{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T11:25:46Z","timestamp":1787743546576,"version":"build-2784847793"},"reference-count":51,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T00:00:00Z","timestamp":1787702400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animals"],"abstract":"<jats:p>The liver plays a central role in fatty acid (FA) metabolism, triacylglycerol synthesis, and energy homeostasis. The study aims to evaluate how a four-week dietary intervention with fish-based (EF), milk-based (EM), and standard diets (ES) affects relationships between mineral levels, FA profiles and indices, and oxidative stress parameters in female Wistar rats. Liver tissue samples were collected and analyzed for these variables. Post hoc analysis revealed significant differences in trace elements between the EM and EF and the EM and ES groups, and in toxic trace elements only between the EM and EF groups. Individual mineral differences were observed for calcium (Ca), iron (Fe), copper (Cu), zinc (Zn), arsenic (As), mercury (Hg), and lead (Pb), all showing large effect sizes (\u03b7p2 = 0.32\u20130.63). The strongest mineral\u2013FA correlations occurred mainly in the ES group (15\/25) and, to a lesser extent, in EF (9\/25), involving 14 minerals, while only one mineral was significant in EM. Individual mineral correlations were most frequent in ES (13\/25), followed by EF (8\/25) and EM (4\/25). Zn was the strongest predictor of malondialdehyde (MDA) in EF (90.6%), and Cu was the main determinant in ES (72.9%). We concluded that EM showed minimal interactions, limited to Fe and oleic acid, whereas EF and ES displayed multiple strong mineral\u2013FA correlations, with ES exhibiting the most extensive and complex interaction network.<\/jats:p>","DOI":"10.3390\/ani16172678","type":"journal-article","created":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T10:59:23Z","timestamp":1787741963000},"page":"2678","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Change in Association Between Minerals, Fatty Acids and Oxidative Stress Parameters in Wistar Rats with Different Diets"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3991-6492","authenticated-orcid":false,"given":"Slavica","family":"Rankovi\u0107","sequence":"first","affiliation":[{"name":"Institute for Medical Research, National Institute of Republic of Serbia, University of Belgrade, Dr Suboti\u0107a 4, 11000 Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamara","family":"Popovi\u0107","sequence":"additional","affiliation":[{"name":"Institute for Medical Research, National Institute of Republic of Serbia, University of Belgrade, Dr Suboti\u0107a 4, 11000 Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6931-3695","authenticated-orcid":false,"given":"Nevena","family":"Vidovi\u0107","sequence":"additional","affiliation":[{"name":"Institute for Medical Research, National Institute of Republic of Serbia, University of Belgrade, Dr Suboti\u0107a 4, 11000 Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sa\u0161a","family":"Jankovi\u0107","sequence":"additional","affiliation":[{"name":"Institute of Meat Hygiene and Technology, Ka\u0107anskog 13, 11040 Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-7749-864X","authenticated-orcid":false,"given":"Mirjana","family":"Luki\u0107","sequence":"additional","affiliation":[{"name":"Institute of Meat Hygiene and Technology, Ka\u0107anskog 13, 11040 Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7051-9375","authenticated-orcid":false,"given":"Nikola","family":"Prvulovi\u0107","sequence":"additional","affiliation":[{"name":"Institute for Medical Research, National Institute of Republic of Serbia, University of Belgrade, Dr Suboti\u0107a 4, 11000 Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9605-3793","authenticated-orcid":false,"given":"Jasmina Debeljak","family":"Marta\u010di\u0107","sequence":"additional","affiliation":[{"name":"Institute for Medical Research, National Institute of Republic of Serbia, University of Belgrade, Dr Suboti\u0107a 4, 11000 Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,8,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1113\/EP092001","article-title":"The ins and outs of liver fat metabolism: The effect of phenotype and diet on risk of intrahepatic triglyceride accumulation","volume":"110","author":"Smith","year":"2025","journal-title":"Exp. 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