{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T18:19:58Z","timestamp":1779214798437,"version":"3.51.4"},"reference-count":30,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2018,5,31]],"date-time":"2018-05-31T00:00:00Z","timestamp":1527724800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003329","name":"Ministerio de Econom\u00eda y Competitividad","doi-asserted-by":"publisher","award":["AGL2014-54124R"],"award-info":[{"award-number":["AGL2014-54124R"]}],"id":[{"id":"10.13039\/501100003329","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003339","name":"Consejo Superior de Investigaciones Cient\u00edficas","doi-asserted-by":"publisher","award":["201540E084"],"award-info":[{"award-number":["201540E084"]}],"id":[{"id":"10.13039\/501100003339","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003176","name":"Ministerio de Educaci\u00f3n, Cultura y Deporte","doi-asserted-by":"publisher","award":["FPU15\/01630"],"award-info":[{"award-number":["FPU15\/01630"]}],"id":[{"id":"10.13039\/501100003176","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animals"],"abstract":"<jats:p>Early postnatal nutrition may have a significant subsequent impact on metabolic disorders during the entire lifespan of lambs. The aim of the present study was to describe the changes in biochemical, immunological, hepatic, and ruminal parameters of fattening lambs derived from early feed restriction during the suckling phase. Twenty-four merino lambs (average body weight, BW, 4.81 \u00b1 0.256 kg) were used, 12 of them were milk-fed ad libitum (ADL) remaining permanently with their dams, whereas the other 12 lambs (restricted, RES) were subjected to milk restriction. After weaning, all the lambs were fed 35 g\/kg BW per day of the same complete pelleted diet to ensure no differences between groups in dry matter intake (603 vs. 607 g\/day for ADL and RES lambs, respectively, p = 0.703), and were slaughtered at a BW of 27 kg. Biochemical profiles revealed higher concentrations of ceruloplasmin and low-density lipoproteins, whereas insulin concentration was lower in the RES lambs compared to the ADL group. Liver thiobarbituric acid reactive substances were lower in the RES lambs. No significant differences in ruminal or blood immunological parameters were found. In conclusion, early feed restriction promoted metabolic disorders not related to ruminal acidosis occurrence, which can compromise the health status during the fattening period of merino lambs.<\/jats:p>","DOI":"10.3390\/ani8060083","type":"journal-article","created":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T03:02:50Z","timestamp":1527822170000},"page":"83","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Early Feed Restriction Programs Metabolic Disorders in Fattening Merino Lambs"],"prefix":"10.3390","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2275-8926","authenticated-orcid":false,"given":"Javier","family":"Frutos","sequence":"first","affiliation":[{"name":"Instituto de Ganader\u00eda de Monta\u00f1a, CSIC-Universidad de Le\u00f3n, Finca Marzanas s\/n, 24346 Grulleros, Le\u00f3n, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonia","family":"Andr\u00e9s","sequence":"additional","affiliation":[{"name":"Instituto de Ganader\u00eda de Monta\u00f1a, CSIC-Universidad de Le\u00f3n, Finca Marzanas s\/n, 24346 Grulleros, Le\u00f3n, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1644-1911","authenticated-orcid":false,"given":"Erminio","family":"Trevisi","sequence":"additional","affiliation":[{"name":"Faculty of Agriculture, Food and Environmental Science, Institute of Zootechnics, Universit\u00e0 Cattolica del Sacro Cuore, Via Emilia Parmense 84, 29122 Piacenza, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4397-3905","authenticated-orcid":false,"given":"David","family":"Y\u00e1\u00f1ez-Ruiz","sequence":"additional","affiliation":[{"name":"Estaci\u00f3n Experimental del Zaid\u00edn, CSIC, Profesor Albareda 1, 18008 Granada, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6267-683X","authenticated-orcid":false,"given":"Secundino","family":"L\u00f3pez","sequence":"additional","affiliation":[{"name":"Instituto de Ganader\u00eda de Monta\u00f1a, CSIC-Universidad de Le\u00f3n, Finca Marzanas s\/n, 24346 Grulleros, Le\u00f3n, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alba","family":"Santos","sequence":"additional","affiliation":[{"name":"Instituto de Ganader\u00eda de Monta\u00f1a, CSIC-Universidad de Le\u00f3n, Finca Marzanas s\/n, 24346 Grulleros, Le\u00f3n, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Gir\u00e1ldez","sequence":"additional","affiliation":[{"name":"Instituto de Ganader\u00eda de Monta\u00f1a, CSIC-Universidad de Le\u00f3n, Finca Marzanas s\/n, 24346 Grulleros, Le\u00f3n, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2018,5,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1136\/bmj.307.6918.1524","article-title":"Growth in-utero and serum-cholesterol concentrations in adult life","volume":"307","author":"Barker","year":"1993","journal-title":"BMJ"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"19353","DOI":"10.1074\/jbc.M114.549204","article-title":"Early and long-term undernutrition in female rats exacerbates the metabolic risk associated with nutritional rehabilitation","volume":"290","author":"Ros","year":"2015","journal-title":"J. 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