{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T01:35:09Z","timestamp":1780364109246,"version":"3.54.1"},"reference-count":36,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2017,9,5]],"date-time":"2017-09-05T00:00:00Z","timestamp":1504569600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Gift from anonymous donors towards the Equine and Comparative Neurology Research Group"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animals"],"abstract":"<jats:p>Horses are a precocious species that must accomplish several milestones that are critical to survival in the immediate post-birth period for their survival. One essential milestone is the successful transition from the intrauterine unconsciousness to an extrauterine state of consciousness or awareness. This transition involves a complex withdrawal of consciousness inhibitors and an increase in neuroactivating factors that support awareness. This process involves neuroactive hormones as well as inputs related to factors such as cold, visual, olfactory, and auditory stimuli. One factor not previously considered in this birth transition is a yet unreported direct neural reflex response to labor-induced physical compression of the fetus in the birth canal (squeezing). Neonatal maladjustment syndrome (NMS) is a disorder of the newborn foal characterized by altered behavior, low affinity for the mare, poor awareness of the environment, failure to bond to the mother, abnormal sucking, and other neurologically-based abnormalities. This syndrome has been associated with altered events during birth, and was believed to be caused exclusively by hypoxia and ischemia. However, recent findings revealed an association of the NMS syndrome with the persistence of high concentrations of in utero neuromodulating hormones (neurosteroids) in the postnatal period. Anecdotal evidence demonstrated that a novel physical compression (squeeze) method that applies 20 min of sustained pressure to the thorax of some neonatal foals with this syndrome might rapidly hasten recovery. This survey provides information about outcomes and time frames to recovery comparing neonatal foals that were given this squeeze treatment to foals treated with routine medical therapy alone. Results revealed that the squeeze procedure, when applied for 20 min, resulted in a faster full recovery of some foals diagnosed with NMS. The adjunctive use of a non-invasive squeeze method may improve animal welfare by hastening recovery and foal\u2013mare interactions that minimize health problems. This would also avoid or reduce costs arising from hospitalization associated with veterinary and nursing care that sometimes leads owners to elect for euthanasia.<\/jats:p>","DOI":"10.3390\/ani7090069","type":"journal-article","created":{"date-parts":[[2017,9,5]],"date-time":"2017-09-05T11:26:19Z","timestamp":1504610779000},"page":"69","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Survey of Veterinarians Using a Novel Physical Compression Squeeze Procedure in the Management of Neonatal Maladjustment Syndrome in Foals"],"prefix":"10.3390","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5811-9520","authenticated-orcid":false,"given":"Monica","family":"Aleman","sequence":"first","affiliation":[{"name":"Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis, CA 95616, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kalie","family":"Weich","sequence":"additional","affiliation":[{"name":"Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis, CA 95616, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Madigan","sequence":"additional","affiliation":[{"name":"Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis, CA 95616, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2017,9,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1080\/00480169.2014.969349","article-title":"Survival implications of the development of behavioural responsiveness and awareness in different groups of mammalian young","volume":"63","author":"Mellor","year":"2015","journal-title":"N. Z. Vet. J."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1111\/evj.12120","article-title":"Birth transitions: Pathophysiology, the onset of consciousness and possible implications for neonatal maladjustment syndrome in the foal","volume":"45","author":"Diesch","year":"2013","journal-title":"Equine Vet. J."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1080\/00480169.2007.36742","article-title":"Birth and hatching: Key events in the onset of awareness in the lamb and chick","volume":"55","author":"Mellor","year":"2007","journal-title":"N. Z. Vet. J."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1016\/0007-1935(88)90025-5","article-title":"Integration of perinatal events, pathophysiological changes and consequences for the newborn lamb","volume":"144","author":"Mellor","year":"1988","journal-title":"Br. Vet. J."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.applanim.2006.04.012","article-title":"Onset of sentience: The potential for suffering in fetal and newborn farm animals","volume":"100","author":"Mellor","year":"2006","journal-title":"Appl. Anim. Behav. Sci."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"94","DOI":"10.3138\/jvme.37.1.94","article-title":"Galloping colts, fetal feelings, and reassuring regulations: Putting animal-welfare science into practice","volume":"37","author":"Mellor","year":"2010","journal-title":"J. Vet. Med. Educ."},{"key":"ref_7","unstructured":"UC Davis International Animal Welfare Training Institute (IAWATI) (2016, November 04). Normal Foal vs. Maladjusted Foal. Available online: https:\/\/vimeo.com\/190318093\/06efdc9bfe."},{"key":"ref_8","first-page":"658","article-title":"Equine neonatal disease: A review","volume":"23","author":"Rossdale","year":"1975","journal-title":"J. Reprod. Fertil."},{"key":"ref_9","first-page":"222","article-title":"Historical factors, clinicopathologic findings, clinical features, and outcome of equine neonates presenting with or developing signs of central nervous system disease","volume":"41","author":"Bernard","year":"1995","journal-title":"Proc. Am. Assoc. Equine Pract."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1111\/j.1939-1676.2010.0645.x","article-title":"Biomarkers of brain injury in foals with hypoxic-ischemic encephalopathy","volume":"25","author":"Ringger","year":"2011","journal-title":"J. Vet. Intern. Med."},{"key":"ref_11","first-page":"207","article-title":"Factors associated with outcome in 94 hospitalised foals diagnosed with neonatal encephalopathy","volume":"49","author":"Giguere","year":"2016","journal-title":"Equine Vet. J."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1111\/evj.12065","article-title":"Abnormal plasma neuroactive progestagen derivatives in ill, neonatal foals presented to the neonatal intensive care unit","volume":"45","author":"Aleman","year":"2013","journal-title":"Equine Vet. J."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"S109","DOI":"10.1111\/j.2042-3306.2011.00504.x","article-title":"Allopregnanolone infusion induced neurobehavioral alterations in a neonatal foal: Is this a clue to the pathogenesis of neonatal maladjustment syndrome?","volume":"44","author":"Madigan","year":"2012","journal-title":"Equine Vet. J."},{"key":"ref_14","unstructured":"Estell, K.E., Aleman, M., Pickles, K.J., Conley, A.J., Stanley, S., Williams, D.C., Riley, R., and Madigan, J.E. (2013, January 12\u201315). Clinical signs, neurobehavioral score, and electroencephalography recordings associated with infusion of a pregnenolone derivative to induce neonatal maladjustment syndrome. Proceedings of the Annual Forum American College of Veterinary Internal Medicine, Seattle, WA, USA."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1881","DOI":"10.2460\/ajvr.73.12.1881","article-title":"Evaluation of squeeze-induced somnolence in neonatal foals","volume":"73","author":"Toth","year":"2012","journal-title":"Am. J. Vet. Res."},{"key":"ref_16","unstructured":"UC Davis School of Veterinary Medicine (2017, April 29). Vet Med News. Available online: http:\/\/www.vetmed.ucdavis.edu\/whatsnew\/article.cfm?id=3508."},{"key":"ref_17","first-page":"75","article-title":"The maladjusted foal: Influences of intrauterine growth retardation and birth trauma","volume":"50","author":"Rossdale","year":"2004","journal-title":"Proc. Am. Assoc. Equine Pract."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1111\/j.2042-3306.2011.00476.x","article-title":"Parturition, dystocia and foal survival: A retrospective study of 1047 births","volume":"41","author":"McCue","year":"2012","journal-title":"Equine Vet. J."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1111\/j.2042-3306.1972.tb03892.x","article-title":"Modern concepts of neonatal disease in foals","volume":"4","author":"Rossdale","year":"1972","journal-title":"Equine Vet. J."},{"key":"ref_20","first-page":"S517","article-title":"Plasma progestagens in the mare, fetus and newborn foal","volume":"44","author":"Holtan","year":"1991","journal-title":"J. Reprod. Fertil."},{"key":"ref_21","first-page":"S609","article-title":"Plasma progestagen concentrations in the normal and dysmature newborn foal","volume":"44","author":"Houghton","year":"1991","journal-title":"J. Reprod. Fertil."},{"key":"ref_22","first-page":"101","article-title":"Gumshoe sleuthing in the world of infectious disease and neonatology: Discoveries that changed equine and human health","volume":"60","author":"Madigan","year":"2014","journal-title":"Proc. Am. Assoc. Equine Pract."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/j.brainresrev.2005.01.006","article-title":"The importance of \u2018awareness\u2019 for understanding fetal pain","volume":"49","author":"Mellor","year":"2005","journal-title":"Brain Res. Brain Res. Rev."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1213\/ANE.0000000000001429","article-title":"Synergistic modulation of gamma-aminobutyric acid type a receptor-mediated synaptic inhibition in cortical networks by allopregnanolone and propofol","volume":"123","author":"Drexler","year":"2016","journal-title":"Anesth. Analg."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.jsbmb.2015.03.002","article-title":"New steps forward in the neuroactive steroid field","volume":"153","author":"Giatti","year":"2015","journal-title":"J. Steroid. Biochem. Mol. Biol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1152\/ajplegacy.1927.82.2.294","article-title":"The physiological actions of cholesterol","volume":"82","author":"Cashin","year":"1972","journal-title":"Am. J. Physiol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.eplepsyres.2009.02.017","article-title":"The role of neurosteroids in the pathophysiology and treatment of catamenial epilepsy","volume":"85","author":"Reddy","year":"2009","journal-title":"Epilepsy Res."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1514","DOI":"10.1016\/S0028-3908(99)00222-1","article-title":"Characterisation of GABA(A) receptors in fetal, neonatal and adult ovine brain: Region and age related changes and the effects of allopregnanolone","volume":"39","author":"Crossley","year":"2000","journal-title":"Neuropharmacology"},{"key":"ref_29","first-page":"CS002771","article-title":"Kangaroo mother care to reduce morbidity and mortality in low birthweight infants","volume":"16","author":"Beliza","year":"2011","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1891\/1058-1243.26.3.117","article-title":"Kangaroo mother care 1: Alleviation of physiological problems in premature infants","volume":"26","author":"Bear","year":"2017","journal-title":"J. Perinat. Educ."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Bear, R.J., and Mellor, D.J. (2017). Kangaroo mother care 2: Potential beneficial impacts on brain development in premature infants. J. Perinat. Educ., 26, in press.","DOI":"10.1891\/1058-1243.26.4.177"},{"key":"ref_32","first-page":"CD003519","article-title":"Early skin-to-skin contact for mothers and their healthy newborn infants","volume":"11","author":"Moore","year":"2016","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1038\/jp.2016.268","article-title":"Skin-to-skin contact after birth and the natural course of neurosteroid levels in healthy term newborns","volume":"37","author":"McCallie","year":"2017","journal-title":"J. Perinatol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1812","DOI":"10.1016\/j.clinph.2009.08.004","article-title":"Neurophysiologic assessment of brain maturation after an 8-week trial of skin-to-skin contact on preterm infants","volume":"120","author":"Scher","year":"2009","journal-title":"Clin. Neurophysiol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0165-0173(01)00109-6","article-title":"Biosynthesis and action of neurosteroids","volume":"37","author":"Mellon","year":"2001","journal-title":"Brain Res. Brain Res. Rev."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1038\/scientificamericanmind0715-30","article-title":"The social power of touch","volume":"26","author":"Denworth","year":"2017","journal-title":"Sci. Am. 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