{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T05:07:24Z","timestamp":1779340044726,"version":"3.51.4"},"reference-count":53,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T00:00:00Z","timestamp":1778803200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animals"],"abstract":"<jats:p>Coilia nasus, a nutritionally and economically valuable migratory fish, has long relied on natural bait for its cultivation. However, the inherent instability of natural bait supplies poses a major bottleneck for large-scale aquaculture, necessitating a transition to formulated diets. To elucidate the adaptive response mechanisms underlying this dietary transition, we conducted sampling at three critical stages of feed domestication. This research revealed that while dietary shifts led to moderate alterations in muscle lipid and protein content, overall growth performance remained largely unaffected. During domestication, we observed significant structural remodeling of the stomach, intestine, and liver, along with increased activities of trypsin and lipase. The intestinal microbiota shifted, with Firmicutes abundance increasing notably during the domestication process, although the natural bait group exhibited even higher Firmicutes abundance than the formulated-feed group. Multi-omics analysis of intestinal samples from key domestication stages revealed significant enrichment of lipid metabolism pathways. It suggests that changes in genes and metabolites may be associated with the adaptive response to formulated-feed, including alterations in membrane stability, lipid metabolism and inflammatory state. This study provides the first comprehensive characterization of the structural and molecular adaptations of the digestive system of C. nasus during formulated-feed domestication. These findings offer a theoretical foundation for optimizing feeding protocols and supporting the sustainable aquaculture of this species.<\/jats:p>","DOI":"10.3390\/ani16101518","type":"journal-article","created":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T14:19:29Z","timestamp":1778854769000},"page":"1518","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Dynamic Structural Adaptation and Molecular Response of the Digestive Organs During Feed Domestication in Coilia nasus"],"prefix":"10.3390","volume":"16","author":[{"given":"Aili","family":"Sun","sequence":"first","affiliation":[{"name":"College of Fisheries, Key Lab of Freshwater Animal Breeding, Ministry of Agriculture\/Key Lab of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education\/Engineering Research Center of Green Development for Conventional Aquatic Biological Industry in the Yangtze River Economic Belt, Ministry of Education, Huazhong Agricultural University, Wuhan 430070, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenxin","family":"Hao","sequence":"additional","affiliation":[{"name":"College of Fisheries, Key Lab of Freshwater Animal Breeding, Ministry of Agriculture\/Key Lab of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education\/Engineering Research Center of Green Development for Conventional Aquatic Biological Industry in the Yangtze River Economic Belt, Ministry of Education, Huazhong Agricultural University, Wuhan 430070, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuangmeng","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Fisheries, Key Lab of Freshwater Animal Breeding, Ministry of Agriculture\/Key Lab of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education\/Engineering Research Center of Green Development for Conventional Aquatic Biological Industry in the Yangtze River Economic Belt, Ministry of Education, Huazhong Agricultural University, Wuhan 430070, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue","family":"Yu","sequence":"additional","affiliation":[{"name":"College of Fisheries, Key Lab of Freshwater Animal Breeding, Ministry of Agriculture\/Key Lab of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education\/Engineering Research Center of Green Development for Conventional Aquatic Biological Industry in the Yangtze River Economic Belt, Ministry of Education, Huazhong Agricultural University, Wuhan 430070, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zexia","family":"Gao","sequence":"additional","affiliation":[{"name":"College of Fisheries, Key Lab of Freshwater Animal Breeding, Ministry of Agriculture\/Key Lab of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education\/Engineering Research Center of Green Development for Conventional Aquatic Biological Industry in the Yangtze River Economic Belt, Ministry of Education, Huazhong Agricultural University, Wuhan 430070, China"},{"name":"Hubei Hongshan Laboratory, Wuhan 430070, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiming","family":"Wan","sequence":"additional","affiliation":[{"name":"College of Fisheries, Key Lab of Freshwater Animal Breeding, Ministry of Agriculture\/Key Lab of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education\/Engineering Research Center of Green Development for Conventional Aquatic Biological Industry in the Yangtze River Economic Belt, Ministry of Education, Huazhong Agricultural University, Wuhan 430070, China"},{"name":"Hubei Hongshan Laboratory, Wuhan 430070, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,5,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1111\/jwas.12406","article-title":"Biosecure Shrimp Feeds and Feeding Practices: Guidelines for Future Development","volume":"48","author":"Tacon","year":"2017","journal-title":"World Aquac. Soc."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Fan, H., Huang, P., Zhu, J.Y., Li, J., Jian, S., Hou, J., Wang, Z., Li, L., and Zhao, D. (2025). Effects of Artificial Compound Feed for Live Fish Feed on Growth Performance, Nutrient Composition, Digestive Performance, and Gut Microbiota of Giant Salamander (Andrias davidianus). Fishes, 10.","DOI":"10.3390\/fishes10010011"},{"key":"ref_3","first-page":"91","article-title":"Experimental study on bait domestication with expanded feed in Coilia nasus fingerlings","volume":"46","author":"Xu","year":"2016","journal-title":"Freshw. Fish."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"e10499","DOI":"10.1002\/ece3.10499","article-title":"A Comparison of Digestive Strategies for Fishes with Different Feeding Habits: Digestive Enzyme Activities, Intestinal Morphology, and Gut Microbiota","volume":"13","author":"Jiao","year":"2023","journal-title":"Ecol. Evol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1007\/s00227-005-0149-4","article-title":"Gut Length and Mass in Herbivorous and Carnivorous Prickleback Fishes (Teleostei: Stichaeidae): Ontogenetic, Dietary, and Phylogenetic Effects","volume":"148","author":"German","year":"2006","journal-title":"Mar. Biol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1007\/s10499-025-02332-x","article-title":"The Effect of Different Live Feed Organisms and Formulated Diet on Lumpfish (Cyclopterus lumpus) Larval Development: Part 1\u2014Effects on Growth, Liver, Bone Development, Lipids, and Microbiology","volume":"33","author":"Vo","year":"2025","journal-title":"Aquac. Int."},{"key":"ref_7","first-page":"331","article-title":"Digestive Enzymes and Metabolic Profile of Pseudoplatystoma corruscans (Teleostei: Siluriformes) in Response to Diet Composition","volume":"137","author":"Lundstedt","year":"2004","journal-title":"CBPB"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"102706","DOI":"10.1016\/j.aqrep.2025.102706","article-title":"Effects of Dietary \u03b1-Ketoglutarate Supplementation on Growth Performance, Digestive Enzyme Activity, Immune Gene Expression, and Intestinal Morphology of Largemouth Bass (Micropterus salmoides) Fed High Soybean Diet","volume":"41","author":"Zheng","year":"2025","journal-title":"Aquac. Rep."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Bazina, W.K., Tawfik, W.A., Abd Elghany, N.A., Saadony, S., Abdul Kari, Z., Alamoudi, M.O., Aly, M.Y.M., Younis, A.E., Mathew, R.T., and Eissa, M.E.H. (2025). Effects of Nano-Selenium and\/or Vitamin E Supplementation on Growth Performance, Antioxidant Status, Histopathology and Resistance to Aspergillus Flavus in Nile Tilapia (Oreochromis niloticus). BMC Vet. Res., 21.","DOI":"10.1186\/s12917-025-04471-y"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Zhang, W.X., Xia, S.L., Liu, B., Tian, H.Y., Liu, F., Yang, W.P., Yu, Y.B., Zhao, C.Y., Dewangan, N.K., and Wang, A.M. (2025). Effects of Dietary Protein Levels on Growth Performance, Plasma Parameters, and Digestive Enzyme Activities in Different Intestinal Segments of Megalobrama Amblycephala at Two Growth Stages. Fishes, 10.","DOI":"10.3390\/fishes10020060"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"102599","DOI":"10.1016\/j.aqrep.2024.102599","article-title":"Pumpkin Seed Oil-Loaded Chitosan Nanoparticles Enhance Growth, Digestive Enzymes, and Immune Response in Whiteleg Shrimp (Litopenaeus vannamei): Impacts on Histopathology and Survival against Vibrio Parahaemolyticus","volume":"40","author":"Eissa","year":"2025","journal-title":"Aquac. Rep."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.fsi.2021.07.007","article-title":"The Functionality of Probiotics in Aquaculture: An Overview","volume":"117","author":"Alagawany","year":"2021","journal-title":"Fish Shellfish Immun."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1750","DOI":"10.1111\/jam.12663","article-title":"Comparative Study on Gastrointestinal Microbiota of Eight Fish Species with Different Feeding Habits","volume":"117","author":"Li","year":"2014","journal-title":"J. Appl. Microbiol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1111\/1751-7915.13323","article-title":"Diet and Diet-Associated Bacteria Shape Early Microbiome Development in Yellowtail Kingfish (Seriola lalandi)","volume":"12","author":"Wemheuer","year":"2019","journal-title":"Microb. Biotechnol."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Ofek, T., Lalzar, M., Laviad-Shitrit, S., Izhaki, I., and Halpern, M. (2021). Comparative Study of Intestinal Microbiota Composition of Six Edible Fish Species. Front. Microbiol., 12.","DOI":"10.3389\/fmicb.2021.760266"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"740777","DOI":"10.1016\/j.aquaculture.2024.740777","article-title":"Identification of SNPs and Candidate Genes Associated with Growth Using GWAS and Transcriptome Analysis in Coilia nasus","volume":"586","author":"Yu","year":"2024","journal-title":"Aquaculture"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.margen.2015.02.005","article-title":"Ovary Transcriptome Profiling of (Coilia nasus) during Spawning Migration Stages by Illumina Sequencing","volume":"21","author":"Duan","year":"2015","journal-title":"Mar. Genom."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Wang, M.Y., Xu, G.C., Tang, Y.K., and Xu, P. (2020). Transcriptome Analysis of the Brain Provides Insights into the Regulatory Mechanism for Coilia nasus Migration. BMC Genom., 21.","DOI":"10.1186\/s12864-020-06816-3"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"149333","DOI":"10.1016\/j.scitotenv.2021.149333","article-title":"Full-Length Transcriptomic Analysis Reveals Osmoregulatory Mechanisms in Coilia Nasus Eyes Reared under Hypotonic and Hyperosmotic Stress","volume":"799","author":"Gao","year":"2021","journal-title":"Sci. Total Environ."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Hou, X., Wu, H., Yue, R., Zhou, X., Chen, Y., Luo, L., Lin, S., Ge, H., and He, Y. (2025). Effects of Dietary Rapeseed Meal on Growth Performance, Intestinal Structure, Gut Microbiota, and Related Gene Expression of Juvenile Largemouth Bass (Micropterus salmoides). Microorganisms, 13.","DOI":"10.3390\/microorganisms13112535"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1023\/A:1013713905833","article-title":"Metabolomics\u2014The Link between Genotypes and Phenotypes","volume":"48","author":"Fiehn","year":"2002","journal-title":"Plant Mol. Biol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"103229","DOI":"10.1016\/j.aqrep.2025.103229","article-title":"Dietary Periplaneta Americana Residue Modulate Immunometabolic Homeostasis and Antioxidant Defense in Juvenile Oncorhynchus Mykiss: Mechanistic Insights from Integrative Metabolomics and Transcriptomics","volume":"45","author":"Chen","year":"2025","journal-title":"Aquac. Rep."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"103235","DOI":"10.1016\/j.fochx.2025.103235","article-title":"1H NMR Metabolomic Responses Correlated to Meat Quality of Nile Tilapia (Oreochromis niloticus) Reared under Combined Dietary Salt and Water Salinity Conditions","volume":"32","author":"Watchasit","year":"2025","journal-title":"Food Chem. X"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/s11306-025-02356-7","article-title":"Identifying Sex-Linked Metabolomic Biomarkers in Fish Gonads after Bacterial Infection","volume":"21","author":"Huertas","year":"2025","journal-title":"Metabolomics"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"102020","DOI":"10.1016\/j.aqrep.2024.102020","article-title":"Effects of Dietary Tea Polyphenols on Intestinal Microflora and Metabonomics in Juvenile Hybrid Sturgeon (Acipenser baerii \u2640 \u00d7 A. schrenckii \u2642)","volume":"35","author":"Zhao","year":"2024","journal-title":"Aquac. Rep."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Yan, Y.Y., Zhang, Y., Dong, J.J., Wang, F.B., Zhang, H.T., Gao, F.Y., Ye, X., Wu, C.B., and Sun, C.F. (2025). Integrated Transcriptomic and Metabolomic Analysis Reveals the Molecular Mechanisms Involved in the Adaptations of Mandarin Fish (Siniperca chuatsi) to Compound Feed. Fishes, 10.","DOI":"10.3390\/fishes10080379"},{"key":"ref_27","unstructured":"(2014). Determination of Moisture in Feedstuffs (Standard No. GB\/T 6435-2014)."},{"key":"ref_28","unstructured":"(2007). Animal Feeding Stuffs\u2014Determination of Crude Ash (Standard No. GB\/T 6438-2007)."},{"key":"ref_29","unstructured":"(2018). Determination of Crude Protein in Feeds\u2014Kjeldahl Method (Standard No. GB\/T 6432-2018)."},{"key":"ref_30","unstructured":"(2006). Determination of crude fat in feeds (Standard No. GB\/T 6433-2006)."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Guan, W.Z., Qiu, G.F., and Liu, F. (2020). Transcriptome Analysis of the Growth Performance of Hybrid Mandarin Fish after Food Conversion. PLoS ONE, 15.","DOI":"10.1371\/journal.pone.0240308"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"740776","DOI":"10.1016\/j.aquaculture.2024.740776","article-title":"Impact of Live Feed Substitution with Formulated Diets on the Development, Digestive Capacity, Biochemical Composition, and Rearing Water Quality of European Lobster (Homarus gammarus, L.) Larvae","volume":"586","author":"Goncalves","year":"2024","journal-title":"Aquaculture"},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Zhang, Z., Yuan, X.P., Wu, H., Gao, J.W., Wu, J.Y., Xiong, Z.Z., Feng, Z.F., Xie, M., Li, S.M., and Xie, Z.G. (2024). The Effect of Short-Term Artificial Feed Domestication on the Expression of Oxidative-Stress-Related Genes and Antioxidant Capacity in the Liver and Gill Tissues of Mandarin Fish (Siniperca chuatsi). Genes, 15.","DOI":"10.3390\/genes15040487"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1002\/lipd.12449","article-title":"Impact of Cobalt Levels on Fatty Acid Profile and Nutritional Quality of Common Carp Muscle (Cyprinus carpio)","volume":"60","author":"Chetoui","year":"2025","journal-title":"Lipids"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/j.aquaculture.2006.02.034","article-title":"Relationship between Intestinal Brush Border Enzymatic Activity and Growth Rate in Tilapias Fed Diets Containing 30% or 48% Protein","volume":"257","author":"Hakim","year":"2006","journal-title":"Aquaculture"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1111\/j.1365-2095.2008.00569.x","article-title":"Comparison of Dietary Phospholipids and Neutral Lipids: Effects on Gut, Liver and Pancreas Histology in Atlantic Cod (Gadus morha L.) Larvae","volume":"15","author":"Wold","year":"2009","journal-title":"Aquac. Nutr."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1080\/1745039X.2013.776329","article-title":"Effect of Different Fat Sources in Parental Diets on Growth Performance, Villus Morphology, Digestive Enzymes and Colorectal Microbiota in Pigeon Squabs","volume":"67","author":"Xie","year":"2013","journal-title":"Arch. Anim. Nutr."},{"key":"ref_38","first-page":"483","article-title":"Study on the Recovery Growth after Starvation and Amylase Activity in Pangasius polyuranodon","volume":"22","author":"Zheng","year":"2003","journal-title":"J. Huazhong Agric. Univ."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1007\/s11154-019-09512-0","article-title":"Dietary Lipids, Gut Microbiota and Lipid Metabolism","volume":"20","author":"Schoeler","year":"2019","journal-title":"Rev. Endocr. Metab. Disord."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1016\/j.tibtech.2015.06.011","article-title":"Proteobacteria: Microbial Signature of Dysbiosis in Gut Microbiota","volume":"33","author":"Shin","year":"2015","journal-title":"Trends Biotechnol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"e00395-21","DOI":"10.1128\/AEM.00395-21","article-title":"Determining Gut Microbial Dysbiosis: A Review of Applied Indexes for Assessment of Intestinal Microbiota Imbalances","volume":"87","author":"Wei","year":"2021","journal-title":"Appl. Environ. Microbiol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"112678","DOI":"10.1016\/j.biopha.2022.112678","article-title":"The Links between Gut Microbiota and Obesity and Obesity Related Diseases","volume":"147","author":"Geng","year":"2022","journal-title":"Biomed. Pharmacother."},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Ring\u00f8, E., Hoseinifar, S.H., Ghosh, K., Doan, H.V., Beck, B.R., and Song, S.K. (2018). Lactic Acid Bacteria in Finfish\u2014An Update. Front. Microbiol., 9.","DOI":"10.3389\/fmicb.2018.01818"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/j.fsi.2018.03.020","article-title":"Effects of Dietary Lactobacillus rhamnosus JCM1136 and Lactococcus Lactis Subsp. Lactis JCM5805 on the Growth, Intestinal Microbiota, Morphology, Immune Response and Disease Resistance of Juvenile Nile Tilapia, Oreochromis Niloticus","volume":"76","author":"Xia","year":"2018","journal-title":"Fish Shellfish Immunol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1093\/advances\/nmx009","article-title":"Butyrate: A Double-Edged Sword for Health?","volume":"9","author":"Liu","year":"2018","journal-title":"Adv. Nutr."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/j.aninu.2020.12.007","article-title":"Effects of Dietary Sodium Butyrate on Growth, Digestive Enzymes, Body Composition and Nutrient Retention-Related Gene Expression of Juvenile Yellow Catfish (Pelteobagrus fulvidraco)","volume":"7","author":"Zhao","year":"2021","journal-title":"Anim. Nutr."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.1016\/j.bbamem.2017.04.006","article-title":"The Critical Role of Phosphatidylcholine and Phosphatidylethanolamine Metabolism in Health and Disease","volume":"1859","author":"Kennelly","year":"2017","journal-title":"BBA Biomembr."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/tra.12230","article-title":"Phospholipid Synthesis and Transport in Mammalian Cells","volume":"16","author":"Vance","year":"2015","journal-title":"Traffic"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"12735","DOI":"10.1038\/s41598-019-48893-9","article-title":"Evolution, Dynamic Expression Changes and Regulatory Characteristics of Gene Families Involved in the Glycerophosphate Pathway of Triglyceride Synthesis in Chicken (Gallus gallus)","volume":"9","author":"Yang","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"8578","DOI":"10.1038\/s41467-024-52379-2","article-title":"FGF21 Modulates Immunometabolic Homeostasis via the ALOX15\/15-HETE Axis in Early Liver Graft Injury","volume":"15","author":"Yang","year":"2024","journal-title":"Nat. Commun."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.tips.2013.04.005","article-title":"Toward Clinical Application of the Keap1\u2013Nrf2 Pathway","volume":"34","author":"Suzuki","year":"2013","journal-title":"Trends Pharmacol. Sci."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"R676","DOI":"10.1152\/ajpregu.00237.2016","article-title":"Deletion of Soluble Epoxide Hydrolase Enhances Coronary Reactive Hyperemia in Isolated Mouse Heart: Role of Oxylipins and PPAR\u03b3","volume":"311","author":"Hanif","year":"2016","journal-title":"Am. J. Physiol.-Regul. Integr."},{"key":"ref_53","first-page":"235","article-title":"Phospholipase A2 Enzymes in Metabolic and Cardiovascular Diseases","volume":"23","author":"Hui","year":"2012","journal-title":"Curr. Opin. Infect."}],"container-title":["Animals"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-2615\/16\/10\/1518\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T04:15:57Z","timestamp":1779336957000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-2615\/16\/10\/1518"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,15]]},"references-count":53,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2026,5]]}},"alternative-id":["ani16101518"],"URL":"https:\/\/doi.org\/10.3390\/ani16101518","relation":{},"ISSN":["2076-2615"],"issn-type":[{"value":"2076-2615","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,15]]}}}