{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T19:10:56Z","timestamp":1791486656455,"version":"4.3.4"},"reference-count":76,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2023,2,24]],"date-time":"2023-02-24T00:00:00Z","timestamp":1677196800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antibodies"],"abstract":"<jats:p>Flaviviruses are enveloped RNA viruses from the family Flaviviridae that comprise many important human pathogenic arboviruses such as Yellow Fever, Dengue, and Zika viruses. Because they belong to the same genus, these viruses show sequence and structural homology among them, which results in serological cross-reactivity. Upon infection, the immune system produces both species-specific and cross-reactive antibodies, and depending on the virus, in a successive flavivirus infection, cross-reactive antibodies either enhance protection or exacerbate the disease\u2014the latter usually due to antibody-dependent enhancement. These antigenic relationships between different flaviviruses that lead to serological cross-reactivity make them difficult to be identified through serological methods, especially when it comes to successive flavivirus infections. We present here an overview of the main structural, epidemiological, and immunological aspects of flaviviruses, highlighting the role of neutralizing antibodies in fighting viral infections and in the \u201coriginal antigenic sin\u201d problem. Finally, we draw attention to the importance of developing a rapid serological diagnostic test for flaviviruses with high sensitivity and specificity, especially when considering that cross-reactive immunity can influence the outcome of these infections.<\/jats:p>","DOI":"10.3390\/antib12010018","type":"journal-article","created":{"date-parts":[[2023,2,27]],"date-time":"2023-02-27T02:04:11Z","timestamp":1677463451000},"page":"18","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Serological Cross-Reactivity in Zoonotic Flaviviral Infections of Medical Importance"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8384-0640","authenticated-orcid":false,"given":"Priscilla","family":"Gomes da Silva","sequence":"first","affiliation":[{"name":"ICBAS\u2014School of Medicine and Biomedical Sciences, Porto University, 4050-313 Porto, Portugal"},{"name":"Epidemiology Research Unit (EPIunit), Institute of Public Health, Porto University, 4050-600 Porto, Portugal"},{"name":"Laborat\u00f3rio para a Investiga\u00e7\u00e3o Integrativa e Translacional em Sa\u00fade Populacional (ITR), 4050-600 Porto, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Augusto","family":"Seixas dos Reis","sequence":"additional","affiliation":[{"name":"Centro Universit\u00e1rio Fametro, Manaus 69050-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1495-2681","authenticated-orcid":false,"given":"Marcio","family":"Nogueira Rodrigues","sequence":"additional","affiliation":[{"name":"Centro Universit\u00e1rio Fametro, Manaus 69050-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qu\u00e9zia","family":"da Silva Ardaya","sequence":"additional","affiliation":[{"name":"Centro Universit\u00e1rio Fametro, Manaus 69050-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8769-8103","authenticated-orcid":false,"given":"Jo\u00e3o Rodrigo","family":"Mesquita","sequence":"additional","affiliation":[{"name":"ICBAS\u2014School of Medicine and Biomedical Sciences, Porto University, 4050-313 Porto, Portugal"},{"name":"Epidemiology Research Unit (EPIunit), Institute of Public Health, Porto University, 4050-600 Porto, Portugal"},{"name":"Laborat\u00f3rio para a Investiga\u00e7\u00e3o Integrativa e Translacional em Sa\u00fade Populacional (ITR), 4050-600 Porto, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,2,24]]},"reference":[{"key":"ref_1","unstructured":"Payne, S. 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