{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T17:09:49Z","timestamp":1785431389531,"version":"3.56.0"},"reference-count":37,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T00:00:00Z","timestamp":1782777600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100013129","name":"Ministry of SMEs and Startups","doi-asserted-by":"publisher","award":["RS-2024-00468832"],"award-info":[{"award-number":["RS-2024-00468832"]}],"id":[{"id":"10.13039\/501100013129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013129","name":"Ministry of SMEs and Startups","doi-asserted-by":"publisher","award":["RS-2024-00508846"],"award-info":[{"award-number":["RS-2024-00508846"]}],"id":[{"id":"10.13039\/501100013129","id-type":"DOI","asserted-by":"publisher"}]},{"award":["RS-2024-00468832"],"award-info":[{"award-number":["RS-2024-00468832"]}],"id":[{"id":"https:\/\/ror.org\/022c4zk48","id-type":"ROR","asserted-by":"publisher"}]},{"award":["RS-2024-00508846"],"award-info":[{"award-number":["RS-2024-00508846"]}],"id":[{"id":"https:\/\/ror.org\/022c4zk48","id-type":"ROR","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001459","name":"Ministry of Education","doi-asserted-by":"publisher","award":["2026-RISE [Glocal University 30]-05-011"],"award-info":[{"award-number":["2026-RISE [Glocal University 30]-05-011"]}],"id":[{"id":"10.13039\/501100001459","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animals"],"abstract":"<jats:p>Atopic dermatitis (AD) is a chronic inflammatory skin disease requiring long-term management in companion animals. This study evaluated the butanol fraction of Aster yomena extract (AY BuOH) as an orally administered dietary supplement candidate for atopic skin health using a DNCB-induced AD-like mouse model. AY BuOH was chemically profiled by UPLC-ESI-QToF-MS\/MS and quantified for major marker compounds. Male SKH-1 mice were allocated to normal control, DNCB control, oclacitinib-treated, or AY BuOH-treated groups (2.5\u2013640 mg\/kg\/day) for five weeks. AY BuOH contained abundant rutin and dicaffeoylquinic acid (DCQA) isomers, including 3,4-, 3,5-, and 4,5-DCQA isomers. Oral AY BuOH administration, particularly at intermediate doses, reduced modified dermatitis severity scores, gross skin lesions, serum immunoglobulin E levels, and cutaneous interleukin-4 and interleukin-13 concentrations, with effects comparable to those observed in the oclacitinib reference group in selected endpoints. AY BuOH also partially restored splenic Th1\/Th2 balance and attenuated epidermal and dermal thickening. The highest dose, 640 mg\/kg\/day, was associated with body weight loss and elevated hepatic enzyme activities, suggesting potential hepatic stress. These findings provide preclinical evidence that AY BuOH may serve as a standardized plant-derived dietary supplement or functional feed additive candidate for companion animal skin health, pending target-species safety and efficacy validation.<\/jats:p>","DOI":"10.3390\/ani16132003","type":"journal-article","created":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T08:26:15Z","timestamp":1782807975000},"page":"2003","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Oral Administration of Aster yomena Butanol Fraction Attenuates DNCB-Induced Atopic Dermatitis-like Skin Inflammation in Mice: Implications as a Dietary Supplement Candidate for Companion Animals"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-0943-9297","authenticated-orcid":false,"given":"Hyeon Jeong","family":"Moon","sequence":"first","affiliation":[{"name":"Department of Veterinary Pathology, College of Veterinary Medicine, Chonnam National University, Gwangju 61186, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-1029-5669","authenticated-orcid":false,"given":"Chung-Do","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Veterinary Pathology, College of Veterinary Medicine and BK21 FOUR Program, Chonnam National University, Gwangju 61186, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seon-Jin","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Integrative Food, Bioscience and Biotechnology, Graduate School of Chonnam National University, Gwangju 61186, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-5545-4464","authenticated-orcid":false,"given":"Gun","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Veterinary Pathology, College of Veterinary Medicine and BK21 FOUR Program, Chonnam National University, Gwangju 61186, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-6049-049X","authenticated-orcid":false,"given":"Jaewoo","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Veterinary Pathology, College of Veterinary Medicine, Chonnam National University, Gwangju 61186, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geon Woo","family":"Kim","sequence":"additional","affiliation":[{"name":"Twell Co., Ltd., Yeongcheon 38882, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun Bong","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Food and Environmental Hygiene, College of Veterinary Medicine, Chonnam National University, Gwangju 61186, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7163-3591","authenticated-orcid":false,"given":"Jun-Gyu","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Veterinary Zoonotic Diseases, College of Veterinary Medicine, Chonnam National University, Gwangju 61186, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1703-7742","authenticated-orcid":false,"given":"Yeong-Bin","family":"Baek","sequence":"additional","affiliation":[{"name":"Department of Veterinary Pathology, College of Veterinary Medicine and BK21 FOUR Program, Chonnam National University, Gwangju 61186, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1709-0324","authenticated-orcid":false,"given":"Sang-Ik","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Veterinary Pathology, College of Veterinary Medicine and BK21 FOUR Program, Chonnam National University, Gwangju 61186, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,6,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1111\/cea.12495","article-title":"Pathogenesis of atopic dermatitis","volume":"45","author":"Peng","year":"2015","journal-title":"Clin. 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