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This case series reports four dogs diagnosed with gallbladder mucocele, all presenting with hyperlipidemia, three with overweight or obesity, and one with hypothyroidism. The dogs were treated using a multimodal protocol combining pharmacological therapy with nutritional strategies. The pharmacological protocol included ursodeoxycholic acid, silymarin, S-adenosyl-L-methionine, bezafibrate, and omega-3 fatty acids, with doses adjusted according to body weight. Nutritional interventions were individualized and included weight-loss diets and a low-fat gastrointestinal diet. Clinical and ultrasonographic outcomes varied among cases, with partial or complete resolution observed over different follow-up periods. These findings suggest that clinical management combined with individualized nutritional protocols may be a potential approach for asymptomatic dogs with gallbladder mucocele, particularly when surgery is not feasible, and could inform future investigations.<\/jats:p>","DOI":"10.3390\/ani16172771","type":"journal-article","created":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T09:20:43Z","timestamp":1788427243000},"page":"2771","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical and Nutritional Management of Gallbladder Mucocele in Dogs: A Four-Case Series"],"prefix":"10.3390","volume":"16","author":[{"given":"Nat\u00e1lia M. C.","family":"Oliveira","sequence":"first","affiliation":[{"name":"Veterinary Nutrology Service, Veterinary Teaching Hospital, School of Veterinary Medicine and Animal Science, University of Sao Paulo, Sao Paulo 05508-270, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-0103-8785","authenticated-orcid":false,"given":"Pedro H.","family":"Marchi","sequence":"additional","affiliation":[{"name":"Pet Nutrology Research Center, Department of Animal Nutrition and Production, School of Veterinary Medicine and Animal Science, University of Sao Paulo, Pirassununga 13635-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-7245-6962","authenticated-orcid":false,"given":"Leonardo A.","family":"Pr\u00edncipe","sequence":"additional","affiliation":[{"name":"Pet Nutrology Research Center, Department of Animal Nutrition and Production, School of Veterinary Medicine and Animal Science, University of Sao Paulo, Pirassununga 13635-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andressa R.","family":"Amaral","sequence":"additional","affiliation":[{"name":"Veterinary Nutrology Service, Veterinary Teaching Hospital, School of Veterinary Medicine and Animal Science, University of Sao Paulo, Sao Paulo 05508-270, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-1911-1224","authenticated-orcid":false,"given":"Gabriela P. 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F.","family":"Pappalardo","sequence":"additional","affiliation":[{"name":"Veterinary Nutrology Service, Veterinary Teaching Hospital, School of Veterinary Medicine and Animal Science, University of Sao Paulo, Sao Paulo 05508-270, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-4562-8930","authenticated-orcid":false,"given":"Nicolle P. N.","family":"Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"Veterinary Nutrology Service, Veterinary Teaching Hospital, School of Veterinary Medicine and Animal Science, University of Sao Paulo, Sao Paulo 05508-270, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0540-1850","authenticated-orcid":false,"given":"J\u00falio C. 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