{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T11:19:49Z","timestamp":1790767189216,"version":"4.1.0"},"reference-count":64,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2019,7,20]],"date-time":"2019-07-20T00:00:00Z","timestamp":1563580800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003359","name":"Generalitat Valenciana","doi-asserted-by":"publisher","award":["GV2015-062"],"award-info":[{"award-number":["GV2015-062"]}],"id":[{"id":"10.13039\/501100003359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003359","name":"Generalitat Valenciana","doi-asserted-by":"publisher","award":["PROMETEO\/2018\/078"],"award-info":[{"award-number":["PROMETEO\/2018\/078"]}],"id":[{"id":"10.13039\/501100003359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003508","name":"Universitat de Val\u00e8ncia","doi-asserted-by":"publisher","award":["UV-INV-PRECOMP14-206372"],"award-info":[{"award-number":["UV-INV-PRECOMP14-206372"]}],"id":[{"id":"10.13039\/501100003508","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["CB16\/11\/00486"],"award-info":[{"award-number":["CB16\/11\/00486"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animals"],"abstract":"<jats:p>Obesity and metabolic syndrome (MetS) have become a growing problem for public health and clinical practice, given their increased prevalence due to the rise of sedentary lifestyles and excessive caloric intake from processed food rich in fat and sugar. There are several definitions of MetS, but most of them describe it as a cluster of cardiovascular and metabolic alterations such as abdominal obesity, reduced high-density lipoprotein (HDL) and elevated low-density lipoprotein (LDL) cholesterol, elevated triglycerides, glucose intolerance, and hypertension. Diagnosis requires three out of these five criteria to be present. Despite the increasing prevalence of MetS, the understanding of its pathophysiology and relationship with disease is still limited. Indeed, the pathological consequences of MetS components have been reported individually, but investigations that have studied the effect of the combination of MeS components on organ pathological remodeling are almost nonexistent. On the other hand, animal models are a powerful tool in understanding the mechanisms that underlie pathological processes such as MetS. In the first part of the review, we will briefly overview the advantages, disadvantages and pathological manifestations of MetS in porcine, canine, rodent, and rabbit diet-induced experimental models. Then, we will focus on the different dietary regimes that have been used in rabbits to induce MetS by means of high-fat, cholesterol, sucrose or fructose-enriched diets and their effects on physiological systems and organ remodeling. Finally, we will discuss the use of dietary regimes in different transgenic strains and special rabbit breeds.<\/jats:p>","DOI":"10.3390\/ani9070463","type":"journal-article","created":{"date-parts":[[2019,7,22]],"date-time":"2019-07-22T02:55:37Z","timestamp":1563764137000},"page":"463","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Diet-Induced Rabbit Models for the Study of Metabolic Syndrome"],"prefix":"10.3390","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3604-8527","authenticated-orcid":false,"given":"Wilson M.","family":"Lozano","sequence":"first","affiliation":[{"name":"Department of Physiology, Universitat de Val\u00e8ncia, 46010 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oscar J.","family":"Arias-Mutis","sequence":"additional","affiliation":[{"name":"Department of Physiology, Universitat de Val\u00e8ncia, 46010 Valencia, Spain"},{"name":"CIBERCV, Instituto de Salud Carlos III, 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Conrado J.","family":"Calvo","sequence":"additional","affiliation":[{"name":"Department of Physiology, Universitat de Val\u00e8ncia, 46010 Valencia, Spain"},{"name":"CIBERCV, Instituto de Salud Carlos III, 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco J.","family":"Chorro","sequence":"additional","affiliation":[{"name":"CIBERCV, Instituto de Salud Carlos III, 28029 Madrid, Spain"},{"name":"Department of Cardiology, Hospital Cl\u00ednico Universitario, 46010 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Zarzoso","sequence":"additional","affiliation":[{"name":"Department of Physiotherapy, Universitat de Val\u00e8ncia, 46010 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,7,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.1161\/CIRCULATIONAHA.109.192644","article-title":"Harmonizing the metabolic syndrome: a joint interim statement of the international diabetes federation task force on epidemiology and prevention; national heart, lung, and blood institute; American heart association; world heart federation; international atherosclerosis society; and international association for the study of obesity","volume":"120","author":"Alberti","year":"2009","journal-title":"Circulation"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.2337\/diab.37.12.1595","article-title":"Role of insulin resistance in human disease","volume":"37","author":"Reaven","year":"1988","journal-title":"Diabetes"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1161\/CIRCULATIONAHA.104.516948","article-title":"Metabolic syndrome and 10-year cardiovascular disease risk in the Hoorn Study","volume":"112","author":"Dekker","year":"2005","journal-title":"Circulation"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1093\/eurheartj\/sui022","article-title":"Epidemiology of the metabolic syndrome and the RISC study","volume":"7","author":"Balkau","year":"2005","journal-title":"Eur. Heart J. Suppl."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1016\/j.jacc.2010.05.034","article-title":"The metabolic syndrome and cardiovascular risk: A systematic review and meta-analysis","volume":"56","author":"Mottillo","year":"2010","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1161\/01.CIR.0000111245.75752.C6","article-title":"Definition of Metabolic Syndrome: Report of the National Heart, Lung, and Blood Institute\/American Heart Association Conference on Scientific Issues Related to Definition","volume":"109","author":"Grundy","year":"2004","journal-title":"Circulation"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1111\/apha.12230","article-title":"The metabolic syndrome: Is it the mother\u2019s fault?","volume":"210","author":"Schmerbach","year":"2014","journal-title":"Acta Physiol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"943162","DOI":"10.1155\/2014\/943162","article-title":"A comprehensive review on metabolic syndrome","volume":"2014","author":"Kaur","year":"2014","journal-title":"Cardiol. Res. Pract."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.trsl.2017.01.001","article-title":"Cardiovascular consequences of metabolic syndrome","volume":"183","author":"Tune","year":"2017","journal-title":"Transl. Res."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"431","DOI":"10.3389\/fphys.2017.00431","article-title":"Cardiac ion channel regulation in obesity and the metabolic syndrome: Relevance to long QT syndrome and atrial fibrillation","volume":"8","author":"Aromolaran","year":"2017","journal-title":"Front. Physiol."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Rozendaal, Y.J.W., Wang, Y., Paalvast, Y., Tambyrajah, L.L., Li, Z., Van Dijk, K.W., Rensen, P.C.N., Kuivenhoven, J.A., Groen, A.K., and Hilbers, P.A.J. (2018). In vivo and in silico dynamics of the development of Metabolic Syndrome. PLoS Comput. Biol., 14.","DOI":"10.1371\/journal.pcbi.1006145"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Van Vliet-Ostaptchouk, J.V., Nuotio, M.-L., Slagter, S.N., Doiron, D., Fischer, K., Foco, L., Gaye, A., G\u00f6gele, M., Heier, M., and Hiekkalinna, T. (2014). The prevalence of metabolic syndrome and metabolically healthy obesity in Europe: A collaborative analysis of ten large cohort studies. BMC Endocr. Disord., 14.","DOI":"10.1186\/1472-6823-14-9"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1016\/j.biopha.2017.03.010","article-title":"Animal models for assessing the impact of natural products on the aetiology and metabolic pathophysiology of Type 2 diabetes","volume":"89","author":"Asrafuzzaman","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Arias-Mutis, O.J., Marrachelli, V.G., Ruiz-Sauri, A., Alberola, A., Morales, J.M., Such-Miquel, L., Monle\u00f3n, D., Chorro, F.J., Such, L., and Zarzoso, M. (2017). Development and characterization of an experimental model of diet-induced metabolic syndrome in rabbit. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0178315"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1186\/s12986-016-0123-9","article-title":"Animal models of metabolic syndrome: A review","volume":"13","author":"Wong","year":"2016","journal-title":"Nutr. Metab."},{"key":"ref_16","first-page":"e57117","article-title":"An Experimental Model of Diet-Induced Metabolic Syndrome in Rabbit: Methodological Considerations, Development, and Assessment","volume":"134","author":"Calvo","year":"2018","journal-title":"J. Vis. Exp."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1093\/bmb\/60.1.103","article-title":"Animal models and programming of the metabolic syndrome","volume":"60","author":"Bertram","year":"2001","journal-title":"Br. Med. Bull."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1177\/0192623316630835","article-title":"Investigating the Metabolic Syndrome","volume":"44","author":"Zhang","year":"2016","journal-title":"Toxicol. Pathol."},{"key":"ref_19","first-page":"H373","article-title":"Hypertension, cardiac hypertrophy, and neurohumoral activity in a new animal model of obesity","volume":"271","author":"Carroll","year":"1996","journal-title":"Am. J. Physiol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1017\/S0954422410000168","article-title":"High-fat diet-induced obesity in animal models","volume":"23","author":"Hariri","year":"2010","journal-title":"Nutr. Res. Rev."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1093\/jn\/138.2.397","article-title":"The development of porcine models of obesity and the metabolic syndrome","volume":"138","author":"Spurlock","year":"2008","journal-title":"J. Nutr."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"17835","DOI":"10.1038\/s41598-018-36388-y","article-title":"Experimental Metabolic Syndrome Model Associated with Mechanical and Structural Degenerative Changes of the Aortic Valve","volume":"8","author":"Go","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.atherosclerosis.2010.07.051","article-title":"High-fat diet without excess calories induces metabolic disorders and enhances atherosclerosis in rabbits","volume":"213","author":"Waqar","year":"2010","journal-title":"Atherosclerosis"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"26","DOI":"10.5551\/jat1994.7.26","article-title":"Cholesterol-fed Atherosclerosis and Transgenic Rabbit Models for the Study of Atherosclerosis","volume":"7","author":"Fan","year":"2000","journal-title":"J. Atheroscler. Thromb."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.pharmthera.2014.09.009","article-title":"Rabbit models for the study of human atherosclerosis: From pathophysiological mechanisms to translational medicine","volume":"146","author":"Fan","year":"2015","journal-title":"Pharmacol. Ther."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/S0022-2275(20)34780-5","article-title":"Animal lipoproteins: Chemistry, structure, and comparative aspects","volume":"21","author":"Chapman","year":"1980","journal-title":"J. Lipid Res."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1111\/j.1749-6632.1997.tb51997.x","article-title":"Transgenic rabbit models for the study of atherosclerosis","volume":"811","author":"Taylor","year":"1997","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"8724","DOI":"10.1073\/pnas.91.18.8724","article-title":"Overexpression of hepatic lipase in transgenic rabbits leads to a marked reduction of plasma high density lipoproteins and intermediate density lipoproteins","volume":"91","author":"Fan","year":"1994","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1021\/bi00705a004","article-title":"Changes in Apolipoproteins and Properties of Rabbit Very Low Density Lipoproteins on Induction of Cholesteremia","volume":"13","author":"Shore","year":"1974","journal-title":"Biochemistry"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"212","DOI":"10.3390\/ani8110212","article-title":"Dietary cold pressed watercress and coconut oil mixture enhances growth performance, intestinal microbiota, antioxidant status, and immunity of growing rabbits","volume":"8","author":"Alagawany","year":"2018","journal-title":"Animals"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"3274","DOI":"10.1111\/j.1743-6109.2009.01467.x","article-title":"Testosterone Partially Ameliorates Metabolic Profile and Erectile Responsiveness to PDE5 Inhibitors in an Animal Model of Male Metabolic Syndrome","volume":"6","author":"Filippi","year":"2009","journal-title":"J. Sex. Med."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1111\/j.1365-2613.2010.00753.x","article-title":"Impaired glucose tolerance plus hyperlipidaemia induced by diet promotes retina microaneurysms in New Zealand rabbits","volume":"92","author":"Helfenstein","year":"2011","journal-title":"Int. J. Exp. Pathol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/s12986-015-0024-3","article-title":"High-fructose and high-fat diet-induced insulin resistance enhances atherosclerosis in Watanabe heritable hyperlipidemic rabbits","volume":"12","author":"Ning","year":"2015","journal-title":"Nutr. Metab."},{"key":"ref_34","first-page":"179","article-title":"A diet high in saturated fat and sucrose alters glucoregulation and induces aortic fatty streaks in New Zealand White rabbits","volume":"3","author":"Yin","year":"2002","journal-title":"Int. J. Exp. Diabetes Res."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.diabres.2015.12.012","article-title":"Improvement of cardiac dysfunction by bilateral surgical renal denervation in animals with diabetes induced by high fructose and high fat diet","volume":"115","author":"Liu","year":"2016","journal-title":"Diabetes Res. Clin. Pract."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1016\/j.joca.2012.02.007","article-title":"High dietary fat and the development of osteoarthritis in a rabbit model","volume":"20","author":"Brunner","year":"2012","journal-title":"Osteoarthr. Cartil."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"55","DOI":"10.3390\/ani2010055","article-title":"Effects of Dietary Fatty Acids on Lipid Traits in the Muscle and Perirenal Fat of Growing Rabbits Fed Mixed Diets","volume":"2","author":"Peiretti","year":"2012","journal-title":"Animals"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1097\/FJC.0b013e31825c3c4c","article-title":"Beneficial Cardiac Effects of Cicletanine in Conscious Rabbits With Metabolic Syndrome","volume":"60","author":"Drimba","year":"2012","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.atherosclerosis.2015.12.002","article-title":"ApoE knockout rabbits: A novel model for the study of human hyperlipidemia","volume":"245","author":"Niimi","year":"2016","journal-title":"Atherosclerosis"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1097\/MOL.0b013e3283544956","article-title":"Determinants of VLDL-triglycerides production","volume":"23","author":"Nielsen","year":"2012","journal-title":"Curr. Opin. Lipidol."},{"key":"ref_41","first-page":"382","article-title":"Role of triglyceride-fatty acid cycle in controlling fat metabolism in humans during and after exercise","volume":"258","author":"Wolfe","year":"1990","journal-title":"Am. J. Physiol. Metab."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1038\/oby.2007.608","article-title":"High-fat Diets: Modeling the Metabolic Disorders of Human Obesity in Rodents","volume":"15","author":"Buettner","year":"2007","journal-title":"Obesity"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1038\/s41366-018-0020-6","article-title":"High fat diet-induced metabolically obese and normal weight rabbit model shows early vascular dysfunction: Mechanisms involved","volume":"42","author":"Alarcon","year":"2018","journal-title":"Int. J. Obes."},{"key":"ref_44","first-page":"71","article-title":"Growth of Rabbits under Different Environmental Temperatures Using High Fat Diets","volume":"5","author":"Cervera","year":"1997","journal-title":"World Rabbit Sci."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1016\/j.jnutbio.2009.10.002","article-title":"High Fat Diet-Induced Animal Model of a Age-associated Obesity and Osteoporosis","volume":"21","author":"Halade","year":"2010","journal-title":"J. Nutr. Biochem."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1093\/ajcn\/86.2.285","article-title":"Comparative review of diets for the metabolic syndrome: Implications for nonalcoholic fatty liver disease","volume":"86","author":"Zivkovic","year":"2007","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.mce.2014.11.005","article-title":"Metabolic syndrome-associated sperm alterations in an experimental rabbit model: Relation with metabolic profile, testis and epididymis gene expression and effect of tamoxifen treatment","volume":"401","author":"Marchiani","year":"2015","journal-title":"Mol. Cell. Endocrinol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1002\/pros.22584","article-title":"Mechanism of action of phosphodiesterase type 5 inhibition in metabolic syndrome-associated prostate alterations: An experimental study in the rabbit","volume":"73","author":"Morelli","year":"2013","journal-title":"Prostate"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.mce.2016.01.015","article-title":"Tadalafil reduces visceral adipose tissue accumulation by promoting preadipocytes differentiation towards a metabolically healthy phenotype: Studies in rabbits","volume":"424","author":"Maneschi","year":"2016","journal-title":"Mol. Cell. Endocrinol."},{"key":"ref_50","unstructured":"Murray, R.K., Mayes, P.A., Granner, D.K., and Rodwell, V.W. (2012). Harper\u2019s Illustrated Biochemistry, Mc Graw-Hill Education. [29th ed.]. Section 2: Bioenergetics and the Metabolism of Carbohydrates and Lipids."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1111\/j.1439-0396.2007.00723.x","article-title":"Diet-induced central obesity and insulin resistance in rabbits","volume":"92","author":"Zhao","year":"2008","journal-title":"J. Anim. Physiol. Anim. Nutr."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1093\/ajcn\/86.4.895","article-title":"How bad is fructose?","volume":"86","author":"Bray","year":"2007","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"S61","DOI":"10.2337\/dc08-S061","article-title":"Nutrition Recommendations and Interventions for Diabetes: A position statement of the American Diabetes Association","volume":"31","author":"Bantle","year":"2008","journal-title":"Diabetes Care"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1038\/oby.2005.136","article-title":"Consuming Fructose-sweetened Beverages Increases Body Adiposity in Mice","volume":"13","author":"Haass","year":"2005","journal-title":"Obes. Res."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/1743-7075-2-5","article-title":"Fructose, insulin resistance, and metabolic dyslipidemia","volume":"2","author":"Basciano","year":"2005","journal-title":"Nutr. Metab."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1093\/ajcn\/76.5.911","article-title":"Fructose, weight gain, and the insulin resistance syndrome","volume":"76","author":"Elliott","year":"2002","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1186\/1743-7075-7-82","article-title":"Health implications of fructose consumption: A review of recent data","volume":"7","author":"Rizkalla","year":"2010","journal-title":"Nutr. Metab."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1093\/ajcn\/86.4.899","article-title":"Potential role of sugar (fructose) in the epidemic of hypertension, obesity and the metabolic syndrome, diabetes, kidney disease, and cardiovascular disease","volume":"86","author":"Johnson","year":"2007","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1016\/S0022-2275(20)41963-7","article-title":"Rabbit hepatic lipase cDNA sequence: Low activity is associated with low messenger RNA levels","volume":"32","author":"Warren","year":"1991","journal-title":"J. Lipid Res."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1016\/S0022-2275(20)40761-8","article-title":"Apolipoproteins, membrane cholesterol domains, and the regulation of cholesterol efflux","volume":"33","author":"Rothblat","year":"1992","journal-title":"J. Lipid Res."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"7521","DOI":"10.1074\/jbc.M311514200","article-title":"Overexpression of Lipoprotein Lipase in Transgenic Watanabe Heritable Hyperlipidemic Rabbits Improves Hyperlipidemia and Obesity","volume":"279","author":"Koike","year":"2004","journal-title":"J. Biol. Chem."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.metabol.2004.07.021","article-title":"High lipoprotein lipase activity increases insulin sensitivity in transgenic rabbits","volume":"54","author":"Liu","year":"2005","journal-title":"Metabolism"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.tibtech.2013.04.004","article-title":"ZFN, TALEN, and CRISPR\/Cas-based methods for genome engineering","volume":"31","author":"Gaj","year":"2013","journal-title":"Trends Biotechnol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.accreview.2004.10.018","article-title":"Sugar-sweetened beverages, weight gain, and incidence of type 2 diabetes in young and middle-aged women","volume":"13","author":"Schulze","year":"2004","journal-title":"ACC Curr. J. Rev."}],"container-title":["Animals"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2076-2615\/9\/7\/463\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:07:51Z","timestamp":1760188071000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2076-2615\/9\/7\/463"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,20]]},"references-count":64,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2019,7]]}},"alternative-id":["ani9070463"],"URL":"https:\/\/doi.org\/10.3390\/ani9070463","relation":{},"ISSN":["2076-2615"],"issn-type":[{"value":"2076-2615","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7,20]]}}}