{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T13:13:47Z","timestamp":1788527627552,"version":"build-2803163510"},"reference-count":44,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T00:00:00Z","timestamp":1788480000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Modern Agricultural Industrial System Project","award":["CARS-39-16"],"award-info":[{"award-number":["CARS-39-16"]}]},{"name":"Qinghai Province \u201cKunlun Talents High-End Innovation and Entrepreneurial Talents\u201d Top Talent Project"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animals"],"abstract":"<jats:p>Przewalski\u2019s gazelle (Procapra przewalskii) is an endangered ungulate endemic to the Qinghai\u2013Tibet Plateau of China. Increasing habitat alteration and close contact with domestic livestock have raised concerns about cross-species pathogen transmission, yet infectious disease studies in this species remain limited. To determine the etiology of illness in two deceased gazelles from a conservation facility in Qinghai Province, we screened samples for a panel of pathogens, including Mycoplasma ovipneumoniae, Clostridium perfringens toxin genes, Mannheimia haemolytica, Klebsiella pneumoniae, Mycoplasma capricolum subsp. capripneumoniae, Pasteurella multocida, Peste des petits ruminants virus (PPRV), Bovine viral diarrhea virus (BVDV), and Infectious bovine rhinotracheitis virus (IBRV), using PCR and RT-PCR. BVDV-specific nucleic acids were detected in tissue samples from both individuals, whereas all other targeted pathogens tested negative. The virus was successfully isolated in Madin\u2013Darby Bovine Kidney (MDBK) cells and confirmed by RT-PCR, followed by whole-genome sequencing of the isolate, which was designated QH PSYL 2026. Phylogenetic analysis based on the full-length genome and 5\u2032UTR sequences assigned the isolate to the BVDV-1c subgenotype. Notably, its 5\u2032UTR sequence shared 100% identity with those of local cattle-derived BVDV strains, providing molecular evidence suggestive of an epidemiological linkage between wildlife and livestock. Integrating clinical signs, gross pathology, and laboratory results, the cases were consistent with BVDV infection as the primary presumptive etiology. To our knowledge, this is the first report of BVDV infection, virus isolation, and genomic characterization in Przewalski\u2019s gazelle. The detection of a BVDV-1c strain in this endangered species highlights the potential threat that livestock-associated pathogens pose to wildlife on the Qinghai\u2013Tibet Plateau. These findings furnish crucial baseline data for disease surveillance, molecular epidemiology, and conservation management of Przewalski\u2019s gazelle and provide valuable scientific evidence for wildlife disease prevention and control in plateau ecosystems.<\/jats:p>","DOI":"10.3390\/ani16172781","type":"journal-article","created":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T12:20:46Z","timestamp":1788524446000},"page":"2781","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["First Isolation and Genomic Characterization of BVDV-1c in Przewalski\u2019s Gazelle (Procapra przewalskii) from the Qinghai\u2013Tibet Plateau, China"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-2823-0151","authenticated-orcid":false,"given":"Yue","family":"Zhang","sequence":"first","affiliation":[{"name":"Qinghai Provincial Key Laboratory of Pathogen Diagnosis for Animal Diseases and Green 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Biodiversity Conservation Research Center, Gonghe 813099, China"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"resources","vocabulary":"credit"}]},{"given":"Mingxue","family":"Wang","sequence":"additional","affiliation":[{"name":"Qinghai Lake Biodiversity Conservation Research Center, Gonghe 813099, China"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"resources","vocabulary":"credit"}]},{"given":"Lili","family":"Huo","sequence":"additional","affiliation":[{"name":"Qinghai Lake Biodiversity Conservation Research Center, Gonghe 813099, China"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"resources","vocabulary":"credit"}]},{"given":"Yingna","family":"Jian","sequence":"additional","affiliation":[{"name":"Qinghai Provincial Key Laboratory of Pathogen Diagnosis for Animal Diseases and Green Technical Research for Prevention and Control, Academy of Animal Sciences and Veterinary, Qinghai University, Xining 810016, 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