{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T11:49:09Z","timestamp":1776167349820,"version":"3.50.1"},"reference-count":81,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T00:00:00Z","timestamp":1776124800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"the Program for Improving the Scientific Research Ability of Youth Teachers of Inner Mongolia Agricultural University","award":["BR230102"],"award-info":[{"award-number":["BR230102"]}]},{"DOI":"10.13039\/501100004763","name":"the Natural Science Foundation of Inner Mongolia Autonomous Region","doi-asserted-by":"publisher","award":["2024LHMS03006"],"award-info":[{"award-number":["2024LHMS03006"]}],"id":[{"id":"10.13039\/501100004763","id-type":"DOI","asserted-by":"publisher"}]},{"name":"The First-Class Discipline Research Special Project of the Department of Education of Inner Mongolia Autonomous Region","award":["YLXKZX-NND-044"],"award-info":[{"award-number":["YLXKZX-NND-044"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animals"],"abstract":"<jats:p>Blood metabolism in dairy cows is crucial for milk quality, functioning primarily through the \u201cblood\u2013milk\u201d metabolic axis. Allium mongolicum Regel (AMR), a functional Allium herb, has been shown to regulate on ruminant lipid metabolism. This study investigated the impact of AMR ethanol extract (AME) on lactation performance, blood lipid parameters, and blood\u2013milk metabolomes. Twelve mid-lactation Holsteins (606 \u00b1 11 kg; milk yield 33.14 \u00b1 2.08 kg\/d) of parity 2\u20133 were assigned to either a basal diet (CON) or a diet supplemented with 54 g\/d of AME (AEE). Results indicated that AME significantly decreased plasma triglycerides (TG), C15:0, C16:1, C18:1 n-9 c, C18:3 n-6, monounsaturated fatty acids (p &lt; 0.05) and significantly increased C18:2 n-6 c, polyunsaturated fatty acids (p &lt; 0.05). Lactation performance, including the average daily dry matter intake, daily yields of milk fat, protein and lactose, remained unaffected by the AME addition (p &gt; 0.05). Metabolomic profiling revealed that AME significantly enriched the glycerophospholipid metabolism pathway in plasma, upregulating key phospholipid precursors such as L-serine and Sphinganine. Concurrently, milk metabolomics showed an upregulation of short-chain Acylcarnitines. Plasma TG correlated negatively with both plasma L-serine and milk Acylcarnitines, whereas low-density lipoprotein correlated positively with these energy-driven milk metabolites. These findings suggest that AME may contribute to remodeling the plasma lipid metabolic profile in a manner that could facilitate plasma-to-milk lipid flux. This appears to occur through enhanced hepatic lipid processing and increased mammary lipid utilization, offering preliminary insights into potential nutritional strategies for supporting lipid metabolism in dairy cows.<\/jats:p>","DOI":"10.3390\/ani16081191","type":"journal-article","created":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T10:29:08Z","timestamp":1776162548000},"page":"1191","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Allium mongolicum Regel Ethanol Extract Remodels Plasma Metabolome and Lipid Metabolism While Modulating Milk Metabolite Profiles in Dairy Cows"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0491-6414","authenticated-orcid":false,"given":"Chen","family":"Bai","sequence":"first","affiliation":[{"name":"Key Laboratory of Animal Nutrition and Feed Science at Universities of Inner Mongolia Autonomous Region, College of Animal Science, Inner Mongolia Agricultural University, Zhaowuda Road 306, Saihan District, Hohhot 010008, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyuan","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Animal Nutrition and Feed Science at Universities of Inner Mongolia Autonomous Region, College of Animal Science, Inner Mongolia Agricultural University, Zhaowuda Road 306, Saihan District, Hohhot 010008, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guoli","family":"Han","sequence":"additional","affiliation":[{"name":"Key Laboratory of Animal Nutrition and Feed Science at Universities of Inner Mongolia Autonomous Region, College of Animal Science, Inner Mongolia Agricultural University, Zhaowuda Road 306, Saihan District, Hohhot 010008, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qina","family":"Cao","sequence":"additional","affiliation":[{"name":"Key Laboratory of Animal Nutrition and Feed Science at Universities of Inner Mongolia Autonomous Region, College of Animal Science, Inner Mongolia Agricultural University, Zhaowuda Road 306, Saihan District, Hohhot 010008, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yankai","family":"Zheng","sequence":"additional","affiliation":[{"name":"Key Laboratory of Animal Nutrition and Feed Science at Universities of Inner Mongolia Autonomous Region, College of Animal Science, Inner Mongolia Agricultural University, Zhaowuda Road 306, Saihan District, Hohhot 010008, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiayu","family":"Duan","sequence":"additional","affiliation":[{"name":"Key Laboratory of Animal Nutrition and Feed Science at Universities of Inner Mongolia Autonomous Region, College of Animal Science, Inner Mongolia Agricultural University, Zhaowuda Road 306, Saihan District, Hohhot 010008, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huabei","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of Animal Nutrition and Feed Science at Universities of Inner Mongolia Autonomous Region, College of Animal Science, Inner Mongolia Agricultural University, Zhaowuda Road 306, Saihan District, Hohhot 010008, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Changjin","family":"Ao","sequence":"additional","affiliation":[{"name":"Key Laboratory of Animal Nutrition and Feed Science at Universities of Inner Mongolia Autonomous Region, College of Animal Science, Inner Mongolia Agricultural University, Zhaowuda Road 306, Saihan District, Hohhot 010008, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9199-5773","authenticated-orcid":false,"given":"Khas","family":"Erdene","sequence":"additional","affiliation":[{"name":"Key Laboratory of Animal Nutrition and Feed Science at Universities of Inner Mongolia Autonomous Region, College of Animal Science, Inner Mongolia Agricultural University, Zhaowuda Road 306, Saihan District, Hohhot 010008, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,4,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"108887","DOI":"10.1016\/j.jnutbio.2021.108887","article-title":"The phytonutrient cinnamaldehyde limits intestinal inflammation and enteric parasite infection","volume":"100","author":"Zhu","year":"2022","journal-title":"J. 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