{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T09:33:43Z","timestamp":1771234423849,"version":"3.50.1"},"reference-count":41,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2019,5,6]],"date-time":"2019-05-06T00:00:00Z","timestamp":1557100800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Key Projects of China Agriculture Research System","award":["CARS-35"],"award-info":[{"award-number":["CARS-35"]}]},{"name":"Operating Funds for Guangdong Provincial Key Laboratory of Animal Breeding and Nutrition","award":["2014B030301054"],"award-info":[{"award-number":["2014B030301054"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animals"],"abstract":"<jats:p>Birth is one of the most important events of animal production agriculture, as newborns are abruptly forced to adapt to environmental and nutritional disruptions that can lead to oxidative damage and delay in growth. Taurine (Tau) is an important regulator of oxidative stress and possesses growth-enhancing properties. In the present study, we investigated the effects of dietary Tau supplementation in gilts during late gestation and lactation on the growth performance of piglets by assessing intestinal morphology and barrier function, and oxidative stress status. Sixteen gilts were randomly allocated to the Con (basal diet) and Tau (basal diet with 1% Tau) groups from 75 d of gestation to weaning. Maternal dietary Tau supplementation significantly increased weaning weight and average daily gain weight in piglets. Piglets in the Tau group had higher villus height and villus height-to-crypt depth ratio (VCR), ZO-1 protein expression, and secretory immunoglobulin A (sIgA) content in the jejunum. Meanwhile, Tau bebeficial affected the milk quality of gilts, as indicated by decreased malondialdehyde (MDA) concentration and increased total superoxide dismutase (T-SOD), total antioxidative capability (T-AOC), glutathione peroxidase (GPx), and catalase (CAT) activity. Furthermore, Tau supplementation increased T-SOD activity in plasma and SOD2 protein expression in the jejunum in the piglets. In conclusion, this study provides evidence that dietary Tau supplementation to gilts improves growth performance in piglets, owing to improved intestinal morphology and barrier function, as well as inhibition of oxidative stress.<\/jats:p>","DOI":"10.3390\/ani9050220","type":"journal-article","created":{"date-parts":[[2019,5,9]],"date-time":"2019-05-09T11:22:35Z","timestamp":1557400955000},"page":"220","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Effects of Dietary Taurine Supplementation to Gilts during Late Gestation and Lactation on Offspring Growth and Oxidative Stress"],"prefix":"10.3390","volume":"9","author":[{"given":"Mengmeng","family":"Xu","sequence":"first","affiliation":[{"name":"Key Laboratory for Animal Disease-Resistant Nutrition of the Ministry of Education of China, Institute of Animal Nutrition, Sichuan Agricultural University, Chengdu 611130, Sichuan, China"},{"name":"State Key Laboratory of Livestock and Poultry Breeding, Ministry of Agriculture Key Laboratory of Animal Nutrition and Feed Science in South China, Guangdong Public Laboratory of Animal Breeding and Nutrition, Guangdong Key Laboratory of Animal Breeding and Nutrition, Institute of Animal Science, Guangdong Academy of Agricultural Sciences, Guangdong 510640, Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Long","family":"Che","sequence":"additional","affiliation":[{"name":"Key Laboratory for Animal Disease-Resistant Nutrition of the Ministry of Education of China, Institute of Animal Nutrition, Sichuan Agricultural University, Chengdu 611130, Sichuan, China"},{"name":"State Key Laboratory of Livestock and Poultry Breeding, Ministry of Agriculture Key Laboratory of Animal Nutrition and Feed Science in South China, Guangdong Public Laboratory of Animal Breeding and Nutrition, Guangdong Key Laboratory of Animal Breeding and Nutrition, Institute of Animal Science, Guangdong Academy of Agricultural Sciences, Guangdong 510640, Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7749-2099","authenticated-orcid":false,"given":"Kaiguo","family":"Gao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Livestock and Poultry Breeding, Ministry of Agriculture Key Laboratory of Animal Nutrition and Feed Science in South China, Guangdong Public Laboratory of Animal Breeding and Nutrition, Guangdong Key Laboratory of Animal Breeding and Nutrition, Institute of Animal Science, Guangdong Academy of Agricultural Sciences, Guangdong 510640, Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Livestock and Poultry Breeding, Ministry of Agriculture Key Laboratory of Animal Nutrition and Feed Science in South China, Guangdong Public Laboratory of Animal Breeding and Nutrition, Guangdong Key Laboratory of Animal Breeding and Nutrition, Institute of Animal Science, Guangdong Academy of Agricultural Sciences, Guangdong 510640, Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuefen","family":"Yang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Livestock and Poultry Breeding, Ministry of Agriculture Key Laboratory of Animal Nutrition and Feed Science in South China, Guangdong Public Laboratory of Animal Breeding and Nutrition, Guangdong Key Laboratory of Animal Breeding and Nutrition, Institute of Animal Science, Guangdong Academy of Agricultural Sciences, Guangdong 510640, Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaolu","family":"Wen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Livestock and Poultry Breeding, Ministry of Agriculture Key Laboratory of Animal Nutrition and Feed Science in South China, Guangdong Public Laboratory of Animal Breeding and Nutrition, Guangdong Key Laboratory of Animal Breeding and Nutrition, Institute of Animal Science, Guangdong Academy of Agricultural Sciences, Guangdong 510640, Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zongyong","family":"Jiang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Livestock and Poultry Breeding, Ministry of Agriculture Key Laboratory of Animal Nutrition and Feed Science in South China, Guangdong Public Laboratory of Animal Breeding and Nutrition, Guangdong Key Laboratory of Animal Breeding and Nutrition, Institute of Animal Science, Guangdong Academy of Agricultural Sciences, Guangdong 510640, Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7025-823X","authenticated-orcid":false,"given":"De","family":"Wu","sequence":"additional","affiliation":[{"name":"Key Laboratory for Animal Disease-Resistant Nutrition of the Ministry of Education of China, Institute of Animal Nutrition, Sichuan Agricultural University, Chengdu 611130, Sichuan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2019,5,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1586\/1744666X.2014.942288","article-title":"Immune responses in neonates","volume":"10","author":"Basha","year":"2014","journal-title":"Expert Rev. Clin. Immunol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"S75","DOI":"10.1016\/S0378-3782(01)00209-2","article-title":"Oxidative stress in the neonate","volume":"65","author":"Robles","year":"2001","journal-title":"Early Hum. Dev."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"503S","DOI":"10.1093\/jn\/137.2.503S","article-title":"Advances in our understanding of the biology of human milk and its effects on the offspring","volume":"137","author":"Schacknielsen","year":"2007","journal-title":"J. Nutr."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Barbero, A., Astiz, S., Lopezbote, C.J., Perezsolana, M.L., Ayuso, M., Garciareal, I., and Gonzalezbulnes, A. (2013). Maternal malnutrition and offspring sex determine juvenile obesity and metabolic disorders in a swine model of leptin resistance. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0078424"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1111\/cbdd.12478","article-title":"Antibiotic adjuvants: Diverse strategies for controlling drug-resistant pathogens","volume":"85","author":"Gill","year":"2015","journal-title":"Chem. Biol. Drug Des."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"2207","DOI":"10.1007\/s00726-011-0960-9","article-title":"Dietary l-arginine supplementation enhances placental growth and reproductive performance in sows","volume":"42","author":"Gao","year":"2012","journal-title":"Amino Acids"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"2783S","DOI":"10.1093\/jn\/134.10.2783S","article-title":"Arginine nutrition in neonatal pigs","volume":"134","author":"Wu","year":"2004","journal-title":"J. Nutr."},{"key":"ref_8","first-page":"262","article-title":"Taurine: A conditionally essential amino acid in humans? An overview in health and disease","volume":"17","year":"2002","journal-title":"Nutr. Hosp."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1007\/978-1-4899-0117-0_56","article-title":"The role of taurine in infant nutrition","volume":"442","author":"Chesney","year":"1998","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1007\/s00726-002-0211-1","article-title":"Dietary taurine enhances cholesterol degradation and reduces serum and liver cholesterol concentrations in rats fed a high-cholesterol diet","volume":"23","author":"Yokogoshi","year":"2002","journal-title":"Amino Acids"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1080\/00071668.2010.506984","article-title":"Effect of taurine on intestinal morphology and utilisation of soy oil in chickens","volume":"51","author":"Yuan","year":"2010","journal-title":"Br. Poult. Sci."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1007\/s00383-015-3828-3","article-title":"Effect of taurine on intestinal recovery following intestinal ischemia-reperfusion injury in a rat","volume":"32","author":"Sukhotnik","year":"2016","journal-title":"Pediatr. Surg. Int."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.livsci.2014.08.014","article-title":"Excessive dietary taurine supplementation reduces growth performance, liver and intestinal health of weaned pigs","volume":"168","author":"Yue","year":"2014","journal-title":"Livest. Sci."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.biochi.2008.09.006","article-title":"Hypoglycaemic, antioxidative and nephroprotective effects of taurine in alloxan diabetic rabbits","volume":"91","author":"Winiarska","year":"2009","journal-title":"Biochimie"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.1186\/1423-0127-17-S1-S2","article-title":"Physiological roles of taurine in heart and muscle","volume":"17","author":"Schaffer","year":"2010","journal-title":"J. Biomed. Sci."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.taap.2012.01.015","article-title":"Mangiferin exerts hepatoprotective activity against d-galactosamine induced acute toxicity and oxidative\/nitrosative stress via Nrf2-NF\u03baB pathways","volume":"260","author":"Das","year":"2012","journal-title":"Toxicol. Appl. Pharm."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"3889","DOI":"10.1038\/ncomms4889","article-title":"High-fat maternal diet during pregnancy persistently alters the offspring microbiome in a primate model","volume":"5","author":"Ma","year":"2014","journal-title":"Nat. Commun."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1590\/1414-431X20122561","article-title":"Maternal protein restriction affects gene expression and enzyme activity of intestinal disaccharidases in adult rat offspring","volume":"46","author":"Pinheiro","year":"2013","journal-title":"Braz. J. Med. Biol. Res."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1080\/19490976.2014.997610","article-title":"Maternal exposure to fish oil primes offspring to harbor intestinal pathobionts associated with altered immune cell balance","volume":"6","author":"Gibson","year":"2015","journal-title":"Gut Microbes"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1038\/nrm2256","article-title":"ROS as signalling molecules: Mechanisms that generate specificity in ROS homeostasis","volume":"8","author":"Toledano","year":"2007","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.jss.2009.11.430","article-title":"High throughput functional profiling of intestinal bacteria in milk fed and formula fed newborn humans and piglets","volume":"158","author":"Morowitz","year":"2010","journal-title":"J. Surg. Res."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.lfs.2010.11.006","article-title":"Effect of dietary selenite on development and intestinal absorption in offspring rats","volume":"88","author":"Delgado","year":"2011","journal-title":"Life Sci."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Xu, M., Che, L., Yang, Z., Zhang, P., Shi, J., Li, J., Lin, Y., Fang, Z., Che, L., and Feng, B. (2016). Effect of high fat dietary intake during maternal gestation on offspring ovarian health in a pig model. Nutrients, 8.","DOI":"10.3390\/nu8080498"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"3304","DOI":"10.2527\/1992.70113304x","article-title":"Relationship of milk production, milk expected progeny difference, and calf weaning weight in angus and simmental cow-calf pairs","volume":"70","author":"Marston","year":"1992","journal-title":"J. Anim. Sci."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"562","DOI":"10.2527\/1990.682562x","article-title":"Energy utilization in pregnant and lactating sows: Modeling of energy requirements","volume":"68","author":"Noblet","year":"1990","journal-title":"J. Anim. Sci."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"2026","DOI":"10.2527\/2000.7882026x","article-title":"The influence of suckling interval on milk production of sows","volume":"78","author":"Auldist","year":"2000","journal-title":"J. Anim. Sci."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1079\/BJN2003896","article-title":"Antioxidative probiotic fermented goats\u2019 milk decreases oxidative stress-mediated atherogenicity in human subjects","volume":"90","author":"Tiiu","year":"2003","journal-title":"Br. J. Nutr."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1136\/adc.2005.084798","article-title":"Effects of exclusive formula or breast milk feeding on oxidative stress in healthy preterm infants","volume":"91","author":"Korchazhkina","year":"2006","journal-title":"Arch. Dis. Child."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.semcdb.2017.10.012","article-title":"Milk lipid regulation at the maternal-offspring interface","volume":"81","author":"Yang","year":"2018","journal-title":"Semin. Cell Dev. Biol."},{"key":"ref_30","first-page":"761","article-title":"Diet-induced modifications to milk composition have long-term effects on offspring growth in rabbits","volume":"95","author":"Huebeauvais","year":"2017","journal-title":"J. Anim. Sci."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1093\/oxfordjournals.bmb.a072627","article-title":"Free radicals in inflammation: Second messengers and mediators of tissue destruction","volume":"49","author":"Winrow","year":"1993","journal-title":"Br. Med. Bull."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1007\/BF00930968","article-title":"The role of free oxygen radicals in the expulsion of primary infections of Nippostrongylus brasiliensis","volume":"75","author":"Smith","year":"1989","journal-title":"Parasitol. Res."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"14724","DOI":"10.1021\/acsami.7b03377","article-title":"Biogenic nanoselenium particles effectively attenuate oxidative stress-induced intestinal epithelial barrier injury by activating the Nrf2 antioxidant pathway","volume":"9","author":"Song","year":"2017","journal-title":"ACS Appl. Mater. Interface"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1080\/00365520410003605","article-title":"Oxidative stress contributes to methotrexate-induced small intestinal toxicity in rats","volume":"39","author":"Miyazono","year":"2004","journal-title":"Scand. J. Gastroenterol."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Liu, P., Che, L., Yang, Z., Feng, B., Che, L., Xu, S., Lin, Y., Fang, Z., Li, J., and Wu, D. (2016). A maternal high-energy diet promotes intestinal development and intrauterine growth of offspring. Nutrients, 8.","DOI":"10.3390\/nu8050258"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1540","DOI":"10.3945\/jn.114.194001","article-title":"Glycine stimulates protein synthesis and inhibits oxidative stress in pig small intestinal epithelial cells","volume":"144","author":"Wang","year":"2014","journal-title":"J. Nutr."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1093\/jn\/138.1.60","article-title":"Intrauterine growth restriction affects the proteomes of the small intestine, liver, and skeletal muscle in newborn pigs","volume":"138","author":"Wang","year":"2008","journal-title":"J. Nutr."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1083\/jcb.141.1.199","article-title":"ZO-3, a novel member of the MAGUK protein family found at the tight junction, interacts with ZO-1 and occludin","volume":"141","author":"Haskins","year":"1998","journal-title":"J. Cell Biol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1007\/s00018-012-1070-x","article-title":"Regulation of intestinal epithelial permeability by tight junctions","volume":"70","author":"Suzuki","year":"2013","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_40","first-page":"100","article-title":"Intestinal mucosal immune defense mechanisms","volume":"12","author":"Keren","year":"1988","journal-title":"Am. J. Surg. Pathol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1186\/s40104-018-0273-x","article-title":"Alginate oligosaccharide-induced intestinal morphology, barrier function and epithelium apoptosis modifications have beneficial effects on the growth performance of weaned pigs","volume":"9","author":"Wan","year":"2018","journal-title":"J. Anim. Sci. Biotechnol."}],"container-title":["Animals"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-2615\/9\/5\/220\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T12:49:34Z","timestamp":1760186974000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-2615\/9\/5\/220"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,6]]},"references-count":41,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2019,5]]}},"alternative-id":["ani9050220"],"URL":"https:\/\/doi.org\/10.3390\/ani9050220","relation":{},"ISSN":["2076-2615"],"issn-type":[{"value":"2076-2615","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,5,6]]}}}