{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T03:45:41Z","timestamp":1782704741603,"version":"3.54.5"},"reference-count":31,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2026,6,28]],"date-time":"2026-06-28T00:00:00Z","timestamp":1782604800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animals"],"abstract":"<jats:p>Background: The aim of the present retrospective observational study is to compare the required doses of propofol (PPF) for anaesthesia induction in dogs presented with intervertebral disc disease (IVDD)-related thoracolumbar or cervical myelopathy. Methods: The anaesthetic records of dogs with either cervical- or thoracolumbar-related myelopathy anaesthetised for diagnostic or surgical procedures from September 2021 to July 2023 were evaluated. Inclusion criteria were premedication with the same dose of dexmedetomidine (DEX) (180 \u03bcg m\u22122), and induction with PPF. The sedation score (SS), Glasgow Composite Measure Pain Scale-Short Form (GCMPS-SF) results and the total PPF dose required for intubation were collected. Data were analysed with the Shapiro\u2013Wilk test, independent samples t-test and Spearman\u2019s rho test. A value of p &lt; 0.05 was considered statistically significant. Results: Fifty-five records were included in the study, 27 dogs with cervical and 28 with thoracolumbar myelopathy due to IVDD. Statistically significant higher doses of PPF were required in the dogs with cervical (mean 3.2 mg kg\u22121, \u00b1SD 1.25 mg kg\u22121) than with thoracolumbar (mean 1.9 mg kg\u22121, \u00b1SD 0.65 mg kg\u22121) myelopathy (t-test, p &lt; 0.001). The SS in the dogs with cervical\u2013cervicothoracic myelopathy (CCTM) (median 6, \u00b1min 2 max 10) also differed from the SS of the dogs with thoracolumbar myelopathy (TLM) (median 7.5, min 2 max 12) (t-test, p = 0.02). Sedation score and the dose of PPF were significantly negatively correlated (Spearman\u2019s rho \u22120.311, p = 0.021). Sedation score and GCMPS-SF were also significantly negatively correlated (Spearman\u2019s rho \u22120.363, p = 0.007). However, no statistically significant negative correlation was found between PPF dose and GCMPS-SF score (Spearman\u2019s rho = 0.248, p = 0.068). Conclusions: Our findings should be considered when planning anaesthetic protocols in patients suffering from IVVD-related myelopathy in order to optimize safety in these patients.<\/jats:p>","DOI":"10.3390\/ani16131992","type":"journal-article","created":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T02:16:44Z","timestamp":1782699404000},"page":"1992","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Propofol Requirements for Induction of Anaesthesia in Dogs with Cervical or Thoracolumbar Myelopathy Due to Intervertebral Disc Disease"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8703-6994","authenticated-orcid":false,"given":"Eirini","family":"Sarpekidou","sequence":"first","affiliation":[{"name":"Surgery & Obstetrics Unit, Companion Animal Clinic, School of Veterinary Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, 54627 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Koura","sequence":"additional","affiliation":[{"name":"Anesthesia and Intensive Care Unit, Companion Animal Clinic, School of Veterinary Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, 54627 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1771-3811","authenticated-orcid":false,"given":"Kiriaki","family":"Pavlidou","sequence":"additional","affiliation":[{"name":"Anesthesia and Intensive Care Unit, Companion Animal Clinic, School of Veterinary Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, 54627 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6452-2989","authenticated-orcid":false,"given":"Vasileios","family":"Zapridis","sequence":"additional","affiliation":[{"name":"Anesthesia and Intensive Care Unit, Companion Animal Clinic, School of Veterinary Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, 54627 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5575-7244","authenticated-orcid":false,"given":"Ioannis","family":"Savvas","sequence":"additional","affiliation":[{"name":"Anesthesia and Intensive Care Unit, Companion Animal Clinic, School of Veterinary Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, 54627 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4039-2398","authenticated-orcid":false,"given":"Zoe","family":"Polizopoulou","sequence":"additional","affiliation":[{"name":"Diagnostic Laboratory, Companion Animal Clinic, School of Veterinary Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, 54627 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6678-2824","authenticated-orcid":false,"given":"George","family":"Kazakos","sequence":"additional","affiliation":[{"name":"Surgery & Obstetrics Unit, Companion Animal Clinic, School of Veterinary Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, 54627 Thessaloniki, Greece"},{"name":"Anesthesia and Intensive Care Unit, Companion Animal Clinic, School of Veterinary Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, 54627 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,6,28]]},"reference":[{"key":"ref_1","first-page":"329","article-title":"Myelopathies: Disorders of the Spinal Cord","volume":"Volume 4","author":"Dewey","year":"2016","journal-title":"Practical Guide to Canine and Feline Neurology"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"da Costa, R.C., De Decker, S., Lewis, M.J., and Volk, H. 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Assoc."}],"container-title":["Animals"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-2615\/16\/13\/1992\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T03:07:59Z","timestamp":1782702479000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-2615\/16\/13\/1992"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,28]]},"references-count":31,"journal-issue":{"issue":"13","published-online":{"date-parts":[[2026,7]]}},"alternative-id":["ani16131992"],"URL":"https:\/\/doi.org\/10.3390\/ani16131992","relation":{},"ISSN":["2076-2615"],"issn-type":[{"value":"2076-2615","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,28]]}}}