{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T18:39:20Z","timestamp":1785436760117,"version":"3.56.0"},"reference-count":125,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T00:00:00Z","timestamp":1776384000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004001","name":"Guizhou Provincial Science and Technology Department","doi-asserted-by":"publisher","award":["Qiankehe Jichu-ZK [2023] Yiban 267"],"award-info":[{"award-number":["Qiankehe Jichu-ZK [2023] Yiban 267"]}],"id":[{"id":"10.13039\/501100004001","id-type":"DOI","asserted-by":"publisher"}]},{"award":["Qiankehe Jichu-ZK [2023] Yiban 267"],"award-info":[{"award-number":["Qiankehe Jichu-ZK [2023] Yiban 267"]}],"id":[{"id":"https:\/\/ror.org\/00kwnh405","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animals"],"abstract":"<jats:p>Against the backdrop of the full implementation of \u201cantibiotic ban\u201d and \u201czinc restriction\u201d policies in livestock and poultry breeding, and the growing consumer demand for safe livestock and poultry products, the development of natural and efficient green feed additives has become crucial for the sustainable development of the animal husbandry industry. Curcumin, a natural polyphenolic compound extracted from the rhizome of Curcuma longa L., has attracted extensive attention in poultry production due to its various biological activities and safety. This paper thoroughly reviews the chemical structure and physicochemical properties of curcumin, and elaborates on its core molecular mechanisms of action, which mainly involve the regulation of nuclear factor erythroid 2-related factor 2 (Nrf2)\/antioxidant response element (ARE), nuclear factor-\u03baB (NF-\u03baB), peroxisome proliferator-activated receptor \u03b3 (PPAR-\u03b3), and mitogen-activated protein kinase (MAPK) pathways to exert antioxidant, anti-inflammatory, antibacterial, immunomodulatory and lipid metabolism regulatory effects. It further clarifies the practical application value of curcumin in major poultry species including broilers, laying hens, ducks and quails, showing that curcumin can significantly improve poultry production performance, optimize meat and egg quality, protect intestinal health, and enhance the ability of poultry to resist stress and diseases. Meanwhile, the review notes curcumin\u2019s current application limitations (low bioavailability, poor stability, unclear standardized dosage, and high industrialization cost) and proposes targeted future research directions to address these issues. In conclusion, curcumin is a promising green feed additive alternative to antibiotics, and its large-scale and standardized application in poultry production will effectively promote the green, healthy and sustainable development of the poultry industry.<\/jats:p>","DOI":"10.3390\/ani16081242","type":"journal-article","created":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T14:24:51Z","timestamp":1776435891000},"page":"1242","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Curcumin as a Green Antibiotic Substitute: Mechanisms and Applications in Poultry Production and Health Promotion"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4789-5687","authenticated-orcid":false,"given":"Xiaopeng","family":"Tang","sequence":"first","affiliation":[{"name":"State Engineering Technology Institute for Karst Desertfication Control, School of Karst Science, Guizhou Normal University, Guiyang 550025, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baoshan","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Engineering Technology Institute for Karst Desertfication Control, School of Karst Science, Guizhou Normal University, Guiyang 550025, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayuan","family":"Yang","sequence":"additional","affiliation":[{"name":"State Engineering Technology Institute for Karst Desertfication Control, School of Karst Science, Guizhou Normal University, Guiyang 550025, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youyuan","family":"Xie","sequence":"additional","affiliation":[{"name":"State Engineering Technology Institute for Karst Desertfication Control, School of Karst Science, Guizhou Normal University, Guiyang 550025, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kangning","family":"Xiong","sequence":"additional","affiliation":[{"name":"State Engineering Technology Institute for Karst Desertfication Control, School of Karst Science, Guizhou Normal University, Guiyang 550025, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,4,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Scazzocchio, B., Minghetti, L., and D\u2019Archivio, M. (2020). Interaction between gut microbiota and curcumin: A new key of understanding for the health effects of curcumin. Nutrients, 12.","DOI":"10.3390\/nu12092499"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"871","DOI":"10.2174\/1381612825666190402163940","article-title":"Ethnobotany, phytochemistry and traditional uses of Curcuma spp. and pharmacological profile of two important species (C. longa and C. zedoaria): A Review","volume":"25","author":"Ayati","year":"2019","journal-title":"Curr. Pharm. Des."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Jin, S., Yang, H., Jiao, Y., Pang, Q., Wang, Y., Wang, M., Shan, A., and Feng, X. (2021). Dietary curcumin alleviated acute ileum damage of ducks (Anas platyrhynchos) induced by AFB1 through regulating Nrf2-ARE and NF-\u03baB signaling pathways. Foods, 10.","DOI":"10.3390\/foods10061370"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"110535","DOI":"10.1016\/j.vetmic.2025.110535","article-title":"Curcumin activates the JAK-STAT signaling pathway to enhance the innate immune response against porcine epidemic diarrhea virus infection in vivo and in vitro","volume":"305","author":"Jiang","year":"2025","journal-title":"Vet. Microbiol."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Tang, X., Xiong, K., Zeng, Y., and Fang, R. (2024). The Mechanism of Zinc Oxide in Alleviating Diarrhea in Piglets after Weaning: A Review from the Perspective of Intestinal Barrier Function. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms251810040"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Tang, X., Xiong, K., Wassie, T., and Wu, X. (2022). Curcumin and Intestinal Oxidative Stress of Pigs with Intrauterine Growth Retardation: A Review. Front. Nutr., 9.","DOI":"10.3389\/fnut.2022.847673"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1039\/C7FO01242J","article-title":"Curcumin as a functional food-derived factor: Degradation products, metabolites, bioactivity, and future perspectives","volume":"9","author":"Tsuda","year":"2018","journal-title":"Food Funct."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"110502","DOI":"10.1016\/j.jfoodeng.2021.110502","article-title":"Microencapsulation of curcumin using coconut milk whey and Gum Arabic","volume":"298","author":"Adsare","year":"2021","journal-title":"J. Food Eng."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Alallam, B., Doolaanea, A.A., Alfatama, M., and Lim, V. (2023). Phytofabrication and Characterisation of Zinc Oxide Nanoparticles Using Pure Curcumin. Pharmaceuticals, 16.","DOI":"10.3390\/ph16020269"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"140449","DOI":"10.1016\/j.foodchem.2024.140449","article-title":"Physical properties and antioxidant activity of curcumin\u2013zinc metal\u2013organic frameworks","volume":"460","author":"Chen","year":"2024","journal-title":"Food Chem."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"3809","DOI":"10.1007\/s42250-024-01004-2","article-title":"Preparation, Characterization and Antiviral Evaluation of Nano-formulations Comprising Curcumin-PLGA and Curcumin-metal Oxide Nanocomposite against SARS-CoV-2","volume":"7","author":"Elbadawy","year":"2024","journal-title":"Chem. Afr."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Zhang, B., Guo, W., Chen, Z., Chen, Y., Zhang, R., Liu, M., Yang, J., and Zhang, J. (2025). Physicochemical Characterization and Oral Bioavailability of Curcumin\u2013Phospholipid Complex Nanosuspensions Prepared Based on Microfluidic System. Pharmaceutics, 17.","DOI":"10.3390\/pharmaceutics17030395"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1002\/jps.23335","article-title":"Development of Curcumin Nanocrystal: Physical Aspects","volume":"102","author":"Rachmawati","year":"2013","journal-title":"J. Pharm. Sci."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1893","DOI":"10.1007\/s43630-024-00639-x","article-title":"Visible light potentiates rapid cell destruction and death by curcumin in vitro","volume":"23","author":"DePasquale","year":"2024","journal-title":"Photochem. Photobiol. Sci."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1016\/j.foodchem.2010.09.071","article-title":"Stability and release properties of curcumin encapsulated in Saccharomyces cerevisiae, \u03b2-cyclodextrin and modified starch","volume":"125","author":"Paramera","year":"2011","journal-title":"Food Chem."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Bielak-Zmijewska, A., Grabowska, W., Ciolko, A., Bojko, A., Mosieniak, G., Bijoch, \u0141., and Sikora, E. (2019). The Role of curcumin in the modulation of ageing. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20051239"},{"key":"ref_17","first-page":"2680","article-title":"Antioxidant and free radical scavenging activity of curcumin determined by using different in vitro and ex vivo models","volume":"7","author":"Borra","year":"2013","journal-title":"J. Med. Plants Res."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Avenda\u00f1o-Brise\u00f1o, K.A., Escutia-Mart\u00ednez, J., Hern\u00e1ndez-Cruz, E.Y., and Pedraza-Chaverri, J. (2025). Antioxidant Effect of Curcumin and Its Impact on Mitochondria: Evidence from Biological Models. J. Xenobiot., 15.","DOI":"10.3390\/jox15050139"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"117957","DOI":"10.1016\/j.biopha.2025.117957","article-title":"Curcumin-mediated NRF2 induction limits inflammatory damage in, preclin-ical models of cystic fibrosis","volume":"186","author":"Bureau","year":"2025","journal-title":"Biomed. Pharmacother."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"106253","DOI":"10.1016\/j.archoralbio.2025.106253","article-title":"Sitagliptin regulates the AMPK\/NF-\u03baB signaling pathway to alleviate lipopolysaccharide-induced inflammatory responses and promote osteogenic differentiation in rat bone marrow mesenchymal stem cells","volume":"175","author":"Yao","year":"2025","journal-title":"Arch. Oral Biol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/j.envpol.2019.05.026","article-title":"Deoxynivalenol induced apoptosis and inflammation of IPEC-J2 cells by promoting ROS production","volume":"251","author":"Kang","year":"2019","journal-title":"Environ. Pollut."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Wu, Z., Zhao, Y., Wang, Y., Li, H., Xu, F., Zhang, W., Fu, H., Yin, L., Amevor, F.K., and Lin, J. (2025). Investigating Protective Effect of Suspension of Paeoniflorin in Combination with Curcumin Against Acute Liver Injury Based on Inhibition of TLR4\/NF-\u03baB\/NLRP3 Inflammatory Pathway. Int. J. Mol. Sci., 26.","DOI":"10.3390\/ijms26136324"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1610711","DOI":"10.3389\/fphar.2025.1610711","article-title":"Hydroxyethyl starch-curcumin nanoparticles ameliorate DSS-induced ulcerative colitis in mice via synergistic TLR4\/NF-\u03baB suppression, Nrf2 activation, intestinal barrier restoration, and gut microbiota modulation","volume":"16","author":"Li","year":"2025","journal-title":"Front. Pharmacol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"e4030","DOI":"10.1002\/cbf.4030","article-title":"NF-\u03baB pathway as a molecular target for curcumin in diabetes mellitus treatment: Focusing on oxidative stress and inflammation","volume":"42","author":"Zamanian","year":"2024","journal-title":"Cell Biochem. Funct."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"3474","DOI":"10.4049\/jimmunol.163.6.3474","article-title":"Curcumin Blocks Cytokine-Mediated NF-\u03baB Activation and Proinflammatory Gene Expression by Inhibiting Inhibitory Factor I-\u03baB Kinase Activity","volume":"163","author":"Jobin","year":"1999","journal-title":"J. Immunol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"111909","DOI":"10.1016\/j.cellsig.2025.111909","article-title":"Curcumin alleviates lipopolysaccharide-induced alveolar epithelial Glycocalyx damage by modulating the Rac1\/NF-\u03baB\/HPSE pathway","volume":"134","author":"Xu","year":"2025","journal-title":"Cell. Signal."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"116908","DOI":"10.1016\/j.bcp.2025.116908","article-title":"Understanding the peroxisome proliferator-activated receptor gamma (PPAR-\u03b3) role in periodontitis and diabetes mellitus: A molecular perspective","volume":"237","author":"Nicchio","year":"2025","journal-title":"Biochem. Pharmacol."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Liu, Z.J., Li, Z.H., Liu, L., Tang, W.X., Wang, Y., Dong, M.R., and Xiao, C. (2016). Curcumin Attenuates Beta-Amyloid-Induced Neuroinflammation via Activation of Peroxisome Proliferator-Activated Receptor-Gamma Function in a Rat Model of Alzheimer\u2019s Disease. Front. Pharmacol., 7.","DOI":"10.3389\/fphar.2016.00261"},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Ju, Z., Su, M., Li, D., Hong, J., Im, D.S., Kim, S., Kim, E.L., and Jung, J.H. (2019). An Algal Metabolite-Based PPAR-\u03b3 Agonist Displayed Anti-Inflammatory Effect via Inhibition of the NF-\u03baB Pathway. Mar. Drugs, 17.","DOI":"10.3390\/md17060321"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"4927430","DOI":"10.1155\/2019\/4927430","article-title":"Curcumin Attenuates Asthmatic Airway Inflammation and Mucus Hypersecretion Involving a PPAR\u03b3-Dependent NF-\u03baB Signaling Pathway In Vivo and In Vitro","volume":"2019","author":"Zhu","year":"2019","journal-title":"Mediat. Inflamm."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"7983","DOI":"10.1039\/C9FO02159K","article-title":"Curcumin inhibits cigarette smoke-induced inflammation via modulating the PPAR\u03b3-NF-\u03baB signaling pathway","volume":"10","author":"Li","year":"2019","journal-title":"Food Funct."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"189","DOI":"10.4167\/jbv.2012.42.3.189","article-title":"Mitogen-activated Protein Kinases in Inflammation","volume":"42","author":"Manzoor","year":"2012","journal-title":"J. Bacteriol. Virol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"2686","DOI":"10.1007\/s12035-023-03706-z","article-title":"Polyphenols Targeting MAP Kinase Signaling Pathway in Neurological Diseases: Understanding Molecular Mechanisms and Therapeutic Targets","volume":"61","author":"Islam","year":"2023","journal-title":"Mol. Neurobiol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"755","DOI":"10.3892\/etm.2022.11690","article-title":"Anti-inflammatory effects of Nypa fruticans Wurmb via NF-\u03baB and MAPK signaling pathways in macrophages","volume":"24","author":"Park","year":"2022","journal-title":"Exp. Ther. Med."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1002\/ptr.6324","article-title":"Curcuminoids: Implication for inflammation and oxidative stress in cardiovascular diseases","volume":"33","author":"Li","year":"2019","journal-title":"Phytother. Res."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1538","DOI":"10.1016\/j.biopha.2017.11.069","article-title":"Curcumin suppresses JNK pathway to attenuate BPA-induced insulin resistance in LO2 cells","volume":"97","author":"Geng","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.fsi.2022.09.074","article-title":"Modulatory effects of curcumin on Singapore grouper iridovirus infection-associated apoptosis and autophagy in vitro","volume":"131","author":"Wang","year":"2022","journal-title":"Fish Shellfish Immunol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1007\/s10787-021-00912-w","article-title":"Curcumin alleviates lipopolysaccharides-induced inflammation and apoptosis in vascular smooth muscle cells via inhibition of the NF-\u03baB and JNK signaling pathways","volume":"30","author":"Ruan","year":"2022","journal-title":"Inflammopharmacology"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"155415","DOI":"10.1016\/j.phymed.2024.155415","article-title":"Effects of folate-chicory acid liposome on macrophage polarization and TLR4\/NF-\u03baB signaling pathway in ulcerative colitis mouse","volume":"128","author":"Yang","year":"2024","journal-title":"Phytomedicine"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1352946","DOI":"10.3389\/fimmu.2024.1352946","article-title":"Macrophage polarization: An important role in inflammatory diseases","volume":"15","author":"Luo","year":"2024","journal-title":"Front. Immunol."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Cordeiro, M.C.C., Tom\u00e9, F.D., Arruda, F.S., da Fonseca, S.G., Nagib, P.R.A., and Celes, M.R.N. (2023). Curcumin as a Stabilizer of Macrophage Polarization during Plasmodium Infection. Pharmaceutics, 15.","DOI":"10.3390\/pharmaceutics15102505"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"9976912","DOI":"10.1155\/2021\/9976912","article-title":"Anti-Inflammatory Effect of Curcumin on the Mouse Model of Myocardial Infarction through Regulating Macrophage Polarization","volume":"2021","author":"Yan","year":"2021","journal-title":"Mediat. Inflamm."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"104892","DOI":"10.1016\/j.micpath.2021.104892","article-title":"Anti-MRSA activity of curcumin in planktonic cells and biofilms and determination of possible action mechanisms","volume":"155","author":"Silva","year":"2021","journal-title":"Microb. Pathog."},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Dai, C., Lin, J., Li, H., Shen, Z., Wang, Y., Velkov, T., and Shen, J. (2022). The Natural Product Curcumin as an Antibacterial Agent: Current Achievements and Problems. Antioxidants, 11.","DOI":"10.3390\/antiox11030459"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1007\/s10266-020-00514-y","article-title":"Effect of curcumin on growth, biofilm formation and virulence factor gene expression of Porphyromonas gingivalis","volume":"109","author":"Kumbar","year":"2020","journal-title":"Odontology"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"e2000171","DOI":"10.1002\/cbdv.202000171","article-title":"Antibacterial Mechanism of Curcumin: A Review","volume":"17","author":"Heng","year":"2020","journal-title":"Chem. Biodivers."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Wang, Z., Yang, H., Li, Z., and Liu, J. (2024). Non-Thermal Treatment Mediated by Curcumin for Enhancing Food Product Quality. Foods, 13.","DOI":"10.3390\/foods13233980"},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Jamil, S.N.H., Ali, A.H., Feroz, S.R., Lam, S.D., Agustar, H.K., Mohd Abd Razak, M.R., and Latip, J. (2023). Curcumin and Its Derivatives as Potential Antimalarial and Anti-Inflammatory Agents: A Review on Structure\u2013Activity Relationship and Mechanism of Action. Pharmaceuticals, 16.","DOI":"10.3390\/ph16040609"},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Hafez, M.H., El-Kazaz, S.E., Alharthi, B., Ghamry, H.I., Alshehri, M.A., Sayed, S., Shukry, M., and El-Sayed, Y. (2022). The Impact of Curcumin on Growth Performance, Growth-Related Gene Expression, Oxidative Stress, and Immunological Biomarkers in Broiler Chickens at Different Stocking Densities. Animals, 12.","DOI":"10.3390\/ani12080958"},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Jin, S., Yang, H., Liu, F., Pang, Q., Shan, A., and Feng, X. (2021). Effect of Dietary Curcumin Supplementation on Duck Growth Performance, Antioxidant Capacity and Breast Meat Quality. Foods, 10.","DOI":"10.3390\/foods10122981"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"2280","DOI":"10.1002\/jsfa.70337","article-title":"Dietary curcumin alleviates aflatoxin B1-induced liver injury and improves growth performance in broilers via Nrf2 activation and NLRP3 inflammasome inhibition","volume":"106","author":"Wang","year":"2026","journal-title":"J. Sci. Food Agric."},{"key":"ref_52","first-page":"10","article-title":"The impact of curcumin nanoparticles (CurNPs) on growth performance, antioxidant indices, blood biochemistry, gut morphology and cecal microbial profile of broiler chickens","volume":"73","author":"Fathi","year":"2024","journal-title":"Acta Agric. Scand. Sect. A Anim. Sci."},{"key":"ref_53","first-page":"1","article-title":"Effect of Adding Different Levels of Silver-Curcumin Nanoparticles on Some Productive Traits, Blood Parameters and Antioxidant Status of Broiler Chickens","volume":"10","year":"2023","journal-title":"Muthanna J. Agric. Sci."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"skae296","DOI":"10.1093\/jas\/skae296","article-title":"Dietary curcumin supplementation enhances growth performance and Anti-inflammatory functions by modulating gut microbiota, microbiota-derived metabolites, and expression of inflammation-related genes in Broilers","volume":"102","author":"Chen","year":"2024","journal-title":"J. Anim. Sci."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"104144","DOI":"10.1016\/j.jtherbio.2025.104144","article-title":"Using curcumin (Curcuma longa) as a dietary supplement modulates performance, behavior, blood metabolites, antioxidant status, and histomorphological changes in heat-stressed broiler chickens","volume":"130","author":"Gharib","year":"2025","journal-title":"J. Therm. Biol."},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Eleiwa, N., El-Shabrawi, A., Ibrahim, D., Abdelwarith, A., Younis, E., Davies, S., Metwally, M., and Abu-Zeid, E. (2023). Dietary Curcumin Modulating Effect on Performance, Antioxidant Status, and Immune-Related Response of Broiler Chickens Exposed to Imidacloprid Insecticide. Animals, 13.","DOI":"10.3390\/ani13233650"},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Chen, Y., Liu, L., Yu, L., Li, S., Zhu, N., and You, J. (2024). Curcumin Supplementation Improves Growth Performance and Anticoccidial Index by Improving the Antioxidant Capacity, Inhibiting Inflammatory Responses, and Maintaining Intestinal Barrier Function in Eimeria tenella-Infected Broilers. Animals, 14.","DOI":"10.3390\/ani14081223"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"3880","DOI":"10.1021\/jf505889b","article-title":"Effect of various levels of dietary curcumin on meat quality and antioxidant profile of breast muscle in broilers","volume":"63","author":"Zhang","year":"2015","journal-title":"J. Agric. Food Chem."},{"key":"ref_59","first-page":"104740","article-title":"Dietary incorporation of biological curcumin nanoparticles improved growth performance, ileal architecture, antioxidative status, serum lipid profile, and humoral immune response of heat-stressed broiler chickens","volume":"104","author":"Mesalam","year":"2024","journal-title":"Poult. Sci."},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"El-Hack, M.E.A., Alaidaroos, B.A., Farsi, R.M., Abou-Kassem, D.A., El-Saadony, M.T., Saad, A.S., Shafi, M.E., Albaqami, N.A., Taha, A.E., and Ashour, E.A. (2021). Impacts of Supplementing Broiler Diets with Biological Curcumin, Zinc Nanoparticles and Bacillus licheniformis on Growth, Carcass Traits, Blood Indices, Meat Quality and Cecal Microbial Load. Animals, 11.","DOI":"10.3390\/ani11071878"},{"key":"ref_61","first-page":"103916","article-title":"Combination of herbal components (curcumin, carvacrol, thymol, cinnamaldehyde) in broiler chicken feed: Impacts on response parameters, performance, fatty acid profiles, meat quality and control of coccidia and bacteria","volume":"136","author":"Galli","year":"2019","journal-title":"Microb. Pathog."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.3382\/ps\/pex408","article-title":"Curcumin attenuates heat-stress-induced oxidant damage by simultaneous activation of GSH-related antioxidant enzymes and Nrf2-mediated phase II detoxifying enzyme systems in broiler chickens","volume":"97","author":"Zhang","year":"2018","journal-title":"Poult. Sci."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1093\/jas\/sky009","article-title":"Curcumin attenuates hepatic mitochondrial dysfunction through the maintenance of thiol pool, inhibition of mtDNA damage, and stimulation of the mitochondrial thioredoxin system in heat-stressed broilers","volume":"96","author":"Zhang","year":"2018","journal-title":"J. Anim. Sci."},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Salah, A., Ahmed-Farid, O., Nassan, M.M., and El-Tarabany, M.S. (2021). Dietary Curcumin Improves Energy Metabolism, Brain Monoamines, Carcass Traits, Muscle Oxidative Stability and Fatty Acid Profile in Heat-Stressed Broiler Chickens. Antioxidants, 10.","DOI":"10.3390\/antiox10081265"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.jtherbio.2019.07.002","article-title":"Effects of dietary curcumin and acetylsalicylic acid supplements on performance, muscle amino acid and fatty acid profiles, antioxidant biomarkers and blood chemistry of heat-stressed broiler chickens","volume":"84","author":"Salah","year":"2019","journal-title":"J. Therm. Biol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"103132","DOI":"10.1016\/j.psj.2023.103132","article-title":"Dietary curcumin supplementation alleviates diquat-induced oxidative stress in the liver of broilers","volume":"102","author":"Wu","year":"2023","journal-title":"Poult. Sci."},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Zhang, J., Sun, X., Chai, X., Jiao, Y., Sun, J., Wang, S., Yu, H., and Feng, X. (2024). Curcumin Mitigates Oxidative Damage in Broiler Liver and Ileum Caused by Aflatoxin B1-Contaminated Feed through Nrf2 Signaling Pathway. Animals, 14.","DOI":"10.3390\/ani14030409"},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Damiano, S., Jarriyawattanachaikul, W., Girolami, F., Longobardi, C., Nebbia, C., Andretta, E., Lauritano, C., Dabbou, S., Avantaggiato, G., and Schiavone, A. (2022). Curcumin Supplementation Protects Broiler Chickens Against the Renal Oxidative Stress Induced by the Dietary Exposure to Low Levels of Aflatoxin B1. Front. Vet. Sci., 8.","DOI":"10.3389\/fvets.2021.822227"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"5936","DOI":"10.1016\/j.psj.2020.08.046","article-title":"The effects of different doses of curcumin compound on growth performance, antioxidant status, and gut health of broiler chickens challenged with Eimeria species","volume":"99","author":"Yadav","year":"2020","journal-title":"Poult. Sci."},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Hern\u00e1ndez-Garc\u00eda, P., Granados-Rivera, L., Orzuna-Orzuna, J., V\u00e1zquez-Silva, G., D\u00edaz-Galv\u00e1n, C., and Razo-Ort\u00edz, P. (2025). Meta-Analysis of Dietary Curcumin Supplementation in Broiler Chickens: Growth Performance, Antioxidant Status, Intestinal Morphology, and Meat Quality. Antioxidants, 14.","DOI":"10.3390\/antiox14040460"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"422","DOI":"10.3382\/ps\/pey315","article-title":"Curcumin supplementation regulates lipid metabolism in broiler chickens","volume":"98","author":"Xie","year":"2019","journal-title":"Poult. Sci."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"325","DOI":"10.21608\/epsj.2020.81756","article-title":"Effect of dietary curcumin and curcumin nanoparticles supplementation on growth performance, immune response and antioxidant of broilers chickens","volume":"40","author":"Badran","year":"2020","journal-title":"Egypt. Poult. Sci. J."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"44","DOI":"10.2141\/jpsa.0120065","article-title":"Effect of Dietary Supplementation of Curcumin on Growth Performance, Intestinal Morphology and Nutrients Utilization of Broiler Chickens","volume":"50","author":"Rajput","year":"2013","journal-title":"J. Poult. Sci."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"1656","DOI":"10.2527\/jas.2014-8244","article-title":"Dietary curcumin supplementation protects against heat-stress-impaired growth performance of broilers possibly through a mitochondrial pathway","volume":"93","author":"Zhang","year":"2015","journal-title":"J. Anim. Sci."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1080\/1828051X.2017.1290510","article-title":"Effects of curcumin and nanocurcumin on growth performance, blood gas indices and ascites mortalities of broiler chickens reared under normal and cold stress conditions","volume":"16","author":"Rahmani","year":"2017","journal-title":"Ital. J. Anim. Sci."},{"key":"ref_76","doi-asserted-by":"crossref","unstructured":"Guo, S., Hu, J., Ai, S., Li, L., Ding, B., Zhao, D., Wang, L., and Hou, Y. (2023). Effects of Pueraria Extract and Curcumin on Growth Performance, Antioxidant Status and Intestinal Integrity of Broiler Chickens. Animals, 13.","DOI":"10.3390\/ani13081276"},{"key":"ref_77","doi-asserted-by":"crossref","unstructured":"Shu, Y., Wu, F., Yang, W., Qi, W., Li, R., and Zhang, Z. (2024). Dietary Effect of Curcumin on Amino Acid, Fatty Acid, and Volatile Compound Profiles of Chicken Meat. Foods, 13.","DOI":"10.3390\/foods13142230"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.aninu.2024.11.028","article-title":"Integrative analysis of metabolomics and transcriptomics reveals alterations in egg quality and hepatic lipid metabolism in hens supplemented with curcumin","volume":"21","author":"Zou","year":"2025","journal-title":"Anim. Nutr."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"2196","DOI":"10.1016\/j.psj.2019.12.001","article-title":"Effect of curcumin on laying performance, egg quality, endocrine hormones, and immune activity in heat-stressed hens","volume":"99","author":"Liu","year":"2020","journal-title":"Poult. Sci."},{"key":"ref_80","doi-asserted-by":"crossref","unstructured":"Li, C., Gao, J., Guo, S., He, B., and Wang, W. (2023). Effects of Curcumin on the Egg Quality and Hepatic Lipid Metabolism of Laying Hens. Animals, 14.","DOI":"10.3390\/ani14010138"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.rvsc.2018.01.022","article-title":"Feed addition of curcumin to laying hens showed anticoccidial effect, and improved egg quality and animal health","volume":"118","author":"Galli","year":"2018","journal-title":"Res. Vet. Sci."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"104355","DOI":"10.1016\/j.psj.2024.104355","article-title":"Supplementation of curcumin promotes the intestinal structure, immune barrier function and cecal microbiota composition of laying hens in early laying period","volume":"103","author":"Xu","year":"2024","journal-title":"Poult. Sci."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"26","DOI":"10.29252\/rap.9.22.26","article-title":"Effect of Different Levels of Nanoparticle Curcumin on Egg Quality, Blood Parameters, Immune Response and Digestibility in Laying Hens","volume":"9","author":"Daliri","year":"2018","journal-title":"Res. Anim. Prod."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"105540","DOI":"10.1016\/j.psj.2025.105540","article-title":"Research note: Dietary curcumin cocrystals enhance egg quality and lipid metabolism in laying hens","volume":"104","author":"Kong","year":"2025","journal-title":"Poult. Sci."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"102618","DOI":"10.1016\/j.jtherbio.2020.102618","article-title":"Curcumin addition in diet of laying hens under cold stress has antioxidant and antimicrobial effects and improves bird health and egg quality","volume":"91","author":"Dazuk","year":"2020","journal-title":"J. Therm. Biol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1080\/1828051X.2021.1913653","article-title":"Protective effects of curcumin on laying hens fed soybean meal with heat-induced protein oxidation","volume":"20","author":"Gu","year":"2021","journal-title":"Ital. J. Anim. Sci."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1080\/1828051X.2022.2071774","article-title":"Dietary curcumin supplementation regulates the lipid metabolism in laying hens","volume":"21","author":"Cui","year":"2022","journal-title":"Ital. J. Anim. Sci."},{"key":"ref_88","first-page":"331","article-title":"The Combination of Attapulgite, Betaine, and Chromium with Curcumin on Lipid Metabolism in Laying Hens under Tropical Conditions","volume":"14","author":"Muhshi","year":"2024","journal-title":"J. World\u2019s Poult. Res."},{"key":"ref_89","doi-asserted-by":"crossref","unstructured":"Tang, X., Zeng, Y., and Li, M. (2025). Clostridium butyricum: A promising approach to enhancing intestinal health in poultry. Front. Vet. Sci., 12.","DOI":"10.3389\/fvets.2025.1544519"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"102449","DOI":"10.1016\/j.jtherbio.2019.102449","article-title":"Effect of dietary curcumin on the antioxidant status of laying hens under high- temperature condition","volume":"86","author":"Nawab","year":"2019","journal-title":"J. Therm. Biol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/j.jtherbio.2019.07.003","article-title":"Effect of curcumin supplementation on TLR4 mediated non-specific immune responses in liver of laying hens under high-temperature conditions","volume":"84","author":"Nawab","year":"2019","journal-title":"J. Therm. Biol."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"102573","DOI":"10.1016\/j.jtherbio.2020.102573","article-title":"Dietary curcumin supplementation effects on blood immunological profile and liver enzymatic activity of laying hens after exposure to high temperature conditions","volume":"90","author":"Nawab","year":"2020","journal-title":"J. Therm. Biol."},{"key":"ref_93","doi-asserted-by":"crossref","unstructured":"Kang, K., Gao, W., Cui, Y., Xiao, M., An, L., and Wu, J. (2024). Curcumin Changed the Number, Particle Size, and miRNA Profile of Serum Exosomes in Roman Laying Hens under Heat Stress. Genes, 15.","DOI":"10.3390\/genes15020217"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"113593","DOI":"10.1016\/j.fct.2022.113593","article-title":"Curcumin attenuates AFB1-induced duck liver injury by inhibiting oxidative stress and lysosomal damage","volume":"172","author":"Qiao","year":"2023","journal-title":"Food Chem. Toxicol."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1007\/s12550-024-00524-7","article-title":"Curcumin attenuates aflatoxin B1-induced ileum injury in ducks by inhibiting NLRP3 inflammasome and regulating TLR4\/NF-\u03baB signaling pathway","volume":"40","author":"Pan","year":"2024","journal-title":"Mycotoxin Res."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1016\/j.psj.2019.10.041","article-title":"Protective effect of curcumin on ochratoxin A-induced liver oxidative injury in duck is mediated by modulating lipid metabolism and the intestinal microbiota","volume":"99","author":"Zhai","year":"2020","journal-title":"Poult. Sci."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1017\/S1751731118000678","article-title":"Effects of curcumin on performance, antioxidation, intestinal barrier and mitochondrial function in ducks fed corn contaminated with ochratoxin A","volume":"13","author":"Ruan","year":"2019","journal-title":"Animal"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.1002\/jsfa.12252","article-title":"Curcumin: A potential exogenous additive for the prevention of LPS-induced duck ileitis by the alleviation of inflammation and oxidative stress","volume":"103","author":"Yang","year":"2023","journal-title":"J. Sci. Food Agric."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"6603","DOI":"10.1002\/jsfa.12027","article-title":"Curcumin alleviated lipopolysaccharide-induced lung injury via regulating the Nrf2-ARE and NF-\u03baB signaling pathways in ducks","volume":"102","author":"Liu","year":"2022","journal-title":"J. Sci. Food Agric."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"112350","DOI":"10.1016\/j.ecoenv.2021.112350","article-title":"Protective effects of curcumin on ATO-induced nephrotoxicity in ducks in relation to suppressed autophagy, apoptosis and dyslipidemia by regulating oxidative stress","volume":"219","author":"Wu","year":"2021","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"112965","DOI":"10.1016\/j.ecoenv.2021.112965","article-title":"The neuroprotective effect of curcumin against ATO triggered neurotoxicity through Nrf2 and NF-\u03baB signaling pathway in the brain of ducks","volume":"228","author":"Wu","year":"2021","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"115820","DOI":"10.1016\/j.taap.2021.115820","article-title":"Curcumin alleviates arsenic-induced injury in duck skeletal muscle via regulating the PINK1\/Parkin pathway and protecting mitochondrial function","volume":"434","author":"Lan","year":"2022","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_103","doi-asserted-by":"crossref","unstructured":"Jin, S., Yang, H., Wang, Y., Pang, Q., Jiao, Y., Shan, A., and Feng, X. (2021). Dietary Curcumin Alleviated Aflatoxin B1-Induced Acute Liver Damage in Ducks by Regulating NLRP3-Caspase-1 Signaling Pathways. Foods, 10.","DOI":"10.3390\/foods10123086"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"3705","DOI":"10.3382\/ps\/pez058","article-title":"Dietary curcumin enhances intestinal antioxidant capacity in ducklings via altering gene expression of antioxidant and key detoxifying enzymes","volume":"98","author":"Ruan","year":"2019","journal-title":"Poult. Sci."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.toxicon.2022.01.010","article-title":"Curcumin activates the Nrf2 Pathway to alleviate AFB1-induced immunosuppression in the spleen of ducklings","volume":"209","author":"Wan","year":"2022","journal-title":"Toxicon"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"skad229","DOI":"10.1093\/jas\/skad229","article-title":"Lipopolysaccharide promotes apoptosis and oxidative injury of porcine small intestinal epithelial cells by down-regulating the expression of glutamine transporter ASCT2","volume":"101","author":"Tang","year":"2023","journal-title":"J. Anim. Sci."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"130584","DOI":"10.1016\/j.jhazmat.2022.130584","article-title":"Aflatoxin B1 exposure triggers hepatic lipotoxicity via p53 and perilipin 2 interaction-mediated mitochondria-lipid droplet contacts: An in vitro and in vivo assessment","volume":"445","author":"Che","year":"2023","journal-title":"J. Hazard. Mater."},{"key":"ref_108","doi-asserted-by":"crossref","unstructured":"Cui, Y., Wang, Q., Zhang, X., Yang, X., Shi, Y., Li, Y., and Song, M. (2023). Curcumin Alleviates Aflatoxin B1-Induced Liver Pyroptosis and Fibrosis by Regulating the JAK2\/NLRP3 Signaling Pathway in Ducks. Foods, 12.","DOI":"10.3390\/foods12051006"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1007\/s12550-025-00586-1","article-title":"Protective effect of curcumin against endoplasmic reticulum stress and lipid metabolism disorders in AFB1-intoxicated duck liver","volume":"41","author":"Su","year":"2025","journal-title":"Mycotoxin Res."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"109815","DOI":"10.1016\/j.cbpc.2023.109815","article-title":"Multi-omics reveals the protective effects of curcumin against AFB1-induced oxidative stress and inflammatory damage in duckling intestines","volume":"276","author":"Jiang","year":"2024","journal-title":"Comp. Biochem. Physiol. C Toxicol. Pharmacol."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1007\/s12550-023-00504-3","article-title":"Curcumin alleviates AFB1-induced nephrotoxicity in ducks: Regulating mitochondrial oxidative stress, ferritinophagy, and ferroptosis","volume":"39","author":"Liu","year":"2023","journal-title":"Mycotoxin Res."},{"key":"ref_112","doi-asserted-by":"crossref","unstructured":"Yang, X., Gao, Y., Yan, Q., Bao, X., Zhao, S., Wang, J., and Zheng, N. (2019). Transcriptome Analysis of Ochratoxin A-Induced Apoptosis in Differentiated Caco-2 Cells. Toxins, 12.","DOI":"10.3390\/toxins12010023"},{"key":"ref_113","doi-asserted-by":"crossref","unstructured":"Liu, J., Jiang, X., Peng, X., Yuan, Y., Shen, Y., Li, Y., Yan, Z., Yuan, X., Yang, Y., and Zhai, S. (2022). Effects of embryo injected with ochratoxins A on hatching quality and jejunum antioxidant capacity of ducks at hatching. Front. Vet. Sci., 9.","DOI":"10.3389\/fvets.2022.944891"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"75344","DOI":"10.1007\/s11356-022-20691-3","article-title":"Curcumin antagonizes inflammation and autophagy induced by arsenic trioxide through immune protection in duck spleen","volume":"29","author":"Tang","year":"2022","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"2503","DOI":"10.1007\/s12011-022-03321-4","article-title":"Curcumin Alleviates Arsenic Trioxide-Induced Inflammation and Pyroptosis via the NF-\u03baB\/NLRP3 Signaling Pathway in the Hypothalamus of Ducks","volume":"201","author":"Gan","year":"2023","journal-title":"Biol. Trace Elem. Res."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1080\/00439339.2022.2150926","article-title":"Updates in research on quail nutrition and feeding: A review","volume":"79","author":"Lima","year":"2023","journal-title":"World\u2019s Poult. Sci. J."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"2173","DOI":"10.1007\/s00484-024-02742-1","article-title":"Mechanisms underlying reproductive responses of Japanese quails to heat stress conditions","volume":"68","author":"Egbuniwe","year":"2024","journal-title":"Int. J. Biometeorol."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"5432","DOI":"10.3382\/ps\/pez327","article-title":"Heat shock protein 70 protects the quail cecum against oxidant stress, inflammatory injury, and microbiota imbalance induced by cold stress","volume":"98","author":"Liu","year":"2019","journal-title":"Poult. Sci."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1177\/03009858251324641","article-title":"Pathology of Clostridium colinum infection in quail","volume":"62","author":"Koehler","year":"2025","journal-title":"Vet. Pathol."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"103233","DOI":"10.1016\/j.psj.2023.103233","article-title":"Curcumin improves the egg quality, antioxidant activity, and intestinal microbiota of quails during the late laying period","volume":"103","author":"Liu","year":"2024","journal-title":"Poult. Sci."},{"key":"ref_121","doi-asserted-by":"crossref","unstructured":"Reda, F.M., El-Saadony, M.T., Elnesr, S.S., Alagawany, M., and Tufarelli, V. (2020). Effect of Dietary Supplementation of Biological Curcumin Nanoparticles on Growth and Carcass Traits, Antioxidant Status, Immunity and Caecal Microbiota of Japanese Quails. Animals, 10.","DOI":"10.3390\/ani10050754"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"4035","DOI":"10.1016\/j.fct.2012.08.029","article-title":"Curcumin ameloriates heat stress via inhibition of oxidative stress and modulation of Nrf2\/HO-1 pathway in quail","volume":"50","author":"Sahin","year":"2012","journal-title":"Food Chem. Toxicol."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"114192","DOI":"10.1016\/j.anifeedsci.2019.05.015","article-title":"Curcumin in the diet of quail in cold stress improves performance and egg quality","volume":"254","author":"Marchiori","year":"2019","journal-title":"Anim. Feed Sci. Technol."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"223","DOI":"10.36380\/jwpr.2021.27","article-title":"Improved Quality of Quail\u2019s Egg after the Induction of Hepatitis B Vaccine and Curcumin","volume":"11","author":"Saraswati","year":"2021","journal-title":"J. World\u2019s Poult. Res."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/s13568-025-02006-0","article-title":"Protective effects of Curcumin-Zinc complex on inflammatory damage of IPEC-J2 cells induced by bacterial lipopolysaccharide","volume":"16","author":"Tang","year":"2026","journal-title":"AMB Express"}],"container-title":["Animals"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-2615\/16\/8\/1242\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T14:39:48Z","timestamp":1776436788000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-2615\/16\/8\/1242"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,17]]},"references-count":125,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2026,4]]}},"alternative-id":["ani16081242"],"URL":"https:\/\/doi.org\/10.3390\/ani16081242","relation":{},"ISSN":["2076-2615"],"issn-type":[{"value":"2076-2615","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,17]]}}}