{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,12]],"date-time":"2026-07-12T05:07:17Z","timestamp":1783832837298,"version":"3.55.0"},"reference-count":58,"publisher":"MDPI AG","issue":"14","license":[{"start":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T00:00:00Z","timestamp":1783641600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005046","name":"Heilongjiang Provincial Natural Science Foundation of China","doi-asserted-by":"crossref","award":["ZL2024C016"],"award-info":[{"award-number":["ZL2024C016"]}],"id":[{"id":"10.13039\/501100005046","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animals"],"abstract":"<jats:p>Long-term maize storage causes oxidative deterioration, but its effects on intestinal redox status, systemic inflammation, and liver-related responses in ruminants remain unclear. Laminaria japonica polysaccharide (LJP) has antioxidant, immunomodulatory, and microbiota-regulating properties, but its efficacy during aged-maize feeding is unknown. This study evaluated whether LJP mitigates oxidative and inflammatory responses in Hu sheep fed aged maize and characterized cecal microbiome and metabolome alterations. Twenty-one Hu sheep (39.05 \u00b1 3.55 kg) were assigned to three diets (n = 7) and fed for 10 weeks (a 14-day adaptation period followed by 8 weeks of treatment): normal maize (CK), aged maize (AM), or aged maize with 0.5% LJP (AML). Compared with CK, AM increased plasma lipopolysaccharide (0.428 vs. 0.379 EU\/mL), TNF-\u03b1, and IL-1\u03b2, and raised ileal reactive oxygen species (248.79 vs. 166.23 fluorescence intensity\/mg; p &lt; 0.001) and malondialdehyde (1.87 vs. 1.63 nmol\/L; p = 0.006), consistent with systemic inflammation and intestinal oxidative stress. AML lowered these inflammatory and oxidative indices and increased hepatic T-AOC (p = 0.009) and catalase activity (p = 0.013). Integrated 16S rRNA and untargeted metabolomic analysis revealed treatment-associated cecal microbe\u2013metabolite associations. These findings indicate that aged-maize feeding was associated with intestinal and systemic redox\u2013inflammatory changes in Hu sheep, whereas dietary LJP was associated with partial mitigation, potentially involving microbial and metabolic remodeling.<\/jats:p>","DOI":"10.3390\/ani16142146","type":"journal-article","created":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T14:14:25Z","timestamp":1783692865000},"page":"2146","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Dietary Laminaria japonica Polysaccharide Alleviates Aged-Maize-Associated Intestinal Oxidative Stress and Systemic Inflammation in Hu Sheep: Associations with Cecal Microbiome\u2013Metabolome Remodeling"],"prefix":"10.3390","volume":"16","author":[{"given":"Jiaxuan","family":"Dong","sequence":"first","affiliation":[{"name":"College of Animal Science and Technology, Northeast Agricultural University, Harbin 150030, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuhan","family":"Li","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Northeast Agricultural University, Harbin 150030, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6708-454X","authenticated-orcid":false,"given":"Jiamei","family":"Song","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Northeast Agricultural University, Harbin 150030, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuansheng","family":"Ma","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Northeast Agricultural University, Harbin 150030, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hangshu","family":"Xin","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Northeast Agricultural University, Harbin 150030, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yonggen","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Northeast Agricultural University, Harbin 150030, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangning","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Northeast Agricultural University, Harbin 150030, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"104187","DOI":"10.1016\/j.jcs.2025.104187","article-title":"Comprehensive quality grading and dynamic prediction of physicochemical indicators of maize during storage based on clustering and time-series prediction models","volume":"123","author":"Bi","year":"2025","journal-title":"J. Cereal Sci."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Topan, C., Nicolescu, M., Simedru, D., and Becze, A. (2023). Complex evaluation of storage impact on maize (Zea mays L.) quality using chromatographic methods. Separations, 10.","DOI":"10.3390\/separations10070412"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"101541","DOI":"10.1016\/j.psj.2021.101541","article-title":"Effects of naturally oxidized corn oil on inflammatory reaction and intestinal health of broilers","volume":"101","author":"Zhang","year":"2022","journal-title":"Poult. Sci."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"102437","DOI":"10.1016\/j.psj.2022.102437","article-title":"Oxidized corn oil changes the liver lipid metabolism of broilers by upregulating peroxisome proliferators activate receptor-\u03b1","volume":"102","author":"Zhang","year":"2023","journal-title":"Poult. Sci."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Zheng, Y., Wu, W., Sun, C., Liu, H., and Dou, J. (2024). Occurrence and Fate Analysis of Mycotoxins in Maize During the Post-Harvest Period. Toxins, 16.","DOI":"10.3390\/toxins16110459"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"172323","DOI":"10.1016\/j.scitotenv.2024.172323","article-title":"Prevalence and concentration of mycotoxins in bovine feed and feed components: A global systematic review and meta-analysis","volume":"929","author":"Chhaya","year":"2024","journal-title":"Sci. Total Environ."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1186\/s40104-025-01213-w","article-title":"Contamination of aflatoxin B1, deoxynivalenol and zearalenone in feeds in China from 2021 to 2024","volume":"16","author":"Liu","year":"2025","journal-title":"J. Anim. Sci. Biotechnol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"802","DOI":"10.15232\/aas.2024-02602","article-title":"Mycotoxins in ruminant livestock production: An underestimated and overlooked risk and opportunity?","volume":"40","author":"Bandyk","year":"2024","journal-title":"Appl. Anim. Sci."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"e0091521","DOI":"10.1128\/msystems.00915-21","article-title":"Metagenomic sequencing reveals that high-grain feeding alters the composition and metabolism of cecal microbiota and induces cecal mucosal injury in sheep","volume":"6","author":"Xie","year":"2021","journal-title":"mSystems"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"9644","DOI":"10.3168\/jds.2023-23359","article-title":"A high-concentrate diet induces colonic inflammation and barrier damage in Hu sheep","volume":"106","author":"Chen","year":"2023","journal-title":"J. Dairy Sci."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.chom.2022.02.004","article-title":"Gut microbiota-derived bile acids in intestinal immunity, inflammation, and tumorigenesis","volume":"30","author":"Cai","year":"2022","journal-title":"Cell Host Microbe"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"2172671","DOI":"10.1080\/19490976.2023.2172671","article-title":"Bile acids as modulators of gut microbiota composition and function","volume":"15","author":"Larabi","year":"2023","journal-title":"Gut Microbes"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Saha, P., and Hartmann, P. (2025). Impact of gut microbiome on gut permeability in liver and gut diseases. Microorganisms, 13.","DOI":"10.3390\/microorganisms13061188"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Zheng, Z., and Wang, B. (2021). The gut-liver axis in health and disease: The role of gut microbiota-derived signals in liver injury and regeneration. Front. Immunol., 12.","DOI":"10.3389\/fimmu.2021.775526"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Shannon, E., Conlon, M., and Hayes, M. (2021). Seaweed components as potential modulators of the gut microbiota. Mar. Drugs, 19.","DOI":"10.3390\/md19070358"},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Cheong, K.-L., Zhang, Y., Li, Z., Li, T., Ou, Y., Shen, J., Zhong, S., and Tan, K. (2023). Role of polysaccharides from marine seaweed as feed additives for methane mitigation in ruminants: A critical review. Polymers, 15.","DOI":"10.3390\/polym15153153"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"103878","DOI":"10.1016\/j.algal.2024.103878","article-title":"Non-starch polysaccharides composition of 23 macroalgae and their potential as future feeds for ruminants","volume":"85","author":"Curtasu","year":"2025","journal-title":"Algal Res."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Zhang, Y., Yang, L., Zhao, N., Hong, Z., Cai, B., Le, Q., Yang, T., Shi, L., and He, J. (2021). Soluble polysaccharide derived from Laminaria japonica attenuates obesity-related nonalcoholic fatty liver disease associated with gut microbiota regulation. Mar. Drugs, 19.","DOI":"10.3390\/md19120699"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"7382","DOI":"10.1021\/acs.jafc.2c08731","article-title":"Laminaria japonica polysaccharide improved the productivities and systemic health of ducks by mediating the gut microbiota and metabolome","volume":"71","author":"Liu","year":"2023","journal-title":"J. Agric. Food Chem."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"21148","DOI":"10.1021\/acs.jafc.5c03896","article-title":"Mechanisms of Laminaria japonica Polysaccharide Digestion and Absorption: Structure, In Vivo Fluorescence Imaging, and Gut Microbiota","volume":"73","author":"Lin","year":"2025","journal-title":"J. Agric. Food Chem."},{"key":"ref_21","unstructured":"(2008). Seed Storage of Agricultural Crops (Standard No. GB\/T 7415-2008)."},{"key":"ref_22","unstructured":"(2017). Hygienical Standard for Feeds (Standard No. GB 13078-2017)."},{"key":"ref_23","unstructured":"National Research Council (2007). Nutrient Requirements of Small Ruminants: Sheep, Goats, Cervids, and New World Camelids, The National Academies Press."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1093\/nar\/gks808","article-title":"Evaluation of general 16S ribosomal RNA gene PCR primers for classical and next-generation sequencing-based diversity studies","volume":"41","author":"Klindworth","year":"2013","journal-title":"Nucleic Acids Res."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1038\/s41587-019-0209-9","article-title":"Reproducible, interactive, scalable and extensible microbiome data science using QIIME 2","volume":"37","author":"Bolyen","year":"2019","journal-title":"Nat. Biotechnol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1038\/nmeth.3869","article-title":"DADA2: High-resolution sample inference from Illumina amplicon data","volume":"13","author":"Callahan","year":"2016","journal-title":"Nat. Methods"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1093\/molbev\/mst010","article-title":"MAFFT multiple sequence alignment software version 7: Improvements in performance and usability","volume":"30","author":"Katoh","year":"2013","journal-title":"Mol. Biol. Evol."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Price, M.N., Dehal, P.S., and Arkin, A.P. (2010). FastTree 2\u2013approximately maximum-likelihood trees for large alignments. PLoS ONE, 5.","DOI":"10.1371\/journal.pone.0009490"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1186\/s40168-018-0470-z","article-title":"Optimizing taxonomic classification of marker-gene amplicon sequences with QIIME 2\u2032s q2-feature-classifier plugin","volume":"6","author":"Bokulich","year":"2018","journal-title":"Microbiome"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1038\/ismej.2011.139","article-title":"An improved Greengenes taxonomy with explicit ranks for ecological and evolutionary analyses of bacteria and archaea","volume":"6","author":"McDonald","year":"2012","journal-title":"ISME J."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1038\/nmeth.3393","article-title":"MS-DIAL: Data-independent MS\/MS deconvolution for comprehensive metabolome analysis","volume":"12","author":"Tsugawa","year":"2015","journal-title":"Nat. Methods"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1038\/s41587-020-0548-6","article-title":"PICRUSt2 for prediction of metagenome functions","volume":"38","author":"Douglas","year":"2020","journal-title":"Nat. Biotechnol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1007\/s11306-018-1367-3","article-title":"Guidelines and considerations for the use of system suitability and quality control samples in mass spectrometry assays applied in untargeted clinical metabolomic studies","volume":"14","author":"Broadhurst","year":"2018","journal-title":"Metabolomics"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1007\/s11605-021-05188-7","article-title":"The role of gut-derived lipopolysaccharides and the intestinal barrier in fatty liver diseases","volume":"26","author":"An","year":"2022","journal-title":"J. Gastrointest. Surg."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Chang, L., Liu, Y., Li, H., Yan, J., Wu, W., Chen, N., Ma, C., Zhao, X., Chen, J., and Zhang, J. (2025). Gut microbiome and its metabolites in liver cirrhosis: Mechanisms and clinical implications. Front. Cell. Infect. Microbiol., 15.","DOI":"10.3389\/fcimb.2025.1717696"},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Ye, X., Liu, Y., Hu, J., Gao, Y., Ma, Y., and Wen, D. (2021). Chlorogenic acid-induced gut microbiota improves metabolic endotoxemia. Front. Endocrinol., 12.","DOI":"10.3389\/fendo.2021.762691"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"112754","DOI":"10.1016\/j.ecoenv.2021.112754","article-title":"Aflatoxin B1 alters meat quality associated with oxidative stress, inflammation, and gut-microbiota in sheep","volume":"225","author":"Cao","year":"2021","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1038\/s41538-022-00145-3","article-title":"Dietary supplementation with biogenic selenium nanoparticles alleviate oxidative stress-induced intestinal barrier dysfunction","volume":"6","author":"Qiao","year":"2022","journal-title":"npj Sci. Food"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"e70043","DOI":"10.1002\/mnfr.70043","article-title":"Apigenin Alleviates Intestinal Ischemia\/Reperfusion Injury via Upregulating Nrf2-Mediated Tight Junction Integrity","volume":"69","author":"Xu","year":"2025","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Yuan, Z., Huang, L., Hu, Z., Deng, J., Duan, Y., Jiang, Q., Tan, B., Ma, X., Zhang, C., and Tang, X. (2025). Lactobacillus fermentum ZC529 protects intestinal epithelial barrier integrity by activating the Keap1-Nrf2 signaling pathway and inhibiting the NF-\u03baB signaling pathway. Antioxidants, 14.","DOI":"10.3390\/antiox14060732"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"137811","DOI":"10.1016\/j.ijbiomac.2024.137811","article-title":"Fucoidan from Stichopus chloronotus relieved DSS induced ulcerative colitis through inhibiting intestinal barrier disruption and oxidative stress","volume":"283","author":"Li","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Tang, Y.-F., Xie, W.-Y., Wu, H.-Y., Guo, H.-X., Wei, F.-H., Ren, W.-Z., Gao, W., and Yuan, B. (2024). Huaier polysaccharide alleviates dextran sulphate sodium salt-induced colitis by inhibiting inflammation and oxidative stress, maintaining the intestinal barrier, and modulating gut microbiota. Nutrients, 16.","DOI":"10.3390\/nu16091368"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"133699","DOI":"10.1016\/j.ijbiomac.2024.133699","article-title":"Alginate oligosaccharide improves 5-fluorouracil-induced intestinal mucositis by enhancing intestinal barrier and modulating intestinal levels of butyrate and isovalerate","volume":"276","author":"Teng","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1186\/s12944-025-02483-z","article-title":"Fucoidan ameliorates lipid accumulation, oxidative stress, and NF-\u03baB-mediated inflammation by regulating the PI3K\/AKT\/Nrf2 signaling pathway in a free fatty acid-induced NAFLD spheroid model","volume":"24","author":"Chu","year":"2025","journal-title":"Lipids Health Dis."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"128853","DOI":"10.1016\/j.ijbiomac.2023.128853","article-title":"Laminaria japonica polysaccharide alleviates type 2 diabetes by regulating the microbiota-gut-liver axis: A multi-omics mechanistic analysis","volume":"258","author":"Tong","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"119411","DOI":"10.1016\/j.carbpol.2022.119411","article-title":"Saccharina japonica fucan suppresses high fat diet-induced obesity and enriches fucoidan-degrading gut bacteria","volume":"290","author":"Wei","year":"2022","journal-title":"Carbohydr. Polym."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1111\/1751-7915.12000","article-title":"The potential of bacteria isolated from ruminal contents of seaweed-eating North Ronaldsay sheep to hydrolyse seaweed components and produce methane by anaerobic digestion in vitro","volume":"6","author":"Williams","year":"2013","journal-title":"Microb. Biotechnol."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Ejima, R., Akiyama, M., Sato, H., Tomioka, S., Yakabe, K., Kimizuka, T., Seki, N., Fujimura, Y., Hirayama, A., and Fukuda, S. (2021). Seaweed dietary fiber sodium alginate suppresses the migration of colonic inflammatory monocytes and diet-induced metabolic syndrome via the gut microbiota. Nutrients, 13.","DOI":"10.3390\/nu13082812"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1186\/s40168-025-02176-w","article-title":"Sulfated dietary fiber protects gut microbiota from antibiotics","volume":"13","author":"Wu","year":"2025","journal-title":"Microbiome"},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Garcia, G., Soto, J., Valenzuela, C., Bernal, M., Barreto, J., Luzardo, M.d.l.C., Kazlauskaite, R., Waslidge, N., Bavington, C., and Cano, R.d.J. (2025). Gut Microbiome Modulation and Health Benefits of a Novel Fucoidan Extract from Saccharina latissima: A Double-Blind, Placebo-Controlled Trial. Microorganisms, 13.","DOI":"10.3390\/microorganisms13071545"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1136\/gutjnl-2020-321565","article-title":"Microbiota tryptophan metabolism induces aryl hydrocarbon receptor activation and improves alcohol-induced liver injury","volume":"70","author":"Wrzosek","year":"2021","journal-title":"Gut"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1111\/apt.16602","article-title":"Therapeutic aspects of bile acid signalling in the gut-liver axis","volume":"54","author":"Simbrunner","year":"2021","journal-title":"Aliment. Pharmacol. Ther."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1924","DOI":"10.1111\/1751-7915.14293","article-title":"Akkermansia muciniphila alleviates high-fat-diet-related metabolic-associated fatty liver disease by modulating gut microbiota and bile acids","volume":"16","author":"Wu","year":"2023","journal-title":"Microb. Biotechnol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"148202","DOI":"10.1016\/j.ijbiomac.2025.148202","article-title":"Water-soluble Poria cocos polysaccharide improves alcoholic liver disease via modulation of gut microbiota-mediated intestinal bile acids-farnesoid X receptor","volume":"330","author":"Huang","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"e21458","DOI":"10.1096\/fj.202000763RRR","article-title":"Porphyran-derived oligosaccharides alleviate NAFLD and related cecal microbiota dysbiosis in mice","volume":"35","author":"Wang","year":"2021","journal-title":"FASEB J."},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Singh, S.B., Coffman, C.N., Varga, M.G., Carroll-Portillo, A., Braun, C.A., and Lin, H.C. (2022). Intestinal alkaline phosphatase prevents sulfate reducing bacteria-induced increased tight junction permeability by inhibiting snail pathway. Front. Cell. Infect. Microbiol., 12.","DOI":"10.3389\/fcimb.2022.882498"},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Lobo de S\u00e1, F.D., Backert, S., Nattramilarasu, P.K., Mousavi, S., Sandle, G.I., Bereswill, S., Heimesaat, M.M., Schulzke, J.-D., and B\u00fccker, R. (2021). Vitamin D reverses disruption of gut epithelial barrier function caused by Campylobacter jejuni. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22168872"},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Abramov, V.M., Kosarev, I.V., Machulin, A.V., Deryusheva, E.I., Priputnevich, T.V., Panin, A.N., Chikileva, I.O., Abashina, T.N., Manoyan, A.M., and Ivanova, O.E. (2024). Consortium of Lactobacillus crispatus 2029 and Ligilactobacillus salivarius 7247 strains shows in vitro bactericidal effect on Campylobacter jejuni and, in combination with prebiotic, protects against intestinal barrier dysfunction. Antibiotics, 13.","DOI":"10.3390\/antibiotics13121143"}],"container-title":["Animals"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-2615\/16\/14\/2146\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,12]],"date-time":"2026-07-12T04:15:44Z","timestamp":1783829744000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-2615\/16\/14\/2146"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,10]]},"references-count":58,"journal-issue":{"issue":"14","published-online":{"date-parts":[[2026,7]]}},"alternative-id":["ani16142146"],"URL":"https:\/\/doi.org\/10.3390\/ani16142146","relation":{},"ISSN":["2076-2615"],"issn-type":[{"value":"2076-2615","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,10]]}}}