{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T15:24:24Z","timestamp":1779290664493,"version":"3.51.4"},"reference-count":63,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T00:00:00Z","timestamp":1779235200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"the earmarked fund for the China Agriculture Research System","award":["CARS\u201346"],"award-info":[{"award-number":["CARS\u201346"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animals"],"abstract":"<jats:p>Histamine is a significant risk factor in brown fishmeal and negatively affects histamine-sensitive fish species. The present study aimed to explore the potential protective effects of dietary sanguinarine supplementation against the adverse impacts of excessive dietary histamine on growth and intestinal and hepatic health in American eels. Four experimental diets were formulated: the basal diet (control diet), the basal diet supplemented with 500 mg kg\u22121 of histamine (HH diet), and the HH diet supplemented with 100 mg kg\u22121 and 200 mg kg\u22121 of sanguinarine (HH+SAN100 and HH+SAN200 diets, respectively). After a 10-week feeding trial, both sanguinarine supplementation diets alleviated HH-diet-induced growth retardation, reduced feed utilization, serum dyslipidemia, and hepatic and intestinal structural damage; decreased hepatic and intestinal antioxidant capacity; increased intestinal and hepatic malondialdehyde levels; inhibited intestinal lipase activities; elevated intestinal pro-inflammatory-related gene abundance; and lowered intestinal anti-inflammatory-related gene expression. Furthermore, the HH+SAN100 diet partially ameliorated HH-diet-induced gut microbiota dysbiosis and intestinal metabolic disturbances. Collectively, these findings identify sanguinarine as a functional dietary additive that mitigates histamine-associated growth suppression and intestinal and hepatic injury in American eels, promoting the sustainable utilization of brown fishmeal in American eel culture.<\/jats:p>","DOI":"10.3390\/ani16101556","type":"journal-article","created":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T14:12:54Z","timestamp":1779286374000},"page":"1556","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Sanguinarine Alleviates the Adverse Effects of Excessive Dietary Histamine on Growth and Intestinal and Hepatic Health in Juvenile American Eels (Anguilla rostrata)"],"prefix":"10.3390","volume":"16","author":[{"given":"Yichuang","family":"Xu","sequence":"first","affiliation":[{"name":"Fisheries College, Jimei University, Xiamen 361021, China"},{"name":"Engineering Research Center of the Modern Technology for Eel Industry, Ministry of Education, Xiamen 361021, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Runan","family":"Chen","sequence":"additional","affiliation":[{"name":"Fisheries College, Jimei University, Xiamen 361021, China"},{"name":"Engineering Research Center of the Modern Technology for Eel Industry, Ministry of Education, Xiamen 361021, China"},{"name":"Qingdao Conson Oceantec Valley Development Co., Ltd., Qingdao 266003, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinyu","family":"Hu","sequence":"additional","affiliation":[{"name":"Fisheries College, Jimei University, Xiamen 361021, China"},{"name":"Engineering Research Center of the Modern Technology for Eel Industry, Ministry of Education, Xiamen 361021, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuqin","family":"Yan","sequence":"additional","affiliation":[{"name":"Fisheries College, Jimei University, Xiamen 361021, China"},{"name":"Engineering Research Center of the Modern Technology for Eel Industry, Ministry of Education, Xiamen 361021, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinyue","family":"Yang","sequence":"additional","affiliation":[{"name":"College of Ocean Food and Biological Engineering, Jimei University, Xiamen 361021, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5930-6464","authenticated-orcid":false,"given":"Shaowei","family":"Zhai","sequence":"additional","affiliation":[{"name":"Fisheries College, Jimei University, Xiamen 361021, China"},{"name":"Engineering Research Center of the Modern Technology for Eel Industry, Ministry of Education, Xiamen 361021, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,5,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1186\/s40168-025-02172-0","article-title":"Lactiplantibacillus plantarum Attenuate gossypol-induced hepatic lipotoxicity by altering intestinal microbiota for enriching microbial tryptophan metabolites in nile tilapia (Oreochromis niloticus)","volume":"13","author":"Ding","year":"2025","journal-title":"Microbiome"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2351","DOI":"10.1021\/acs.est.2c06330","article-title":"Phosphorus Overload promotes hepatic lipolysis by suppressing GSK3\u03b2-dependent phosphorylation of PPAR\u03b1 at Ser84 and Thr265 in a freshwater teleost","volume":"57","author":"Xu","year":"2023","journal-title":"Environ. Sci. Technol."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Zhai, S., Wang, Y., He, Y., and Chen, X. (2020). Oligomeric Proanthocyanidins counteracts the negative effects of high level of dietary histamine on American eel (Anguilla rostrata). Front. Mar. Sci., 7.","DOI":"10.3389\/fmars.2020.549145"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"203","DOI":"10.2478\/cjf-2020-0020","article-title":"Evaluation of histamine contents during the fish meal production process","volume":"78","author":"Mih","year":"2020","journal-title":"Croat. J. Fish."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"2960","DOI":"10.1080\/10408398.2020.1791049","article-title":"Considering histamine in functional gastrointestinal disorders","volume":"61","author":"Schnedl","year":"2021","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.fsi.2021.07.017","article-title":"Effect of dietary histamine on intestinal morphology, inflammatory status, and gut microbiota in yellow catfish (Pelteobagrus fulvidraco)","volume":"117","author":"Li","year":"2021","journal-title":"Fish Shellfish Immunol."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Liu, Y., Fu, X., Huang, H., Fan, J., Zhou, H., Deng, J., and Tan, B. (2022). High dietary histamine induces digestive tract oxidative damage in juvenile striped catfish (Pangasianodon hypophthalmus). Antioxidants, 11.","DOI":"10.3390\/antiox11112276"},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Liu, Z.Y., Yang, H.L., Hu, L.H., Yang, W., Ai, C.X., and Sun, Y.Z. (2021). Dose-dependent effects of histamine on growth, immunity and intestinal health in juvenile grouper (Epinephelus coioides). Front. Mar. Sci., 8.","DOI":"10.3389\/fmars.2021.685720"},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Zhang, Y., Zhou, H., Liu, Y., Zhu, L., Fan, J., Huang, H., Jiang, W., Deng, J., and Tan, B. (2023). Dietary histamine impairs the digestive physiology function and muscle quality of hybrid grouper (Epinephelus fuscoguttatus\u2640 \u00d7 Epinephelus lanceolatus\u2642). Antioxidants, 12.","DOI":"10.3390\/antiox12020502"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"743233","DOI":"10.1016\/j.aquaculture.2025.743233","article-title":"Effects of triterpene-rich olive extract alone or in combination with green tea extract and Eucommia ulmoides extract on growth performance and health status of mandarin fish (Siniperca chuatsi)","volume":"612","author":"Li","year":"2026","journal-title":"Aquaculture"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"735291","DOI":"10.1016\/j.aquaculture.2020.735291","article-title":"The Growth promoting and immunomodulatory effects of a medicinal plant leaf extract obtained from Salvia officinalis and Lippia citriodora in gilthead seabream (Sparus aurata)","volume":"524","author":"Firmino","year":"2020","journal-title":"Aquaculture"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"116406","DOI":"10.1016\/j.biopha.2024.116406","article-title":"Bioactivity and mechanism of action of sanguinarine and its derivatives in the past 10 years","volume":"173","author":"Huang","year":"2024","journal-title":"Biomed. Pharmacother."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.fsi.2022.05.013","article-title":"Sanguinarine attenuates hydrogen peroxide\u2013induced toxicity in liver of Monopterus albus: Role of oxidative stress, inflammation and apoptosis","volume":"125","author":"Shi","year":"2022","journal-title":"Fish Shellfish Immunol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"735521","DOI":"10.1016\/j.aquaculture.2020.735521","article-title":"Dietary sanguinarine supplementation on the growth performance, immunity and intestinal health of grass carp (Ctenopharyngodon idellus) fed cottonseed and rapeseed meal diets","volume":"528","author":"Liu","year":"2020","journal-title":"Aquaculture"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Shi, Y., Liu, Y., Xie, K., Zhang, J., Wang, Y., Hu, Y., and Zhong, L. (2023). Sanguinarine improves intestinal health in grass carp fed high-fat diets: Involvement of antioxidant, physical and immune barrier, and intestinal microbiota. Antioxidants, 12.","DOI":"10.3390\/antiox12071366"},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Zhang, L., Ma, L., Yang, Q., Liu, Y., Ai, X., and Dong, J. (2022). Sanguinarine protects channel catfish against Aeromonas hydrophila infection by inhibiting aerolysin and biofilm formation. Pathogens, 11.","DOI":"10.3390\/pathogens11030323"},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Lu, W., Yu, H., Liang, Y., and Zhai, S. (2023). Effects of white fish meal replaced by low-quality brown fish meal with compound additives on growth performance and intestinal health of juvenile American eel (Anguilla rostrata). Animals, 13.","DOI":"10.3390\/ani13182873"},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Xu, Y., Xu, Q., Hu, X., Yang, J., and Zhai, S. (2026). Excessive dietary histamine inhibits growth performance and impairs intestinal and hepatic health in juvenile American eel (Anguilla rostrata). Front. Physiol., 17.","DOI":"10.3389\/fphys.2026.1797772"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"103296","DOI":"10.1016\/j.aqrep.2025.103296","article-title":"Effects of dietary iron supplementation on growth performance, iron utilization, and intestinal health in juvenile American eels (Anguilla rostrata)","volume":"46","author":"Xu","year":"2026","journal-title":"Aquac. Rep."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"102656","DOI":"10.1016\/j.aqrep.2025.102656","article-title":"Appropriate dietary phosphorus levels promote growth performance, mineral retention, and hepatic lipid metabolism in juvenile American eels (Anguilla rostrata)","volume":"41","author":"Xu","year":"2025","journal-title":"Aquac. Rep."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Liu, Z.Y., Yang, H.L., Hu, L.H., Yang, W., Ai, C.X., and Sun, Y.Z. (2021). Autochthonous Probiotics alleviate the adverse effects of dietary histamine in juvenile grouper (Epinephelus coioides). Front. Microbiol., 12.","DOI":"10.3389\/fmicb.2021.792718"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/j.aninu.2024.04.014","article-title":"Macleaya cordata extract exhibits some potential as a surrogate antibiotic by improving gastrointestinal epithelial status and humoral response in goats","volume":"18","author":"Yan","year":"2024","journal-title":"Anim. Nutr."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"8020","DOI":"10.1021\/acs.est.2c00585","article-title":"Sirt3\u2013Sod2\u2013mROS\u2013mediated manganese triggered hepatic mitochondrial dysfunction and lipotoxicity in a freshwater teleost","volume":"56","author":"Zhao","year":"2022","journal-title":"Environ. Sci. Technol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1016\/j.jhep.2024.06.016","article-title":"Inflammasomes in chronic liver disease: Hepatic injury, fibrosis progression and systemic inflammation","volume":"81","author":"Taru","year":"2024","journal-title":"J. Hepatol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1080\/15548627.2021.1895658","article-title":"The M\u00e9nage \u00e0 Trois of autophagy, lipid droplets and liver disease","volume":"18","author":"Hunter","year":"2022","journal-title":"Autophagy"},{"key":"ref_26","first-page":"817","article-title":"The past and present of serum aminotransferases and the future of liver injury biomarkers","volume":"15","author":"McGill","year":"2016","journal-title":"EXCLI J."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.jpba.2018.06.065","article-title":"Investigation of the hepatoprotective effect of Corydalis saxicola bunting on carbon tetrachloride\u2013induced liver fibrosis in rats by 1H-NMR-based metabonomics and network pharmacology approaches","volume":"159","author":"Liu","year":"2018","journal-title":"J. Pharm. Biomed. Anal."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Wang, M., Huang, X., Liu, Y., and Zeng, J. (2022). Effects of Macleaya cordata extract on blood biochemical indices and intestinal flora in heat-stressed mice. Animals, 12.","DOI":"10.3390\/ani12192589"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"7479","DOI":"10.1080\/10408398.2025.2472882","article-title":"Anti\u2013inflammatory and antioxidant effects of anthocyanins in nonalcoholic fatty liver disease (NAFLD): A systematic review of in vivo studies","volume":"65","author":"Dias","year":"2025","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1893","DOI":"10.1007\/s00204-025-03997-2","article-title":"Antioxidants: A comprehensive review","volume":"99","author":"Gulcin","year":"2025","journal-title":"Arch. Toxicol."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Hissen, K.L., He, W., Wu, G., and Criscitiello, M.F. (2023). Immunonutrition: Facilitating mucosal immune response in teleost intestine with amino acids through oxidant-antioxidant balance. Front. Immunol., 14.","DOI":"10.3389\/fimmu.2023.1241615"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"106402","DOI":"10.1016\/j.phrs.2022.106402","article-title":"A network meta-analysis on the comparative effect of nutraceuticals on lipid profile in adults","volume":"183","author":"Osadnik","year":"2022","journal-title":"Pharmacol. Res."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"102946","DOI":"10.1016\/j.aqrep.2025.102946","article-title":"Dietary chlorogenic acid supplementation to alleviate intestinal damage in juvenile American eel (Anguilla rostrata) under histamine stress","volume":"43","author":"Cai","year":"2025","journal-title":"Aquac. Rep."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"107398","DOI":"10.1016\/j.phrs.2024.107398","article-title":"The effect of synbiotics on liver enzymes, obesity indices, blood pressure, lipid profile, and inflammation in patients with non-alcoholic fatty liver: A systematic review and meta-analysis of randomized controlled trials","volume":"208","author":"Musazadeh","year":"2024","journal-title":"Pharmacol. Res."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Chen, R., Huang, L., and Zhai, S. (2022). Effects of Macleaya Cordata extract on growth performance, serum biochemical parameters, and intestinal health of juvenile American eel (Anguilla rostrata). Fishes, 7.","DOI":"10.3390\/fishes7050229"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1186\/s12944-026-02887-5","article-title":"Lipidome remodeling in primary biliary cholangitis","volume":"25","author":"Rogalska","year":"2026","journal-title":"Lipids Health Dis."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/s41577-019-0268-7","article-title":"Host-microbiota interactions in inflammatory bowel disease","volume":"20","author":"Caruso","year":"2020","journal-title":"Nat. Rev. Immunol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"103380","DOI":"10.1016\/j.redox.2024.103380","article-title":"Oxidative stress-related biomarkers as promising indicators of inflammatory bowel disease activity: A systematic review and meta-analysis","volume":"77","author":"Locatelli","year":"2024","journal-title":"Redox Biol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1038\/s41577-024-01008-6","article-title":"Strategies for targeting cytokines in inflammatory bowel disease","volume":"24","author":"Neurath","year":"2024","journal-title":"Nat. Rev. Immunol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1007\/s00018-018-2943-4","article-title":"An insight into gut microbiota and its functionalities","volume":"76","author":"Adak","year":"2019","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1805","DOI":"10.1007\/s10695-021-01004-w","article-title":"Dietary sodium butyrate supplementation attenuates intestinal inflammatory response and improves gut microbiota composition in largemouth bass (Micropterus salmoides) fed with a high soybean meal diet","volume":"47","author":"Chen","year":"2021","journal-title":"Fish Physiol. Biochem."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/j.it.2005.04.008","article-title":"Commensal gut bacteria: Mechanisms of immune modulation","volume":"26","author":"Kelly","year":"2005","journal-title":"Trends Immunol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1007\/s10695-024-01314-9","article-title":"The impact of diets containing hermetia illucens meal on the growth, intestinal health, and microbiota of gilthead seabream (Sparus aurata)","volume":"50","author":"Rimoldi","year":"2024","journal-title":"Fish Physiol. Biochem."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"105818","DOI":"10.1016\/j.micpath.2022.105818","article-title":"Pathogenicity of Plesiomonas shigelloides and Citrobacter freundii isolated from the endangered Chinese sturgeon (Acipenser sinensis)","volume":"173","author":"Deng","year":"2022","journal-title":"Microb. Pathog."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Wang, Z., Gu, S., Lv, W., Chen, J., Xue, M., Liu, S., Mao, J., and Chen, G. (2025). Genomic and transcriptomic profiling of a highly virulent Plesiomonas shigelloides strain: Insights into pathogenicity and host immune response. Microorganisms, 13.","DOI":"10.3390\/microorganisms13092168"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"741822","DOI":"10.1016\/j.aquaculture.2024.741822","article-title":"Unraveling the causation of flatulence on silver pomfret after starvation aquaculture involved in intestinal microbiota structure, enzyme, and histology","volume":"596","author":"Nie","year":"2025","journal-title":"Aquaculture"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"102389","DOI":"10.1016\/j.aqrep.2024.102389","article-title":"Dietary high plant protein and high lipid impaired the intestine health of grouper by disrupting oxidative stress, immune response, and protein metabolism","volume":"39","author":"Xu","year":"2024","journal-title":"Aquac. Rep."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Melchionna, R., Trono, P., Tocci, A., and Nistic\u00f2, P. (2021). Actin cytoskeleton and regulation of TGF\u03b2 signaling: Exploring their links. Biomolecules, 11.","DOI":"10.3390\/biom11020336"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1186\/s12931-017-0544-7","article-title":"The roles and regulation of the actin cytoskeleton, intermediate filaments and microtubules in smooth muscle cell migration","volume":"18","author":"Tang","year":"2017","journal-title":"Respir. Res."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"2222961","DOI":"10.1080\/19490976.2023.2222961","article-title":"Larginine metabolism as pivotal interface of mutual host\u2013microbe interactions in the gut","volume":"15","author":"Holland","year":"2023","journal-title":"Gut Microbes"},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Kim, M.H., and Kim, H. (2017). The Roles of glutamine in the intestine and its implication in intestinal diseases. Int. J. Mol. Sci., 18.","DOI":"10.3390\/ijms18051051"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"2601376","DOI":"10.1080\/19490976.2025.2601376","article-title":"Ornithine lipids from Akkermansia muciniphila are dynamically modulated in colitis and shape macrophage inflammatory responses","volume":"17","author":"Selmi","year":"2025","journal-title":"Gut Microbes"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"101129","DOI":"10.1016\/j.xcrm.2023.101129","article-title":"Targeting phenylpyruvate restrains excessive NLRP3 inflammasome activation and pathological inflammation in diabetic wound healing","volume":"4","author":"Lv","year":"2023","journal-title":"Cell Rep. Med."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1039\/D3NP00037K","article-title":"The shikimate pathway: Gateway to metabolic diversity","volume":"41","author":"Shende","year":"2024","journal-title":"Nat. Prod. Rep."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/j.jff.2015.12.003","article-title":"Structure-activity relationship of antioxidant dipeptides: Dominant role of Tyr, Trp, Cys and Met Residues","volume":"21","author":"Zheng","year":"2016","journal-title":"J. Funct. Foods"},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Bravo Iniguez, A., Sun, Q., Cui, Q., Du, M., and Zhu, M.J. (2024). Cannabidiol enhances mitochondrial metabolism and antioxidant defenses in human intestinal epithelial Caco-2 cells. Nutrients, 16.","DOI":"10.3390\/nu16223843"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1002\/eji.201142079","article-title":"Sphingosine regulates the NLRP3-inflammasome and IL-1\u03b2 release from macrophages","volume":"42","author":"Luheshi","year":"2012","journal-title":"Eur. J. Immunol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1039\/C8NP00019K","article-title":"Sphingolipid biosynthesis in man and microbes","volume":"35","author":"Harrison","year":"2018","journal-title":"Nat. Prod. Rep."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.tem.2023.03.001","article-title":"Serine signaling governs metabolic homeostasis and health","volume":"34","author":"He","year":"2023","journal-title":"Trends Endocrinol. Metab. TEM"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/s00726-017-2508-0","article-title":"Insulin Resistance and Glycine Metabolism in Humans","volume":"50","year":"2018","journal-title":"Amino Acids"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"G439","DOI":"10.1152\/ajpgi.00351.2019","article-title":"Methionine dietary supplementation potentiates ionizing radiation\u2013induced gastrointestinal syndrome","volume":"318","author":"Miousse","year":"2020","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1017\/S0954422409990138","article-title":"Intestinal Metabolism of Sulfur Amino Acids","volume":"22","author":"Stoll","year":"2009","journal-title":"Nutr. Res. Rev."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s12986-022-00654-8","article-title":"Changes in the intestinal expression of drug metabolism\u2013related genes in a piglet model of parenteral nutrition","volume":"19","author":"Dai","year":"2022","journal-title":"Nutr. Metab."}],"container-title":["Animals"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-2615\/16\/10\/1556\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T14:31:39Z","timestamp":1779287499000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-2615\/16\/10\/1556"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,20]]},"references-count":63,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2026,5]]}},"alternative-id":["ani16101556"],"URL":"https:\/\/doi.org\/10.3390\/ani16101556","relation":{},"ISSN":["2076-2615"],"issn-type":[{"value":"2076-2615","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,20]]}}}