{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T14:25:11Z","timestamp":1788531911295,"version":"build-2803163510"},"reference-count":32,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T00:00:00Z","timestamp":1788480000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animals"],"abstract":"<jats:p>Fecal microbiota transplantation (FMT) is a promising adjunctive treatment for dogs with chronic enteropathy (CE), but response is usually assessed at scheduled follow-up visits, potentially overlooking day-to-day fluctuations. This prospective observational study evaluated temporal response after a single FMT administered by retention enema using daily owner-completed Canine Inflammatory Bowel Disease Activity Index (CIBDAI) monitoring. Fourteen dogs with CE refractory or incompletely responsive to dietary management were enrolled. CIBDAI scores were assigned by a veterinarian at baseline and on days 7 and 30, while owners completed a daily clinical diary for 30 days. Changes over time were assessed using the Friedman test, longitudinal trends using a generalized additive mixed model, and agreement between owner and veterinarian-assigned scores using quadratic-weighted Cohen\u2019s kappa and Bland\u2013Altman analysis. Clinician-assigned CIBDAI scores showed a significant overall effect of time (p &lt; 0.01), but no pairwise comparison remained significant after correction. Daily monitoring showed a significant nonlinear pattern in the primary diary-only model, although no interval of significant change was identified. In the secondary baseline-inclusive model, the derivative was significantly negative between Days 2 and 5. In within-dog descriptive comparisons, dogs experienced a median of 3.5 days (range: 0\u201314) with daily CIBDAI scores at or above their individual T0 value. Weighted kappa was 0.680 (95% CI: 0.266\u20131.000) at T7 and 0.821 (95% CI: 0.690\u20130.952) at T30. Bland\u2013Altman analysis identified no proportional bias at T7, whereas significant proportional bias was observed at T30, indicating greater divergence between owner and veterinarian-assigned scores at higher CIBDAI values. Daily owner-reported monitoring captured day-to-day fluctuations that would likely have been missed by conventional outpatient assessments performed only at predefined follow-up time points and may therefore support more individualized post-FMT follow-up in dogs with CE.<\/jats:p>","DOI":"10.3390\/ani16172786","type":"journal-article","created":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T13:50:44Z","timestamp":1788529844000},"page":"2786","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Temporal Dynamics of Clinical Response Following Fecal Microbiota Transplantation in Dogs with Chronic Enteropathy"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1902-2325","authenticated-orcid":false,"given":"Maria Chiara","family":"Sabetti","sequence":"first","affiliation":[{"name":"Department of Veterinary Science, University of Parma, Strada del Taglio, 10, 43126 Parma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7758-2609","authenticated-orcid":false,"given":"Rachel","family":"Pilla","sequence":"additional","affiliation":[{"name":"Department of Veterinary Pathology, Hygiene and Public Health, University of Milan, Via dell\u2019Universit\u00e0, 6, 26900 Lodi, Italy"},{"name":"Gastrointestinal Laboratory, Texas A&M University, College Station, TX 778432, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3444-2910","authenticated-orcid":false,"given":"Francesca","family":"Fidanzio","sequence":"additional","affiliation":[{"name":"Department of Veterinary Science, University of Parma, Strada del Taglio, 10, 43126 Parma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4962-5277","authenticated-orcid":false,"given":"Carla Giuditta","family":"Vecchiato","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medical Sciences, Alma Mater Studiorum-University of Bologna, Via Tolara di Sopra 50, Ozzano dell\u2019Emilia, 40127 Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8132-1310","authenticated-orcid":false,"given":"Giorgia","family":"Galiazzo","sequence":"additional","affiliation":[{"name":"Veterinary Clinical Practice, 45100 Rovigo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-7610-8796","authenticated-orcid":false,"given":"Alessandro","family":"Tirolo","sequence":"additional","affiliation":[{"name":"Department of Veterinary Science, University of Parma, Strada del Taglio, 10, 43126 Parma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3700-1042","authenticated-orcid":false,"given":"Michela","family":"Ablondi","sequence":"additional","affiliation":[{"name":"Department of Veterinary Science, University of Parma, Strada del Taglio, 10, 43126 Parma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Scorza","sequence":"additional","affiliation":[{"name":"Department of Veterinary Science, University of Parma, Strada del Taglio, 10, 43126 Parma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariangela","family":"Colosini","sequence":"additional","affiliation":[{"name":"Department of Veterinary Science, University of Parma, Strada del Taglio, 10, 43126 Parma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan S.","family":"Suchodolski","sequence":"additional","affiliation":[{"name":"Gastrointestinal Laboratory, Texas A&M University, College Station, TX 778432, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1673-8715","authenticated-orcid":false,"given":"Andrea","family":"Corsini","sequence":"additional","affiliation":[{"name":"Department of Veterinary Science, University of Parma, Strada del Taglio, 10, 43126 Parma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,9,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1111\/jsap.12588","article-title":"Inflammatory Bowel Disease versus Chronic Enteropathy in Dogs: Are They One and the Same?","volume":"57","author":"Dandrieux","year":"2016","journal-title":"J. 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