{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T04:41:38Z","timestamp":1789706498284,"version":"4.0.1"},"reference-count":49,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T00:00:00Z","timestamp":1787184000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009967","name":"Xinjiang Production and Construction Corps","doi-asserted-by":"publisher","award":["2025AA01502-2"],"award-info":[{"award-number":["2025AA01502-2"]}],"id":[{"id":"10.13039\/501100009967","id-type":"DOI","asserted-by":"publisher"}]},{"award":["2025AA01502-2"],"award-info":[{"award-number":["2025AA01502-2"]}],"id":[{"id":"https:\/\/ror.org\/03hcmxw73","id-type":"ROR","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015308","name":"Xinjiang Uygur Autonomous Region","doi-asserted-by":"publisher","award":["2024A02004-4"],"award-info":[{"award-number":["2024A02004-4"]}],"id":[{"id":"10.13039\/501100015308","id-type":"DOI","asserted-by":"publisher"}]},{"award":["2024A02004-4"],"award-info":[{"award-number":["2024A02004-4"]}],"id":[{"id":"https:\/\/ror.org\/02vtvez67","id-type":"ROR","asserted-by":"publisher"}]},{"name":"Application of Low-Moisture Silage of Licorice Stems and Leaves in Sheep Production","award":["HS202404"],"award-info":[{"award-number":["HS202404"]}]},{"name":"Bintuan Science and Technology Project","award":["2023TSYCTD0021"],"award-info":[{"award-number":["2023TSYCTD0021"]}]},{"name":"Bintuan Science and Technology Project","award":["NYHXGG2023AA101"],"award-info":[{"award-number":["NYHXGG2023AA101"]}]},{"name":"Bintuan Science and Technology Project","award":["2024AB016"],"award-info":[{"award-number":["2024AB016"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animals"],"abstract":"<jats:p>Growth and body conformation traits are key determinants of meat production efficiency and economic performance in sheep. However, the genetic architecture underlying these complex traits remains incompletely understood, particularly across multi-breed populations. In this study, we performed a genome-wide association study (GWAS) for seven growth and developmental traits in a combined population of 401 sheep, including Qira Black, Kyrgyz, Dorset \u00d7 Hu crossbred, and Suffolk \u00d7 Karakul crossbred sheep. After genotype harmonization and quality control, 47,674 autosomal SNPs were retained for analysis. Population structure was assessed using principal component analysis, and association testing was conducted using a mixed linear model incorporating breed, principal components, and a kinship matrix. A total of 44 independent loci were detected at a nominal significance threshold, encompassing 112 candidate genes. The strongest association was identified for cannon bone circumference near RPS6KA5 (Chr7; p = 1.40 \u00d7 10\u22127). Several biologically relevant genes involved in osteogenesis, cartilage development, and metabolic regulation were detected, including STEAP3, SLC26A2, PPARGC1B, COL11A1, CALN1, and CITED2. Two genomic regions exhibited pleiotropic effects, which were identified as being associated with multiple traits, suggesting shared genetic regulation of correlated skeletal characteristics. These findings are consistent with a polygenic architecture underlying growth trait in sheep and highlight candidate genomic regions potentially involved in skeletal development and body conformation. Although further validation is required, the identified loci provide preliminary evidence for regions that may influence growth-related phenotypes and offer a reference for future molecular breeding efforts in indigenous and crossbred sheep populations.<\/jats:p>","DOI":"10.3390\/ani16162605","type":"journal-article","created":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T09:48:31Z","timestamp":1787219311000},"page":"2605","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Multi-Breed Genome-Wide Association Analysis Reveals Candidate Genes for Growth and Body Conformation Traits in Four Populations of Native and Crossbred Chinese Sheep"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-5354-674X","authenticated-orcid":false,"given":"Erkinbay","family":"Azbergenov","sequence":"first","affiliation":[{"name":"College of Life Science and Technology, Tarim University, Alar 843300, China"},{"name":"Xinjiang Production and Construction Corps Key Laboratory of Tarim Animal Husbandry Science and Technology, Alar 843300, China"},{"name":"Key Laboratory of Livestock and Forage Resource Utilization in the Tarim Basin, Ministry of Agriculture and Rural Affairs, Alar 843300, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Jiang","sequence":"additional","affiliation":[{"name":"Xinjiang Production and Construction Corps Key Laboratory of Tarim Animal Husbandry Science and Technology, Alar 843300, China"},{"name":"Key Laboratory of Livestock and Forage Resource Utilization in the Tarim Basin, Ministry of Agriculture and Rural Affairs, Alar 843300, China"},{"name":"College of Animal Science and Technology, Tarim University, Alar 843300, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruizhi","family":"Yang","sequence":"additional","affiliation":[{"name":"College of Life Science and Technology, Tarim University, Alar 843300, China"},{"name":"Xinjiang Production and Construction Corps Key Laboratory of Tarim Animal Husbandry Science and Technology, Alar 843300, China"},{"name":"Key Laboratory of Livestock and Forage Resource Utilization in the Tarim Basin, Ministry of Agriculture and Rural Affairs, Alar 843300, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qifeng","family":"Gao","sequence":"additional","affiliation":[{"name":"College of Life Science and Technology, Tarim University, Alar 843300, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuming","family":"Kou","sequence":"additional","affiliation":[{"name":"Xinjiang Production and Construction Corps Key Laboratory of Tarim Animal Husbandry Science and Technology, Alar 843300, China"},{"name":"Key Laboratory of Livestock and Forage Resource Utilization in the Tarim Basin, Ministry of Agriculture and Rural Affairs, Alar 843300, China"},{"name":"College of Animal Science and Technology, Tarim University, Alar 843300, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaxuan","family":"Liao","sequence":"additional","affiliation":[{"name":"Xinjiang Production and Construction Corps Key Laboratory of Tarim Animal Husbandry Science and Technology, Alar 843300, China"},{"name":"Key Laboratory of Livestock and Forage Resource Utilization in the Tarim Basin, Ministry of Agriculture and Rural Affairs, Alar 843300, China"},{"name":"College of Animal Science and Technology, Tarim University, Alar 843300, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Yang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Sheep Genetic Improvement and Healthy Breeding, Xinjiang Academy, Shihezi 832000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4602-8570","authenticated-orcid":false,"given":"Shudong","family":"Liu","sequence":"additional","affiliation":[{"name":"Xinjiang Production and Construction Corps Key Laboratory of Tarim Animal Husbandry Science and Technology, Alar 843300, China"},{"name":"Key Laboratory of Livestock and Forage Resource Utilization in the Tarim Basin, Ministry of Agriculture and Rural Affairs, Alar 843300, China"},{"name":"College of Animal Science and Technology, Tarim University, Alar 843300, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,8,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jare.2023.04.012","article-title":"Two mutations at KRT74 and EDAR synergistically drive the fine-wool production in Chinese sheep","volume":"57","author":"Liang","year":"2024","journal-title":"J. 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