{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T17:08:00Z","timestamp":1786122480287,"version":"build-2736575974"},"reference-count":29,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T00:00:00Z","timestamp":1785628800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animals"],"abstract":"<jats:p>A 14-year-old neutered male domestic shorthair cat was evaluated for long-standing, non-pruritic, crusty skin lesions on the pinnae, neck, and ventral abdomen that had persisted for at least 4 years. The histopathological examination of biopsies from the neck and abdomen revealed multicentric squamous cell carcinoma in situ confined to the epidermis. Papillomavirus diagnostics on ear crusts using PCR, rolling circle amplification (RCA), and next-generation sequencing (NGS) identified coinfection with Felis catus papillomavirus type 7 (FcPV7) and a putative novel feline papillomavirus type. This is the first reported case of multicentric carcinoma in situ with coinfection by these two papillomaviruses. The condition was successfully managed medically with topical imiquimod cream applied twice weekly for 3 months, resulting in complete clinical remission. Over 1.5 years of follow-up, they remained well. Two mild recurrences on the dorsal neck were effectively controlled with a short repeat course of imiquimod. This case report documents coinfection with different feline papillomavirus types in a cat and highlights an efficacious, practical, non-surgical treatment with the topical immunomodulatory imiquimod cream.<\/jats:p>","DOI":"10.3390\/ani16152358","type":"journal-article","created":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T06:17:40Z","timestamp":1785737860000},"page":"2358","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Coinfection with Different Feline Papillomaviruses in a Cat with Multicentric Squamous Cell Carcinoma In Situ"],"prefix":"10.3390","volume":"16","author":[{"given":"Ana","family":"Rostaher","sequence":"first","affiliation":[{"name":"Dermatology Unit, Clinic for Small Animal Internal Medicine, Vetsuisse Faculty, University of Zurich, 8057 Zurich, Switzerland"},{"name":"Small Animal Hospital, School of Veterinary Medicine, University of Glasgow, Glasgow G12 8QQ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadine Angie","family":"Werlen","sequence":"additional","affiliation":[{"name":"Institute of Virology, Vetsuisse Faculty, University of Zurich, 8057 Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-1594-1149","authenticated-orcid":false,"given":"Paula","family":"Grest","sequence":"additional","affiliation":[{"name":"Institute of Veterinary Pathology, Vetsuisse Faculty, University of Zurich, 8057 Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0013-7993","authenticated-orcid":false,"given":"Kurt","family":"Tobler","sequence":"additional","affiliation":[{"name":"Institute of Virology, Vetsuisse Faculty, University of Zurich, 8057 Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4741-3972","authenticated-orcid":false,"given":"Anna Sophie","family":"Ramsauer","sequence":"additional","affiliation":[{"name":"Institute of Virology, Vetsuisse Faculty, University of Zurich, 8057 Zurich, Switzerland"},{"name":"Centre for Veterinary Public Health and One Health, Clinical Department for Farm Animals and Food System Transformation, University of Veterinary Medicine Vienna, 1210 Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,8,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Egberink, H., Hartmann, K., Mueller, R., Pennisi, M.G., Bel\u00e1k, S., Tasker, S., M\u00f6stl, K., Addie, D.D., Boucraut-Baralon, C., and Frymus, T. 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