{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T12:10:51Z","timestamp":1778501451389,"version":"3.51.4"},"reference-count":62,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T00:00:00Z","timestamp":1778284800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Key Research and Development Programs of China","award":["2024TZXD027"],"award-info":[{"award-number":["2024TZXD027"]}]},{"name":"Shandong Province Pig Industry Technology System","award":["SDAIT-08-05"],"award-info":[{"award-number":["SDAIT-08-05"]}]},{"name":"Shandong Province Agricultural Major Technology Collaborative Promotion Plan","award":["SDNYXTTG-2025-43"],"award-info":[{"award-number":["SDNYXTTG-2025-43"]}]},{"name":"Taian Daizong Talent Program for Innovation and Entrepreneurship","award":["DZRC202311"],"award-info":[{"award-number":["DZRC202311"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animals"],"abstract":"<jats:p>Sustainable piglet farming faces challenges from weaning stress, which necessitates the exploration of effective, natural antimicrobial alternatives to enhance growth and gut health. So, this study evaluated the effects of algal oligosaccharide (OSA) supplementation (0, 200, 400, 600, 800 mg\/kg) as a natural antimicrobial alternative. Results showed that OSA significantly (p &lt; 0.05) improved slaughter performance and the apparent digestibility of nutrients (OM, CP, amino acids) and energy. OSA increasing serum glucose while decreasing urea nitrogen and cholesterol, suggesting a shift in energy substrate mobilization. Enhanced antioxidant capacity was evidenced by increased T-SOD and GSH-Px activities and reduced MDA content. Immunologically, OSA elevated serum IgA, IgM, and IL-10, while inhibiting pro-inflammatory cytokines (IL-1\u03b2, IL-6). In the jejunum, OSA obviously increased disaccharidase activities and sIgA levels. Microbial analysis revealed that OSA favorably modulated cecal microbiota by increasing the abundance of Firmicutes and beneficial genera while decreasing Proteobacteria and potential pathogens (e.g., Escherichia). In conclusion, dietary OSA improved antioxidant capacity, and immunity while optimizing nutrient utilization and gut microbiota. The optimal dosage was determined to be 600\u2013800 mg\/kg. These findings suggest that OSA serves as a promising antimicrobial alternative in piglet farming.<\/jats:p>","DOI":"10.3390\/ani16101453","type":"journal-article","created":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T10:50:52Z","timestamp":1778496652000},"page":"1453","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Dietary Supplementation with Algal-Derived Oligosaccharides: Impacts on the Growth Potential, Systemic Immunity, and Cecal Microbiota of Weaned Piglets"],"prefix":"10.3390","volume":"16","author":[{"given":"Jianpu","family":"Zhao","sequence":"first","affiliation":[{"name":"Key Laboratory of Efficient Utilization of Non-Grain Feed Resources (Co-Construction by Ministry and Province), Ministry of Agriculture and Rural Affairs, College of Animal Science and Technology, Shandong Agricultural University, Tai\u2019an 271017, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yiping","family":"Xie","sequence":"additional","affiliation":[{"name":"Key Laboratory of Efficient Utilization of Non-Grain Feed Resources (Co-Construction by Ministry and Province), Ministry of Agriculture and Rural Affairs, College of Animal Science and Technology, Shandong Agricultural University, Tai\u2019an 271017, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haichuan","family":"Lin","sequence":"additional","affiliation":[{"name":"Promotion Center for Animal Husbandry Development in Pingyi County, Linyi 273300, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Kong","sequence":"additional","affiliation":[{"name":"Shandong Provincial Animal Husbandry General Station, Shandong Provincial Quality Testing Station for Breeding Livestock and Poultry, Jinan 250109, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weiren","family":"Yang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Efficient Utilization of Non-Grain Feed Resources (Co-Construction by Ministry and Province), Ministry of Agriculture and Rural Affairs, College of Animal Science and Technology, Shandong Agricultural University, Tai\u2019an 271017, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Zhou","sequence":"additional","affiliation":[{"name":"Key Laboratory of Efficient Utilization of Non-Grain Feed Resources (Co-Construction by Ministry and Province), Ministry of Agriculture and Rural Affairs, College of Animal Science and Technology, Shandong Agricultural University, Tai\u2019an 271017, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4943-0322","authenticated-orcid":false,"given":"Shuzhen","family":"Jiang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Efficient Utilization of Non-Grain Feed Resources (Co-Construction by Ministry and Province), Ministry of Agriculture and Rural Affairs, College of Animal Science and Technology, Shandong Agricultural University, Tai\u2019an 271017, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,5,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.aninu.2017.06.002","article-title":"Husbandry practices and gut health outcomes in weaned piglets: A review","volume":"3","author":"Jayaraman","year":"2017","journal-title":"Anim. 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