{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T09:53:32Z","timestamp":1791194012272,"version":"4.1.0"},"reference-count":32,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T00:00:00Z","timestamp":1791072000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32560791"],"award-info":[{"award-number":["32560791"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"award":["32560791"],"award-info":[{"award-number":["32560791"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Hunan Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["2026JJ80664"],"award-info":[{"award-number":["2026JJ80664"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Hunan Agriculture Research System","award":["HARS-08"],"award-info":[{"award-number":["HARS-08"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animals"],"abstract":"<jats:p>Cadmium (Cd) present in soil can accumulate in plants and subsequently affect the safety and quality of animal-derived food products. This study investigated the effects of dietary Cd exposure derived from rice straw on the growth performance, serum biochemical and immune parameters, meat quality, and tissue accumulation of black goats. A 90-day feeding trial was carried out with 42 healthy male black goats at 4 months. Prior to the feeding trial, six goats were slaughtered to establish baseline group, and the remaining 36 goats were randomly assigned to two groups fed with a diet containing Cd-contaminated rice straw (CAD, n = 18) or not (CON, n = 18). At 30, 60, and 90 d, six goats per group (n = 6) were randomly selected and slaughtered for sample collection. The results showed that dietary Cd exposure had no significant effects on growth performance and the indices of heart, liver, spleen, lung, and kidney (p &gt; 0.05). Meanwhile, it induced tissue-specific and time-dependent Cd accumulation, with lymph nodes identified as the primary Cd target tissue in goats, followed by kidney and liver (p &lt; 0.05). The CAD group exhibited higher concentrations of serum urea nitrogen and interleukin-10, and lower concentrations of serum glucose and creatinine. Fecal cadmium deposition efficiency (CdE) ranged from 95.68% to 97.01% in the CON group and from 68.48% to 88.74% in the CAD group, whereas the CdE in muscle and internal organs remained below 2% in both groups. These findings indicate that fecal excretion constitutes the predominant elimination pathway for ingested Cd, with only a negligible proportion retained in edible tissues and internal organs. However, based on the present findings, we cannot recommend the use of Cd-contaminated rice straw as a feed source for goats, nor can we confirm the safety of meat from exposed animals for human consumption. Further long-term studies, including human health risk assessments, are needed before any recommendations can be made.<\/jats:p>","DOI":"10.3390\/ani16193115","type":"journal-article","created":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T08:57:18Z","timestamp":1791190638000},"page":"3115","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Dietary Cadmium Exposure in Black Goats: Impacts on Growth Performance, Serum Biochemical and Immune Parameters, Meat Quality, and Tissue Accumulation"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7659-6777","authenticated-orcid":false,"given":"Yang","family":"Luo","sequence":"first","affiliation":[{"name":"College of Animal Science and Technology, Guangxi University, Nanning 530004, China"},{"name":"Hunan Institute of Animal and Veterinary Science, Changsha 410131, China"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"writing-original-draft","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"},{"role":"data-curation","vocabulary":"credit"},{"role":"project-administration","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4105-9263","authenticated-orcid":false,"given":"Bin","family":"Yang","sequence":"additional","affiliation":[{"name":"School of Biological and Chemical Engineering, Zhejiang University of Science and Technology, Hangzhou 310023, China"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"writing-review-editing","vocabulary":"credit"},{"role":"writing-original-draft","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0835-9347","authenticated-orcid":false,"given":"Qinyang","family":"Jiang","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Guangxi University, Nanning 530004, China"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"conceptualization","vocabulary":"credit"},{"role":"supervision","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]}],"member":"1968","published-online":{"date-parts":[[2026,10,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"5384","DOI":"10.1007\/s11356-023-31457-w","article-title":"Evaluation of metal pollution characteristics using water and moss in the Luanchuan molybdenum mining area, China","volume":"31","author":"Song","year":"2024","journal-title":"Environ. Sci. Pollut. Res."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.envres.2017.03.014","article-title":"Cadmium, lead, and arsenic contamination in paddy soils of a mining area and their exposure effects on human HEPG2 and keratinocyte cell-lines","volume":"156","author":"Xue","year":"2017","journal-title":"Environ. Res."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"181162","DOI":"10.1016\/j.scitotenv.2025.181162","article-title":"Heat shock protein and Cathepsin B genes play important roles in cadmium stress response in whitefly Bemisia tabaci","volume":"1010","author":"Guo","year":"2026","journal-title":"Sci. Total Environ."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"150322","DOI":"10.1016\/j.scitotenv.2021.150322","article-title":"The spatiotemporal variation in heavy metals in China\u2019s farmland soil over the past 20 years: A meta-analysis","volume":"806","author":"Ren","year":"2022","journal-title":"Sci. Total Environ."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1016\/j.ecoenv.2022.113530","article-title":"Root microbiome changes associated with cadmium exposure and\/or overexpression of a transgene that reduces Cd content in rice","volume":"237","author":"Li","year":"2022","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Chen, J., Zou, W., Meng, L., Fan, X., Xu, G., and Ye, G. (2019). Advances in the uptake and transport mechanisms and QTLs mapping of cadmium in rice. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20143417"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.fcr.2015.08.004","article-title":"The dynamic simulation of rice growth parameters under cadmium stress with the assimilation of multi-period spectral indices and crop model","volume":"183","author":"Liu","year":"2015","journal-title":"Field Crops Res."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1111\/joim.13350","article-title":"Review of cadmium exposure and smoking-independent effects on atherosclerotic cardiovascular disease in the general population","volume":"22","author":"Fagerberg","year":"2021","journal-title":"J. Intern. Med."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/j.immuni.2018.10.005","article-title":"Developmental and functional heterogeneity of monocytes","volume":"49","author":"Guilliams","year":"2018","journal-title":"Immunity"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"111881","DOI":"10.1016\/j.ecoenv.2020.111881","article-title":"Single-cell transcriptomics uncovers phenotypic alterations in the monocytes in a Chinese population with chronic cadmium exposure","volume":"211","author":"Lu","year":"2021","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"153997","DOI":"10.1016\/j.scitotenv.2022.153997","article-title":"The burden of coronary heart disease and stroke attributable to dietary cadmium exposure in Chinese adults, 2017","volume":"825","author":"Liu","year":"2022","journal-title":"Sci. Total Environ."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.aninu.2023.06.012","article-title":"Feasibility of feeding cadmium accumulator maize (Zea mays L.) to beef cattle: Discovering a strategy for eliminating phytoremediation residues","volume":"15","author":"Xu","year":"2023","journal-title":"Anim. Nutr."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Xu, X., Xu, Z., Yang, B., Yi, K., He, F., Sun, A., Li, J., Luo, Y., and Wang, J. (2023). Assessing the effects of dietary cadmium exposure on the gastrointestinal tract of beef cattle via microbiota and transcriptome profile. Animals, 13.","DOI":"10.3390\/ani13193104"},{"key":"ref_14","unstructured":"Assiciation of Official Analytical Chemists (AOAC) (1990). Official Methods of Anaysis, AOAC. [15th ed.]. Available online: http:\/\/www.eoma.aoac.org\/."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"3583","DOI":"10.3168\/jds.S0022-0302(91)78551-2","article-title":"Methods for dietary fiber, neutral detergent fiber, and nonstarch polysaccharides in relation to animal nutrition","volume":"74","author":"Robertson","year":"1991","journal-title":"J. Dairy Sci."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Qin, X., Liu, W., Xin, J., Zhang, Y., Zhang, M., Liang, W., Li, J., and Hu, J. (2025). Effect of L-carnitine on muscle quality and antioxidant capacity of hybrid sheep at an early stage. Animals, 15.","DOI":"10.3390\/ani15172564"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"109889","DOI":"10.1016\/j.meatsci.2025.109889","article-title":"Effect of rumen-protected guanidinoacetic acid provision as a dietary supplement on the growth, slaughter performance, and meat quality in simmental bulls","volume":"228","author":"Zhang","year":"2025","journal-title":"Meat Sci."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"2028","DOI":"10.1038\/s41598-025-86312-4","article-title":"Astragaloside IV attenuates cadmium induced nephrotoxicity in rats by activating Nrf2","volume":"15","author":"Li","year":"2025","journal-title":"Sci. Rep."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"skaf033","DOI":"10.1093\/jas\/skaf033","article-title":"Effect of Luteolin on cadmium-inhibited bone growth via suppressing osteoclastogenesis in laying chickens","volume":"103","author":"Tong","year":"2025","journal-title":"J. Anim. Sci."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"e7","DOI":"10.1002\/imt2.7","article-title":"Dietary licorice enhances in vivo cadmium detoxification and modulates gut microbial metabolism in mice","volume":"1","author":"Zheng","year":"2022","journal-title":"iMeta"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1016\/j.envpol.2017.01.087","article-title":"Cadmium in rice: Transport mechanisms, influencing factors, and minimizing measures","volume":"224","author":"Li","year":"2017","journal-title":"Environ. Pollut."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1021\/acs.jafc.2c06562","article-title":"Nano-selenium antagonized cadmium-induced liver fibrosis in chicken","volume":"71","author":"Sun","year":"2022","journal-title":"J. Agric. Food Chem."},{"key":"ref_23","first-page":"1741","article-title":"Oligochaeta ramosa (Roxb.) extract regulates lipid metabolism and exerts hepatoprotective effects in cadmium-induced hepatic injury in rats","volume":"36","author":"Aslam","year":"2022","journal-title":"Evid.-Based Complement. Altern. Med."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Zhang, H., Shi, H., Zhou, S., Wei, G., Xie, W., Meng, M., Chang, G., and Shen, X. (2023). Dietary disodium fumarate supplementation alleviates subacute ruminal acidosis (SARA)-induced liver damage by inhibiting pyroptosis via mitophagy-NLRP3 inflammasome pathway in lactating Hu sheep. Front. Immunol., 14.","DOI":"10.3389\/fimmu.2023.1197133"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"123840","DOI":"10.1016\/j.lfs.2025.123840","article-title":"Microcystin-LR exacerbates chronic kidney disease in rats: Insights into gut microbiome and host proteome dysregulation","volume":"378","author":"Kongsintaweesuk","year":"2025","journal-title":"Life Sci."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1007\/s11307-013-0648-5","article-title":"Pharmacokinetic issues of imaging with nanoparticles: Focusing on carbon nanotubes and quantum dots","volume":"15","author":"Hong","year":"2013","journal-title":"Mol. Imaging Biol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.toxlet.2010.04.029","article-title":"Burden of cadmium in early childhood: Longitudinal assessment of urinary cadmium in rural Bangladesh","volume":"198","author":"Kippler","year":"2010","journal-title":"Toxicol. Lett."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/j.jhazmat.2018.12.014","article-title":"Immunosuppression, oxidative stress, and glycometabolism disorder caused by cadmium in common carp (Cyprinus carpio L.): Application of transcriptome analysis in risk assessment of environmental contaminant cadmium","volume":"366","author":"Chen","year":"2018","journal-title":"J. Hazard. Mater."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.fsi.2018.08.060","article-title":"Impaired immune function and structural integrity in the gills of common carp (Cyprinus carpio L.) caused by chlorpyrifos exposure: Through oxidative stress and apoptosis","volume":"86","author":"Jiao","year":"2019","journal-title":"Fish Shellfish Immunol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"23453","DOI":"10.1007\/s11356-019-05675-0","article-title":"Selenium alleviates cadmium-induced inflammation and meat quality degradation via antioxidant and anti-inflammation in chicken breast muscles","volume":"26","author":"Tang","year":"2019","journal-title":"Environ. Sci. Pollut. Res."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1007\/s11010-021-04298-9","article-title":"Activation of multiple proteolysis systems contributes to acute cadmium cytotoxicity","volume":"477","author":"Yeh","year":"2022","journal-title":"Mol. Cell. Biochem."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.cbi.2014.01.007","article-title":"Interplay of calcium and cadmium in mediating cadmium toxicity","volume":"211","author":"Choong","year":"2014","journal-title":"Chem. Biol. Interact."}],"container-title":["Animals"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-2615\/16\/19\/3115\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T09:15:08Z","timestamp":1791191708000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-2615\/16\/19\/3115"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,4]]},"references-count":32,"journal-issue":{"issue":"19","published-online":{"date-parts":[[2026,10]]}},"alternative-id":["ani16193115"],"URL":"https:\/\/doi.org\/10.3390\/ani16193115","relation":{},"ISSN":["2076-2615"],"issn-type":[{"value":"2076-2615","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,4]]}}}