{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:31:03Z","timestamp":1787027463089,"version":"build-2736575974"},"reference-count":84,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2024,11,29]],"date-time":"2024-11-29T00:00:00Z","timestamp":1732838400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antibodies"],"abstract":"<jats:p>Background\/Objectives: Salivary immunoglobulin A (IgA) is a mediator of local immunity and host defence. Altered IgA levels may predispose to bacterial invasion of the mucosa in the gastrointestinal tract, including the oral cavity. Our study aimed to present the diagnostic trends related to salivary IgA in health and disease based on a bibliometric analysis of published papers between 2009 and 2024. Methods: By 14 September 2024, 1247 English original articles were found in the database Web of Science. We selected 838 records considering the diagnostic usefulness of IgA in human subjects. Based on bibliographic data, we created citation and keyword co-occurrence maps using VOSviewer 1.6.20. Results: Most articles belonged to the \u201cSport Sciences\u201d category (n = 169), followed by the \u201cImmunology\u201d category (n = 93). The Brazilian researcher Alexandre Moreira from the University of Sao Paulo had the most published and most frequently cited papers. Most of the included articles came from the USA (n = 158), England (n = 105), Brazil (n = 95), and Japan (n = 95). The most cited article described research on IgA in response to SARS-CoV-2 infection (n = 690), but the subsequent two papers considered the role of salivary IgA in the dysbiosis of the intestinal microbiota in inflammatory bowel diseases (n = 272) and the formation of systemic immune responses from the gastrointestinal tract (n = 245). Conclusions: Salivary IgA is a widely evaluated diagnostic marker in both patients and healthy individuals. Numerous reports have identified its changes as a result of physical exertion in various groups of athletes, during infections (including SARS-CoV-2) and in the course of local diseases (e.g., periodontal disease) or systemic diseases (e.g., inflammatory bowel disease).<\/jats:p>","DOI":"10.3390\/antib13040098","type":"journal-article","created":{"date-parts":[[2024,12,4]],"date-time":"2024-12-04T11:03:08Z","timestamp":1733310188000},"page":"98","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Salivary Immunoglobulin a Alterations in Health and Disease: A Bibliometric Analysis of Diagnostic Trends from 2009 to 2024"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-0580-8921","authenticated-orcid":false,"given":"Jakub","family":"Jankowski","sequence":"first","affiliation":[{"name":"Department of Conservative Dentistry and Endodontics, Poznan University of Medical Sciences, 60-812 Poznan, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5042-5985","authenticated-orcid":false,"given":"Kacper","family":"Nijakowski","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry and Endodontics, Poznan University of Medical Sciences, 60-812 Poznan, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,11,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1080\/1354750X.2016.1265009","article-title":"The Utility of Saliva for the Assessment of Anti-Pneumococcal Antibodies: Investigation of Saliva as a Marker of Antibody Status in Serum","volume":"23","author":"Heaney","year":"2018","journal-title":"Biomarkers"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.bbi.2018.09.011","article-title":"Negative and Positive Affect as Predictors of Inflammation: Timing Matters","volume":"74","author":"Sin","year":"2018","journal-title":"Brain. Behav. Immun."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Brandtzaeg, P. (2013). Secretory Immunity with Special Reference to the Oral Cavity. J. Oral Microbiol., 5.","DOI":"10.3402\/jom.v5i0.20401"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1016\/j.bbi.2024.04.039","article-title":"Timing Matters: A Meta-Analysis on the Dynamic Effect of Stress on Salivary Immunoglobulin","volume":"119","author":"Seizer","year":"2024","journal-title":"Brain. Behav. Immun."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.bbi.2015.08.017","article-title":"Psychological Distress and Salivary Secretory Immunity","volume":"52","author":"Engeland","year":"2016","journal-title":"Brain. Behav. Immun."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/S0074-7742(02)52011-0","article-title":"Stress and Secretory Immunity","volume":"Volume 52","author":"Bosch","year":"2002","journal-title":"International Review of Neurobiology"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.ijom.2016.10.005","article-title":"Relationship between Salivary Biomarkers and Postoperative Swelling after the Extraction of Impacted Lower Third Molars","volume":"46","year":"2017","journal-title":"Int. J. Oral Maxillofac. Surg."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/S0917-2394(04)70017-8","article-title":"Circadian Rhythms of S-IgA and Cortisol in Whole Saliva\u2014Compensatory Mechanism of Oral Immune System for Nocturnal Fall of Saliva Secretion","volume":"14","author":"Shirakawa","year":"2004","journal-title":"Pediatr. Dent. J."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.tem.2009.12.011","article-title":"Interactions of the Circadian CLOCK System and the HPA Axis","volume":"21","author":"Nader","year":"2010","journal-title":"Trends Endocrinol. Metab."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1203\/PDR.0b013e318232169e","article-title":"Slow Salivary Secretory IgA Maturation May Relate to Low Microbial Pressure and Allergic Symptoms in Sensitised Children","volume":"70","author":"Fageras","year":"2011","journal-title":"Pediatr. Res."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1590\/S1806-83242010000100004","article-title":"Salivary IgA and IgE Levels in Healthy Subjects: Relation to Age and Gender","volume":"24","author":"Jafarzadeh","year":"2010","journal-title":"Braz. Oral Res."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1177\/0022034520915486","article-title":"Salivary Factors That Maintain the Normal Oral Commensal Microflora","volume":"99","author":"Carpenter","year":"2020","journal-title":"J. Dent. Res."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"G807","DOI":"10.1152\/ajpgi.00243.2009","article-title":"Probiotic Bacteria and Intestinal Epithelial Barrier Function","volume":"298","author":"Ohland","year":"2010","journal-title":"Am. J. Physiol.-Gastrointest. Liver Physiol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.maturitas.2013.02.004","article-title":"Probiotics and Prebiotics and Health in Ageing Populations","volume":"75","author":"Duncan","year":"2013","journal-title":"Maturitas"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"4586","DOI":"10.1073\/pnas.1000097107","article-title":"Composition, Variability, and Temporal Stability of the Intestinal Microbiota of the Elderly","volume":"108","author":"Claesson","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"581","DOI":"10.3357\/ASEM.2705.2010","article-title":"Considerations for the Use of Salivary IgA for Monitoring Mucosal Immune Function","volume":"81","author":"Dwyer","year":"2010","journal-title":"Aviat. Space Environ. Med."},{"key":"ref_17","first-page":"5","article-title":"Mucosal Immune Responses and Risk of Respiratory Illness in Elite Athletes","volume":"6","author":"Gleeson","year":"2000","journal-title":"Exerc. Immunol. Rev."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.7205\/MILMED.172.9.1006","article-title":"Effect of a Probiotics Supplementation on Respiratory Infections and Immune and Hormonal Parameters during Intense Military Training","volume":"172","author":"Tiollier","year":"2007","journal-title":"Mil. Med."},{"key":"ref_19","first-page":"1203","article-title":"Salivary Immunoglobulin-A as a Marker of Stress during Strenuous Physical Training","volume":"73","author":"Carins","year":"2002","journal-title":"Aviat. Space Environ. Med."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"4444","DOI":"10.2741\/3540","article-title":"Acute and Chronic Effects of Exercise on Markers of Mucosal Immunity","volume":"14","author":"Bishop","year":"2009","journal-title":"Front. Biosci.-Landmark"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"eabd2223","DOI":"10.1126\/scitranslmed.abd2223","article-title":"IgA Dominates the Early Neutralizing Antibody Response to SARS-CoV-2","volume":"13","author":"Sterlin","year":"2021","journal-title":"Sci. Transl. Med."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/dnares\/dst037","article-title":"Dysbiosis of Salivary Microbiota in Inflammatory Bowel Disease and Its Association With Oral Immunological Biomarkers","volume":"21","author":"Said","year":"2014","journal-title":"DNA Res."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1842","DOI":"10.1111\/j.1365-2222.2009.03326.x","article-title":"Influence of Early Gut Microbiota on the Maturation of Childhood Mucosal and Systemic Immune Responses","volume":"39","author":"Sjogren","year":"2009","journal-title":"Clin. Exp. Allergy"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1248\/bpb.34.13","article-title":"Proteomic analysis of two types of exosomes in human whole saliva","volume":"34","author":"Ogawa","year":"2011","journal-title":"Biol. Pharm. Bull."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1123\/ijsnem.21.1.55","article-title":"Daily probiotic\u2019s (Lactobacillus casei Shirota) reduction of infection incidence in athletes","volume":"21","author":"Gleeson","year":"2011","journal-title":"Int. J. Sport Nutr. Exerc. Metab."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Randad, P.R., Pisanic, N., Kruczynski, K., Manabe, Y.C., Thomas, D., Pekosz, A., Klein, S.L., Betenbaugh, M.J., Clarke, W.A., and Laeyendecker, O. (2021). COVID-19 Serology at Population Scale: SARS-CoV-2-Specific Antibody Responses in Saliva. J. Clin. Microbiol.","DOI":"10.1101\/2020.05.24.20112300"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1136\/bjsm.2007.044628","article-title":"Oral administration of the probiotic Lactobacillus fermentum VRI-003 and mucosal immunity in endurance athletes","volume":"44","author":"Cox","year":"2010","journal-title":"Br. J. Sports Med."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Roda, A., Cavalera, S., Di Nardo, F., Calabria, D., Rosati, S., Simoni, P., Colitti, B., Baggiani, C., Roda, M., and Anfossi, L. (2021). Dual Lateral Flow Optical\/Chemiluminescence Immunosensors for the Rapid Detection of Salivary and Serum IgA in Patients with COVID-19 Disease. Biosens. Bioelectron., 172.","DOI":"10.1016\/j.bios.2020.112765"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1111\/j.1600-0838.2010.01272.x","article-title":"Respiratory Infection Risk in Athletes: Association with Antigen-Stimulated IL-10 Production and Salivary IgA Secretion","volume":"22","author":"Gleeson","year":"2012","journal-title":"Scand. J. Med. Sci. Sports"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"2783","DOI":"10.1519\/JSC.0b013e318241e174","article-title":"Muscle damage, endocrine, and immune marker response to a soccer match","volume":"26","author":"Thorpe","year":"2012","journal-title":"J. Strength Cond. Res."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1017\/S0007114513004261","article-title":"Xylo-oligosaccharides alone or in synbiotic combination with Bifidobacterium animalis subsp. lactis induce bifidogenesis and modulate markers of immune function in healthy adults: A double-blind, placebo-controlled, randomised, factorial cross-over study","volume":"111","author":"Childs","year":"2014","journal-title":"Br. J. Nutr."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Aan\u00e6s, K. (2013). Bacterial sinusitis can be a focus for ini-tial lung colonisation and chronic lung infection in patients with cystic fibrosis. J. Cyst. Fibros.","DOI":"10.1016\/S1569-1993(13)00150-1"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/s12979-015-0051-y","article-title":"Probiotic Strain Bacillus Subtilis CU1 Stimulates Immune System of Elderly during Common Infectious Disease Period: A Randomised, Double-Blind Placebo-Controlled Study","volume":"12","author":"Lefevre","year":"2015","journal-title":"Immun. Ageing"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"5135","DOI":"10.1038\/s41467-022-32389-8","article-title":"SARS-CoV-2 Vaccination Induces Mucosal Antibody Responses in Previously Infected Individuals","volume":"13","author":"Sano","year":"2022","journal-title":"Nat. Commun."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1111\/eos.12182","article-title":"Interindividual variation, correlations, and sex-related differences in the salivary biochemistry of young healthy adults","volume":"123","author":"Prodan","year":"2015","journal-title":"Eur. J. Oral Sci."},{"key":"ref_36","first-page":"285","article-title":"Plasma Glutamine and Upper Respiratory Tract Infection during Intensified Training in Swimmers","volume":"28","author":"Mackinnon","year":"1996","journal-title":"Med. Sci. Sports Exerc."},{"key":"ref_37","first-page":"8","article-title":"Sex Differences in Upper Respiratory Symptoms Prevalence and Oral-Respiratory Mucosal Immunity in Endurance Athletes","volume":"20","author":"He","year":"2014","journal-title":"Exerc. Immunol. Rev."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"2569","DOI":"10.1519\/JSC.0b013e31827fd85c","article-title":"Salivary Hormones, IgA, and Performance During Intense Training and Tapering in Judo Athletes","volume":"27","author":"Papacosta","year":"2013","journal-title":"J. Strength Cond. Res."},{"key":"ref_39","first-page":"6","article-title":"Position Statement. Part One: Immune Function and Exercise","volume":"17","author":"Walsh","year":"2011","journal-title":"Exerc. Immunol. Rev."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1055\/s-2003-42018","article-title":"Immune and Oxidative Changes During and Following the Western States Endurance Run","volume":"24","author":"Nieman","year":"2003","journal-title":"Int. J. Sports Med."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1139\/apnm-2015-0242","article-title":"Mucosal Immunity and Upper Respiratory Tract Symptoms in Recreational Endurance Runners","volume":"41","author":"Ihalainen","year":"2016","journal-title":"Appl. Physiol. Nutr. Metab."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1249\/MSS.0b013e3181ef9d6b","article-title":"Mucosal Immunity and Illness Incidence in Elite Rugby Union Players across a Season","volume":"43","author":"Cunniffe","year":"2011","journal-title":"Med. Sci. Sports Exerc."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/s40750-015-0028-2","article-title":"Before, During, and After: How Phases of Competition Differentially Affect Testosterone, Cortisol, and Estradiol Levels in Women Athletes","volume":"2","author":"Casto","year":"2016","journal-title":"Adapt. Hum. Behav. Physiol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1111\/cei.13500","article-title":"Characteristics and Roles of Severe Acute Respiratory Syndrome Coronavirus 2-Specific Antibodies in Patients with Different Severities of Coronavirus 19","volume":"202","author":"Huang","year":"2020","journal-title":"Clin. Exp. Immunol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1094.e7","DOI":"10.1016\/j.cmi.2020.05.028","article-title":"Comparison of Diagnostic Accuracies of Rapid Serological Tests and ELISA to Molecular Diagnostics in Patients with Suspected Coronavirus Disease 2019 Presenting to the Hospital","volume":"26","author":"Ong","year":"2020","journal-title":"Clin. Microbiol. Infect."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"6472","DOI":"10.1016\/j.vaccine.2016.11.008","article-title":"Modular Virus-like Particles for Sublingual Vaccination against Group A Streptococcus","volume":"34","author":"Seth","year":"2016","journal-title":"Vaccine"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1016\/j.jdent.2018.08.010","article-title":"The Role of Natural Salivary Defences in Maintaining a Healthy Oral Microbiota","volume":"80","author":"Pedersen","year":"2019","journal-title":"J. Dent."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1111\/idh.12311","article-title":"Influence of a Preschool Preventive Dental Programme on Caries Prevalence, Oral Care and Secretory Immunity to Streptococcus mutans in Young Adults","volume":"16","author":"Aida","year":"2018","journal-title":"Int. J. Dent. Hyg."},{"key":"ref_49","first-page":"ZC61","article-title":"Salivary IgA versus HIV and Dental Caries","volume":"10","author":"Mandal","year":"2016","journal-title":"J. Clin. Diagn. Res."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.riam.2011.07.004","article-title":"Phosphoglycerate Kinase and Fructose Bisphosphate Aldolase of Candida albicans as New Antigens Recognised by Human Salivary IgA","volume":"29","author":"Calcedo","year":"2012","journal-title":"Rev. Iberoam. Micol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.archoralbio.2014.08.003","article-title":"Salivary Antibody Response to Streptococci in Preterm and Fullterm Children: A Prospective Study","volume":"60","author":"Borges","year":"2015","journal-title":"Arch. Oral Biol."},{"key":"ref_52","first-page":"10","article-title":"Comparison of Salivary IgA Levels in Caries Free and Caries Active Children","volume":"2","author":"Doifode","year":"2011","journal-title":"Int. J. Clin. Dent. Sci."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1111\/adj.12059","article-title":"Association of Dental Caries and Salivary sIgA with Tobacco Smoking","volume":"58","author":"Zakavi","year":"2013","journal-title":"Aust. Dent. J."},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Parizi, M.K., Akbari, H., Malek-mohamadi, M., Parizi, M.K., and Kakoei, S. (2019). Association of Salivary Levels of Immunoglobulin-a and Amylase with Oral-Dental Manifestations in Patients with Controlled and Non-Controlled Type 2 Diabetes. BMC Oral Health, 19.","DOI":"10.1186\/s12903-019-0868-4"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1111\/jop.12345","article-title":"Oral Lichen Planus: Salival Biomarkers Cortisol, Immunoglobulin A, Adiponectin","volume":"45","author":"Tvarijonaviciute","year":"2016","journal-title":"J. Oral Pathol. Med."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1111\/jop.12350","article-title":"Characteristic Changes of Saliva and Taste in Burning Mouth Syndrome Patients","volume":"45","author":"Imura","year":"2016","journal-title":"J. Oral Pathol. Med."},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Lopez-Jornet, P., Castillo Felipe, C., Pardo-Marin, L., Ceron, J.J., Pons-Fuster, E., and Tvarijonaviciute, A. (2020). Salivary Biomarkers and Their Correlation with Pain and Stress in Patients with Burning Mouth Syndrome. J. Clin. Med., 9.","DOI":"10.3390\/jcm9040929"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.jpain.2003.09.002","article-title":"Sialochemical and Gustatory Analysis in Patients with Oral Sensory Complaints","volume":"5","author":"Nagler","year":"2004","journal-title":"J. Pain"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/j.jpain.2005.03.010","article-title":"Association Between Regional Idiopathic Neuropathy and Salivary Involvement as the Possible Mechanism for Oral Sensory Complaints","volume":"6","author":"Granot","year":"2005","journal-title":"J. Pain"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/j.archoralbio.2004.01.012","article-title":"Biochemical Analysis of Saliva and Taste Acuity Evaluation in Patients with Burning Mouth Syndrome, Xerostomia and\/or Gustatory Disturbances","volume":"49","author":"Hershkovich","year":"2004","journal-title":"Arch. Oral Biol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1016\/j.archoralbio.2009.04.003","article-title":"The Role of Salivary Factors in Persistent Oral Carriage of Candida in Humans","volume":"54","author":"Hibino","year":"2009","journal-title":"Arch. Oral Biol."},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Nijakowski, K., Rutkowski, R., Eder, P., Korybalska, K., Witowski, J., and Surdacka, A. (2021). Changes in Salivary Parameters of Oral Immunity after Biologic Therapy for Inflammatory Bowel Disease. Life, 11.","DOI":"10.3390\/life11121409"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/BF02939578","article-title":"Salivary SIgA and SIgA 1 in Coeliac Disease, Inflammatory Bowel Disease and Controls","volume":"168","author":"Warner","year":"1999","journal-title":"Ir. J. Med. Sci."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1111\/odi.13537","article-title":"Salivary Changes in Oxidative Stress Related to Inflammation in Oral and Gastrointestinal Diseases","volume":"27","author":"Jansakova","year":"2021","journal-title":"Oral Dis."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"49","DOI":"10.4103\/0973-029X.92973","article-title":"Determination of Levels of Salivary IgA Subclasses in Patients with Minor Recurrent Aphthous Ulcer","volume":"16","author":"Saluja","year":"2012","journal-title":"J. Oral Maxillofac. Pathol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1097\/MEG.0b013e3283583e5c","article-title":"The Trend in Newly Diagnosed Crohn\u2019s Disease and Extraintestinal Manifestations of Crohn\u2019s Disease in Central China: A Retrospective Study of a Single Center","volume":"24","author":"Yi","year":"2012","journal-title":"Eur. J. Gastroenterol. Hepatol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1097\/MPG.0b013e3181ca4db4","article-title":"Extraintestinal Manifestations of Pediatric Inflammatory Bowel Disease and Their Relation to Disease Type and Severity","volume":"51","author":"Dotson","year":"2010","journal-title":"J. Pediatr. Gastroenterol. Nutr."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1038\/mi.2015.107","article-title":"Salivary IgA from the Sublingual Compartment as a Novel Noninvasive Proxy for Intestinal Immune Induction","volume":"9","author":"Aase","year":"2016","journal-title":"Mucosal Immunol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1016\/j.psyneuen.2010.02.001","article-title":"Child Care Setting Affects Salivary Cortisol and Antibody Secretion in Young Children","volume":"35","author":"Watamura","year":"2010","journal-title":"Psychoneuroendocrinology"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.ejphar.2007.11.071","article-title":"Central Effects of Stress Hormones in Health and Disease: Understanding the Protective and Damaging Effects of Stress and Stress Mediators","volume":"583","author":"McEwen","year":"2008","journal-title":"Eur. J. Pharmacol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1016\/j.psyneuen.2011.02.018","article-title":"Investigation into the Cross-Correlation of Salivary Cortisol and Alpha-Amylase Responses to Psychological Stress","volume":"36","author":"Engert","year":"2011","journal-title":"Psychoneuroendocrinology"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"366","DOI":"10.3109\/10253891003615473","article-title":"Academic Stress Differentially Influences Perceived Stress, Salivary Cortisol, and Immunoglobulin-A in Undergraduate Students","volume":"13","author":"Murphy","year":"2010","journal-title":"Stress. Int. J. Biol. Stress"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"221","DOI":"10.2220\/biomedres.29.221","article-title":"The Effects of Examination Stress on Salivary Cortisol, Immunoglobulin A, and Chromogranin A in Nursing Students","volume":"29","author":"Takatsuji","year":"2008","journal-title":"Biomed. Res."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1016\/j.physbeh.2011.10.014","article-title":"Effects of Psychosocial Stress on the Pattern of Salivary Protein Release","volume":"105","author":"Trueba","year":"2012","journal-title":"Physiol. Behav."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1007\/s12291-012-0213-z","article-title":"Antarctic Harsh Environment as Natural Stress Model: Impact on Salivary Immunoglobulins, Transforming Growth Factor-\u03b2 and Cortisol Level","volume":"27","author":"Mishra","year":"2012","journal-title":"Indian J. Clin. Biochem."},{"key":"ref_76","doi-asserted-by":"crossref","unstructured":"Gong, W., Qiao, Y., Li, B., Zheng, X., Xu, R., Wang, M., Mi, X., and Li, Y. (2021). The Alteration of Salivary Immunoglobulin A in Autism Spectrum Disorders. Front. Psychiatry, 12.","DOI":"10.3389\/fpsyt.2021.669193"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1080\/15622975.2019.1593502","article-title":"Is There a Link between Stress and Immune Biomarkers and Salivary Opiorphin in Patients with a Restrictive-Type of Anorexia Nervosa?","volume":"21","author":"Paszynska","year":"2020","journal-title":"World J. Biol. Psychiatry"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"418","DOI":"10.3357\/ASEM.3162.2012","article-title":"Transient Immune Impairment After a Simulated Long-Haul Flight","volume":"83","author":"Mustafa","year":"2012","journal-title":"Aviat. Space Environ. Med."},{"key":"ref_79","doi-asserted-by":"crossref","unstructured":"Buchheim, J.-I., Matzel, S., Rykova, M., Vassilieva, G., Ponomarev, S., Nichiporuk, I., H\u00f6rl, M., Moser, D., Biere, K., and Feuerecker, M. (2019). Stress Related Shift Toward Inflammaging in Cosmonauts After Long-Duration Space Flight. Front. Physiol., 10.","DOI":"10.3389\/fphys.2019.00085"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1007\/s10875-012-9824-7","article-title":"Immune System Dysregulation Occurs During Short Duration Spaceflight on Board the Space Shuttle","volume":"33","author":"Crucian","year":"2013","journal-title":"J. Clin. Immunol."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"15013","DOI":"10.1038\/npjmgrav.2015.13","article-title":"Alterations in Adaptive Immunity Persist during Long-Duration Spaceflight","volume":"1","author":"Crucian","year":"2015","journal-title":"npj Microgravity"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.bbi.2014.05.014","article-title":"Multiple Latent Viruses Reactivate in Astronauts during Space Shuttle Missions","volume":"41","author":"Mehta","year":"2014","journal-title":"Brain. Behav. Immun."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/s41526-017-0015-y","article-title":"Latent Virus Reactivation in Astronauts on the International Space Station","volume":"3","author":"Mehta","year":"2017","journal-title":"npj Microgravity"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1152\/japplphysiol.00560.2019","article-title":"Salivary Antimicrobial Proteins and Stress Biomarkers Are Elevated during a 6-Month Mission to the International Space Station","volume":"128","author":"Agha","year":"2020","journal-title":"J. Appl. Physiol."}],"container-title":["Antibodies"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2073-4468\/13\/4\/98\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T16:42:56Z","timestamp":1760114576000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2073-4468\/13\/4\/98"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,29]]},"references-count":84,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["antib13040098"],"URL":"https:\/\/doi.org\/10.3390\/antib13040098","relation":{},"ISSN":["2073-4468"],"issn-type":[{"value":"2073-4468","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,29]]}}}