{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T04:06:20Z","timestamp":1760241980338,"version":"build-2065373602"},"reference-count":44,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2018,11,12]],"date-time":"2018-11-12T00:00:00Z","timestamp":1541980800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["Open-Access-Publikationsfonds der DFG"],"award-info":[{"award-number":["Open-Access-Publikationsfonds der DFG"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Boehringer Ingelheim Vetmedica","award":["not available"],"award-info":[{"award-number":["not available"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animals"],"abstract":"<jats:p>Lawsonia intracellularis infections are a common reason for antibiotic treatment in pig production. Experimental studies in animals naturally infected with Lawsonia intracellularis comparing the course of an experimental Salmonella infection in piglets previously treated with tylosin or vaccinated against Lawsonia intracellularis are scarce. A total of 72 seven-week-old Salmonella-free pigs were taken from a herd with a Lawsonia intracellularis history in piglet rearing. The pigs were divided into two groups with three replicates each. Animals had either been previously treated with tylosin (10 mg\/kg body weight) for seven days (AB+VAC\u2212) or had been vaccinated as suckling pigs by drenching (Enterisol\u00aeIleitis; AB\u2212VAC+). Two animals per replicate were primarily infected with Salmonella Derby (1.04 \u00d7 108 colony-forming units per animal). The detection of Salmonella in faeces (p &lt; 0.0001, odds ratio: 3.8364) and in the ileocaecal lymph nodes (p = 0.0295, odds ratio: 3.5043) was significantly more frequent in AB+VAC\u2212 animals. Overall, the odds ratio for detecting Salmonella in any substrate or organ was significantly higher in the AB+VAC\u2212 group animals (p = 0.0004, odds ratio: 5.9091). Treatment with tylosin can significantly increase the spread of a Salmonella infection, which is not observed after early Lawsonia intracellularis vaccination.<\/jats:p>","DOI":"10.3390\/ani8110206","type":"journal-article","created":{"date-parts":[[2018,11,14]],"date-time":"2018-11-14T02:42:41Z","timestamp":1542163361000},"page":"206","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Spread of an Experimental Salmonella Derby Infection in Antibiotic-Treated or Lawsonia intracellularis Vaccinated Piglets"],"prefix":"10.3390","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1497-5709","authenticated-orcid":false,"given":"Christian","family":"Visscher","sequence":"first","affiliation":[{"name":"Institute for Animal Nutrition, University of Veterinary Medicine Hannover, Foundation, Bischofsholer Damm 15, D-30173 Hanover, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jasmin","family":"Mischok","sequence":"additional","affiliation":[{"name":"Institute for Animal Nutrition, University of Veterinary Medicine Hannover, Foundation, Bischofsholer Damm 15, D-30173 Hanover, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saara","family":"Sander","sequence":"additional","affiliation":[{"name":"Institute for Animal Nutrition, University of Veterinary Medicine Hannover, Foundation, Bischofsholer Damm 15, D-30173 Hanover, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jutta","family":"Verspohl","sequence":"additional","affiliation":[{"name":"Institute for Microbiology, University of Veterinary Medicine Hannover, Foundation, Bischofsholer Damm 15, D-30173 Hannover, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva-Ursula","family":"Peitzmeier","sequence":"additional","affiliation":[{"name":"Tierarztpraxis Dr. Peitzmeier, Meente 24, D-32479 Hille, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabel","family":"Von dem Busche","sequence":"additional","affiliation":[{"name":"Tierarztpraxis Dr. Peitzmeier, Meente 24, D-32479 Hille, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josef","family":"Kamphues","sequence":"additional","affiliation":[{"name":"Institute for Animal Nutrition, University of Veterinary Medicine Hannover, Foundation, Bischofsholer Damm 15, D-30173 Hanover, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2018,11,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1136\/vr.140.22.579","article-title":"Estimate of direct financial losses due to porcine proliferative enteropathy","volume":"140","author":"McOrist","year":"1997","journal-title":"Vet. 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