{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T12:57:46Z","timestamp":1776430666854,"version":"3.51.2"},"reference-count":19,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T00:00:00Z","timestamp":1776384000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"veterinary hospital of the Universidade Federal Rural do Semi-\u00c1rido, Brazil"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animals"],"abstract":"<jats:p>Diseases of the nasal cavity have a diverse etiology and cause severe disorders in animals. Conidiobolomycosis is a type of zygomycosis caused by the fungus Conidiobolus spp., occurring more frequently in sheep. The objective of this study is to describe the clinical and epidemiological characteristics, as well as microbiological and histopathological findings, of an outbreak of conidiobolomycosis in sheep. A total of 12 animals out of a herd of 70 were affected, representing a morbidity of 17.1%; mortality and lethality were 11.4% (8\/70) and 66.6% (8\/12), respectively, of which 4 sheep died spontaneously and 4 were euthanized for diagnostic purposes due to the severity of the clinical condition. Necropsy was performed on 4 (33.3%) of the 12 affected animals, and after opening the skull in the sagittal section, a friable mass with coloration ranging from whitish-yellow to gray-green, as well as areas of necrosis, were evident in regions such as the nasal meatus, conchae, nasopharynx, hard palate, cribriform plate, meninges, and frontal lobe of the brain. Conidiobolus lamprauges was isolated from samples collected from 6 animals from nasal discharge, fungal granuloma, and intranasal swab. Reproductive structures consistent as kind of zygospores with C. lamprauges and C. incongruus were also identified. Regarding the clinical form, animals 1, 2, 3, and 4 presented manifestations of the nasopharyngeal form, with the first three progressing to the rhinocerebral form; in animal 5, the clinical form found was rhinofacial. It is concluded that clinical signs may vary with the presentation of the disease as well as the involved agent. Early diagnostic alternatives such as fungal isolation from material collected from intranasal swabs can be useful and employed in affected herds, enabling earlier intervention.<\/jats:p>","DOI":"10.3390\/ani16081231","type":"journal-article","created":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T11:53:46Z","timestamp":1776426826000},"page":"1231","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical, Laboratory and Anatomopathological Findings of an Outbreak of Conidiobolomycosis in Sheep in the State of Rio Grande do Norte, Brazil"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6774-5304","authenticated-orcid":false,"given":"Carlos Alberto Queiroz de","family":"Aquino","sequence":"first","affiliation":[{"name":"Department of Animal Science, Universidade Federal Rural do Semi-\u00c1rido, Mossor\u00f3 59625-900, RN, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geovana Kelly dos Santos","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"Department of Animal Science, Universidade Federal Rural do Semi-\u00c1rido, Mossor\u00f3 59625-900, RN, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruan da Cruz","family":"Paulino","sequence":"additional","affiliation":[{"name":"Department of Animal Science, Universidade Federal Rural do Semi-\u00c1rido, Mossor\u00f3 59625-900, RN, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6489-7326","authenticated-orcid":false,"given":"Laynaslan Abreu","family":"Soares","sequence":"additional","affiliation":[{"name":"Rural Health and Technology Center, Universidade Federal de Campina Grande, Patos 58708-110, PB, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanca G\u00f3es dos Santos","family":"Soares","sequence":"additional","affiliation":[{"name":"Rural Health and Technology Center, Universidade Federal de Campina Grande, Patos 58708-110, PB, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jael Soares","family":"Batista","sequence":"additional","affiliation":[{"name":"Department of Animal Science, Universidade Federal Rural do Semi-\u00c1rido, Mossor\u00f3 59625-900, RN, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7941-8949","authenticated-orcid":false,"given":"Francisco Marlon Carneiro","family":"Feij\u00f3","sequence":"additional","affiliation":[{"name":"Department of Animal Science, Universidade Federal Rural do Semi-\u00c1rido, Mossor\u00f3 59625-900, RN, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jefferson Filgueira","family":"Alcindo","sequence":"additional","affiliation":[{"name":"Department of Animal Science, Universidade Federal Rural do Semi-\u00c1rido, Mossor\u00f3 59625-900, RN, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,4,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"94","DOI":"10.3767\/003158513X666330","article-title":"Phylogenetic lineages in Entomophthoromycota","volume":"30","author":"Gryganskyi","year":"2013","journal-title":"Persoonia"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1177\/1040638720958338","article-title":"Conidiobolomycosis, cryptococcosis, and aspergillosis in sheep and goats: A review","volume":"32","author":"Carmo","year":"2020","journal-title":"J. Vet. Diagn. Invest."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"2210","DOI":"10.1590\/0103-8478cr20131472","article-title":"Aspectos epidemiol\u00f3gicos da conidiobolomicose em ovinos na regi\u00e3o semi\u00e1rida do nordeste do Brasil","volume":"44","author":"Aguiar","year":"2014","journal-title":"Cienc. Rural"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1590\/S0100-736X2008000100012","article-title":"Conidiobolomicose em ovinos no estado de Mato Grosso","volume":"28","author":"Boabaid","year":"2008","journal-title":"Pesq. Vet. Bras."},{"key":"ref_5","first-page":"862","article-title":"Conidiobolomicose rinocerebral e rinofar\u00edngea em ovinos","volume":"41","author":"Batista","year":"2011","journal-title":"Cienc. Rural"},{"key":"ref_6","first-page":"241","article-title":"Conidiobolomycosis in sheep in the state of Pernambuco","volume":"34","author":"Albuquerque","year":"2012","journal-title":"Braz. J. Vet. Med."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"5","DOI":"10.15361\/2175-0106.2022v38n1p05-12","article-title":"Conidiobolomicose em ovinos no estado do Acre, Brasil","volume":"38","author":"Silva","year":"2022","journal-title":"ARS Vet."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1590\/S0100-736X2007000400010","article-title":"Epidemiologia e sinais cl\u00ednicos da conidiobolomicose em ovinos no Estado do Piau\u00ed, Brasil","volume":"27","author":"Silva","year":"2007","journal-title":"Pesq. Vet. Bras."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.jcpa.2012.12.002","article-title":"Pathology of nasal infection caused by Condiobolus lamprauges and Pythium insidiosum in sheep","volume":"149","author":"Ubiali","year":"2013","journal-title":"J. Comp. Pathol."},{"key":"ref_10","first-page":"29","article-title":"Surtos de zigomicose rinofacial e rinofar\u00edngea em ovinos na Para\u00edba, Nordeste do Brasil","volume":"28","author":"Dantas","year":"2008","journal-title":"Pesq. Vet. Bras."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"252","DOI":"10.29374\/2527-2179.bjvm018017","article-title":"Surtos de conidiobolomicose ovina por Conidiobolus lamprauges no Estado da Bahia, Nordeste do Brasil","volume":"39","author":"Peixoto","year":"2017","journal-title":"Braz. J. Vet. Med."},{"key":"ref_12","unstructured":"Prophet, E.B., Mills, B., Arrington, J.B., and Sobin, L.H. (1992). AFIP Laboratory Methods in Histotechnology, American Registry of Pathology. [1st ed.]."},{"key":"ref_13","unstructured":"Macfaddin, J.F. (2000). Biochemical Tests for Identification of Medical Bacteria, Lippincott Willians & Wilkins. [3rd ed.]."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1128\/JCM.01589-09","article-title":"Morphologic and phylogenetic characterization of Conidiobolus lamprauges recovered from infected sheep","volume":"48","author":"Vilela","year":"2010","journal-title":"J. Clin. Microbiol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1354\/vp.44-3-314","article-title":"Conidiobolomycosis in sheep in Brazil","volume":"44","author":"Silva","year":"2007","journal-title":"Vet. Pathol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1590\/S0100-736X2009000100002","article-title":"Hemograma, proteinograma, ionograma e dosagens bioqu\u00edmicas e enzim\u00e1ticas de ovinos acometidos por conidiobolomicose no nordeste do Brasil","volume":"29","author":"Batista","year":"2009","journal-title":"Pesq. Vet. Bras."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1111\/j.1751-0813.1992.tb15556.x","article-title":"Rhinocerebral and nasal zygomycosis in sheep caused by Conidiobolus incongruus","volume":"69","author":"Ketterer","year":"1992","journal-title":"Aust. Vet. J."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1128\/CMR.00014-18","article-title":"Human pathogenic entomophthorales","volume":"31","author":"Vilela","year":"2018","journal-title":"Clin. Microbiol. Rev."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Brooks, M.B., Harr, K.E., Seelig, D.M., Wardrop, K.J., and Weiss, D.J. (2022). Schalm\u2019s Veterinary Hematology, Wiley Blackwell. [7th ed.].","DOI":"10.1002\/9781119500537"}],"container-title":["Animals"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-2615\/16\/8\/1231\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T12:12:37Z","timestamp":1776427957000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-2615\/16\/8\/1231"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,17]]},"references-count":19,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2026,4]]}},"alternative-id":["ani16081231"],"URL":"https:\/\/doi.org\/10.3390\/ani16081231","relation":{},"ISSN":["2076-2615"],"issn-type":[{"value":"2076-2615","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,17]]}}}