","journal-title":"J. Appl. Physiol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1111\/j.1939-1676.1999.tb02207.x","article-title":"Coccygeal muscle injury in English Pointers (limber tail)","volume":"13","author":"Steiss","year":"1999","journal-title":"J. Vet. Intern. Med."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"100078","DOI":"10.1016\/j.animal.2020.100078","article-title":"An in-depth diagnostic exploration of an inflammation and necrosis syndrome in a population of newborn piglets","volume":"15","author":"Kuehling","year":"2021","journal-title":"Animal"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/0007-1935(91)90082-X","article-title":"Histopathology of intact and docked pigtails","volume":"147","author":"Simonsen","year":"1991","journal-title":"Br. Vet. J."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"105079","DOI":"10.1016\/j.applanim.2020.105079","article-title":"Tail postures and tail motion in pigs: A review","volume":"230","author":"Camerlink","year":"2020","journal-title":"Appl. Anim. Behav. Sci."},{"key":"ref_44","first-page":"814","article-title":"Health parameters in tail biters and bitten pigs in a case-control study","volume":"7","author":"Munsterhjelm","year":"2013","journal-title":"Animals"},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Van de Weerd, H., and Ison, S. (2019). Providing effective environmental enrichment to pigs: How far have we come?. Animals, 9.","DOI":"10.3390\/ani9050254"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.applanim.2010.09.010","article-title":"A meta-analysis of the combined effect of housing and environmental enrichment characteristics on the behaviour and performance of pigs","volume":"127","author":"Brossard","year":"2010","journal-title":"Appl. Anim. Behav. Sci."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Gody\u0144, D., Nowicki, J., and Herbut, P. (2019). Effects of environmental enrichment on pig welfare\u2014A review. Animals, 9.","DOI":"10.3390\/ani9060383"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"105923","DOI":"10.1016\/j.applanim.2023.105923","article-title":"Validation of non-invasive sensor technologies to measure interaction with enrichment material in weaned fattening pigs","volume":"263","author":"Veldkamp","year":"2023","journal-title":"Appl. Anim. Behav. Sci."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Nalon, E., and De Briyne, N. (2019). Efforts to ban the routine tail docking of pigs and give pigs enrichment materials via EU law: Where do we stand a quarter of a century on?. Animals, 9.","DOI":"10.3390\/ani9040132"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1","DOI":"10.5713\/ajas.17.0138","article-title":"Effects of environmental enrichment on behaviour, physiology and performance of pigs\u2014A review","volume":"32","author":"Mkwanazi","year":"2019","journal-title":"Asian-Australas. J. Anim. Sci."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"12","DOI":"10.54846\/jshap\/1074","article-title":"Effects of pigs per feeder hole and group size on feed intake onset, growth performance, and ear and tail lesions in nursery pigs with consistent space allowance","volume":"27","author":"Laskoski","year":"2019","journal-title":"J. Swine Health Prod."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"104533","DOI":"10.1016\/j.livsci.2021.104533","article-title":"Effects of different feeder and floor space allowances on growth performance and welfare aspects in nursery pigs","volume":"249","author":"Laskoski","year":"2021","journal-title":"Livest. Sci."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/s13028-023-00716-8","article-title":"Impact of feed, light and access to manipulable material on tail biting in pigs with intact tails","volume":"66","author":"Wallgren","year":"2024","journal-title":"Acta Vet. Scand."},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"van der Meer, Y., Gerrits, W.J.J., Jansman, A.J.M., Kemp, B., and Bolhuis, J.E. (2023). A link between damaging behaviour in pigs, sanitary conditions, and dietary protein and amino acid supply. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0174688"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"14299","DOI":"10.1038\/s41598-023-41232-z","article-title":"Phenotypic link between protein efficiency and pig welfare suggests no apparent trade-offs for mitigating nitrogen pollution","volume":"13","author":"Roch","year":"2023","journal-title":"Sci. Rep."},{"key":"ref_56","first-page":"95","article-title":"Effet d\u2019un ajout de fibres e de tryptophane et du niveau de plafonnement alimentaire sur l\u2019\u00e9tat des queues de porcs charcutier sans caudectomie","volume":"53","author":"Roux","year":"2021","journal-title":"J. Rech. Porc."},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Chou, J.-Y., O\u2019Driscoll, K., Sandercock, D.A., and D\u2019Eath, R.B. (2020). Can increased dietary fibre level and a single enrichment device reduce the risk of tail biting in undocked growing-finishing pigs in fully-slatted systems?. PLoS ONE, 15.","DOI":"10.1371\/journal.pone.0241619"},{"key":"ref_58","unstructured":"Kauselmann, K., Schrader, L., Glitz, B., Gallmann, E., Schrade, H., and Krause, E.T. (2020). Turning the gaze to maize: The effects of maize kernels in straw as enrichment on exploration in pigs. Berl. M\u00fcnchener Tier\u00e4rztliche Wochenschr., 133."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"100239","DOI":"10.1016\/j.animal.2021.100239","article-title":"Tasty straw pellets\u2014Exploration of flavoured rooting material by pigs","volume":"15","author":"Kauselmann","year":"2021","journal-title":"Animal"},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Kauselmann, K., Schrader, L., Schrade, H., and Krause, E.T. (2021). The effects of refilling additional rooting material on exploration duration and tail damages in rearing and fattening pigs. Front. Anim. Sci., 2.","DOI":"10.3389\/fanim.2021.749583"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"105261","DOI":"10.1016\/j.applanim.2021.105261","article-title":"Effect of plant-based enrichment materials on exploration in rearing and fattening pigs (Sus scrofa domesticus)","volume":"236","author":"Kauselmann","year":"2021","journal-title":"Appl. Anim. Behav. Sci."},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Henry, M., Shoveller, A.K., O\u2019Sullivan, T.L., Niel, L., and Friendship, R. (2022). Effect of varying levels of dietary tryptophan on aggression and abnormal behavior in growing pigs. Front. Vet. Sci., 9.","DOI":"10.3389\/fvets.2022.849970"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"skaf030","DOI":"10.1093\/jas\/skaf030","article-title":"Exploring the effects of dietary lysine and tryptophan on the social behavior of pigs","volume":"103","author":"Hewett","year":"2025","journal-title":"J. Anim. Sci."},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Kogut, M.H., and Arsenault, R.J. (2016). Editorial: Gut health: The new paradigm in food animal production. Front. Vet. Sci., 3.","DOI":"10.3389\/fvets.2016.00071"},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Colombino, E., Prieto-Botella, D., and Capucchio, M.T. (2021). Gut health in veterinary medicine: A bibliometric analysis of the literature. Animals, 11.","DOI":"10.3390\/ani11071997"},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Walter, M.P., Miotto Galli, G., Zem Fraga, A., Santos Silva, A., Furtado, J.C.V., Viera Ascari, P.J., and Andretta, I. (2025). Assessing intestinal health in pigs: Recognizing unaddressed areas and prospective research avenues. Vet. Sci., 12.","DOI":"10.3390\/vetsci12050475"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-0-387-09550-9_1","article-title":"Overview of gut immunology","volume":"635","author":"Mason","year":"2008","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.aninu.2021.01.001","article-title":"Gut health: The results of microbial and mucosal immune interactions in pigs","volume":"7","author":"Peng","year":"2021","journal-title":"Anim. Nutr."},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Szab\u00f3, C., Kachungwa Lugata, J., and Ortega, A.D.S.V. (2023). Gut health and influencing factors in pigs. Animals, 13.","DOI":"10.3390\/ani13081350"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1080\/19490976.2019.1690363","article-title":"Interactions between host and gut microbiota in domestic pigs: A review","volume":"11","author":"Patil","year":"2020","journal-title":"Gut Microbes"},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Kubasova, T., Davidova-Gerzova, L., Babak, V., Cejkova, D., Montagne, L., Le-Floc\u2019h, N., and Rychlik, I. (2018). Effects of host genetics and environmental conditions on fecal microbiota composition of pigs. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0201901"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1186\/s40168-020-00888-9","article-title":"Gut microbiome composition differences among breeds impact feed efficiency in swine","volume":"8","author":"Bergamaschi","year":"2020","journal-title":"Microbiome"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1007\/s10123-023-00449-8","article-title":"Composition and evolutionary characterization of the gut microbiota in pigs","volume":"27","author":"Zhang","year":"2024","journal-title":"Int. Microbiol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"e00477-21","DOI":"10.1128\/msystems.00477-21","article-title":"Comprehensive cultivation of the swine gut microbiome reveals high bacterial diversity and guides bacterial isolation in pigs","volume":"6","author":"Wang","year":"2021","journal-title":"mSystems"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"12727","DOI":"10.1038\/s41598-018-30932-6","article-title":"Chracterization of bacterial microbiota compositions along the intestinal tract in pigs and their interactions and functions","volume":"8","author":"Revilla","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1186\/s40104-022-00790-4","article-title":"Maintenance of gut microbiome stability for optimum intestinal health in pigs\u2014A review","volume":"13","author":"Upadhaya","year":"2022","journal-title":"J. Anim. Sci. Biotechnol."},{"key":"ref_77","doi-asserted-by":"crossref","unstructured":"Olszewski, J., Zabielski, R., Skrzypek, T., Matyba, P., Wierzbicka, M., Adamski, A., Grzesiuk, E., Sady, M., Gajewski, Z., and Ferenc, K. (2021). Differences in intestinal barrier development between intrauterine growth restricted and normal birth weight piglets. Animals, 11.","DOI":"10.3390\/ani11040990"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1017\/S0007114510005660","article-title":"Intestinal barrier function and absorption in pigs after weaning: A review","volume":"105","author":"Wijtten","year":"2011","journal-title":"Br. J. Nutr."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"104512","DOI":"10.1016\/j.dci.2022.104512","article-title":"Pigs\u2019 intestinal barrier function is more refined with aging","volume":"136","author":"Yang","year":"2022","journal-title":"Dev. Comp. Immunol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1017\/S1466252316000141","article-title":"Health relevance of intestinal protein fermentation in young pigs","volume":"17","author":"Pieper","year":"2016","journal-title":"Anim. Health Res. Rev."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"4407","DOI":"10.2527\/jas.2014-7673","article-title":"Impact of acute water and feed deprivation events on growth performance, intestinal characteristics, and serum stress markers in weaned pigs","volume":"92","author":"Horn","year":"2014","journal-title":"J. Anim. Sci."},{"key":"ref_82","doi-asserted-by":"crossref","unstructured":"Sattar, A.A., Good, C.R., Saletes, M., Brand\u00e3o, J., and Jackson, S.K. (2022). Endotoxin as a marker for water quality. Int. J. Environ. Res. Public Health, 19.","DOI":"10.3390\/ijerph192416528"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"5444","DOI":"10.2527\/jas.2014-8407","article-title":"Short-term exposure to heat stress attenuates appetite and intestinal integrity in growing pigs","volume":"92","author":"Pearce","year":"2014","journal-title":"J. Anim. Sci."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.2527\/jas.2011-4627","article-title":"Growth and development symposium: Endotoxin, inflammation, and intestinal function in livestock","volume":"90","author":"Mani","year":"2012","journal-title":"J. Anim. Sci."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.taap.2009.03.003","article-title":"The food contaminant deoxynivalenol, decreases intestinal barrier permeability and reduces claudin expression","volume":"137","author":"Pinton","year":"2009","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"G173","DOI":"10.1152\/ajpgi.00197.2006","article-title":"Stress signaling pathways activated by weaning mediate intestinal dysfunction in the pig","volume":"292","author":"Moeser","year":"2007","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.1136\/gutjnl-2019-318427","article-title":"The leaky gut: Mechanisms, measurement and clinical implications in humans","volume":"68","author":"Camilleri","year":"2019","journal-title":"Gut"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"747","DOI":"10.4014\/jmb.2312.12031","article-title":"Diet-induced gut dysbiosis and leaky gut syndrome","volume":"34","author":"Chae","year":"2024","journal-title":"J. Microbiol. Biotechnol."},{"key":"ref_89","doi-asserted-by":"crossref","unstructured":"Obrenovich, M.E.M. (2018). Leaky gut, leaky brain?. Microorganisms, 6.","DOI":"10.3390\/microorganisms6040107"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1172\/JCI76304","article-title":"Gut\/brain axis and the microbiota","volume":"125","author":"Mayer","year":"2015","journal-title":"J. Clin. Investig."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.trsl.2016.10.002","article-title":"Feeding the microbiota-gut-brain axis: Diet, microbiome, and neuropsychiatry","volume":"179","author":"Sandhu","year":"2017","journal-title":"Transl. Res."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.jcmgh.2018.04.003","article-title":"The brain-gut-microbiome axis","volume":"6","author":"Martin","year":"2018","journal-title":"Cell. Mol. Gastroenterol. Hepatol."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1146\/annurev.pathol.4.110807.092135","article-title":"Epithelial barriers in homeostasis and disease","volume":"5","author":"Marchiando","year":"2010","journal-title":"Annu. Rev. Pathol. Mech. Dis."},{"key":"ref_94","doi-asserted-by":"crossref","unstructured":"Homer, B., Judd, J., Dehcheshmeh, M.M., Ebrahimie, E., and Trott, D.J. (2023). Gut microbiota and behavioural issues in production, performance, and companion animals: A systematic review. Animals, 13.","DOI":"10.3390\/ani13091458"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"20547","DOI":"10.1038\/s41598-021-99741-8","article-title":"The gut microbiota and microbial metabolites are associated with tail biting in pigs","volume":"11","author":"Verbeek","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.cell.2015.02.047","article-title":"Indigenous bacteria from the gut microbiota regulate host serotonin biosynthesis","volume":"161","author":"Yano","year":"2015","journal-title":"Cell"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.physbeh.2015.02.049","article-title":"Evidence for a link between tail biting and central monoamine metabolism in pigs (Sus scrofa domestica)","volume":"143","author":"Valros","year":"2015","journal-title":"Physiol. Behav."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"3243","DOI":"10.1038\/s41380-022-01661-0","article-title":"The serotonin theory of depression: A systematic umbrella review of the evidence","volume":"28","author":"Moncrieff","year":"2023","journal-title":"Mol. Psychiatry"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.biochi.2018.06.008","article-title":"Serotonin in the gut: Blessing or a curse","volume":"161","author":"Banskota","year":"2018","journal-title":"Biochimie"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"e14346","DOI":"10.1111\/nmo.14346","article-title":"Direct and indirect mechanisms by which the gut microbiota influence host serotonin systems","volume":"34","author":"Legan","year":"2022","journal-title":"Neurogastroenterol. Motil."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"646","DOI":"10.2174\/1389200220666190725115503","article-title":"The relationship between the serotonin metabolism, gut-microbiota and the gut-brain axis","volume":"20","author":"Stasi","year":"2019","journal-title":"Curr. Drug Metab."},{"key":"ref_102","doi-asserted-by":"crossref","unstructured":"Jian, X., Zheng, D., Pang, S., Mu, P., Jiang, J., Wang, X., Yan, X., Wu, Y., and Wang, Y. (2025). Review: Gut-microbiota\u2014A powerful tool for improving pig welfare by influencing behavior through the gut-brain-axis. Animals, 15.","DOI":"10.3390\/ani15131886"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"105514","DOI":"10.1016\/j.applanim.2021.105514","article-title":"Diet and microbiota-gut-brain-axis in relation to tail biting in pigs: A review","volume":"246","author":"Canibe","year":"2022","journal-title":"Appl. Anim. Behav. Sci."},{"key":"ref_104","first-page":"275","article-title":"Gut microbiota, intestinal permeability, and systemic inflammation: A narrative review","volume":"19","author":"Petito","year":"2023","journal-title":"Intern. Emerg. Med."},{"key":"ref_105","first-page":"375","article-title":"Transport stress\u2014Consequences for bacterial translocation, endogenous contamination and bactericidal activity of serum of slaughter pigs","volume":"114","author":"Seidler","year":"2001","journal-title":"Berl. M\u00fcnchener Tier\u00e4rztliche Wochenschr."},{"key":"ref_106","doi-asserted-by":"crossref","unstructured":"Jamshed, L., Debnath, A., Jamshed, S., Wish, J.V., Raine, J.C., Tomy, G.T., Thomas, P.J., and Holloway, A.C. (2022). An emerging cross-species marker for organismal health: Tryptophan-Kynurenine pathway. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23116300"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"1178646917691938","DOI":"10.1177\/1178646917691938","article-title":"Kynurenine pathway of tryptophan metabolism: Regulatory and functional aspects","volume":"10","author":"Badawy","year":"2017","journal-title":"Int. J. Tryptophan Res."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1111\/febs.14026","article-title":"Regulating the balance between the kynurenine and serotonin pathways of tryptophan metabolism","volume":"284","author":"Li","year":"2017","journal-title":"FEBS J."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1007\/s10753-024-02135-x","article-title":"The kynurenine pathway in gut permeability and inflammation","volume":"48","author":"Kearns","year":"2025","journal-title":"Inflammation"},{"key":"ref_110","first-page":"973548","article-title":"Endotoxin-induced tryptophan degradation along the kynurenine pathway: The role of indolamine 2,3-dioxygenase aryl hydrocarbon receptor-mediated immunosuppressive effects in endotoxin tolerance and cancer and its implications for immunoparalysis","volume":"2015","author":"Wirtghen","year":"2015","journal-title":"J. Amino Acids"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1007\/s40495-019-00208-2","article-title":"Neuropathology of kynurenine pathway of tryptophan metabolism","volume":"6","author":"Tutakhail","year":"2020","journal-title":"Curr. Pharmacol. Rep."},{"key":"ref_112","doi-asserted-by":"crossref","unstructured":"Nordgreen, J., Edwards, S.A., Boyle, L.A., Bolhuis, J.E., Veit, C., Sayyari, A., Marin, D.E., Dimitrov, I., Janczak, A.M., and Valros, A. (2020). A proposed role for pro-inflammatory cytokines in damaging behavior in pigs. Front. Vet. Sci., 7.","DOI":"10.3389\/fvets.2020.00646"},{"key":"ref_113","first-page":"305","article-title":"Dysgalactia in the sow post partum\u2014A review with special emphasis on pathogenesis","volume":"37","author":"Reiner","year":"2009","journal-title":"Tierarztl. Prax."},{"key":"ref_114","doi-asserted-by":"crossref","unstructured":"Becker, S., Hindenlang, K., Kuehling, J., Lechner, M., and Reiner, G. (2025). Inflammation and necrosis syndrome in young piglets\u2014A longitudinal study. Vet. Sci., 12.","DOI":"10.3390\/vetsci12080752"},{"key":"ref_115","doi-asserted-by":"crossref","unstructured":"Koenders-van Gog, K., Wijnands, T., Lechner, M., Reiner, G., and Fink-Gremmels, J. (2025). Screening of piglets for signs of inflammation and necrosis as early life indicators of animal health and welfare hazards. Animals, 15.","DOI":"10.3390\/ani15030378"},{"key":"ref_116","doi-asserted-by":"crossref","unstructured":"Micout, S., Fortune, H., and Reiner, G. (2025). Prevalence and consequences of swine inflammation and necrosis syndrome (SINS) in French herds. Vet. Sci., 12.","DOI":"10.3390\/vetsci12090853"},{"key":"ref_117","doi-asserted-by":"crossref","unstructured":"Koenders-van Gog, K., Wijnands, T., Lechner, M., and Reiner, G. (2026). Logitundinal study: Swine inflammation and necrosis syndrome in suckling and weaned piglets is associated with tail length and integritiy in slaughter pigs. Animals, 16.","DOI":"10.3390\/ani16010056"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/s40813-021-00194-2","article-title":"The effects of boar susceptibility to swine inflammation and necrosis syndrome in piglets","volume":"7","author":"Kuehling","year":"2021","journal-title":"Porc. Health Manag."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1007\/s00335-023-10011-6","article-title":"GWAS reveals genomic associations with swine inflammation and necrosis syndrome","volume":"34","author":"Gerhards","year":"2023","journal-title":"Mamm. Genome"},{"key":"ref_120","doi-asserted-by":"crossref","unstructured":"Gerhards, K., Becker, S., Kuehling, J., Lechner, M., Willems, H., Ringseis, R., and Reiner, G. (2025). Screening for transcriptomic associations with swine inflammation and necrosis syndrome. BMC Vet. Res., 21.","DOI":"10.1186\/s12917-024-04469-y"},{"key":"ref_121","doi-asserted-by":"crossref","unstructured":"Gerhards, K., Becker, S., K\u00fchling, J., Mickan, J., Lechner, M., Willems, H., and Reiner, G. (2025). Fine mapping identifies candidate genes associated with swine inflammation and necrosis syndrome. Vet. Sci., 12.","DOI":"10.3390\/vetsci12050508"},{"key":"ref_122","doi-asserted-by":"crossref","unstructured":"Becker, S., Kochendorfer, E., Kuehling, J., Gerhards, K., Lechner, M., Zinner, S., Lautner, M., and Reiner, G. (2025). Breed- and line-dependent severity of inflammation and necrosis syndrome in AI boars, and the related risk of inflammation and necrosis in their progeny. Vet. Sci., 12.","DOI":"10.3390\/vetsci12100967"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"skaf431","DOI":"10.1093\/jas\/skaf431","article-title":"Genetic architecture of swine inflammation and necrosis syndrome and its genetic correlation with repeated skin damage scores","volume":"104","author":"Garcia","year":"2026","journal-title":"J. Anim. Sci."},{"key":"ref_124","doi-asserted-by":"crossref","unstructured":"Ringseis, R., Gessner, D.K., Loewenstein, F., Kuehling, J., Becker, S., Willems, H., Lechner, M., Eder, K., and Reiner, G. (2021). Swine inflammation and necrosis syndrome is associated with plasma metabolites and liver transcriptome in affected pigs. Animals, 11.","DOI":"10.3390\/ani11030772"},{"key":"ref_125","doi-asserted-by":"crossref","unstructured":"Loewenstein, F., Becker, S., Kuehling, J., Schrade, H., Lechner, M., Ringseis, R., Eder, K., Moritz, A., and Reiner, G. (2022). Inflammation and necrosis syndrome is associated with alterations in blood and metabolism in pigs. BMC Vet. Res., 18.","DOI":"10.1186\/s12917-021-03107-1"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"757","DOI":"10.2478\/aoas-2014-0055","article-title":"Effect of feed structure on nutrient digestibility, growth performance, and gastrointestinal tract of pigs\u2014A review","volume":"14","author":"Flis","year":"2014","journal-title":"Ann. Anim. Sci."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.anifeedsci.2017.09.012","article-title":"Gastrointestinal functionality in animal nutrition and health: New opportunities for sustainable animal production","volume":"234","author":"Celi","year":"2017","journal-title":"Anim. Feed Sci. Technol."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.aninu.2017.12.004","article-title":"Gastrointestinal tract (gut) health in the young pig","volume":"4","author":"Pluske","year":"2018","journal-title":"Anim. Nutr."},{"key":"ref_129","doi-asserted-by":"crossref","unstructured":"Arnaud, E.A., Gardiner, G.E., and Lawlor, P.G. (2023). Selected nutrition and management strategies in suckling pigs to improve post-weaning outcomes. Animals, 13.","DOI":"10.20944\/preprints202305.1092.v1"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1017\/S0029665107005484","article-title":"Nutritional management of gut health in pigs around weaning","volume":"66","author":"Bosi","year":"2007","journal-title":"Proc. Nutr. Soc."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/2049-1891-4-1","article-title":"Feed- and feed additives-related aspects of gut health and development in weanling pigs","volume":"4","author":"Pluske","year":"2013","journal-title":"J. Anim. Sci. Biotechnol."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1128\/spectrum.00688-21","article-title":"Dynamic distribution of gut microbiota in pigs at different growth stages: Composition and contribution","volume":"10","author":"Luo","year":"2022","journal-title":"Microbiol. Spectr."},{"key":"ref_133","doi-asserted-by":"crossref","unstructured":"St-Pierre, B., Perez Palencia, J.Y., and Samuel, R.S. (2023). Impact of early weaning on development of the swine gut microbiome. Microorganisms, 11.","DOI":"10.3390\/microorganisms11071753"},{"key":"ref_134","first-page":"139","article-title":"Effect of early rearing environment and tail docking on later behaviour and production in fattening pigs","volume":"45","author":"Simonsen","year":"1995","journal-title":"Acta Agric. Scand."},{"key":"ref_135","doi-asserted-by":"crossref","unstructured":"Henry, M., Jansen, H., Amezcua, M.d.R., O\u2019Sullivan, T.L., Niel, L., Shoveller, A.K., and Friendship, R.M. (2021). Tail-biting in pigs: A scoping review. Animals, 11.","DOI":"10.3390\/ani11072002"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.anifeedsci.2016.05.003","article-title":"Nutritional value of feed ingredients of plant origin fed to pigs","volume":"218","author":"Stein","year":"2016","journal-title":"Anim. Feed Sci. Technol."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1111\/jgh.13703","article-title":"What is gluten?","volume":"32","author":"Biesiekierski","year":"2017","journal-title":"J. Gastroentrol. Hepatol."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"771","DOI":"10.3390\/nu5030771","article-title":"The dietary intake of wheat and other cereal grains and their role in inflammation","volume":"5","author":"Pruimboom","year":"2013","journal-title":"Nutrients"},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1111\/1541-4337.12475","article-title":"Adverse reactions to wheat or wheat components","volume":"18","author":"Brouns","year":"2019","journal-title":"Compr. Rev. Food Sci. Food Saf."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"2230","DOI":"10.1002\/jsfa.7340","article-title":"Wheat and barley differently affect porcine intestinal microbiota","volume":"96","author":"Weiss","year":"2016","journal-title":"J. Sci. Food. Agric."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"2652","DOI":"10.2527\/jas.2011-4381","article-title":"Barley-derived \u03b2-glucans increases gut permeability, ex vivo epithelial cell binding to E. coli, and na\u0457ve T-cell proportions in weanling pigs","volume":"90","author":"Ewaschuk","year":"2012","journal-title":"J. Anim. Sci."},{"key":"ref_142","first-page":"101343","article-title":"Araboxylan as well as \u03b2-glucan in barley promotes GLP-1 secretion by increasing short-chain fatty acids production","volume":"32","author":"Mio","year":"2022","journal-title":"Biochem. Biophys. Rep."},{"key":"ref_143","doi-asserted-by":"crossref","unstructured":"He, B., Bai, Y., Jiang, L., Wang, W., Li, T., Liu, P., Tao, S., Zhao, J., Han, D., and Wang, J. (2018). Effects of oat bran on nutrient digestibility, intestinal microbiota, and inflammatory responses in the hindgut of growing pigs. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19082407"},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"skaf008","DOI":"10.1093\/jas\/skaf008","article-title":"Dietary inclusion of high-amylose cornstarch increased Lactobacillus and Terrisporobacter and decreased Streptococcus in the cecal digesta of weanling piglets","volume":"103","author":"Wellington","year":"2025","journal-title":"J. Anim. Sci."},{"key":"ref_145","doi-asserted-by":"crossref","unstructured":"Yang, C., Wang, M., Tang, X., Yang, H., Li, F., Wang, Y., Li, J., and Yin, Y. (2021). Effect of dietary amylose\/amylopectin ratio on intestinal health and cecal microbes\u2019 profiles of weaned pigs undergoing feed transition or challenged with Escherichia coli lipopolysaccharide. Front. Microbiol., 12.","DOI":"10.3389\/fmicb.2021.693839"},{"key":"ref_146","doi-asserted-by":"crossref","unstructured":"Liu, P., Zhao, J., Wang, W., Gup, P., Lu, W., Wang, C., Liu, L., Johnston, L.J., Zhao, Y., and Wu, X. (2018). Dietary corn bran altered the diversity of microbial communities and cytokine production in weaned pigs. Front. Microbiol., 9.","DOI":"10.3389\/fmicb.2018.02090"},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1080\/09540101003596644","article-title":"Effects of glycinin and \u03b2-conglycinin on enterocyte apoptosis, proliferation and migration of piglets","volume":"21","author":"Zhao","year":"2010","journal-title":"Food Agric. Immunol."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1080\/1828051X.2016.1200441","article-title":"Allergens and intestinal damage induced by soybean antigen proteins in weaned piglets","volume":"15","author":"Wu","year":"2016","journal-title":"Ital. J. Anim. Sci."},{"key":"ref_149","doi-asserted-by":"crossref","unstructured":"Wang, L., Liu, Y., Zhang, D., Ding, H., Feng, S., Zhao, C., Wu, J., and Wang, X. (2023). Soybean antigen protein-induced intestinal barrier damage by trigging endoplasmic reticulum stress and disordering gut microbiota in weaned piglets. Molecules, 28.","DOI":"10.3390\/molecules28186500"},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"2262","DOI":"10.1017\/S1751731120001123","article-title":"Effects of soybean isoflavones on the growth performance, intestinal morphology and antioxidative properties in pigs","volume":"14","author":"Li","year":"2020","journal-title":"Animal"},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.anifeedsci.2013.07.011","article-title":"Nutritive value of wheat and wheat by-products in pig nutrition: A review","volume":"185","author":"Rosenfelder","year":"2013","journal-title":"Anim. Feed Sci. Technol."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"txae106","DOI":"10.1093\/tas\/txae106","article-title":"Nutritional guide to feeding wheat and wheat co-products to swine: A review","volume":"8","author":"Stas","year":"2024","journal-title":"Transl. Anim. Sci."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1177\/2050640614535929","article-title":"Wheat-related disorders: A broad spectrum of \u2018evolving\u2019 diseases","volume":"2","author":"Gasbarrini","year":"2014","journal-title":"United Eur. Gastroenterol. J."},{"key":"ref_154","doi-asserted-by":"crossref","unstructured":"Tuck, C.J., Biesiekierski, J.R., Schmid-Grendelmeier, P., and Pohl, D. (2019). Food intolerances. Nutrients, 11.","DOI":"10.3390\/nu11071684"},{"key":"ref_155","doi-asserted-by":"crossref","unstructured":"Sharma, N., Bhatia, S., Chunduri, V., Kaur, S., Sharma, S., Kapoor, P., Kumari, A., and Garg, M. (2020). Pathogenesis of celiac disease and other gluten delated disorders in wheat and strategies for mitigating them. Front. Nutr., 7.","DOI":"10.3389\/fnut.2020.00006"},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1017\/S0954422413000152","article-title":"Use of pigs as a potential model for research into dietary modulation of the human gut microbiota","volume":"26","author":"Heinritz","year":"2013","journal-title":"Nutr. Res. Rev."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1017\/S0954422416000020","article-title":"Critical review evaluating the pig as a model for human nutritional physiology","volume":"29","author":"Roura","year":"2016","journal-title":"Nutr. Res. Rev."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"441","DOI":"10.2527\/jas.2015-9788","article-title":"Review: The pig as a model for humans: Effects of nutritional factors on intestinal function and health","volume":"94","author":"Sciascia","year":"2016","journal-title":"J. Anim. Sci."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1111\/1541-4337.12265","article-title":"Barley starch: Composition, structure, properties, and modifications","volume":"16","author":"Zhu","year":"2017","journal-title":"Compr. Rev. Food Sci. Food Saf."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"115550","DOI":"10.1016\/j.anifeedsci.2022.115550","article-title":"Diet nutrient digestibility and growth performance in weaned pigs fed barley differing in fermentable starch and fibre profile","volume":"295","author":"Wang","year":"2023","journal-title":"Anim. Feed Sci. Technol."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"2730175","DOI":"10.1155\/2023\/2730175","article-title":"Nutritional and phytochemical composition and associated health benefits of oat (Avena sativa) grains and oat-based fermented food-products","volume":"2023","author":"Alemayehu","year":"2023","journal-title":"Sci. World J."},{"key":"ref_162","doi-asserted-by":"crossref","unstructured":"Gell, G., Bugyi, Z., Florides, C.G., Birinyi, Z., R\u00e9der, D., Szeg\u0151, Z., Mucsi, E., Schall, E., \u00c1cs, K., and Lang\u00f3, B. (2021). Investigation of protein and epitope characteristics of oats and its implications for celiac disease. Front. Nutr., 8.","DOI":"10.3389\/fnut.2021.702352"},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1111\/nyas.12396","article-title":"Global maize production, utilization, and consumption","volume":"1312","author":"Ranum","year":"2014","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"skad384","DOI":"10.1093\/jas\/skad384","article-title":"Effect of heating, microbial fermentation, and enzymatic hydrolysis of soybean meal on growth performance, nutrient digestibility, and intestinal microbiota of weaned piglets","volume":"101","author":"Tang","year":"2023","journal-title":"J. Anim. Sci."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.tifs.2017.02.003","article-title":"Inactivation methods of soybean trypsin inhibitor\u2014A review","volume":"64","author":"Vagadia","year":"2017","journal-title":"Trends Food Sci. Technol."},{"key":"ref_166","doi-asserted-by":"crossref","unstructured":"Luo, Z., Zhu, Y., Xiang, Z., Wang, Z., Jiang, Z., Zhao, X., Sun, X., and Guo, Z. (2025). Advancements in Inactivation of Soybean Trypsin Inhibitors. Foods, 14.","DOI":"10.3390\/foods14060975"},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.5713\/ajas.15.0627","article-title":"Role of Fermentation in Improving Nutritional Quality of Soybean Meal\u2014A Review","volume":"29","author":"Mukherjee","year":"2016","journal-title":"Asian-Australas. J. Anim. Sci."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.livsci.2010.06.117","article-title":"Strategic use of feed ingredients and feed additives to stimulate gut health and development in young pigs","volume":"134","author":"Pluske","year":"2010","journal-title":"Livest. Sci."},{"key":"ref_169","doi-asserted-by":"crossref","unstructured":"Xiong, X., Tan, B., Song, M., Ji, P., Kim, K., Yin, Y., and Liu, Y. (2019). Nutritional intervention for the intestinal development and health of weaned pigs. Front. Vet. Sci., 6.","DOI":"10.3389\/fvets.2019.00046"},{"key":"ref_170","unstructured":"Edwards, L. (2018). Drinking Water Quality and Its Impact on the Health and Performance of Pigs, Co-Operative Research Centre for High Integrity Australian Pork. Available online: https:\/\/porkcrc.com.au\/wp-content\/uploads\/2018\/08\/2A-118-Drinking-Water-Quality-Final-Report.pdf."},{"key":"ref_171","unstructured":"Nyachoti, M., and Kiarie, E. (2010, January 3\u20134). Water in swine production: A review of its significance and conservation strategies. Proceedings of the 24th Manitoba Swine Seminar, Winnipeg, MB, Canada."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"632","DOI":"10.2337\/db13-0981","article-title":"pH of drinking water influences the composition of gut microbiome and type 1 diabetes incidence","volume":"63","author":"Sofi","year":"2014","journal-title":"Diabetes"},{"key":"ref_173","doi-asserted-by":"crossref","unstructured":"Rodrigues, L.A., Koo, B., Nyachoti, M., and Columbus, D.A. (2022). Formulating diets for improved health status of pigs: Current knowledge and perspectives. Animals, 12.","DOI":"10.3390\/ani12202877"},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/2049-1891-5-15","article-title":"Fiber effects in nutrition and gut health in pigs","volume":"5","author":"Lindberg","year":"2014","journal-title":"J. Anim. Sci. Biotechnol."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1017\/S1751731115000919","article-title":"Review: Dietary fiber utilization and its effects on physiological functions and gut health of swine","volume":"9","author":"Jha","year":"2015","journal-title":"Animal"},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"4639","DOI":"10.1002\/fsn3.2421","article-title":"Variations on gut health and energy metabolism in pigs and humans by intake of different dietary fibers","volume":"9","author":"Yang","year":"2021","journal-title":"Food Sci. Nutr."},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1017\/S1751731113000062","article-title":"Impact of dietary protein on microbiota composition and activity in the gastrointestinal tract of piglets in relation to gut health: A review","volume":"7","author":"Rist","year":"2013","journal-title":"Animal"},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.aninu.2021.08.001","article-title":"Fate of undigested proteins in the pig large intestine: What impact on the colon epithelium?","volume":"9","author":"Blachier","year":"2022","journal-title":"Anim. Nutr."},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1017\/S0007114513003498","article-title":"Diets high in fermentable protein and fibre alter tight junction protein composition with minor effects on barrier function in piglet colon","volume":"111","author":"Richter","year":"2014","journal-title":"Br. J. Nutr."},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"G159","DOI":"10.1152\/ajpgi.00319.2017","article-title":"Protein fermentation in the gut; implications for intestinal dysfunction in humans, pigs, and poultry","volume":"315","author":"Gilbert","year":"2018","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"4446","DOI":"10.1039\/C9FO02652E","article-title":"Inflences of dietary starch structure on intestinal morphology, barrier functions, and epithelium apoptosis in weaned pigs","volume":"11","author":"Gao","year":"2020","journal-title":"Food Funct."},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.anifeedsci.2011.12.020","article-title":"The role of carbohydrates in intestinal health of pigs","volume":"173","author":"Hedemann","year":"2012","journal-title":"Anim. Feed Sci. Technol."},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.aninu.2018.04.001","article-title":"Application of resistant starch in swine and poultry diets with particular reference to gut health and function","volume":"4","author":"Regassa","year":"2018","journal-title":"Anim. Nutr."},{"key":"ref_184","doi-asserted-by":"crossref","unstructured":"Sun, Y., Su, Y., and Zhu, W. (2016). Microbiome-metabolome responses in the cecum and colon of pig to a high resistant starch diet. Front. Microbiol., 7.","DOI":"10.3389\/fmicb.2016.00779"},{"key":"ref_185","doi-asserted-by":"crossref","unstructured":"Yang, Z., and Liao, S.F. (2019). Physiological effects of dietary amino acids on gut health and functions of swine. Front. Vet. Sci., 6.","DOI":"10.3389\/fvets.2019.00169"},{"key":"ref_186","doi-asserted-by":"crossref","unstructured":"Chalvon-Demersay, T., Luise, D., Le Flo\u2019ch, N., Tesseraud, S., Lambert, W., Bosi, P., Trevisi, P., Beaumont, M., and Corrent, E. (2021). Functional amino acids in pigs and chickens: Implication for gut health. Front. Vet. Sci., 8.","DOI":"10.3389\/fvets.2021.663727"},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1159\/000485782","article-title":"Lysine restriction affects feed intake and amino acid metabolism via gut microbiome in piglets","volume":"44","author":"Yin","year":"2017","journal-title":"Cell Physiol. Biochem."},{"key":"ref_188","doi-asserted-by":"crossref","unstructured":"Liang, H., Dai, Z., Liu, N., Ji, Y., Chen, J., Zhang, Y., Yang, Y., Li, J., Wu, Z., and Wu, G. (2018). Dietary L-tryptophan modulates the structural and functional composition of the intestinal microbiome in weaned pigs. Front. Microbiol., 9.","DOI":"10.3389\/fmicb.2018.01736"},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1111\/1750-3841.13603","article-title":"Dietary tryptophan enhanced the expression of tight junction protein ZO-1 in intestine","volume":"82","author":"Liu","year":"2017","journal-title":"J. Food Sci."},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"2735","DOI":"10.1007\/s00394-017-1539-3","article-title":"Effects of dietary L-methionine supplementation on intestinal integrity and oxidative status in intrauterine growth-retarded weanling piglets","volume":"57","author":"Su","year":"2017","journal-title":"Eur. J. Nutr."},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"5530","DOI":"10.2527\/jas.2014-7830","article-title":"Effect of feed grade L-methionine on growth performance and gut health in nursery pigs compared with conventional DL-methionine","volume":"92","author":"Shen","year":"2014","journal-title":"J. Anim. Sci."},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1017\/S000711451000365X","article-title":"Dietary L-arginin supplementation enhances intestinal development and expression of vascular endothelial growth factor in weanling piglets","volume":"105","author":"Yao","year":"2011","journal-title":"Br. J. Nutr."},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1177\/1753425912456223","article-title":"Effect of L-arginine on intestinal mucosal immune barrier function in weaned pigs after Escherichia coli LPS challenge","volume":"19","author":"Zhu","year":"2012","journal-title":"Innate Immun."},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1007\/s00726-013-1643-5","article-title":"Dietary arginine supplementation enhances intestinal expression of SLC7A7 and SLC7A1 and ameliorates growth depression in mycotoxin-challenged pigs","volume":"46","author":"Yin","year":"2013","journal-title":"Amino Acids"},{"key":"ref_195","doi-asserted-by":"crossref","unstructured":"Duan, J., Yin, J., Wu, M., Liao, P., Deng, D., Liu, G., Wen, Q., Wang, Y., Qiu, W., and Liu, Y. (2014). Dietary glutamate supplementation ameliorates mycotoxin-induced abnormalities in the intestinal structure and expression of amino acid transporters in young pigs. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0112357"},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1017\/S0007114511001152","article-title":"Glutamine supplementation improves intestinal barrier function in a weaned piglet model of Escherichia coli infection","volume":"106","author":"Ewaschuk","year":"2011","journal-title":"Br. J. Nutr."},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.3390\/toxins6051615","article-title":"Effect of deoxynivalenol and other type B trichothecenes on the intestine: A review","volume":"6","author":"Pinton","year":"2014","journal-title":"Toxins"},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"602","DOI":"10.2460\/ajvr.1989.50.04.602","article-title":"Effects of aflatoxin, deoxynivalenol, and their combinations in the diets of growing pigs","volume":"50","author":"Harvey","year":"1989","journal-title":"Am. J. Vet. Res."},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"2071","DOI":"10.3390\/toxins7062071","article-title":"Deoxynivalenol impairs weight gain and affects markers of gut health after low-dose, short-term exposure of growing pigs","volume":"7","author":"Alizadeh","year":"2015","journal-title":"Toxins"},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/s40813-016-0041-2","article-title":"Impact of two mycotoxins deoxynivalenol and fumonisin on pig intestinal health","volume":"2","author":"Pierron","year":"2016","journal-title":"Porc. Health Manag."},{"key":"ref_201","doi-asserted-by":"crossref","unstructured":"Grosu, I.A., Bulgaru, C.V., Pistol, G.C., Cismileanu, A., Marin, D.E., and Taranu, I. (2023). Effects of exposure to low zearalenone concentrations close to the EU recommended value on weaned piglets\u2019 colon. Toxins, 15.","DOI":"10.3390\/toxins15030206"},{"key":"ref_202","doi-asserted-by":"crossref","unstructured":"Guerre, P. (2020). Mycotoxin and gut microbiota interactions. Toxins, 12.","DOI":"10.3390\/toxins12120769"},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"111373","DOI":"10.1016\/j.fct.2020.111373","article-title":"Effects of deoxynivalenol on the porcine growth performance and intestinal microbiota and potential remediation by a modified HSCAS binder","volume":"141","author":"Liu","year":"2020","journal-title":"Food Chem. Toxicol."},{"key":"ref_204","doi-asserted-by":"crossref","unstructured":"Reddy, K.E., Jeong, J.Y., Song, J., Lee, Y., Lee, H.-J., Kim, D.-W., Jung, H.J., Kim, K.H., Kim, M., and Oh, Y.K. (2018). Colon microbiome of pigs fed diet contaminated with commercial purified deoxynivalenol and zearalenone. Toxins, 10.","DOI":"10.3390\/toxins10090347"},{"key":"ref_205","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1136\/vr.104385","article-title":"Role of mycotoxins in herds with and without problems with tail necrosis in neonatal pigs","volume":"181","author":"Devreese","year":"2017","journal-title":"Vet. Rec."},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.anifeedsci.2017.06.016","article-title":"Importance of feed structure (particle size) and feed form (mash vs. pellets) in pig nutrition\u2014A review","volume":"233","author":"Rakita","year":"2017","journal-title":"Anim. Feed Sci. Technol."},{"key":"ref_207","doi-asserted-by":"crossref","unstructured":"Cappai, M.G., Picciau, M., and Pinna, W. (2013). Ulcerogenic risk assessment of diets for pigs in relation to gastric lesion prevalence. BMC Vet. Res., 9.","DOI":"10.1186\/1746-6148-9-36"},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.livsci.2018.03.013","article-title":"A study of associations between gastric ulcers and the behaviour of finisher pigs","volume":"212","author":"Rutherford","year":"2018","journal-title":"Livest. Sci."},{"key":"ref_209","doi-asserted-by":"crossref","unstructured":"Boyle, L.A., Edwards, S.A., Bolhuis, J.E., Pol, F., \u0160merov, M.Z., Sch\u00fctze, S., Nordgreen, J., Bozakova, N., Sossidou, E.N., and Valros, A. (2022). The evidence for a causal link between disease and damaging behaviour in pigs. Front. Vet. Sci., 8.","DOI":"10.3389\/fvets.2021.771682"},{"key":"ref_210","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/s40813-023-00314-0","article-title":"Are biters sick? Health status of tail biters in comparison to control pigs","volume":"9","author":"Czycholl","year":"2023","journal-title":"Porc. Health Manag."},{"key":"ref_211","doi-asserted-by":"crossref","unstructured":"Scollo, A., Abbas, M., Contiero, B., and Gottardo, F. (2023). Undocked Tails, Mycoplasma-like Lesions and Gastric Ulcers in Slaughtering Pigs: What Connection?. Animals, 13.","DOI":"10.3390\/ani13020305"},{"key":"ref_212","doi-asserted-by":"crossref","first-page":"3485","DOI":"10.1128\/AEM.70.6.3485-3492.2004","article-title":"Effects of physical properties of feed on microbial ecology and survival of Salmonelle enterica serovar Tyhphimurium in the pig gastrointestinal tract","volume":"70","author":"Mikkelsen","year":"2004","journal-title":"Appl. Environ. Microbiol."},{"key":"ref_213","doi-asserted-by":"crossref","first-page":"1554","DOI":"10.2527\/2005.8371554x","article-title":"Effect of feed particle size and feed processing on morphological characteristics in the small and large intestine of pigs and on adhesion of Salmonella enterica serovar Typhimurium DT12 in the ileum in vitro","volume":"83","author":"Hedemann","year":"2005","journal-title":"J. Anim. Sci."},{"key":"ref_214","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.2527\/2005.8361287x","article-title":"Feed physical form and formic acid addition to the feed affect the gastrointestinal ecology and growth performance of growing pigs","volume":"83","author":"Canibe","year":"2005","journal-title":"J. Anim. Sci."},{"key":"ref_215","doi-asserted-by":"crossref","first-page":"115519","DOI":"10.1016\/j.anifeedsci.2022.115519","article-title":"Acid-binding capacity of feed in swine nutrition","volume":"295","author":"Wang","year":"2023","journal-title":"Anim. Feed Sci. Technol."},{"key":"ref_216","doi-asserted-by":"crossref","first-page":"732","DOI":"10.5513\/JCEA01\/23.4.3724","article-title":"Determination of buffering capacity of the selected feeds used in swine nutrition","volume":"23","author":"Mihok","year":"2022","journal-title":"J. Cent. Eur. Agric."},{"key":"ref_217","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1186\/2046-0481-58-8-447","article-title":"Measurements of the acid-binding capacity of ingredients used in pig diets","volume":"58","author":"Lawlor","year":"2005","journal-title":"Ir. Vet. J."},{"key":"ref_218","doi-asserted-by":"crossref","first-page":"txac104","DOI":"10.1093\/tas\/txac104","article-title":"Evaluation of the acid-binding capacity of ingredients and complete diets commonly used for weanling pigs","volume":"6","author":"Stas","year":"2022","journal-title":"Transl. Anim. Sci."},{"key":"ref_219","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1017\/S0263967X0000313X","article-title":"The effects of water delivery rate on the voluntary food intake, water use and performance of early-weaned pigs from 3 to 6 weeks of age","volume":"13","author":"Barber","year":"1989","journal-title":"BSAP Occas. Publ."},{"key":"ref_220","doi-asserted-by":"crossref","unstructured":"O\u2019Driscoll, K., and Valros, A. (2024). Risk assessment. Tail Biting in Pigs, Brill Wageningen Academic. [1st ed.].","DOI":"10.1163\/9789004694989"},{"key":"ref_221","doi-asserted-by":"crossref","first-page":"683","DOI":"10.17236\/sat00278","article-title":"Risk factors for tail lesions in undocked fattening pigs reared on Swiss farms","volume":"162","author":"Sell","year":"2020","journal-title":"Schweiz. Arch. Tierheilkd."},{"key":"ref_222","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.2527\/jas.2007-0632","article-title":"Effect of drinker type on water intake and waste in newly weaned piglets","volume":"86","author":"Torrey","year":"2008","journal-title":"J. Anim. Sci."},{"key":"ref_223","doi-asserted-by":"crossref","unstructured":"Larsen, M.L.V., and Pedersen, L.J. (2022). Use of drinkers by finisher pigs depend on drinker location, pig age, time of day, stocking density and tail damage. Front. Vet. Sci., 25.","DOI":"10.3389\/fvets.2022.1029803"},{"key":"ref_224","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1017\/S1751731115001779","article-title":"Does group size have an impact on welfare indicators in fattening pigs?","volume":"10","author":"Lambertz","year":"2016","journal-title":"Animal"},{"key":"ref_225","doi-asserted-by":"crossref","first-page":"txac117","DOI":"10.1093\/tas\/txac117","article-title":"Influence of high cyclic ambient temperature and water drinker design on growth performance and water disappearance of growing-finishing pigs","volume":"6","author":"Grohmann","year":"2022","journal-title":"Transl. Anim. Sci."},{"key":"ref_226","doi-asserted-by":"crossref","unstructured":"Scaff, T.J. (2021). Prediction of Daily Water Intake of Pigs During 41-Day Nursery Phase. [Master\u2019s Thesis, Oklahoma State University].","DOI":"10.1093\/jas\/skaa278.331"},{"key":"ref_227","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1079\/NRR19950010","article-title":"Water in pig nutrition: Physiology, allowances and environmental implications","volume":"8","author":"Mroz","year":"1995","journal-title":"Nutr. Res. Rev."},{"key":"ref_228","first-page":"22","article-title":"Water as feed and key factor for animal health for pigs: Requirement, supply and quality markers\u2014An overview","volume":"3","author":"Lechner","year":"2024","journal-title":"Tier\u00e4rztliche Umsch."},{"key":"ref_229","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1017\/S0007114519002198","article-title":"Whole digesta properties as influenced by feed processing explain variation in gastrointestinal transit times in pigs","volume":"122","author":"Martens","year":"2019","journal-title":"Br. J. Nutr."},{"key":"ref_230","unstructured":"P\u00fctz, S. (2014). Entwicklung und Validierung von Praxistauglichen Ma\u00dfnahmen zum Verzicht des Routinem\u00e4\u00dfigen Schw\u00e4nzekupierens Beim Schwein in der Konventionellen Mast. [Ph.D. Thesis, Georg-August-University]."},{"key":"ref_231","doi-asserted-by":"crossref","unstructured":"Voudouris, K., and Voutsa, D. (2012). Chapter 7 Biofilms impact on drinking water quality. Ecological Water Quality\u2014Water Treatment and Reuse, InTech. [1st ed.].","DOI":"10.5772\/1070"},{"key":"ref_232","doi-asserted-by":"crossref","first-page":"3912","DOI":"10.1111\/1462-2920.15988","article-title":"Tap water as natural vehicle for microorganisms shaping the human gut microbiome","volume":"24","author":"Lugli","year":"2022","journal-title":"Environ. Microbiol."},{"key":"ref_233","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1139\/cjm-2016-0219","article-title":"Microbiome profiling of drinking water in relation to incidence of inflammatory bowel disease","volume":"62","author":"Forbes","year":"2016","journal-title":"Can. J. Microbiol."},{"key":"ref_234","doi-asserted-by":"crossref","first-page":"102707","DOI":"10.1016\/j.psj.2023.102707","article-title":"Growth performance and cecal microbiota of broiler chicks as effected by drinking water disinfection and\/or herbal extract blend supplementation","volume":"102","author":"Meng","year":"2023","journal-title":"Poult. Sci."},{"key":"ref_235","first-page":"34","article-title":"Effects of feeding on the management of undocked pigs","volume":"3","author":"Mascher","year":"2025","journal-title":"Tier\u00e4rztliche Umsch."},{"key":"ref_236","doi-asserted-by":"crossref","first-page":"104873","DOI":"10.1016\/j.applanim.2019.104873","article-title":"Comparison of different scoring keys for tail-biting in pigs to evaluate the importance of one common scoring key to improve the comparability of studies\u2014A review","volume":"221","author":"Honeck","year":"2019","journal-title":"Appl. Anim. Behav. Sci."},{"key":"ref_237","doi-asserted-by":"crossref","unstructured":"O\u2019Driscoll, K., and Valros, A. (2024). The evidence of tail biting: Where, when and how to measure tail lesions. Tail Biting in Pigs: A Comprehensive Guide to Its Aetiology, Impact and Wider Significance in Pig Management, Brill Wageningen Academic. [1st ed.].","DOI":"10.1163\/9789004694989"},{"key":"ref_238","doi-asserted-by":"crossref","unstructured":"Larsen, M.L.V., Pedersen, L.J., and Jensen, D.B. (2019). Prediction of tail biting events in finisher pigs from automatically recorded sensor data. Animals, 9.","DOI":"10.3390\/ani9070458"},{"key":"ref_239","doi-asserted-by":"crossref","unstructured":"Hakansson, F., and Jensen, D.B. (2023). Automatic monitoring and detection of tail-biting behavior in groups of pigs using video-based deep learning methods. Front. Vet. Sci., 9.","DOI":"10.3389\/fvets.2022.1099347"},{"key":"ref_240","doi-asserted-by":"crossref","first-page":"4523","DOI":"10.1038\/s41598-024-55336-7","article-title":"Detecting tail biters by monitoring pig screams in weaning pigs","volume":"14","author":"Heseker","year":"2024","journal-title":"Sci. Rep."},{"key":"ref_241","doi-asserted-by":"crossref","first-page":"349","DOI":"10.17221\/85\/2023-VETMED","article-title":"The importance of slaughterhouses in monitoring the occurrence of tail biting in pigs\u2014Review","volume":"68","author":"Svoboda","year":"2023","journal-title":"Vet. Med."},{"key":"ref_242","doi-asserted-by":"crossref","unstructured":"Valros, A., V\u00e4lim\u00e4ki, E., Nordgren, H., Vugts, J., F\u00e0brega, E., and Heinonen, M. (2020). Intact tails as welfare indicator in finishing pigs? Scoring of tail lesions and defining intact tails in undocked pigs at the abattoir. Front. Vet. Sci., 7.","DOI":"10.3389\/fvets.2020.00405"},{"key":"ref_243","doi-asserted-by":"crossref","first-page":"e000083","DOI":"10.1136\/vetreco-2014-000083","article-title":"Training veterinarians and agricultural advisers on a novel tool for tail biting prevention","volume":"2","author":"Madey","year":"2015","journal-title":"Vet. Rec. Open"},{"key":"ref_244","doi-asserted-by":"crossref","first-page":"105406","DOI":"10.1016\/j.tvjl.2019.105406","article-title":"Reducing estimated tail biting risk in German weaner pigs using a management tool","volume":"254","author":"Krieter","year":"2019","journal-title":"Vet. J."},{"key":"ref_245","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1017\/S1751731118002070","article-title":"Tail lesions in fattening pigs: Relationships with postmortem meat inspection and influence of a tail biting management tool","volume":"13","author":"Karnholz","year":"2019","journal-title":"Animal"},{"key":"ref_246","doi-asserted-by":"crossref","unstructured":"D\u2019Alessio, R.M., Mc Aloon, C.G., Correia-Gomes, C., Hanlon, A., and O\u2019Driscoll, K. (2024). Evaluation of a scheme to identify risks for tail biting in pigs. PLoS ONE, 19.","DOI":"10.1371\/journal.pone.0305960"},{"key":"ref_247","doi-asserted-by":"crossref","unstructured":"Niemi, J.K., Edwards, S.A., Papanastasiou, D.K., Piette, D., Stygar, A.H., Wallenbeck, A., and Valros, A. (2021). Cost-effectiveness analysis of seven measures to reduce tail biting lesions in fattening pigs. Front. Vet. Sci., 8.","DOI":"10.3389\/fvets.2021.682330"}],"container-title":["Animals"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-2615\/16\/8\/1174\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T08:16:38Z","timestamp":1776068198000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-2615\/16\/8\/1174"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,11]]},"references-count":247,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2026,4]]}},"alternative-id":["ani16081174"],"URL":"https:\/\/doi.org\/10.3390\/ani16081174","relation":{},"ISSN":["2076-2615"],"issn-type":[{"value":"2076-2615","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,11]]}}}