{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:54:52Z","timestamp":1792788892275,"version":"4.5.0"},"reference-count":74,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Chiang Mai University","award":["CMUPS2565-080"],"award-info":[{"award-number":["CMUPS2565-080"]}],"id":[{"id":"https:\/\/ror.org\/05m2fqn25","id-type":"ROR","asserted-by":"crossref"}]},{"award":["CMUPS2565-080"],"award-info":[{"award-number":["CMUPS2565-080"]}],"id":[{"id":"https:\/\/ror.org\/05m2fqn25","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animals"],"abstract":"<jats:p>Hypertrophic cardiomyopathy (HCM), the most common cardiac disease in cats, is associated with genetic variants, including MYBPC3, which encodes cardiac myosin-binding protein C (cMyBP-C), a key sarcomeric protein involved in myocardial contractility. Although circulating cMyBP-C has emerged as a biomarker of myocardial injury in humans, its clinical relevance in feline HCM remains unclear. This study characterized plasma cMyBP-C and N-terminal pro-B-type natriuretic peptide (NT-proBNP) concentrations across different stages of feline HCM, evaluated their diagnostic performance, and assessed their associations with echocardiographic parameters. A cross-sectional study included 65 cats: 25 healthy cats, 25 with subclinical HCM, and 15 with clinical HCM (chronic and treated). Plasma NT-proBNP was significantly higher in clinical HCM than in healthy cats (p = 0.0117), whereas plasma cMyBP-C was lower in clinical HCM than in subclinical HCM (p = 0.0462) and healthy cats (p = 0.001). At a cut-off of &lt;1.270 ng\/mL, plasma cMyBP-C showed 76.19% sensitivity and 65.38% specificity for distinguishing HCM. NT-proBNP alone showed higher overall diagnostic accuracy (76.67%) than the combined use of cMyBP-C and NT-proBNP. Neither plasma NT-proBNP nor cMyBP-C correlated significantly with echocardiographic parameters. Reduced circulating cMyBP-C concentrations in cats with chronic, treated HCM suggest a biomarker pattern distinct from that reported in acute myocardial injury and warrant further investigation.<\/jats:p>","DOI":"10.3390\/ani16193084","type":"journal-article","created":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T13:01:19Z","timestamp":1790773279000},"page":"3084","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Reduced Plasma Cardiac Myosin-Binding Protein-C Concentrations in Cats with Hypertrophic Cardiomyopathy: Evidence from Chronic, Treated Disease"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-5805-6085","authenticated-orcid":false,"given":"Nutcha","family":"Tanakwang","sequence":"first","affiliation":[{"name":"Faculty of Veterinary Medicine, Chiang Mai University, Chiang Mai 50100, Thailand"},{"name":"Cardiopulmonary Clinic, Northern Regional Veterinary Healthcare and Learning Center, Faculty of Veterinary Medicine, Chiang Mai University, Chiang Mai 50100, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"writing-original-draft","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"},{"role":"methodology","vocabulary":"credit"},{"role":"data-curation","vocabulary":"credit"},{"role":"funding-acquisition","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"},{"role":"visualization","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-2750-2766","authenticated-orcid":false,"given":"Natcha","family":"Sakunasing","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine, Chiang Mai University, Chiang Mai 50100, Thailand"},{"name":"Cardiopulmonary Clinic, Northern Regional Veterinary Healthcare and Learning Center, Faculty of Veterinary Medicine, Chiang Mai University, Chiang Mai 50100, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"methodology","vocabulary":"credit"},{"role":"data-curation","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4940-7103","authenticated-orcid":false,"given":"Sarawut","family":"Kumphune","sequence":"additional","affiliation":[{"name":"Biomedical Engineering Institute (BMEI), Chiang Mai University, Chiang Mai 50100, Thailand"},{"name":"Biomedical Engineering and Innovation Research Center, Chiang Mai University, Chiang Mai 50100, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"methodology","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7429-0993","authenticated-orcid":false,"given":"Raktham","family":"Mektrirat","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine, Chiang Mai University, Chiang Mai 50100, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"methodology","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4621-9764","authenticated-orcid":false,"given":"Kannika","family":"Na Lampang","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine, Chiang Mai University, Chiang Mai 50100, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"methodology","vocabulary":"credit"},{"role":"formal-analysis","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6888-4469","authenticated-orcid":false,"given":"Chavalit","family":"Boonyapakorn","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine, Chiang Mai University, Chiang Mai 50100, Thailand"},{"name":"Cardiopulmonary Clinic, Northern Regional Veterinary Healthcare and Learning Center, Faculty of Veterinary Medicine, Chiang Mai University, Chiang Mai 50100, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"methodology","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6788-7740","authenticated-orcid":false,"given":"Wanpitak","family":"Pongkan","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine, Chiang Mai University, Chiang Mai 50100, Thailand"},{"name":"Cardiopulmonary Clinic, Northern Regional Veterinary Healthcare and Learning Center, Faculty of Veterinary Medicine, Chiang Mai University, Chiang Mai 50100, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"conceptualization","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"},{"role":"funding-acquisition","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"},{"role":"supervision","vocabulary":"credit"},{"role":"methodology","vocabulary":"credit"},{"role":"writing-original-draft","vocabulary":"credit"}]}],"member":"1968","published-online":{"date-parts":[[2026,9,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1177\/1098612X211021819","article-title":"The Feline Cardiomyopathies: 1. 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