{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T15:01:56Z","timestamp":1785423716259,"version":"3.56.0"},"reference-count":61,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T00:00:00Z","timestamp":1785369600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Hainan Province\u2019s Key Research and Development Project","award":["ZDYF2023XDNY067"],"award-info":[{"award-number":["ZDYF2023XDNY067"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animals"],"abstract":"<jats:p>Background: Antibiotic exposure disrupts gut microbiota and lipid metabolism, hindering healthy poultry farming, especially for medicinal Silky fowls. Given that essential oils are prone to volatilization during the decoction of traditional Chinese medicine, this study evaluated modified Shen Ling Bai Zhu San and its essential oils (SLEO) on growth, lipid metabolism, and intestinal health in Silky fowls. Methods: 540 Silky fowls were divided into CON, ATB, ATB+SLEO, and SLEO groups. The cecal microbiota was analyzed via 16S rRNA sequencing. Results: ATB improved weight gain but increased abdominal fat, liver lipid accumulation, and serum triglycerides\/cholesterol. Lipid transporter and metabolism gene expression was upregulated, while CPT1A and PPAR\u03b1 were downregulated. SLEO alone significantly improved intestinal villus morphology, as evidenced by a higher villus height\/crypt depth (V\/C) ratio compared to the ATB group (p &lt; 0.05), along with reduced mortality and enhanced barrier gene expression, without adverse lipid effects. Antibiotics reduced cecal microbial \u03b1\/\u03b2 diversity, which SLEO reversed. Enriched SLEO-associated strains correlated strongly with lipid metabolism. Conclusion: SLEO may serve as an antibiotic alternative, regulating lipid metabolism, reducing fat deposition, maintaining gut microbiota homeostasis, and alleviating antibiotic-induced adverse effects.<\/jats:p>","DOI":"10.3390\/ani16152333","type":"journal-article","created":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T13:55:11Z","timestamp":1785419711000},"page":"2333","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Modified Shen Ling Bai Zhu San Combined with Its Essential Oil Regulates Growth Performance, Lipid Metabolism and Intestinal Health in Silky Fowls"],"prefix":"10.3390","volume":"16","author":[{"given":"Xiujun","family":"Wang","sequence":"first","affiliation":[{"name":"College of Veterinary Medicine, Henan University of Animal Husbandry and Economy, No. 6 Wenyuan Road, Zhengzhou 450046, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinglin","family":"Gao","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yimu","family":"Ma","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Gao","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuhong","family":"Chai","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Menghui","family":"Cao","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jieyi","family":"Huang","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1176-6664","authenticated-orcid":false,"given":"Weijie","family":"Lv","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Qu","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China"},{"name":"College of Animal Science, Anhui Science and Technology University, Chuzhou 233100, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3066-6906","authenticated-orcid":false,"given":"Shining","family":"Guo","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China"},{"name":"Guangdong Technology Research Center for Traditional Chinese Veterinary Medicine and Nature Medicine, Guangzhou 510642, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1750","DOI":"10.1016\/j.jiph.2021.10.020","article-title":"Antibiotic resistance in microbes: History, mechanisms, therapeutic strategies and future prospects","volume":"14","author":"Uddin","year":"2021","journal-title":"J. Infect. Public Health"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"179867","DOI":"10.1016\/j.scitotenv.2025.179867","article-title":"Antibiotic alternatives in livestock feeding","volume":"989","author":"Liu","year":"2025","journal-title":"Sci. Total Environ."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Auger, L., Saucier, L., Gaucher, M.-L., Vandenberg, G.W., Vincent, A.T., Thibodeau, A., and Deschamps, M.H. (2025). Use, Risk and Revalorization of Veterinary Antibiotics: A Canadian Perspective. Antibiotics, 14.","DOI":"10.3390\/antibiotics14070665"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Han, G., Yu, J., He, J., Zheng, P., Mao, X., and Yu, B. (2024). Subtherapeutic Kitasamycin Promoted Fat Accumulation in the Longissimus Dorsi Muscle in Growing-Finishing Pigs. Animals, 14.","DOI":"10.3390\/ani14071057"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"e13326","DOI":"10.1111\/asj.13326","article-title":"Antibiotics promote abdominal fat accumulation in broilers","volume":"91","author":"Li","year":"2020","journal-title":"Anim. Sci. J."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.1111\/1750-3841.16501","article-title":"Pharmacokinetics, withdrawal time, and dietary risk assessment of enrofloxacin and its metabolite ciprofloxacin, and sulfachloropyridazine-trimethoprim in Taihe black-boned silky fowls","volume":"88","author":"Yuan","year":"2023","journal-title":"J. Food Sci."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"103060","DOI":"10.1016\/j.psj.2023.103060","article-title":"Comparative study of the plasma pharmacokinetics and tissue residues of trimethoprim in silky fowls and 817 broilers after single oral administration","volume":"102","author":"Hu","year":"2023","journal-title":"Poult. Sci."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"101196","DOI":"10.1016\/j.psj.2021.101196","article-title":"Effects of a probiotic-fermented herbal blend on the growth performance, intestinal flora and immune function of chicks infected with Salmonella pullorum","volume":"100","author":"Wang","year":"2021","journal-title":"Poult. Sci."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"102707","DOI":"10.1016\/j.psj.2023.102707","article-title":"Growth performance and cecal microbiota of broiler chicks as affected by drinking water disinfection and\/or herbal extract blend supplementation","volume":"102","author":"Meng","year":"2023","journal-title":"Poult. Sci."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"102714","DOI":"10.1016\/j.psj.2023.102714","article-title":"Effects of dietary polyherbal mixtures on growth performance, antioxidant capacity, immune function and jejunal health of yellow-feathered broilers","volume":"102","author":"Liu","year":"2023","journal-title":"Poult. Sci."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Liu, M., Huang, J., Ma, M., Huang, G., Zhang, Y., Ding, Y., Qu, Q., Lv, W., and Guo, S. (2023). Effects of dietary Chinese herbal mixtures on productive performance, egg quality, immune status, caecal and offspring meconial microbiota of Wenchang breeder hens. Front. Vet. Sci., 10.","DOI":"10.3389\/fvets.2023.1320469"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"105156","DOI":"10.1016\/j.psj.2025.105156","article-title":"Modulatory effects of polyherbal mixture on the immuno-antioxidant capacity and intestinal health of chicks infected with Escherichia coli O78","volume":"104","author":"Qu","year":"2025","journal-title":"Poult. Sci."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"154645","DOI":"10.1016\/j.phymed.2023.154645","article-title":"Transcriptome profiling Revealed the potential mechanisms of Shen Lin Bai Zhu San n-butanol extract on DSS induced Colitis in Mice and LC-MS analysis","volume":"110","author":"Qu","year":"2023","journal-title":"Phytomedicine"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.nutres.2019.10.001","article-title":"Shen-Ling-Bai-Zhu-San alleviates functional dyspepsia in rats and modulates the composition of the gut microbiota","volume":"71","author":"Zhang","year":"2019","journal-title":"Nutr. Res."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Chen, Q., Xiao, Z., He, Q.Y., Zhang, R.R., Chen, S.X., Dong, J.W., Zhang, H., and Chen, X.F. (2022). Effect of Shenling Baizhu powder on immunity to diarrheal disease: A systematic review and meta-analysis. Front. Pharmacol., 13.","DOI":"10.3389\/fphar.2022.938932"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1622","DOI":"10.1016\/j.ijbiomac.2017.02.060","article-title":"Structural modulation of gut microbiota during alleviation of antibiotic-associated diarrhea with herbal formula","volume":"105","author":"Lv","year":"2017","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"138730","DOI":"10.1016\/j.ijbiomac.2024.138730","article-title":"Period circadian clock 3 is crucial for regulation of IL-22-producing type 3 innate lymphoid cells by flavonoids from Shen Ling Bai Zhu San to alleviate colitis","volume":"288","author":"Qu","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"8358151","DOI":"10.1155\/2017\/8358151","article-title":"Structural Modulation of Gut Microbiota during Alleviation of Suckling Piglets Diarrhoea with Herbal Formula","volume":"2017","author":"Liu","year":"2017","journal-title":"Evid. Based Complement. Altern. Med."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"100527","DOI":"10.1016\/j.fpsl.2020.100527","article-title":"Physicochemical, antioxidant and antimicrobial properties of mechanically deboned chicken meat protein films enriched with various essential oils","volume":"25","author":"Turhan","year":"2020","journal-title":"Food Packag. Shelf Life"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1111\/jfs.12129","article-title":"The Efficacy of the Natural Plant Extracts, Thymol and Carvacrol against Colonization in Broiler Chickens","volume":"34","author":"Arsi","year":"2014","journal-title":"J. Food Saf."},{"key":"ref_21","first-page":"6281","article-title":"Construction of black-bone silky fowl (Gallus gallus domesticus) families based on genetic diversity","volume":"49","author":"Liu","year":"2024","journal-title":"Zhongguo Zhong Yao ZA Zhi"},{"key":"ref_22","first-page":"481","article-title":"Study on trace elements in wuji baifeng wan and its preparation","volume":"24","author":"Zhang","year":"2004","journal-title":"Guang PU Xue YU Guang PU Fen XI"},{"key":"ref_23","unstructured":"AOAC International (2012). Official Methods of Analysis of AOAC International, AOAC International. [15th ed.]."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1007\/s00281-025-01043-y","article-title":"Dyslipidemia and female reproductive failures: Perspectives on lipid metabolism and endometrial immune dysregulation","volume":"47","author":"Zhang","year":"2025","journal-title":"Semin. Immunopathol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"2478317","DOI":"10.1080\/07853890.2025.2478317","article-title":"Exploring the role of gut microbiota in antibiotic resistance and prevention","volume":"57","author":"Dongre","year":"2025","journal-title":"Ann. Med."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.aninu.2018.03.002","article-title":"Use of antibiotics in broiler production: Global impacts and alternatives","volume":"4","author":"Mehdi","year":"2018","journal-title":"Anim. Nutr."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"eaaw1944","DOI":"10.1126\/science.aaw1944","article-title":"Global trends in antimicrobial resistance in animals in low- and middle-income countries","volume":"365","author":"Pires","year":"2019","journal-title":"Science"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"8744","DOI":"10.1080\/10408398.2021.1932722","article-title":"Bacteriocinogenic probiotics as an integrated alternative to antibiotics in chicken production-why and how?","volume":"62","author":"Lone","year":"2022","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"155300","DOI":"10.1016\/j.scitotenv.2022.155300","article-title":"Recent developments in antimicrobial growth promoters in chicken health: Opportunities and challenges","volume":"834","author":"Kalia","year":"2022","journal-title":"Sci. Total Environ."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Fu, Q., Wang, P., Zhang, Y., Wu, T., Huang, J., and Song, Z. (2023). Effects of Dietary Inclusion of Asiaticoside on Growth Performance, Lipid Metabolism, and Gut Microbiota in Yellow-Feathered Chickens. Animals, 13.","DOI":"10.3390\/ani13162653"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"100479","DOI":"10.1016\/j.jhepr.2022.100479","article-title":"Lipid alterations in chronic liver disease and liver cancer","volume":"4","author":"Paul","year":"2022","journal-title":"JHEP Rep."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/S1097-2765(00)80332-9","article-title":"Identification of the major intestinal fatty acid transport protein","volume":"4","author":"Stahl","year":"1999","journal-title":"Mol. Cell"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1152\/physrev.00019.2011","article-title":"Role of the gut in lipid homeostasis","volume":"92","author":"Abumrad","year":"2012","journal-title":"Physiol. Rev."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1194\/jlr.R083451","article-title":"Lipid transfer proteins in the assembly of apoB-containing lipoproteins","volume":"59","author":"Sirwi","year":"2018","journal-title":"J. Lipid Res."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1002\/j.2040-4603.2014.tb00548.x","article-title":"Energy metabolism in the liver","volume":"4","author":"Rui","year":"2014","journal-title":"Compr. Physiol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.gene.2011.01.007","article-title":"The resurgence of Hormone-Sensitive Lipase (HSL) in mammalian lipolysis","volume":"477","author":"Lampidonis","year":"2011","journal-title":"Gene"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/1743-7075-3-12","article-title":"Hormone-sensitive lipase knockouts","volume":"3","author":"Kraemer","year":"2006","journal-title":"Nutr. Metab."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1038\/nature17173","article-title":"High-fat diet enhances stemness and tumorigenicity of intestinal progenitors","volume":"531","author":"Beyaz","year":"2016","journal-title":"Nature"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"5935","DOI":"10.1016\/j.csbj.2022.10.030","article-title":"Advances in multi-omics study of biomarkers of glycolipid metabolism disorder","volume":"20","author":"Fang","year":"2022","journal-title":"Comput. Struct. Biotechnol. J."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"105088","DOI":"10.1016\/j.phrs.2020.105088","article-title":"A review of saponin intervention in metabolic syndrome suggests further study on intestinal microbiota","volume":"160","author":"Luo","year":"2020","journal-title":"Pharmacol. Res."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"e66398","DOI":"10.7554\/eLife.66398","article-title":"Tetrahydroxanthohumol, a xanthohumol derivative, attenuates high-fat diet-induced hepatic steatosis by antagonizing PPARgamma","volume":"10","author":"Zhang","year":"2021","journal-title":"eLife"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/j.stem.2018.04.001","article-title":"Fasting Activates Fatty Acid Oxidation to Enhance Intestinal Stem Cell Function during Homeostasis and Aging","volume":"22","author":"Mihaylova","year":"2018","journal-title":"Cell Stem Cell"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1038\/s41388-023-02593-x","article-title":"Nutrient transporters: Connecting cancer metabolism to therapeutic opportunities","volume":"42","author":"Nwosu","year":"2023","journal-title":"Oncogene"},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Chen, L., Tuo, B., and Dong, H. (2016). Regulation of Intestinal Glucose Absorption by Ion Channels and Transporters. Nutrients, 8.","DOI":"10.3390\/nu8010043"},{"key":"ref_45","first-page":"1133","article-title":"Impact of a high-fat diet on intestinal stem cells and epithelial barrier function in middle-aged female mice","volume":"21","author":"Xie","year":"2020","journal-title":"Mol. Med. Rep."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.devcel.2018.03.024","article-title":"Morphogenesis and Compartmentalization of the Intestinal Crypt","volume":"45","author":"Sumigray","year":"2018","journal-title":"Dev. Cell"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"102116","DOI":"10.1016\/j.ceb.2022.102116","article-title":"Stand by me: Fibroblasts regulation of the intestinal epithelium during development and homeostasis","volume":"78","author":"Felsenthal","year":"2022","journal-title":"Curr. Opin. Cell Biol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.mucimm.2023.01.006","article-title":"Stromal regulation of the intestinal barrier","volume":"16","author":"Sylvestre","year":"2023","journal-title":"Mucosal Immunol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1016\/j.cell.2019.10.011","article-title":"Phase Separation of Zonula Occludens Proteins Drives Formation of Tight Junctions","volume":"179","author":"Beutel","year":"2019","journal-title":"Cell"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1146\/annurev-biochem-011520-105053","article-title":"Mucins and the Microbiome","volume":"89","author":"Hansson","year":"2020","journal-title":"Annu. Rev. Biochem."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"G936","DOI":"10.1152\/ajpgi.00053.2021","article-title":"Colon epithelial cell TGFbeta signaling modulates the expression of tight junction proteins and barrier function in mice","volume":"320","author":"Smith","year":"2021","journal-title":"Am. J. Physiol.-Gastrointest. Liver Physiol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"117136","DOI":"10.1016\/j.jep.2023.117136","article-title":"Shen-Ling-Bai-Zhu-San alleviates the imbalance of intestinal homeostasis in dextran sodium sulfate-induced colitis mice by regulating gut microbiota and inhibiting the NLRP3 inflammasome activation","volume":"319","author":"Gao","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1111\/j.1469-185X.2009.00086.x","article-title":"The integration of digestion and osmoregulation in the avian gut","volume":"84","author":"McWhorter","year":"2009","journal-title":"Biol. Rev. Camb. Philos. Soc."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1053\/j.gastro.2020.10.057","article-title":"Metabolism and Metabolic Disorders and the Microbiome: The Intestinal Microbiota Associated With Obesity, Lipid Metabolism, and Metabolic Health-Pathophysiology and Therapeutic Strategies","volume":"160","author":"Warmbrunn","year":"2021","journal-title":"Gastroenterology"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1111\/1462-2920.13589","article-title":"Formation of propionate and butyrate by the human colonic microbiota","volume":"19","author":"Louis","year":"2017","journal-title":"Environ. Microbiol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1038\/s41586-023-06378-w","article-title":"Synergy and oxygen adaptation for development of next-generation probiotics","volume":"620","author":"Khan","year":"2023","journal-title":"Nature"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1136\/gutjnl-2019-320438","article-title":"Mediterranean diet intervention in overweight and obese subjects lowers plasma cholesterol and causes changes in the gut microbiome and metabolome independently of energy intake","volume":"69","author":"Meslier","year":"2020","journal-title":"Gut"},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Parker, B.J., Wearsch, P.A., Veloo, A.C.M., and Rodriguez-Palacios, A. (2020). The Genus Alistipes: Gut Bacteria With Emerging Implications to Inflammation, Cancer, and Mental Health. Front. Immunol., 11.","DOI":"10.3389\/fimmu.2020.00906"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1038\/s41586-023-06466-x","article-title":"Gut microbial carbohydrate metabolism contributes to insulin resistance","volume":"621","author":"Takeuchi","year":"2023","journal-title":"Nature"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"117627","DOI":"10.1016\/j.jep.2023.117627","article-title":"PuRenDan alleviates type 2 diabetes mellitus symptoms by modulating the gut microbiota and its metabolites","volume":"322","author":"Ma","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1038\/s41522-023-00390-8","article-title":"Chicken cecal microbiota reduces abdominal fat deposition by regulating fat metabolism","volume":"9","author":"Chen","year":"2023","journal-title":"Npj Biofilms Microbiomes"}],"container-title":["Animals"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-2615\/16\/15\/2333\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T14:04:27Z","timestamp":1785420267000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-2615\/16\/15\/2333"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,30]]},"references-count":61,"journal-issue":{"issue":"15","published-online":{"date-parts":[[2026,8]]}},"alternative-id":["ani16152333"],"URL":"https:\/\/doi.org\/10.3390\/ani16152333","relation":{},"ISSN":["2076-2615"],"issn-type":[{"value":"2076-2615","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,30]]}}}