{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T09:35:44Z","timestamp":1785404144355,"version":"3.56.0"},"reference-count":25,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T00:00:00Z","timestamp":1776816000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Faculty of Veterinary medicine, Kasetsart University, Bangkok, Thailand","award":["VET.2021-10"],"award-info":[{"award-number":["VET.2021-10"]}]},{"award":["VET.2021-10"],"award-info":[{"award-number":["VET.2021-10"]}],"id":[{"id":"https:\/\/ror.org\/05gzceg21","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animals"],"abstract":"<jats:p>Assessing disease severity and prognosis in canine acute pancreatitis (AP) remains a major clinical challenge. This study evaluated the clinical utility of the Adapted Modified Canine Activity Index (aMCAI), a clinical scoring system refined from the original MCAI. A prospective observational study was conducted on 42 dogs diagnosed with AP, with aMCAI scores assessed on Days 1, 3, and 5. A linear mixed model (LMM) was used to analyze score progression over time and differences between survivors and non-survivors. Receiver operating characteristic (ROC) curves evaluated the prognostic accuracy for 30 day survival. The LMM analysis revealed that non-survivors had significantly higher aMCAI scores than survivors (p = 0.035), and overall scores decreased significantly over time (p &lt; 0.001). ROC analysis showed poor discrimination on Days 1 and 3. However, on Day 5 the aMCAI demonstrated good prognostic performance (AUC = 0.813, p &lt; 0.001). A cutoff value of \u22652.5 on Day 5 yielded 100% sensitivity, a negative likelihood ratio of 0.00 and a 100% negative predictive value, providing clinically relevant prognostic information. These findings suggest that the aMCAI is a practical tool for monitoring disease progression and may support the identification of dogs with a high likelihood of survival.<\/jats:p>","DOI":"10.3390\/ani16091292","type":"journal-article","created":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T14:29:03Z","timestamp":1776868143000},"page":"1292","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical Utility of Adapted Modified Canine Activity Index (aMCAI) in Canine Acute Pancreatitis: A Prospective Observational Study"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-0988-6382","authenticated-orcid":false,"given":"Veerada","family":"Wachirodom","sequence":"first","affiliation":[{"name":"Endocrinology and Gastroenterology Unit, Kasetsart University Veterinary Teaching Hospital, Faculty of Veterinary Medicine, Kasetsart University, 50 Ngamwongwan Rd., Lat Yao, Jatujak, Bangkok 10900, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7342-7879","authenticated-orcid":false,"given":"Sathidpak N.","family":"Assawarachan","sequence":"additional","affiliation":[{"name":"Endocrinology and Gastroenterology Unit, Kasetsart University Veterinary Teaching Hospital, Faculty of Veterinary Medicine, Kasetsart University, 50 Ngamwongwan Rd., Lat Yao, Jatujak, Bangkok 10900, Thailand"},{"name":"Department of Companion Animal Clinical Sciences, Faculty of Veterinary Medicine, Kasetsart University, 50 Ngamwongwan Rd., Lat Yao, Jatujak, Bangkok 10900, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7462-6514","authenticated-orcid":false,"given":"Suwicha","family":"Kasemsuwan","sequence":"additional","affiliation":[{"name":"Department of Veterinary Public Health, Faculty of Veterinary Medicine, Kasetsart University, Kamphaeng Saen Campus, Nakhon Pathom 73140, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanee","family":"Suksamranthaweerat","sequence":"additional","affiliation":[{"name":"Internal Medicine Unit, Kasetsart University Veterinary Teaching Hospital, Faculty of Veterinary Medicine, Kasetsart University, 50 Ngamwongwan Rd., Lat Yao, Jatujak, Bangkok 10900, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kasamapohn","family":"Hutachinda","sequence":"additional","affiliation":[{"name":"Cardiology Unit, Kasetsart University Veterinary Teaching Hospital, Faculty of Veterinary Medicine, Kasetsart University, 50 Ngamwongwan Rd., Lat Yao, Jatujak, Bangkok 10900, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4707-0156","authenticated-orcid":false,"given":"Monchanok","family":"Vijarnsorn","sequence":"additional","affiliation":[{"name":"Department of Companion Animal Clinical Sciences, Faculty of Veterinary Medicine, Kasetsart University, 50 Ngamwongwan Rd., Lat Yao, Jatujak, Bangkok 10900, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-5420-7910","authenticated-orcid":false,"given":"Narudee","family":"Kashemsant","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Veterinary Medicine, Kasetsart University, 50 Ngamwongwan Rd., Lat Yao, Jatujak, Bangkok 10900, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,4,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1111\/jvim.15421","article-title":"Development and validation of a novel clinical scoring system for short-term prediction of death in dogs with acute pancreatitis","volume":"33","author":"Fabres","year":"2019","journal-title":"J. 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