{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T05:06:47Z","timestamp":1788930407811,"version":"build-2803163510"},"reference-count":51,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T00:00:00Z","timestamp":1788652800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"the Project of Young Top-Notch Talent Program of the &quot;Yingcai Xingmeng&quot; Project of Inner Mongolia Autonomous Region; National Natural Science Foundation of China","award":["32160802"],"award-info":[{"award-number":["32160802"]}]},{"award":["32160802"],"award-info":[{"award-number":["32160802"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"publisher"}]},{"name":"Inner Mongolia Autonomous Region Science and Technology Plan Project","award":["2025KYPT0080"],"award-info":[{"award-number":["2025KYPT0080"]}]},{"name":"Team Project of the &quot;Yingcai Xingmeng&quot; Project of Inner Mongolia Autonomous Region","award":["2025TEL18"],"award-info":[{"award-number":["2025TEL18"]}]},{"name":"Special Fund for the National industrial technology system of Cashmere and wool (CARS-39-11).","award":["CARS-39-11"],"award-info":[{"award-number":["CARS-39-11"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animals"],"abstract":"<jats:p>This study investigated the effects of graded dietary barley replacement for corn on growth performance, rumen fermentation, carcass traits, meat quality, fatty acid profiles, and the rumen microbiome in Arbas White Cashmere goats, and further applied untargeted muscle metabolomics to elucidate the metabolic mechanisms underlying meat quality alterations. Growth performance was monitored for all goats (n = 10 per group); rumen fermentation, carcass traits, serum biochemistry and meat quality were determined in six randomly selected goats per group (n = 6); and rumen microbiota profiling and muscle metabolomics were performed on three selected goats per group (n = 3). Partial barley substitution (33% and 67% of starch from barley) significantly improved final body weight and average daily gain (p &lt; 0.05), whereas total replacement (100% barley starch) did not confer additional growth advantages. Moderate barley inclusion increased ruminal propionate concentration (p = 0.001) and enriched the fiber-degrading bacterium Prevotella, while total barley replacement markedly reduced rumen microbial diversity (Sobs, Chao1, ACE, and Shannon indices; p &lt; 0.01) and depleted multiple fibrolytic and hydrogenotrophic genera, including Christensenellaceae_R-7_group, NK4A214_group, and Methanobrevibacter. The 33% barley group exhibited elevated serum total bile acids, FGF-19, and CYP27A1 levels (p &lt; 0.05), suggestive of modulated bile acid metabolism, along with decreased glucose-6-phosphatase (p &lt; 0.05), pointing to suppressed hepatic gluconeogenesis. Muscle metabolomics revealed that moderate barley substitution predominantly affected glycerophospholipid metabolism, with upregulation of PE(P-18:1\/20:4) and PC(16:0\/16:0), whereas total replacement induced extensive metabolic reprogramming characterized by downregulation of glycine and glutathione-related metabolites, indicative of compromised antioxidant defense. The 33% barley group also exhibited the highest muscular C18:3n-3 content (p &lt; 0.01), while the 67% and total replacement groups showed increased C22:6n-3 deposition (p &lt; 0.05). Correlation analysis confirmed that PE(P-18:1\/20:4) and PC(16:0\/16:0) were significantly positively correlated with ruminal propionate and ADG (r = 0.841\u20130.986; p &lt; 0.05), and Prevotella abundance showed a strong negative trend with G-6-Pase (r = \u22120.771). Collectively, these findings demonstrate that replacing one-third of dietary corn starch with barley starch optimally balances productivity, rumen health, and meat quality through enrichment of Prevotella, enhanced propionate production, and modulation of bile acid metabolism, while excessive barley inclusion destabilizes the rumen ecosystem and triggers muscle oxidative stress, providing a theoretical basis for precision grain formulation in intensive cashmere goat production.<\/jats:p>","DOI":"10.3390\/ani16172800","type":"journal-article","created":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T09:23:37Z","timestamp":1788773017000},"page":"2800","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Determining the Optimal Dietary Barley-to-Corn Ratio for Arbas White Cashmere Goats: Insights from Rumen Fermentation, Meat Metabolomics, and Gastrointestinal Microbiota"],"prefix":"10.3390","volume":"16","author":[{"given":"Lu","family":"Jin","sequence":"first","affiliation":[{"name":"Inner Mongolia Academy of Agricultural and Animal Husbandry Sciences, Inner Mongolia Key Laboratory of Herbivores Nutrition, Key Laboratory of Grass-Feeding Livestock Healthy Breeding and Livestock Product Quality Control (Co-Construction by Ministry and Province), Ministry of Agriculture and Rural Affairs, Hohhot 010031, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-1017-6872","authenticated-orcid":false,"given":"Chunhua","family":"Zhang","sequence":"additional","affiliation":[{"name":"Inner Mongolia Academy of Agricultural and Animal Husbandry Sciences, Inner Mongolia Key Laboratory of Herbivores Nutrition, Key Laboratory of Grass-Feeding Livestock Healthy Breeding and Livestock Product Quality Control (Co-Construction by Ministry and Province), Ministry of Agriculture and Rural Affairs, Hohhot 010031, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengli","family":"Li","sequence":"additional","affiliation":[{"name":"Inner Mongolia Academy of Agricultural and Animal Husbandry Sciences, Inner Mongolia Key Laboratory of Herbivores Nutrition, Key Laboratory of Grass-Feeding Livestock Healthy Breeding and Livestock Product Quality Control (Co-Construction by Ministry and Province), Ministry of Agriculture and Rural Affairs, Hohhot 010031, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chula","family":"Sa","sequence":"additional","affiliation":[{"name":"Inner Mongolia Academy of Agricultural and Animal Husbandry Sciences, Inner Mongolia Key Laboratory of Herbivores Nutrition, Key Laboratory of Grass-Feeding Livestock Healthy Breeding and Livestock Product Quality Control (Co-Construction by Ministry and Province), Ministry of Agriculture and Rural Affairs, Hohhot 010031, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Nuo","sequence":"additional","affiliation":[{"name":"Inner Mongolia Academy of Agricultural and Animal Husbandry Sciences, Inner Mongolia Key Laboratory of Herbivores Nutrition, Key Laboratory of Grass-Feeding Livestock Healthy Breeding and Livestock Product Quality Control (Co-Construction by Ministry and Province), Ministry of Agriculture and Rural Affairs, Hohhot 010031, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ding","family":"Yang","sequence":"additional","affiliation":[{"name":"Inner Mongolia Academy of Agricultural and Animal Husbandry Sciences, Inner Mongolia Key Laboratory of Herbivores Nutrition, Key Laboratory of Grass-Feeding Livestock Healthy Breeding and Livestock Product Quality Control (Co-Construction by Ministry and Province), Ministry of Agriculture and Rural Affairs, Hohhot 010031, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenting","family":"Li","sequence":"additional","affiliation":[{"name":"Inner Mongolia Academy of Agricultural and Animal Husbandry Sciences, Inner Mongolia Key Laboratory of Herbivores Nutrition, Key Laboratory of Grass-Feeding Livestock Healthy Breeding and Livestock Product Quality Control (Co-Construction by Ministry and Province), Ministry of Agriculture and Rural Affairs, Hohhot 010031, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Le","family":"Fu","sequence":"additional","affiliation":[{"name":"Inner Mongolia Academy of Agricultural and Animal Husbandry Sciences, Inner Mongolia Key Laboratory of Herbivores Nutrition, Key Laboratory of Grass-Feeding Livestock Healthy Breeding and Livestock Product Quality Control (Co-Construction by Ministry and Province), Ministry of Agriculture and Rural Affairs, Hohhot 010031, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4350-7541","authenticated-orcid":false,"given":"Panliang","family":"Chen","sequence":"additional","affiliation":[{"name":"Inner Mongolia Academy of Agricultural and Animal Husbandry Sciences, Inner Mongolia Key Laboratory of Herbivores Nutrition, Key Laboratory of Grass-Feeding Livestock Healthy Breeding and Livestock Product Quality Control (Co-Construction by Ministry and Province), Ministry of Agriculture and Rural Affairs, Hohhot 010031, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaxing","family":"Zhao","sequence":"additional","affiliation":[{"name":"Inner Mongolia Academy of Agricultural and Animal Husbandry Sciences, Inner Mongolia Key Laboratory of Herbivores Nutrition, Key Laboratory of Grass-Feeding Livestock Healthy Breeding and Livestock Product Quality Control (Co-Construction by Ministry and Province), Ministry of Agriculture and Rural Affairs, Hohhot 010031, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Wang","sequence":"additional","affiliation":[{"name":"Inner Mongolia Academy of Agricultural and Animal Husbandry Sciences, Inner Mongolia Key Laboratory of Herbivores Nutrition, Key Laboratory of Grass-Feeding Livestock Healthy Breeding and Livestock Product Quality Control (Co-Construction by Ministry and Province), Ministry of Agriculture and Rural Affairs, Hohhot 010031, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3429-7642","authenticated-orcid":false,"given":"Haizhou","family":"Sun","sequence":"additional","affiliation":[{"name":"Inner Mongolia Academy of Agricultural and Animal Husbandry Sciences, Inner Mongolia Key Laboratory of Herbivores Nutrition, Key Laboratory of Grass-Feeding Livestock Healthy Breeding and Livestock Product Quality Control (Co-Construction by Ministry and Province), Ministry of Agriculture and Rural 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Feed Sci. Technol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/2049-1891-3-22","article-title":"Barley grain for ruminants: A global treasure or tragedy","volume":"3","author":"Nikkhah","year":"2012","journal-title":"J. Anim. Sci. Biotechnol."},{"key":"ref_4","first-page":"46","article-title":"16S rRNA sequencing reveals the antimicrobial effects of dietary zinc oxide on the intestinal microbiome of pigs","volume":"11","author":"McGover","year":"2020","journal-title":"J. Anim. Sci. Biotechnol."},{"key":"ref_5","first-page":"85","article-title":"Carbohydrate quantitative digestion and absorption in ruminants: From feed with pancreatic and biliary involvement to peripheral tissue utilization","volume":"8","author":"Loncke","year":"2014","journal-title":"Animal"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"3174","DOI":"10.2527\/jas.2011-4441","article-title":"Effects of corn processing method and dietary inclusion of wet distillers grains with solubles on energy metabolism, carbon-nitrogen balance, and methane emissions of cattle","volume":"90","author":"Hales","year":"2012","journal-title":"J. Anim. Sci."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"7445","DOI":"10.3168\/jds.2022-21960","article-title":"Invited review: Effect of subacute ruminal acidosis on gut health of dairy cows","volume":"105","author":"Plaizier","year":"2022","journal-title":"J. Dairy Sci."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1016\/j.rvsc.2012.02.004","article-title":"Interplay between rumen digestive disorders and diet-induced inflammation in dairy cattle","volume":"93","author":"Zebeli","year":"2012","journal-title":"Res. Vet. Sci."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.smallrumres.2011.09.034","article-title":"The effect of feeding systems on the characteristics of products from small ruminants","volume":"101","author":"Zervas","year":"2011","journal-title":"Small Rumin. Res."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Yang, F., Liu, Z., Zhao, M., Mu, Q., Che, T., Xie, Y., Ma, L., Mi, L., Li, J., and Zhao, Y. (2020). Skin transcriptome analysis reveals the key pathways and genes for cashmere growth in Inner Mongolia cashmere goat. BMC Genom., 21.","DOI":"10.1186\/s12864-020-06779-5"},{"key":"ref_11","first-page":"1645","article-title":"Evaluation of diet, milk quality and methanogenesis in dairy cows fed a diet based on corn or barley silage","volume":"84","author":"Benchaar","year":"2001","journal-title":"J. Dairy Sci."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1679","DOI":"10.1053\/j.gastro.2017.01.055","article-title":"Bile acid control of metabolism and inflammation in obesity, type 2 diabetes, dyslipidemia, and nonalcoholic fatty liver disease","volume":"152","author":"Tailleux","year":"2017","journal-title":"Gastroenterology"},{"key":"ref_13","first-page":"13","article-title":"Gut microbiome and omics: A new definition to ruminant production and health","volume":"7","author":"Malmuthuge","year":"2017","journal-title":"Anim. Front."},{"key":"ref_14","first-page":"108025","article-title":"A review of metabolomics approaches and their application in identifying causal mechanisms underlying beef quality","volume":"162","author":"Muroya","year":"2020","journal-title":"Meat Sci."},{"key":"ref_15","first-page":"7","article-title":"A review of factors affecting meat quality attributes and their measurement","volume":"101","author":"Bonny","year":"2015","journal-title":"Meat Sci."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1768","DOI":"10.3168\/jds.S0022-0302(61)89956-6","article-title":"Volatile fatty acid analyses of blood and rumen fluid by gas chromatography","volume":"44","author":"Erwin","year":"1961","journal-title":"J. Dairy Sci."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.2527\/jas.2006-491","article-title":"A direct method for fatty acid methyl ester synthesis: Application to wet meat tissues, oils, and feedstuffs","volume":"85","author":"Busboom","year":"2007","journal-title":"J. Anim. Sci."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1038\/nprot.2011.335","article-title":"Procedures for large-scale metabolic profiling of serum and plasma using gas chromatography and liquid chromatography coupled to mass spectrometry","volume":"6","author":"Dunn","year":"2011","journal-title":"Nat. Protoc."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1039\/C1MB05350G","article-title":"LC-MS-based metabolomics","volume":"8","author":"Zhou","year":"2012","journal-title":"Mol. Biosyst."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"D608","DOI":"10.1093\/nar\/gkx1089","article-title":"HMDB 4.0: The human metabolome database for 2018","volume":"46","author":"Wishart","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1038\/ismej.2012.8","article-title":"Ultra-high-throughput microbial community analysis on the Illumina HiSeq and MiSeq platforms","volume":"6","author":"Caporaso","year":"2012","journal-title":"ISME J."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1038\/nmeth.3869","article-title":"DADA2: High-resolution sample inference from Illumina amplicon data","volume":"13","author":"Callahan","year":"2016","journal-title":"Nat. Methods"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"5069","DOI":"10.1128\/AEM.03006-05","article-title":"Greengenes, a chimera-checked 16S rRNA gene database and workbench compatible with ARB","volume":"72","author":"DeSantis","year":"2006","journal-title":"Appl. Environ. Microbiol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"R60","DOI":"10.1186\/gb-2011-12-6-r60","article-title":"Metagenomic biomarker discovery and explanation","volume":"12","author":"Segata","year":"2011","journal-title":"Genome Biol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"2017","DOI":"10.21105\/joss.02017","article-title":"ggalluvial: Layered grammar for alluvial plots","volume":"5","author":"Brunson","year":"2020","journal-title":"J. Open Source Softw."},{"key":"ref_26","unstructured":"Huang, H. (2026, July 02). linkET: Linkage of Ecological Data. R Package Version 0.0.3. Available online: https:\/\/github.com\/Hy4m\/linkET."},{"key":"ref_27","unstructured":"Pedersen, T.L. (2026, July 02). Tidygraph: A Tidy API for Graph Manipulation. R Package Version 1.2.2. Available online: https:\/\/CRAN.R-project.org\/package=tidygraph."},{"key":"ref_28","unstructured":"Pedersen, T.L. (2026, July 02). Ggraph: An Implementation of Grammar of Graphics for Graphs and Networks. R Package Version 2.0.5. Available online: https:\/\/CRAN.R-project.org\/package=ggraph."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"3322","DOI":"10.1021\/acs.jproteome.5b00354","article-title":"Analysis of the human adult urinary metabolome variations with age, body mass index, and gender by implementing a comprehensive workflow for univariate and OPLS-based statistical analyses","volume":"14","author":"Roux","year":"2015","journal-title":"J. Proteome Res."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1093\/nar\/28.1.27","article-title":"KEGG: Kyoto encyclopedia of genes and genomes","volume":"28","author":"Kanehisa","year":"2000","journal-title":"Nucleic Acids Res."},{"key":"ref_31","first-page":"233","article-title":"Partial replacement of barley grain for corn grain in finishing diets for Awassi lambs","volume":"85","author":"Haddad","year":"2007","journal-title":"J. Anim. Sci."},{"key":"ref_32","first-page":"115554","article-title":"Effects of feeding corn or barley grain either in the form of whole or steam-flaked grains on growth performance, rumen fermentation, and microbial protein synthesis in Holstein calves fed forage-free starter diets","volume":"296","author":"Fatahnia","year":"2023","journal-title":"Anim. Feed Sci. Technol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"852","DOI":"10.2527\/1997.753852x","article-title":"Starch utilization by ruminants: From basics to the bunk","volume":"75","author":"Huntington","year":"1997","journal-title":"J. Anim. Sci."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.tvjl.2007.12.016","article-title":"Subacute ruminal acidosis in dairy cows: The physiological causes, incidence and consequences","volume":"176","author":"Plaizier","year":"2008","journal-title":"Vet. J."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1111\/1462-2920.12724","article-title":"Microbiome-metabolome analysis reveals unhealthy alterations in the composition and metabolism of ruminal microbiota with increasing dietary grain levels in a goat model","volume":"18","author":"Mao","year":"2016","journal-title":"Environ. Microbiol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"14567","DOI":"10.1038\/srep14567","article-title":"Global Rumen Census Collaborators. Rumen microbial community composition varies with diet and host, but a core microbiome is found across a wide geographical range","volume":"5","author":"Henderson","year":"2015","journal-title":"Sci. Rep."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"2331","DOI":"10.1128\/aem.58.7.2331-2333.1992","article-title":"Vitamin B12-dependent propionate production by the ruminal bacterium Prevotella ruminicola 23","volume":"58","author":"Strobel","year":"1992","journal-title":"Appl. Environ. Microbiol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"3619","DOI":"10.1128\/AEM.02812-07","article-title":"Structure of the archaeal community of the rumen","volume":"74","author":"Janssen","year":"2008","journal-title":"Appl. Environ. Microbiol."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Weimer, P.J. (2015). Redundancy, resilience, and host specificity of the ruminal microbiota: Implications for engineering improved ruminal fermentations. Front. Microbiol., 6.","DOI":"10.3389\/fmicb.2015.00296"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"3138","DOI":"10.2527\/1993.71113138x","article-title":"Factors that alter the growth and development of ruminants","volume":"71","author":"Owens","year":"1993","journal-title":"J. Anim. Sci."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.meatsci.2007.04.024","article-title":"Mechanisms controlling pork quality development: The biochemistry controlling postmortem energy metabolism","volume":"77","author":"Scheffler","year":"2007","journal-title":"Meat Sci."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.meatsci.2005.03.003","article-title":"Current research in meat color","volume":"71","author":"Mancini","year":"2005","journal-title":"Meat Sci."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1152\/physrev.1990.70.2.567","article-title":"Energy contributions of volatile fatty acids from the gastrointestinal tract in various species","volume":"70","author":"Bergman","year":"1990","journal-title":"Physiol. Rev."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"674","DOI":"10.3181\/0711-MR-311","article-title":"The importance of the omega-6\/omega-3 fatty acid ratio in cardiovascular disease and other chronic diseases","volume":"233","author":"Simopoulos","year":"2008","journal-title":"Exp. Biol. Med."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1111\/j.1462-2920.2011.02452.x","article-title":"As yet uncultured bacteria phylogenetically classified as Prevotella, Lachnospiraceae incertae sedis and unclassified Bacteroidales, Clostridiales and Ruminococcaceae may play a predominant role in ruminal biohydrogenation","volume":"13","author":"Huws","year":"2011","journal-title":"Environ. Microbiol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"2761","DOI":"10.1096\/fasebj.5.13.1916101","article-title":"Dietary fat: Exogenous determination of membrane structure and cell function","volume":"5","author":"Clandinin","year":"1991","journal-title":"FASEB J."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/0955-2863(96)00034-4","article-title":"Comparative nutrition of pantothenic acid","volume":"7","author":"Smith","year":"1996","journal-title":"J. Nutr. Biochem."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1093\/jn\/134.3.489","article-title":"Glutathione metabolism and its implications for health","volume":"134","author":"Wu","year":"2004","journal-title":"J. Nutr."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1610S","DOI":"10.1093\/jn\/137.6.1610S","article-title":"Unique aspects of lysine nutrition and metabolism","volume":"137","author":"Benevenga","year":"2007","journal-title":"J. Nutr."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1955","DOI":"10.1194\/jlr.R900010-JLR200","article-title":"Bile acids: Regulation of synthesis","volume":"50","author":"Chiang","year":"2009","journal-title":"J. Lipid Res."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/j.cmet.2013.03.013","article-title":"Pleiotropic roles of bile acids in metabolism","volume":"17","author":"Tarling","year":"2013","journal-title":"Cell Metab."}],"container-title":["Animals"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-2615\/16\/17\/2800\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T04:17:26Z","timestamp":1788927446000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-2615\/16\/17\/2800"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,6]]},"references-count":51,"journal-issue":{"issue":"17","published-online":{"date-parts":[[2026,9]]}},"alternative-id":["ani16172800"],"URL":"https:\/\/doi.org\/10.3390\/ani16172800","relation":{},"ISSN":["2076-2615"],"issn-type":[{"value":"2076-2615","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,6]]}}}