{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T08:37:20Z","timestamp":1786523840419,"version":"build-2736575974"},"reference-count":48,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T00:00:00Z","timestamp":1786492800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"The Self-funded Project of Cangzhou Key Research and Development Program","award":["20251205004"],"award-info":[{"award-number":["20251205004"]}]},{"name":"Key Research Project of the Institute of Food Science Technology Nutrition and Health (Cangzhou), Chinese Academy of Agricultural Sciences","award":["CAAS-IFSTNH-CZCY-2024-02"],"award-info":[{"award-number":["CAAS-IFSTNH-CZCY-2024-02"]}]},{"award":["CAAS-IFSTNH-CZCY-2024-02"],"award-info":[{"award-number":["CAAS-IFSTNH-CZCY-2024-02"]}],"id":[{"id":"https:\/\/ror.org\/0313jb750","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animals"],"abstract":"<jats:p>Selenium (Se) is essential for livestock, and selenium-enriched yeast (SY) is widely used to produce Se-enriched eggs. However, the optimal dosage for late-peak laying hens remains unclear. This 8-week trial evaluated graded SY (0, 0.1, 0.3, and 0.5 mg\/kg Se) in 28-week-old Hy-Line Brown laying hens to explore the comprehensive effects. SY did not affect laying performance or egg quality (p &gt; 0.05), whereas egg Se content increased dose-dependently from 0.211 to 0.521 mg\/kg (p &lt; 0.001). SY enhanced antioxidant capacity, with glutathione peroxidase and catalase activities rising from 90.67 and 7.91 U\/mL to 493.33 and 21.43 U\/mL (p &lt; 0.001), and malondialdehyde decreasing from 0.46 to 0.13 nmol\/L (p &lt; 0.001). Serum lipid parameters were markedly improved, with total cholesterol and triglycerides declining from 8.82 and 17.60 mmol\/L to 2.86 and 13.73 mmol\/L (p &lt; 0.001). Humoral immunity was also positively modulated, as immunoglobulin G and A increased from 401.68 and 73.06 \u03bcg\/mL to 756.30 and 115.80 \u03bcg\/mL (p &lt; 0.001). Integrating egg enrichment efficiency, laying hen physiological health, and economic benefits, 0.3 mg\/kg Se was identified as optimal, achieving 0.358 mg\/kg egg Se. This study provides a novel paradigm for standardized and cost-effective commercial production of Se-enriched eggs.<\/jats:p>","DOI":"10.3390\/ani16162506","type":"journal-article","created":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T07:57:26Z","timestamp":1786521446000},"page":"2506","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effects of Selenium-Enriched Yeast on Laying Performance, Egg Quality, Selenium Deposition, and Serum Biochemical Parameters in Laying Hens"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-8603-3482","authenticated-orcid":false,"given":"Qiqi","family":"Chen","sequence":"first","affiliation":[{"name":"Institute of Food Science Technology Nutrition and Health (Cangzhou), Chinese Academy of Agricultural Sciences, Cangzhou 061000, China"},{"name":"Cangzhou Academy of Agriculture and Forestry Sciences, Cangzhou 061001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-7154-2942","authenticated-orcid":false,"given":"Xiaobin","family":"Feng","sequence":"additional","affiliation":[{"name":"Institute of Food Science Technology Nutrition and Health (Cangzhou), Chinese Academy of Agricultural Sciences, Cangzhou 061000, China"},{"name":"Cangzhou Academy of Agriculture and Forestry Sciences, Cangzhou 061001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Song","sequence":"additional","affiliation":[{"name":"Institute of Food Science Technology Nutrition and Health (Cangzhou), Chinese Academy of Agricultural Sciences, Cangzhou 061000, China"},{"name":"Cangzhou Academy of Agriculture and Forestry Sciences, Cangzhou 061001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiwei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Institute of Food Science Technology Nutrition and Health (Cangzhou), Chinese Academy of Agricultural Sciences, Cangzhou 061000, China"},{"name":"Cangzhou Academy of Agriculture and Forestry Sciences, Cangzhou 061001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanli","family":"Jia","sequence":"additional","affiliation":[{"name":"Institute of Food Science Technology Nutrition and Health (Cangzhou), Chinese Academy of Agricultural Sciences, Cangzhou 061000, China"},{"name":"Cangzhou Academy of Agriculture and Forestry Sciences, Cangzhou 061001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kangzhuang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Institute of Food Science Technology Nutrition and Health (Cangzhou), Chinese Academy of Agricultural Sciences, Cangzhou 061000, China"},{"name":"Cangzhou Academy of Agriculture and Forestry Sciences, Cangzhou 061001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyu","family":"Xie","sequence":"additional","affiliation":[{"name":"Institute of Food Science Technology Nutrition and Health (Cangzhou), Chinese Academy of Agricultural Sciences, Cangzhou 061000, China"},{"name":"Cangzhou Academy of Agriculture and Forestry Sciences, Cangzhou 061001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Dong","sequence":"additional","affiliation":[{"name":"Institute of Food Science Technology Nutrition and Health (Cangzhou), Chinese Academy of Agricultural Sciences, Cangzhou 061000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenzhen","family":"Liu","sequence":"additional","affiliation":[{"name":"Institute of Food Science Technology Nutrition and Health (Cangzhou), Chinese Academy of Agricultural Sciences, Cangzhou 061000, China"},{"name":"Cangzhou Academy of Agriculture and Forestry Sciences, Cangzhou 061001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,8,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1016\/j.tjnut.2025.01.014","article-title":"Advances of Selenium in Poultry Nutrition and Health","volume":"155","author":"Xu","year":"2025","journal-title":"J. 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