{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T03:48:06Z","timestamp":1760240886461,"version":"build-2065373602"},"reference-count":39,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2019,10,17]],"date-time":"2019-10-17T00:00:00Z","timestamp":1571270400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010719","name":"Pakistan Agricultural Research Council","doi-asserted-by":"publisher","award":["AS-091"],"award-info":[{"award-number":["AS-091"]}],"id":[{"id":"10.13039\/501100010719","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Animals"],"abstract":"<jats:p>The present study aimed to evaluate the effect of chromium-loaded chitosan nanoparticles (Cr-CNPs) on the electrophysiological indices, gene expression of glucose transporters, and tissue glycogen in broilers. A total of 200 one-day-old broilers were randomly divided into five groups, with each having five replicates (n = 8). Group A was fed a corn\u2013soybean meal diet, while the diets of groups B, C, D, and E were supplemented with 200, 400, 800, and 1200 \u00b5g\/kg of Cr as Cr-CNPs, respectively. On day 35, the jejunum was collected for electrophysiological study, gene expression of glucose transporters, and tissues glycogen determination. The basal short-circuit current and tissue conductance before the addition of glucose was the same in all groups. Following the addition of glucose, the change in short-circuit current decreased (p &lt; 0.05) in the jejunal tissues of birds supplemented with 400 and 1200 \u00b5g Cr-CNPs compared with the control group. Gene expression of SGLT-1 and GLUT-2 remained unaffected with supplementation. The serum glucose and liver glycogen concentration decreased (p &lt; 0.05) linearly with supplementation, while no effect was observed on muscle glycogen. In conclusion, Cr-CNPs supplementation decreases the glucose absorption and liver glycogen content, without affecting the gene expression of glucose transporters.<\/jats:p>","DOI":"10.3390\/ani9100819","type":"journal-article","created":{"date-parts":[[2019,10,17]],"date-time":"2019-10-17T11:07:59Z","timestamp":1571310479000},"page":"819","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Effects of Chromium-Loaded Chitosan Nanoparticles on the Intestinal Electrophysiological Indices and Glucose Transporters in Broilers"],"prefix":"10.3390","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3453-2534","authenticated-orcid":false,"given":"Sajid Khan","family":"Tahir","sequence":"first","affiliation":[{"name":"Department of Physiology, University of Veterinary and Animal Sciences, Lahore 54000, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad Shahbaz","family":"Yousaf","sequence":"additional","affiliation":[{"name":"Department of Physiology, University of Veterinary and Animal Sciences, Lahore 54000, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sohrab","family":"Ahmad","sequence":"additional","affiliation":[{"name":"Department of Physiology, University of Veterinary and Animal Sciences, Lahore 54000, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9346-9411","authenticated-orcid":false,"given":"Muhammad Khurram","family":"Shahzad","sequence":"additional","affiliation":[{"name":"Department of Physiology, University of Veterinary and Animal Sciences, Lahore 54000, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5178-2482","authenticated-orcid":false,"given":"Ather Farooq","family":"Khan","sequence":"additional","affiliation":[{"name":"Interdisciplinary Research Centre in Biomedical Materials, COMSATS University Islamabad, Lahore Campus, Lahore 45550, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohsin","family":"Raza","sequence":"additional","affiliation":[{"name":"Department of Physiology, University of Veterinary and Animal Sciences, Lahore 54000, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khalid Abdul","family":"Majeed","sequence":"additional","affiliation":[{"name":"Department of Physiology, University of Veterinary and Animal Sciences, Lahore 54000, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abia","family":"Khalid","sequence":"additional","affiliation":[{"name":"Department of Physiology, University of Veterinary and Animal Sciences, Lahore 54000, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hafsa","family":"Zaneb","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Histology, University of Veterinary and Animal Sciences, Lahore 54000, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Imtiaz","family":"Rabbani","sequence":"additional","affiliation":[{"name":"Department of Physiology, University of Veterinary and Animal Sciences, Lahore 54000, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8485-7962","authenticated-orcid":false,"given":"Habib","family":"Rehman","sequence":"additional","affiliation":[{"name":"Department of Physiology, University of Veterinary and Animal Sciences, Lahore 54000, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2019,10,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.3382\/ps\/pew018","article-title":"Chromium propionate in broilers: Effect on insulin sensitivity","volume":"95","author":"Brooks","year":"2016","journal-title":"Poult. 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