{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T08:27:48Z","timestamp":1761294468949,"version":"build-2065373602"},"reference-count":90,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2022,4,30]],"date-time":"2022-04-30T00:00:00Z","timestamp":1651276800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antibodies"],"abstract":"<jats:p>Adoptive cell therapy holds great promise for treating a myriad of diseases, especially cancer. Within the last decade, immunotherapy has provided a significant leap in the successful treatment of leukemia. The research conducted throughout this period to understand the interrelationships between cancer cells and infiltrating immune cells winds up having one very common feature, bioenergetics. Cancer cells and immune cells both need ATP to perform their individual functions and cancer cells have adopted means to limit immune cell activity via changes in immune cell bioenergetics that redirect immune cell behavior to encourage tumor growth. Current leading strategies for cancer treatment super-charge an individual\u2019s own immune cells against cancer. Successful Chimeric Antigen Receptor T Cells (CAR T) target pathways that ultimately influence bioenergetics. In the last decade, scientists identified that mitochondria play a crucial role in T cell physiology. When modifying T cells to create chimeras, a unique mitochondrial fitness emerges that establishes stemness and persistence. This review highlights many of the key findings leading to this generation\u2019s CAR T treatments and the work currently being done to advance immunotherapy, to empower not just T cells but other immune cells as well against a variety of cancers.<\/jats:p>","DOI":"10.3390\/antib11020032","type":"journal-article","created":{"date-parts":[[2022,4,30]],"date-time":"2022-04-30T05:44:07Z","timestamp":1651297447000},"page":"32","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Immune Cell Metabolic Fitness for Life"],"prefix":"10.3390","volume":"11","author":[{"given":"Kevin S.","family":"Bittman","sequence":"first","affiliation":[{"name":"Agilent Technologies, Inc., Santa Clara, CA 95051, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,4,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2965","DOI":"10.3389\/fimmu.2019.02965","article-title":"The intriguing history of cancer immunotherapy","volume":"10","author":"Dobosz","year":"2019","journal-title":"Front. Immunol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.cytogfr.2009.07.004","article-title":"Bioimmunoadjuvants for the treatment of neoplastic and infectious disease: Coley\u2019s legacy revisited","volume":"20","author":"Decker","year":"2009","journal-title":"Cytokine Growth Factor Rev."},{"key":"ref_3","first-page":"58","article-title":"Quantitative studies on tissue transplantation immunity. II. The origin, strength and duration of actively and adoptively acquired immunity","volume":"143","author":"Billingham","year":"1954","journal-title":"Proc. R. Soc. London. Ser. B Boil. Sci."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"280ps7","DOI":"10.1126\/scitranslmed.aaa3643","article-title":"Adoptive cellular therapy: A race to the finish line","volume":"7","author":"June","year":"2015","journal-title":"Sci. Transl. Med."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.coi.2009.02.009","article-title":"The promise and potential pitfalls of chimeric antigen receptors","volume":"21","author":"Sadelain","year":"2009","journal-title":"Curr. Opin. Immunol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1038\/nrd1413","article-title":"Antibody-targeted radiation cancer therapy","volume":"3","author":"Milenic","year":"2004","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1038\/scientificamerican0577-62","article-title":"Cancer immunology","volume":"236","author":"Old","year":"1977","journal-title":"Sci. Am."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"4694","DOI":"10.1182\/blood-2013-02-482570","article-title":"Rituximab causes a polarization of B cells that augments its therapeutic function in NK-cell\u2014Mediated antibody-dependent cellular cytotoxicity","volume":"121","author":"Rudnicka","year":"2013","journal-title":"Blood"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S1074-7613(01)00205-9","article-title":"Signaling Takes a breath\u2014New quantitative perspectives on bioenergetics and signal transduction","volume":"15","author":"Krauss","year":"2001","journal-title":"Immunity"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/0014-4827(73)90561-2","article-title":"Changes in the carbohydrate metabolism of mitogenically stimulated human peripheral lymphocytes: II. Relative importance of glycolysis and oxidative phosphorylation on phytohaemagglutinin stimulation","volume":"77","author":"Roos","year":"1973","journal-title":"Exp. Cell Res."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/0014-4827(73)90560-0","article-title":"Effect of phytohaemagglutinin on the carbohydrate metabolism of human blood lymphocytes after inhibition of the oxidative phosphorylation","volume":"77","author":"Roos","year":"1973","journal-title":"Exp. Cell Res."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1038\/ni.2687","article-title":"Rapid effector function of memory CD8+ T cells requires an immediate-early glycolytic switch","volume":"14","author":"Gubser","year":"2013","journal-title":"Nat. Immunol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41467-019-10023-4","article-title":"Akt and STAT5 mediate naive human CD4+ T-cell early metabolic response to TCR stimulation","volume":"10","author":"Jones","year":"2019","journal-title":"Nat. Commun."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.canlet.2022.01.006","article-title":"Remodeling metabolic fitness: Strategies for improving the efficacy of chimeric antigen receptor T cell therapy","volume":"529","author":"Shen","year":"2022","journal-title":"Cancer Lett."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.immuni.2011.12.007","article-title":"Mitochondrial respiratory capacity is a critical regulator of CD8+ T cell memory development","volume":"36","author":"Everts","year":"2012","journal-title":"Immunity"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1042\/BJ20110162","article-title":"Assessing mitochondrial dysfunction in cells","volume":"435","author":"Brand","year":"2011","journal-title":"Biochem. J."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/B978-0-12-801415-8.00016-3","article-title":"Analysis and interpretation of microplate-based oxygen consumption and pH data","volume":"547","author":"Divakaruni","year":"2014","journal-title":"Methods Enzymol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/s41590-018-0311-z","article-title":"The transcription factor c-Myb regulates CD8+ T cell stemness and antitumor immunity","volume":"20","author":"Gautam","year":"2019","journal-title":"Nat. Immunol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.immuni.2016.01.021","article-title":"Distinct signaling of coreceptors regulates specific metabolism pathways and impacts memory development in CAR T cells","volume":"44","author":"Kawalekar","year":"2016","journal-title":"Immunity"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1038\/s41586-021-03861-0","article-title":"An engineered IL-2 partial agonist promotes CD8+ T cell stemness","volume":"597","author":"Mo","year":"2021","journal-title":"Nature"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1182\/bloodadvances.2020003458","article-title":"Polarized mitochondria as guardians of NK cell fitness","volume":"5","author":"Surace","year":"2021","journal-title":"Blood Adv."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1073\/pnas.90.2.720","article-title":"Specific activation and targeting of cytotoxic lymphocytes through chimeric single chains consisting of antibody-binding domains and the gamma or zeta subunits of the immunoglobulin and T-cell receptors","volume":"90","author":"Eshhar","year":"1993","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1038\/s41565-021-01000-4","article-title":"Intercellular nanotubes mediate mitochondrial trafficking between cancer and immune cells","volume":"17","author":"Saha","year":"2021","journal-title":"Nat. Nanotechnol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.immuni.2016.07.009","article-title":"The tumor microenvironment represses T cell mitochondrial biogenesis to drive intratumoral T cell metabolic insufficiency and dysfunction","volume":"45","author":"Scharping","year":"2016","journal-title":"Immunity"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1038\/s41590-020-0725-2","article-title":"Impaired mitochondrial oxidative phosphorylation limits the self-renewal of T cells exposed to persistent antigen","volume":"21","author":"Vardhana","year":"2020","journal-title":"Nat. Immunol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"2040","DOI":"10.1016\/j.cmet.2021.09.002","article-title":"Tumor-derived exosomes drive immunosuppressive macrophages in a pre-metastatic niche through glycolytic dominant metabolic reprogramming","volume":"33","author":"Morrissey","year":"2021","journal-title":"Cell Metab."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"eaaz6119","DOI":"10.1126\/sciadv.aaz6119","article-title":"Label-free sensing of exosomal MCT1 and CD147 for tracking metabolic reprogramming and malignant progression in glioma","volume":"6","author":"Thakur","year":"2020","journal-title":"Sci. Adv."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"2205","DOI":"10.1084\/jem.188.12.2205","article-title":"Viral immune evasion due to persistence of activated T cells without effector function","volume":"188","author":"Zajac","year":"1998","journal-title":"J. Exp. Med."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"e1792","DOI":"10.1038\/cddis.2015.162","article-title":"T-cell exhaustion in the tumor microenvironment","volume":"6","author":"Jiang","year":"2015","journal-title":"Cell Death. Dis."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"4707","DOI":"10.1158\/0008-5472.CAN-20-0524","article-title":"Epigenetic Control of Cdkn2a.Arf Protects Tumor-Infiltrating Lymphocytes from Metabolic Exhaustion","volume":"80","author":"Koss","year":"2020","journal-title":"Cancer Res."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.it.2013.10.001","article-title":"Tolerance and exhaustion: Defining mechanisms of T cell dysfunction","volume":"35","author":"Schietinger","year":"2014","journal-title":"Trends Immunol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1038\/nri3862","article-title":"Molecular and cellular insights into T cell exhaustion","volume":"15","author":"Wherry","year":"2015","journal-title":"Nat. Rev. Immunol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1016\/j.immuni.2007.09.006","article-title":"Molecular signature of CD8+ T cell exhaustion during chronic viral infection","volume":"27","author":"Wherry","year":"2007","journal-title":"Immunity"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.immuni.2015.01.006","article-title":"The transcription factor NFAT promotes exhaustion of activated CD8(+) T cells","volume":"42","author":"Martinez","year":"2015","journal-title":"Immunity"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1016\/j.ccell.2021.06.012","article-title":"The role of exhaustion in CAR T cell therapy","volume":"39","author":"Delgoffe","year":"2021","journal-title":"Cancer Cell"},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Calvo Tardon, M., Marinari, E., Migliorini, D., Bes, V., Tankov, S., Charrier, E., McKee, T.A., Dutoit, V., Dietrich, P.-Y., and Cosset, E. (2020). An Experimentally Defined Hypoxia Gene Signature in Glioblastoma and Its Modulation by Metformin. Biology, 9.","DOI":"10.3390\/biology9090264"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1016\/j.cell.2015.08.016","article-title":"Metabolic competition in the tumor microenvironment is a driver of cancer progression","volume":"162","author":"Chang","year":"2015","journal-title":"Cell"},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Tu, V.Y., Ayari, A., and O\u2019Connor, R.S. (2021). Beyond the Lactate Paradox: How Lactate and Acidity Impact T Cell Therapies against Cancer. Antibodies, 10.","DOI":"10.3390\/antib10030025"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1002\/nbm.1644","article-title":"Imaging pH and metastasis","volume":"24","author":"Hashim","year":"2011","journal-title":"NMR Biomed."},{"key":"ref_40","first-page":"JCST-S1-004","article-title":"Free Base Lysine Increases Survival and Reduces Metastasis in Prostate Cancer Model","volume":"4","author":"Wojtkowiak","year":"2011","journal-title":"J. Cancer Sci. Ther."},{"key":"ref_41","first-page":"916","article-title":"High lactate levels predict likelihood of metastases, tumor recurrence, and restricted patient survival in human cervical cancers","volume":"60","author":"Walenta","year":"2000","journal-title":"Cancer Res."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"4113","DOI":"10.1038\/s41467-020-17756-7","article-title":"T-cells produce acidic niches in lymph nodes to suppress their own effector functions","volume":"11","author":"Wu","year":"2020","journal-title":"Nat. Commun."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"eabb8969","DOI":"10.1126\/scitranslmed.abb8969","article-title":"Metabolic reprogramming of donor T cells enhances graft-versus-leukemia effects in mice and humans","volume":"12","author":"Uhl","year":"2020","journal-title":"Sci. Transl. Med."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1038\/s41586-021-03326-4","article-title":"CTLA-4 blockade drives loss of Treg stability in glycolysis-low tumours","volume":"591","author":"Zappasodi","year":"2021","journal-title":"Nature"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/j.cmet.2022.02.009","article-title":"A genome-scale gain-of-function CRISPR screen in CD8 T cells identifies proline metabolism as a means to enhance CAR-T therapy","volume":"34","author":"Ye","year":"2022","journal-title":"Cell Metab."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"5099","DOI":"10.1038\/s41467-018-07505-2","article-title":"Tumour-elicited neutrophils engage mitochondrial metabolism to circumvent nutrient limitations and maintain immune suppression","volume":"9","author":"Rice","year":"2018","journal-title":"Nat. Commun."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1038\/s41586-018-0597-x","article-title":"IRE1\u03b1\u2013XBP1 controls T cell function in ovarian cancer by regulating mitochondrial activity","volume":"562","author":"Song","year":"2018","journal-title":"Nature"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1038\/s41586-021-04390-6","article-title":"Decade-long leukaemia remissions with persistence of CD4+ CAR T cells","volume":"602","author":"Melenhorst","year":"2022","journal-title":"Nature"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1158\/2326-6066.CIR-18-0466","article-title":"IL15 enhances CAR-T cell antitumor activity by reducing mTORC1 activity and preserving their stem cell memory phenotype","volume":"7","author":"Alizadeh","year":"2019","journal-title":"Cancer Immunol. Res."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1616","DOI":"10.1172\/JCI24480","article-title":"Acquisition of full effector function in vitro paradoxically impairs the in vivo antitumor efficacy of adoptively transferred CD8+ T cells","volume":"115","author":"Gattinoni","year":"2005","journal-title":"J. Clin. Investig."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1016\/j.immuni.2019.03.028","article-title":"The yc family of cytokines: Basic biology to therapeutic ramifications","volume":"50","author":"Leonard","year":"2019","journal-title":"Immunity"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"7310","DOI":"10.1523\/JNEUROSCI.0212-07.2007","article-title":"Spare respiratory capacity rather than oxidative stress regulates glutamate excitotoxicity after partial respiratory inhibition of mitochondrial complex I with rotenone","volume":"27","author":"Yadava","year":"2007","journal-title":"J. Neurosci."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/j.stem.2016.12.013","article-title":"Human iPSC-Derived neural progenitors are an effective drug discovery model for neurological mtDNA disorders","volume":"20","author":"Lorenz","year":"2017","journal-title":"Cell Stem Cell"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"5702","DOI":"10.1038\/s41380-021-01068-3","article-title":"Brain cells derived from Alzheimer\u2019s disease patients have multiple specific innate abnormalities in energy metabolism","volume":"26","author":"Ryu","year":"2021","journal-title":"Mol. Psychiatry"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1979","DOI":"10.1002\/jnr.22650","article-title":"Adaptation of microplate-based respirometry for hippocampal slices and analysis of respiratory capacity","volume":"89","author":"Schuh","year":"2011","journal-title":"J. Neurosci. Res."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"11696","DOI":"10.1073\/pnas.1500624112","article-title":"Parkin loss leads to PARIS-dependent declines in mitochondrial mass and respiration","volume":"112","author":"Stevens","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"104502","DOI":"10.1016\/j.nbd.2019.104502","article-title":"Mitochondrial biogenesis is altered in HIV+ brains exposed to ART: Implications for therapeutic targeting of astroglia","volume":"130","author":"Swinton","year":"2019","journal-title":"Neurobiol. Dis."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/j.stemcr.2017.01.022","article-title":"Reversal of phenotypic abnormalities by crispr\/cas9-mediated gene correction in Huntington disease patient-derived induced pluripotent stem cells","volume":"8","author":"Xu","year":"2017","journal-title":"Stem Cell Rep."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"14670","DOI":"10.1073\/pnas.0903563106","article-title":"Mitochondrial bioenergetic deficit precedes Alzheimer\u2019s pathology in female mouse model of Alzheimer\u2019s disease","volume":"106","author":"Yao","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1084\/jem.20171068","article-title":"4-1BB costimulation induces T cell mitochondrial function and biogenesis enabling cancer immunotherapeutic responses","volume":"215","author":"Menk","year":"2018","journal-title":"J. Exp. Med."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.cell.2016.05.035","article-title":"Mitochondrial dynamics controls T cell fate through metabolic programming","volume":"166","author":"Buck","year":"2016","journal-title":"Cell"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1038\/nature08097","article-title":"Enhancing CD8 T-cell memory by modulating fatty acid metabolism","volume":"460","author":"Pearce","year":"2009","journal-title":"Nature"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.canlet.2020.12.004","article-title":"A metabolic switch to memory CAR T cells: Implications for cancer treatment","volume":"500","author":"Rostamian","year":"2021","journal-title":"Cancer Lett."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"690437","DOI":"10.3389\/fimmu.2021.690437","article-title":"Bispecific Antibody Armed Metabolically Enhanced Headless CAR T Cells","volume":"12","author":"Thakur","year":"2012","journal-title":"Front. Immunol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"2007","DOI":"10.1007\/s00432-020-03260-4","article-title":"Enhanced cytotoxicity against solid tumors by bispecific antibody-armed CD19 CAR T cells: A proof-of-concept study","volume":"146","author":"Thakur","year":"2020","journal-title":"J. Cancer Res. Clin. Oncol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"285193","DOI":"10.1155\/2015\/285193","article-title":"Phase I Study of Anti-CD3 x Anti-Her2 Bispecific Antibody in Metastatic Castrate Resistant Prostate Cancer Patients","volume":"2015","author":"Vaishampayan","year":"2015","journal-title":"Prostate Cancer"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"2455","DOI":"10.1056\/NEJMoa1200694","article-title":"Safety and activity of Anti-PD-L1 antibody in patients with advanced cancer","volume":"366","author":"Brahmer","year":"2012","journal-title":"N. Engl. J. Med."},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Stirling, E.R., Bronson, S.M., Mackert, J.D., Cook, K.L., Triozzi, P.L., and Soto-Pantoja, D.R. (2022). Metabolic Implications of Immune Checkpoint Proteins in Cancer. Cells, 11.","DOI":"10.3390\/cells11010179"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1002\/eji.201445388","article-title":"Deciphering CD137 (4-1BB) signaling in T-cell costimulation for translation into successful cancer immunotherapy","volume":"46","author":"Labiano","year":"2016","journal-title":"Eur. J. Immunol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1016\/j.ccell.2020.05.004","article-title":"Multi-phenotype CRISPR-Cas9 screen identifies p38 kinase as a target for adoptive immunotherapies","volume":"37","author":"Gurusamy","year":"2020","journal-title":"Cancer Cell"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1038\/ni.3415","article-title":"Emerging concepts of T cell metabolism as a target of immunotherapy","volume":"17","author":"Chang","year":"2016","journal-title":"Nat. Immunol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1084\/jem.20151570","article-title":"Immunometabolism governs dendritic cell and macrophage function","volume":"213","author":"Pearce","year":"2016","journal-title":"J. Exp. Med."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"1242454","DOI":"10.1126\/science.1242454","article-title":"Fueling immunity: Insights into metabolism and lymphocyte function","volume":"342","author":"Pearce","year":"2013","journal-title":"Science"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"4479","DOI":"10.1172\/JCI69589","article-title":"Inhibiting glycolytic metabolism enhances CD8+ T cell memory and antitumor function","volume":"123","author":"Sukumar","year":"2013","journal-title":"J. Clin. Investig."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"9543","DOI":"10.1128\/MCB.25.21.9543-9553.2005","article-title":"CTLA-4 and PD-1 receptors inhibit T-cell activation by distinct mechanisms","volume":"25","author":"Parry","year":"2005","journal-title":"Mol. Cell Biol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"6692","DOI":"10.1038\/ncomms7692","article-title":"PD-1 alters T-cell metabolic reprogramming by inhibiting glycolysis and promoting lipolysis and fatty acid oxidation","volume":"6","author":"Patsoukis","year":"2015","journal-title":"Nat. Commun."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"174803","DOI":"10.1016\/j.ejphar.2022.174803","article-title":"Gamma delta (gammadelta) T cells in cancer immunotherapy; where it comes from, where it will go?","volume":"919","author":"Deng","year":"2022","journal-title":"Eur. J. Pharmacol."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.3389\/fimmu.2020.01347","article-title":"Gamma-Delta CAR-T Cells Show CAR-Directed and Independent Activity Against Leukemia","volume":"11","author":"Rozenbaum","year":"2020","journal-title":"Front. Immunol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"101569","DOI":"10.1016\/j.tice.2021.101569","article-title":"Glutamine metabolism is essential for the production of IL-17A in gammadelta T cells and skin inflammation","volume":"71","author":"Li","year":"2021","journal-title":"Tissue Cell"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1007\/s00262-018-2144-x","article-title":"CD137L dendritic cells induce potent response against cancer-associated viruses and polarize human CD8+ T cells to Tc1 phenotype","volume":"67","author":"Dharmadhikari","year":"2018","journal-title":"Cancer Immunol. Immunother."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1016\/j.cmet.2021.03.023","article-title":"Metabolic flexibility determines human NK cell functional fate in the tumor microenvironment","volume":"33","author":"Poznanski","year":"2021","journal-title":"Cell Metab."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"1656","DOI":"10.1038\/s41590-019-0511-1","article-title":"Mitochondrial fragmentation limits NK cell-based tumor immunosurveillance","volume":"20","author":"Zheng","year":"2019","journal-title":"Nat. Immunol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.stem.2020.05.008","article-title":"Metabolic reprograming via deletion of CISH in human iPSC-Derived NK cells promotes in vivo persistence and enhances anti-tumor activity","volume":"27","author":"Zhu","year":"2020","journal-title":"Cell Stem Cell"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"4817","DOI":"10.1182\/blood-2011-04-348540","article-title":"Safety and persistence of adoptively transferred autologous CD19-targeted T cells in patients with relapsed or chemotherapy refractory B-cell leukemias","volume":"118","author":"Brentjens","year":"2011","journal-title":"Blood"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"2386187","DOI":"10.1155\/2018\/2386187","article-title":"Immunotherapy with CAR-Modified T Cells: Toxicities and Overcoming Strategies","volume":"2018","author":"Sun","year":"2018","journal-title":"J. Immunol. Res."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1007\/s12026-021-09236-x","article-title":"Chimeric antigen receptor (CAR) immunotherapy: Basic principles, current advances, and future prospects in neuro-oncology","volume":"69","author":"Yoo","year":"2021","journal-title":"Immunol. Res."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1038\/gt.2010.91","article-title":"Adoptive immunotherapy with genetically engineered T cells: Modification of the IgG1 Fc \u2018spacer\u2019 domain in the extracellular moiety of chimeric antigen receptors avoids \u2018off-target\u2019 activation and unintended initiation of an innate immune response","volume":"17","author":"Hombach","year":"2010","journal-title":"Gene. Ther."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1007\/s00262-011-1116-1","article-title":"A Th1 cytokine-enriched microenvironment enhances tumor killing by activated T cells armed with bispecific antibodies and inhibits the development of myeloid-derived suppressor cells","volume":"61","author":"Thakur","year":"2012","journal-title":"Cancer Immunol. Immunother."},{"key":"ref_89","doi-asserted-by":"crossref","unstructured":"Elesela, S., Morris, S.B., Narayanan, S., Kumar, S., Lombard, D.B., and Lukacs, N.W. (2020). Sirtuin 1 regulates mitochondrial function and immune homeostasis in respiratory syncytial virus infected dendritic cells. PLoS Pathog., 16.","DOI":"10.1371\/journal.ppat.1008319"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"3981","DOI":"10.1172\/jci.insight.120722","article-title":"SIRT3 diminishes inflammation and mitigates endotoxin-induced acute lung injury","volume":"4","author":"Kurundkar","year":"2019","journal-title":"JCI Insight."}],"container-title":["Antibodies"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2073-4468\/11\/2\/32\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T23:04:52Z","timestamp":1760137492000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2073-4468\/11\/2\/32"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,30]]},"references-count":90,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2022,6]]}},"alternative-id":["antib11020032"],"URL":"https:\/\/doi.org\/10.3390\/antib11020032","relation":{},"ISSN":["2073-4468"],"issn-type":[{"type":"electronic","value":"2073-4468"}],"subject":[],"published":{"date-parts":[[2022,4,30]]}}}