{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T04:46:00Z","timestamp":1785818760899,"version":"3.56.0"},"reference-count":34,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100011296","name":"Hubei Key Laboratory of Animal Nutrition and Feed Science","doi-asserted-by":"publisher","award":["ANFS202510"],"award-info":[{"award-number":["ANFS202510"]}],"id":[{"id":"10.13039\/501100011296","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32303068"],"award-info":[{"award-number":["32303068"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"award":["32303068"],"award-info":[{"award-number":["32303068"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002865","name":"Chongqing Science and Technology Commission","doi-asserted-by":"crossref","award":["CSTB2023NSCQ-MSX1092"],"award-info":[{"award-number":["CSTB2023NSCQ-MSX1092"]}],"id":[{"id":"10.13039\/501100002865","id-type":"DOI","asserted-by":"crossref"}]},{"award":["CSTB2023NSCQ-MSX1092"],"award-info":[{"award-number":["CSTB2023NSCQ-MSX1092"]}],"id":[{"id":"https:\/\/ror.org\/05w9erc61","id-type":"ROR","asserted-by":"publisher"}]},{"name":"Science and Technology Research Program of Chongqing Municipal Education Commission","award":["KJZD-K202603501"],"award-info":[{"award-number":["KJZD-K202603501"]}]},{"award":["KJZD-K202603501"],"award-info":[{"award-number":["KJZD-K202603501"]}],"id":[{"id":"https:\/\/ror.org\/031nm5713","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animals"],"abstract":"<jats:p>Spring viremia of carp virus (SVCV) poses a major threat to aquaculture industry, triggering severe economic losses and substantial damage to fish health. Effective antiviral therapeutic approaches are currently insufficient in aquaculture, highlighting an urgent demand for viable intervention strategies. This study assessed the antiviral and immunomodulatory potential of Houttuynia cordata against SVCV in common carp. Combined cellular and in vivo fish experiments demonstrated that Houttuynia cordata markedly suppresses SVCV replication, reduces viral titer, and enhances disease resistance of carp. The extract appears to suppress RAR\u03b1-A, upregulate IFN-1\/CXCL11, and recruit T lymphocytes via CXCL11, thereby enhancing innate and adaptive immunity against SVCV. Experimental results indicate that Houttuynia cordata alleviates hemorrhagic symptoms induced by SVCV infection. Dietary supplementation with this herb realizes dual functions of viral suppression and immune regulation for carp aquaculture. The findings provide a practical prevention and control strategy against SVCV infection and offer novel insights for research on green antiviral agents. Furthermore, this study verifies the potential value of Houttuynia cordata in improving biological safety and facilitating sustainable development of aquaculture, laying a solid foundation for the development of eco-friendly antiviral preparations.<\/jats:p>","DOI":"10.3390\/ani16152350","type":"journal-article","created":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T06:17:40Z","timestamp":1785737860000},"page":"2350","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Houttuynia cordata Extract Alleviates SVCV Infection by Modulating the RAR\u03b1-A\/Type I Interferon Axis in Common Carp"],"prefix":"10.3390","volume":"16","author":[{"given":"Chi","family":"Zhang","sequence":"first","affiliation":[{"name":"Hubei Key Laboratory of Animal Nutrition and Feed Science, School of Animal Science and Nutritional Engineering, Wuhan Polytechnic University, Wuhan 430023, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaqian","family":"Bai","sequence":"additional","affiliation":[{"name":"Hubei Key Laboratory of Animal Nutrition and Feed Science, School of Animal Science and Nutritional Engineering, Wuhan Polytechnic University, Wuhan 430023, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Liu","sequence":"additional","affiliation":[{"name":"Hubei Key Laboratory of Animal Nutrition and Feed Science, School of Animal Science and Nutritional Engineering, Wuhan Polytechnic University, Wuhan 430023, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanwei","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Fisheries, Xinyang Agriculture and Forestry University, Xinyang 464000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianlin","family":"He","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Chongqing Three Gorges Vocational College, Chongqing 404155, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya","family":"Zhou","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Chongqing Three Gorges Vocational College, Chongqing 404155, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2019-7798","authenticated-orcid":false,"given":"Xianqin","family":"Hu","sequence":"additional","affiliation":[{"name":"Hubei Key Laboratory of Animal Nutrition and Feed Science, School of Animal Science and Nutritional Engineering, Wuhan Polytechnic University, Wuhan 430023, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-1488-6273","authenticated-orcid":false,"given":"Jiaqi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Hubei Key Laboratory of Animal Nutrition and Feed Science, School of Animal Science and Nutritional Engineering, Wuhan Polytechnic University, Wuhan 430023, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,8,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e0138725","DOI":"10.1128\/jvi.01387-25","article-title":"SVCV phosphoprotein hijacks phase separation to immobilize the IRF3-TBK1 signaling axis and suppress interferon antiviral immunity","volume":"100","author":"Wang","year":"2026","journal-title":"J. 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