{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T05:06:48Z","timestamp":1779340008997,"version":"3.51.4"},"reference-count":41,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T00:00:00Z","timestamp":1778198400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animals"],"abstract":"<jats:p>Introduction: Idiopathic rhinitis (IR) is one of the most common causes of chronic nasal discharge in dogs. It is a diagnosis of exclusion requiring a comprehensive diagnostic work-up to rule out other differentials. To investigate a possible allergic etiology, allergen-specific IgE antibody superclasses were evaluated. Methods: Dogs with chronic nasal discharge underwent blood testing, whole-body CT, and detailed evaluation of the nasal cavity. Dogs with systemic diseases or corticosteroid treatment within two weeks prior to presentation were excluded. Results: A total of 46 dogs were included: 13 IR, 10 malignant tumors, six benign tumors, eight other inflammatory nasal diseases, and nine controls. All IR dogs were non-brachycephalic and of various breeds. No correlation was found between sinusitis, turbinate destruction, culture-based bacteriology, or IgE positivity. A similarly high number of positive IgE results was observed across all groups. Regarding treatment and follow-up, compared to dogs with other nasal diseases, compliance among IR dog owners was comparably poor. Conclusions: Allergen-specific IgE may be elevated in dogs with IR; however, they are neither diagnostic nor predictive. As owners often perceive the disease as a harmless cold, awareness must be raised about the nasal functions in dogs and possible consequences of untreated nasal discharge.<\/jats:p>","DOI":"10.3390\/ani16101438","type":"journal-article","created":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T20:14:16Z","timestamp":1778530456000},"page":"1438","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Insights into Canine Idiopathic Rhinitis from a Prospective Study: A Multimodal Diagnostic Perspective"],"prefix":"10.3390","volume":"16","author":[{"given":"Sarah","family":"R\u00f6sch","sequence":"first","affiliation":[{"name":"Ear, Nose and Throat Unit, Small Animal Department, College of Veterinary Medicine, Leipzig University, 04102 Leipzig, Germany"},{"name":"Internal Medicine Service, Small Animal Department, Faculty of Veterinary Medicine, Ghent University, 9820 Merelbeke, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2597-3234","authenticated-orcid":false,"given":"Gerhard Ulrich","family":"Oechtering","sequence":"additional","affiliation":[{"name":"Ear, Nose and Throat Unit, Small Animal Department, College of Veterinary Medicine, Leipzig University, 04102 Leipzig, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,5,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e77","DOI":"10.1002\/vrc2.77","article-title":"Severe chronic idiopathic suppurative lymphoplasmacytic rhinitis in a dog","volume":"9","author":"Cagnasso","year":"2021","journal-title":"Vet. 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