{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T23:17:30Z","timestamp":1789168650380,"version":"build-2803163510"},"reference-count":9,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T00:00:00Z","timestamp":1781913600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animals"],"abstract":"<jats:p>Nasal alar arteriopathy (NAA) is a rare dermatologic condition in dogs characterized by ulcerative and potentially severe hemorrhagic lesions of the nasal alar fold. This condition has only previously been reported in German Shepherd Dogs. Achieving clinical remission can be challenging and typically involves a combination of surgical resection of the diseased tissue and immunosuppressive therapies. This report is the first to describe two cases of NAA in which clinical remission was initially achieved with oclacitinib alone. Both cases were presented to the Internal Medicine service with a complaint of unilateral recurrent epistaxis. The first case involved a 7-year-old German Shepherd dog. Clinical remission was first achieved with oclacitinib monotherapy. Relapse occurred following dose tapering, and remission was ultimately regained with dose reescalation of oclacitinib and the addition of cyclosporine. The second case involved a 3-year-old Poodle mix that achieved and maintained clinical remission with oclacitinib alone. These cases suggest that oclacitinib may be an effective and well-tolerated treatment option for NAA, offering an alternative to traditional systemic immunosuppressive therapies. However, additional treatment may be required in severe cases or during oclacitinib dose reduction. Further studies are needed to evaluate long-term outcomes and broader applicability.<\/jats:p>","DOI":"10.3390\/ani16121915","type":"journal-article","created":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T09:49:55Z","timestamp":1782121795000},"page":"1915","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Oclacitinib for the Treatment of Nasal Alar Arteriopathy in Two Dogs"],"prefix":"10.3390","volume":"16","author":[{"given":"Katherine","family":"Bingham","sequence":"first","affiliation":[{"name":"Department of Veterinary Internal Medicine, Shoreline Veterinary Referral and Emergency Center, Shelton, CT 06484, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mara","family":"Kraenzlin","sequence":"additional","affiliation":[{"name":"Department of Veterinary Critical Care Medicine, Shoreline Veterinary Referral and Emergency Center, Shelton, CT 06484, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dianne","family":"Kittrell","sequence":"additional","affiliation":[{"name":"Department of Veterinary Internal Medicine, Shoreline Veterinary Referral and Emergency Center, Shelton, CT 06484, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beth","family":"Whitney","sequence":"additional","affiliation":[{"name":"Department of Veterinary Internal Medicine, Advanced Veterinary Specialists, Santa Barbara, CA 93101, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"McGlinchey","sequence":"additional","affiliation":[{"name":"Department of Veterinary Internal Medicine, Veterinary Referral and Emergency Center, Norwalk, CT 06854, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina","family":"Shoulberg","sequence":"additional","affiliation":[{"name":"Department of Veterinary Dermatology, Veterinary Referral and Emergency Center, Norwalk, CT 06854, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,6,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1046\/j.1365-3164.2002.00309.x","article-title":"Dermal arteritis of the nasal philtrum in a Giant Schnauzer and three Saint Bernard dogs","volume":"13","author":"Torres","year":"2002","journal-title":"Vet. Dermatol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"511-e155","DOI":"10.1111\/vde.12790","article-title":"Dermal arteritis of the nasal philtrum: A retrospective study of 23 dogs","volume":"30","author":"Souza","year":"2019","journal-title":"Vet. Dermatol."},{"key":"ref_3","first-page":"115","article-title":"Successful medical and surgical treatment of dermal arteritis of the nasal philtrum in a Saint Bernard dog","volume":"5","author":"Vuolo","year":"2014","journal-title":"Vet. Med."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"85-e35","DOI":"10.1111\/vde.12502","article-title":"Tacrolimus therapy for dermal arteritis of the nasal philtrum refractory to surgery and anti-inflammatory therapy (doxycycline\/niacinamide and topical fluocinolone) in a dog","volume":"29","author":"Banovic","year":"2018","journal-title":"Vet. Dermatol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1111\/j.1748-5827.2008.00691.x","article-title":"Dermal arteritis of the nasal philtrum: Surgery as an alternative to long-term medical therapy in two dogs","volume":"50","author":"Pratschke","year":"2009","journal-title":"J. Small Anim. Pract."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1111\/vde.13173","article-title":"Clinical and histopathological features of rostrolateral nasal alar arteriopathy of German shepherd dogs","volume":"34","author":"Fleischman","year":"2023","journal-title":"Vet. Dermatol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1111\/vde.13216","article-title":"Successful treatment of sebaceous adenitis with oclacitinib and low-dose prednisolone in a dog","volume":"35","author":"Yotti","year":"2024","journal-title":"Vet. Dermatol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"330-e86","DOI":"10.1111\/vde.12852","article-title":"Rapid response of hyperkeratotic erythema multiforme to oclacitinib in two dogs","volume":"31","author":"High","year":"2020","journal-title":"Vet. Dermatol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1007\/s40744-019-00192-5","article-title":"Filgotinib, a JAK1 inhibitor, modulates disease-related biomarkers in rheumatoid arthritis: Results from two randomized, controlled phase 2b trials","volume":"7","author":"Tarrant","year":"2020","journal-title":"Rheumatol. Ther."}],"container-title":["Animals"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-2615\/16\/12\/1915\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T10:52:17Z","timestamp":1782125537000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-2615\/16\/12\/1915"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,20]]},"references-count":9,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2026,6]]}},"alternative-id":["ani16121915"],"URL":"https:\/\/doi.org\/10.3390\/ani16121915","relation":{},"ISSN":["2076-2615"],"issn-type":[{"value":"2076-2615","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,20]]}}}