{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,9]],"date-time":"2025-11-09T05:27:00Z","timestamp":1762666020341,"version":"build-2065373602"},"reference-count":74,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T00:00:00Z","timestamp":1762473600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Virgen de la Arrixaca University Clinic Hospital","award":["PI19\/01194"],"award-info":[{"award-number":["PI19\/01194"]}]},{"DOI":"10.13039\/100008061","name":"\u201cMutua Madrile\u00f1a\u201d Foundation","doi-asserted-by":"crossref","award":["AP183152023"],"award-info":[{"award-number":["AP183152023"]}],"id":[{"id":"10.13039\/100008061","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antibodies"],"abstract":"<jats:p>B cells have attracted increasing interest in the field of organ transplantation due to their newly discovered immunoregulatory properties in alloimmune responses. Traditionally, B cells have been primarily associated with adaptive immunity to foreign substances and alloreactive immune response to allografts, differentiating into antibody-producing plasma cells or memory cells upon antigen recognition and T cell collaboration. However, the existence of B cells with regulatory functions (Bregs) in humans has been widely confirmed, highlighting the presence of this subset, which has immunosuppressive properties and which might contribute to allograft tolerance, within the B cell compartment in humans and mice. In this mini review, we summarize all the information available in the published reports about the role of regulatory B cells in solid organ transplantation.<\/jats:p>","DOI":"10.3390\/antib14040095","type":"journal-article","created":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T14:55:15Z","timestamp":1762527315000},"page":"95","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Influence and Role of Regulatory B Cells in Organ Transplantation: The State of the Art, Prospects, and Emerging Insights"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-0567-648X","authenticated-orcid":false,"given":"Marina","family":"Fern\u00e1ndez-Gonz\u00e1lez","sequence":"first","affiliation":[{"name":"Immunology Service, University Clinical Hospital Virgen de la Arrixaca, Biomedical Research Institute of Murcia (IMIB), 30120 Murcia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Santiago","family":"Llorente","sequence":"additional","affiliation":[{"name":"Nephrology Service, University Clinical Hospital Virgen de la Arrixaca, Biomedical Research Institute of Murcia (IMIB), 30120 Murcia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9740-0646","authenticated-orcid":false,"given":"Jos\u00e9 Antonio","family":"Gali\u00e1n","sequence":"additional","affiliation":[{"name":"Immunology Service, University Clinical Hospital Virgen de la Arrixaca, Biomedical Research Institute of Murcia (IMIB), 30120 Murcia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6839-0856","authenticated-orcid":false,"given":"Carmen","family":"Botella","sequence":"additional","affiliation":[{"name":"Immunology Service, University Clinical Hospital Virgen de la Arrixaca, Biomedical Research Institute of Murcia (IMIB), 30120 Murcia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-9120-524X","authenticated-orcid":false,"given":"Rosana","family":"Gonz\u00e1lez-L\u00f3pez","sequence":"additional","affiliation":[{"name":"Immunology Service, University Clinical Hospital Virgen de la Arrixaca, Biomedical Research Institute of Murcia (IMIB), 30120 Murcia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Jos\u00e9","family":"Alegr\u00eda","sequence":"additional","affiliation":[{"name":"Immunology Service, University Clinical Hospital Virgen de la Arrixaca, Biomedical Research Institute of Murcia (IMIB), 30120 Murcia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alicia","family":"Hita","sequence":"additional","affiliation":[{"name":"Immunology Service, University Clinical Hospital Virgen de la Arrixaca, Biomedical Research Institute of Murcia (IMIB), 30120 Murcia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3677-6372","authenticated-orcid":false,"given":"Mar\u00eda Rosa","family":"Moya-Quiles","sequence":"additional","affiliation":[{"name":"Immunology Service, University Clinical Hospital Virgen de la Arrixaca, Biomedical Research Institute of Murcia (IMIB), 30120 Murcia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helios","family":"Martinez-Banaclocha","sequence":"additional","affiliation":[{"name":"Immunology Service, University Clinical Hospital Virgen de la Arrixaca, Biomedical Research Institute of Murcia (IMIB), 30120 Murcia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuel","family":"Muro-P\u00e9rez","sequence":"additional","affiliation":[{"name":"Immunology Service, University Clinical Hospital Virgen de la Arrixaca, Biomedical Research Institute of Murcia (IMIB), 30120 Murcia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javier","family":"Muro","sequence":"additional","affiliation":[{"name":"Immunology Service, University Clinical Hospital Virgen de la Arrixaca, Biomedical Research Institute of Murcia (IMIB), 30120 Murcia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2472-5893","authenticated-orcid":false,"given":"Alfredo","family":"Minguela","sequence":"additional","affiliation":[{"name":"Immunology Service, University Clinical Hospital Virgen de la Arrixaca, Biomedical Research Institute of Murcia (IMIB), 30120 Murcia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1140-4313","authenticated-orcid":false,"given":"Isabel","family":"Legaz","sequence":"additional","affiliation":[{"name":"Department of Legal and Forensic Medicine, Biomedical Research Institute of Murcia (IMIB), Faculty of Medicine, Regional Campus of International Excellence \u201cCampus Mare Nostrum\u201d, University of Murcia, 30100 Murcia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9987-0994","authenticated-orcid":false,"given":"Manuel","family":"Muro","sequence":"additional","affiliation":[{"name":"Immunology Service, University Clinical Hospital Virgen de la Arrixaca, Biomedical Research Institute of Murcia (IMIB), 30120 Murcia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,11,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1186\/s12967-024-05964-4","article-title":"Advancements in noninvasive techniques for transplant rejection: From biomarker detection to molecular imaging","volume":"23","author":"Song","year":"2025","journal-title":"J. Transl. Med."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Tamargo, C.L., and Kant, S. (2023). Pathophysiology of Rejection in Kidney Transplantation. J. Clin. Med., 12.","DOI":"10.3390\/jcm12124130"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1034\/j.1600-6143.2003.00135.x","article-title":"Humoral theory of transplantation","volume":"3","author":"Terasaki","year":"2003","journal-title":"Am. J. Transplant."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Alasfar, S., Kodali, L., and Schinstock, C.A. (2023). Current Therapies in Kidney Transplant Rejection. J. Clin. Med., 12.","DOI":"10.3390\/jcm12154927"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"2824","DOI":"10.1111\/ajt.16463","article-title":"Long-term kidney transplant graft survival-Making progress when most needed","volume":"21","author":"Poggio","year":"2021","journal-title":"Am. J. Transplant."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Veh, J., Ludwig, C., Schrezenmeier, H., and Jahrsd\u00f6rfer, B. (2024). Regulatory B Cells-Immunopathological and Prognostic Potential in Humans. Cells, 13.","DOI":"10.3390\/cells13040357"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"2683","DOI":"10.1056\/NEJMc0808481","article-title":"B-cell-depleting induction therapy and acute cellular rejection","volume":"360","author":"Clatworthy","year":"2009","journal-title":"N. Engl. J. Med."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.jacc.2019.04.056","article-title":"CTOT-11 Study Investigators. Accelerated Allograft Vasculopathy with Rituximab After Cardiac Transplantation","volume":"74","author":"Starling","year":"2019","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1093\/intimm\/dxv027","article-title":"Signals controlling the development and activity of regulatory B-lineage cells","volume":"27","author":"Baba","year":"2015","journal-title":"Int. Immunol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"75","DOI":"10.2147\/JIR.S286426","article-title":"The Role of Regulatory B Cells in Health and Diseases: A Systemic Review","volume":"14","author":"Abebe","year":"2021","journal-title":"J. Inflamm. Res."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"2350496","DOI":"10.1002\/eji.202350496","article-title":"Diversity of regulatory B cells: Markers and functions","volume":"54","author":"Bradford","year":"2024","journal-title":"Eur. J. Immunol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"iqae012","DOI":"10.1093\/oxfimm\/iqae012","article-title":"The current understanding of the phenotypic and functional properties of human regulatory B cells (Bregs)","volume":"5","author":"Ahsan","year":"2024","journal-title":"Oxf. Open Immunol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/j.immuni.2015.04.005","article-title":"Regulatory B cells: Origin, phenotype, and function","volume":"42","author":"Rosser","year":"2015","journal-title":"Immunity"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Liao, J., Yang, Y., Li, J., Liu, Z., Song, S., Zeng, Y., and Wang, Y. (2025). Regulatory B cells, the key regulator to induce immune tolerance in organ transplantation. Front. Immunol., 16.","DOI":"10.3389\/fimmu.2025.1561171"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Alfaro, R., Legaz, I., Gonz\u00e1lez-Mart\u00ednez, G., Jimenez-Coll, V., Mart\u00ednez-Banaclocha, H., Gali\u00e1n, J.A., Botella, C., de la Pe\u00f1a-Moral, J., Moya-Quiles, M.R., and Campillo, J.A. (2021). Monitoring of B Cell in Kidney Transplantation: Development of a Novel Clusters Analysis and Role of Transitional B Cells in Transplant Outcome. Diagnostics, 11.","DOI":"10.3390\/diagnostics11040641"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"2699","DOI":"10.1111\/all.14763","article-title":"Regulatory B cells, A to Z","volume":"76","author":"Jansen","year":"2021","journal-title":"Allergy"},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Catal\u00e1n, D., Mansilla, M., Ferrier, A., Soto, L., Oleinika, K., Aguill\u00f3n, J.C., and Aravena, O. (2021). Immunosuppressive Mechanisms of Regulatory B Cells. Front. Immunol., 12.","DOI":"10.3389\/fimmu.2021.611795"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1111\/imr.12941","article-title":"Regulatory B cells in respiratory health and diseases","volume":"299","author":"Menon","year":"2021","journal-title":"Immunol. Rev."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"5997","DOI":"10.1038\/ncomms6997","article-title":"PD-L1hi B cells are critical regulators of humoral immunity","volume":"6","author":"Khan","year":"2015","journal-title":"Nat. Commun."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.immuni.2009.11.009","article-title":"CD19+CD24hiCD38hi B cells exhibit regulatory capacity in healthy individuals but are functionally impaired in systemic lupus erythematosus patients","volume":"32","author":"Blair","year":"2010","journal-title":"Immunity"},{"key":"ref_21","first-page":"173ra23","article-title":"CD19+CD24hiCD38hi B cells maintain regulatory T cells while limiting TH1 and TH17 differentiation","volume":"5","author":"Bosma","year":"2013","journal-title":"Sci. Transl. Med."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"6092","DOI":"10.4049\/jimmunol.178.10.6092","article-title":"Distinct effector cytokine profiles ofmemory and naive human B cell subsets and implication in multiple sclerosis","volume":"178","author":"Duddy","year":"2007","journal-title":"J. Immunol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1182\/blood-2010-07-294249","article-title":"Characterization of a rare IL-10-competent B-cell subset in humans that parallels mouse regulatory B10 cells","volume":"117","author":"Iwata","year":"2011","journal-title":"Blood"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1016\/j.immuni.2014.10.016","article-title":"Interleukin-10-producing plasmablasts exert regulatory function in autoimmune inflammation","volume":"41","author":"Matsumoto","year":"2014","journal-title":"Immunity"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1016\/j.cell.2018.11.035","article-title":"Recirculating intestinal IgA-producing cells regulate neuroinflammation via IL-10","volume":"176","author":"Rojas","year":"2019","journal-title":"Cell"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"eabc7191","DOI":"10.1126\/sciimmunol.abc7191","article-title":"Gut microbiota\u2013specific IGA+ B cells traffic to the CNS in active multiple sclerosis","volume":"5","author":"Zhou","year":"2020","journal-title":"Sci. Immunol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.3389\/fimmu.2019.01368","article-title":"APRIL induces a novel subset of IGA+ regulatory B cells that suppress inflammation via expression of IL-10 and PD-L1","volume":"10","author":"Fehres","year":"2019","journal-title":"Front Immunol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"2468","DOI":"10.1158\/0008-5472.CAN-12-3450","article-title":"Interleukin 21-induced granzyme B-expressing B cells infiltrate tumors and regulate t cells","volume":"73","author":"Lindner","year":"2013","journal-title":"Cancer Res."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.immuni.2012.02.008","article-title":"Lipid antigen presentation by CD1d + B cells is essential for the maintenance of invariant natural killer T cells","volume":"36","author":"Bosma","year":"2012","journal-title":"Immunity"},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Huo, J.L., Wang, Y.T., Fu, W.J., Lu, N., and Liu, Z.S. (2022). The promising immune checkpoint LAG-3 in cancer immunotherapy: Frombasic research to clinical application. Front. Immunol., 13.","DOI":"10.3389\/fimmu.2022.956090"},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Zacca, E.R., Onofrio, L.I., Acosta, C.D.V., Ferrero, P.V., Alonso, S.M., Ramello, M.C., Mussano, E., Onetti, L., Cadile, I.I., and Stancich, M.I. (2018). PD-L1+ regulatory B cells are significantly decreased in rheumatoid arthritis patients and increase after successful treatment. Front. Immunol., 9.","DOI":"10.3389\/fimmu.2018.02241"},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Tousif, S., Wang, Y., Jackson, J., Hough, K.P., Strenkowski, J.G., Athar, M., Thannickal, V.J., McCusker, R.H., Ponnazhagan, S., and Deshane, J.S. (2021). Indoleamine 2, 3-dioxygenase promotes aryl hydrocarbon receptor-dependent differentiation of regulatory B cells in lung cancer. Front. Immunol., 12.","DOI":"10.3389\/fimmu.2021.747780"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"djw144","DOI":"10.1093\/jnci\/djw144","article-title":"Genomic analysis of immune cell infiltrates across 11 tumor types","volume":"108","author":"Iglesia","year":"2016","journal-title":"J. Natl. Cancer Inst."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/1479-5876-12-30","article-title":"Tumor infiltrating B-cells are increased in prostate cancer tissue","volume":"12","author":"Woo","year":"2014","journal-title":"J. Transl. Med."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"26065","DOI":"10.18632\/oncotarget.4569","article-title":"Tumor microenvironment B cells increase bladder cancer metastasis via modulation of the IL-8\/androgen receptor (AR)\/MMPs signals","volume":"6","author":"Ou","year":"2015","journal-title":"Oncotarget"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1676","DOI":"10.1038\/bjc.2013.493","article-title":"The relationship between lymphocyte subsets and clinicopathological determinants of survival in patients with primary operable invasive ductal breast cancer","volume":"109","author":"Mohammed","year":"2013","journal-title":"Br. J. Cancer"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1158\/2159-8290.CD-15-1408","article-title":"PD-1hi identifies a novel regulatory B-cell population in human hepatoma that promotes disease progression","volume":"6","author":"Xiao","year":"2016","journal-title":"Cancer Discov."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1158\/2326-6066.CIR-19-0349","article-title":"B cell-derived IL35 drives STAT3-dependent CD8+ T-cell exclusion in pancreatic cancer","volume":"8","author":"Mirlekar","year":"2020","journal-title":"Cancer Immunol. Res."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1158\/2326-6066.CIR-17-0710","article-title":"IL35 hinders endogenous antitumor T-cell immunity and responsiveness to immunotherapy in pancreatic cancer","volume":"6","author":"Mirlekar","year":"2018","journal-title":"Cancer Immunol. Res."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"3505","DOI":"10.1158\/0008-5472.CAN-10-4316","article-title":"Tumor-evoked regulatory B cells promote breast cancer metastasis by converting resting CD4+ T cells to T regulatory cells","volume":"71","author":"Olkhanud","year":"2011","journal-title":"Cancer Res."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1093\/intimm\/dxw007","article-title":"Mammary-tumor-educated B cells acquire lap\/TGF-\u03b2 and PDl1 expression and suppress antitumor immune responses","volume":"28","author":"Zhang","year":"2016","journal-title":"Int. Immunol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"3121","DOI":"10.1038\/s41467-022-30613-z","article-title":"Ex vivo-expanded human CD19+TIM-1+ regulatory B cells suppress immune responses in vivo and are dependent upon the TIM-1\/STAT3 axis","volume":"13","author":"Shankar","year":"2022","journal-title":"Nat. Commun."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1080\/1744666X.2025.2564399","article-title":"Decoding T and B cell dynamics in inborn errors of immunity: Insights into immune dysfunction","volume":"21","author":"Caka","year":"2025","journal-title":"Expert Rev. Clin. Immunol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"101555","DOI":"10.1016\/j.omtm.2025.101555","article-title":"Hematopoietic stem cell gene therapy for the treatment of X-linked agammaglobulinemia","volume":"33","author":"Luthers","year":"2025","journal-title":"Mol. Ther. Methods Clin. Dev."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Kader, H.A., Sabih Ur Rehman, S., Saraswathiamma, D., Shiek, S.S., Bencomo-Hern\u00e1ndez, A.A., Moorakkan, U.R., Haider, M.T., Munawar, N., Iratni, R., and Serfling, E. (2025). NFATc1 deficiency in B cells ameliorates atopic dermatitis. Sci. Rep., 15.","DOI":"10.1038\/s41598-025-11247-9"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"2824","DOI":"10.1111\/all.16594","article-title":"IFNgamma Signaling Impairs Regulatory B Cell Function Resulting in Worse Control of Esophageal Food Allergy","volume":"80","author":"Clement","year":"2025","journal-title":"Allergy"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"e202451400","DOI":"10.1002\/eji.202451400","article-title":"Escalation of Germinal Center Responses in Chronic Litomosoides sigmodontis Filarial Infection","volume":"55","author":"Steffen","year":"2025","journal-title":"Eur. J. Immunol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/s00436-024-08450-4","article-title":"Regulatory B cells in parasitic infections: Roles and therapeutic potential","volume":"124","author":"Cai","year":"2025","journal-title":"Parasitol. Res."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"104753","DOI":"10.1016\/j.meegid.2021.104753","article-title":"New insights into regulatory B cells biology in viral, bacterial, and parasitic infections","volume":"89","author":"Sanaei","year":"2021","journal-title":"Infect. Genet. Evol."},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Maerz, J.K., Trostel, C., Lange, A., Parusel, R., Michaelis, L., Sch\u00e4fer, A., Yao, H., L\u00f6w, H.C., and Frick, J.S. (2020). Bacterial Immunogenicity Is Critical for the Induction of Regulatory B Cells in Suppressing Inflammatory Immune Responses. Front. Immunol., 10.","DOI":"10.3389\/fimmu.2019.03093"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1042\/CS20160069","article-title":"IL-10-producing regulatory B-cells suppressed effector T-cells but enhanced regulatory T-cells in chronic HBV infection","volume":"130","author":"Liu","year":"2016","journal-title":"Clin. Sci."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"215471","DOI":"10.1155\/2014\/215471","article-title":"The roles of regulatory B cells in cancer","volume":"2014","author":"He","year":"2014","journal-title":"J. Immunol. Res."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1002\/jnr.23749","article-title":"Role of regulatory b cells in neuroimmunologic disorders","volume":"94","author":"Han","year":"2016","journal-title":"J. Neurosci. Res."},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Zheremyan, E.A., Ustiugova, A.S., Karamushka, N.M., Uvarova, A.N., Stasevich, E.M., Bogolyubova, A.V., Kuprash, D.V., and Korneev, K.V. (2024). Breg-Mediated Immunoregulation in the Skin. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25010583"},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Lee, D., Jo, M.G., Min, K.Y., Choi, M.Y., Kim, Y.M., Kim, H.S., and Choi, W.S. (2024). IL-10+ regulatory B cells mitigate atopic dermatitis by suppressing eosinophil activation. Sci. Rep., 14.","DOI":"10.1038\/s41598-024-68660-9"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1016\/j.transproceed.2023.03.029","article-title":"Regulatory B Cells Profile in Kidney Transplant Recipients with Chronic-Active Antibody-Mediated Rejection","volume":"55","author":"Guzel","year":"2023","journal-title":"Transplant. Proc."},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Mai, H.L., Degauque, N., Lorent, M., Rimbert, M., Renaudin, K., Danger, R., Kerleau, C., Tilly, G., Vivet, A., and Le Bot, S. (2023). Kidney allograft rejection is associated with an imbalance of B cells, regulatory T cells and differentiated CD28-CD8+ T cells: Analysis of a cohort of 1095 graft biopsies. Front. Immunol., 14.","DOI":"10.3389\/fimmu.2023.1151127"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"e1775","DOI":"10.1097\/TXD.0000000000001775","article-title":"Comprehensive Phenotyping and Cytokine Production of Circulating B Cells Associate Resting Memory B Cells with Early Antibody-mediated Rejection in Kidney Transplant Recipients","volume":"11","author":"Altulea","year":"2025","journal-title":"Transplant. Direct."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1016\/j.kint.2021.12.027","article-title":"Concomitant loss of regulatory T and B cells is a distinguishing immune feature of antibody-mediated rejection in kidney transplantation","volume":"101","author":"Louis","year":"2022","journal-title":"Kidney Int."},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Perez-Pay\u00e1, I., Garcia, S.G., Clos-Sansalvador, M., Sanroque-Mu\u00f1oz, M., Font-Mor\u00f3n, M., Rodr\u00edguez-Mart\u00ednez, P., Vila-Santandreu, A., Bover, J., Borr\u00e0s, F.E., and Ca\u00f1as, L. (2024). Molecular screening of transitional B cells as a prognostic marker of improved graft outcome and reduced rejection risk in kidney transplant. Front. Immunol., 15.","DOI":"10.3389\/fimmu.2024.1433832"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"106750","DOI":"10.1016\/j.intimp.2020.106750","article-title":"Transitional immature regulatory B cells and regulatory cytokines can discriminate chronic antibody-mediated rejection from stable graft function","volume":"86","author":"Salehi","year":"2020","journal-title":"Int. Immunopharmacol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1111\/ajt.13122","article-title":"Transitional B lymphocytes are associated with protection from kidney allograft rejection: A prospective study","volume":"15","author":"Shabir","year":"2015","journal-title":"Am. J. Transplant."},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Luo, Y., Luo, F., Zhang, K., Wang, S., Zhang, H., Yang, X., Shang, W., Wang, J., Wang, Z., and Pang, X. (2021). Elevated Circulating IL-10 Producing Breg, but Not Regulatory B Cell Levels, Restrain Antibody-Mediated Rejection After Kidney Transplantation. Front. Immunol., 11.","DOI":"10.3389\/fimmu.2020.627496"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1016\/j.ajt.2023.05.036","article-title":"Intragraft B cell differentiation during the development of tolerance to kidney allografts is associated with a regulatory B cell signature revealed by single cell transcriptomics","volume":"23","author":"Guinn","year":"2023","journal-title":"Am. J. Transplant."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1093\/cei\/uxae018","article-title":"The balance between memory and regulatory cell populations in kidney transplant recipients with operational tolerance","volume":"216","author":"Alvarez","year":"2024","journal-title":"Clin. Exp. Immunol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"465","DOI":"10.21037\/atm.2019.08.05","article-title":"The proportion of CD19+CD24hiCD27+ regulatory B cells predicts the occurrence of acute allograft rejection in liver transplantation","volume":"7","author":"Zhou","year":"2019","journal-title":"Ann. Transl. Med."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"172872","DOI":"10.1016\/j.ejphar.2019.172872","article-title":"The advantage of Sirolimus in amplifying regulatory B cells and regulatory T cells in liver transplant patients","volume":"869","author":"Song","year":"2020","journal-title":"Eur. J. Pharmacol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"101245","DOI":"10.1016\/j.trim.2019.101245","article-title":"Peripheral CD19+CD24highCD38high B-regulatory cells in lung transplant recipients","volume":"57","author":"Piloni","year":"2019","journal-title":"Transpl. Immunol."},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Bergantini, L., d\u2019Alessandro, M., De Vita, E., Perillo, F., Fossi, A., Luzzi, L., Paladini, P., Perrone, A., Rottoli, P., and Sestini, P. (2021). Regulatory and Effector Cell Disequilibrium in Patients with Acute Cellular Rejection and Chronic Lung Allograft Dysfunction after Lung Transplantation: Comparison of Peripheral and Alveolar Distribution. Cells, 10.","DOI":"10.3390\/cells10040780"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1016\/j.healun.2021.08.008","article-title":"Gut microbes enlarged the protective effect of transplanted regulatory B cells on rejection of cardiac allografts","volume":"40","author":"Li","year":"2021","journal-title":"J. Heart Lung Transplant."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"339","DOI":"10.3892\/mmr.2021.11978","article-title":"Protective effect of trichostatin A on CD19+CD5+CD1dhigh regulatory B cells in heart transplantation","volume":"23","author":"Zhou","year":"2021","journal-title":"Mol. Med. Rep."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"1728","DOI":"10.1002\/eji.201344062","article-title":"TGF-\u03b2-producing regulatory B cells induce regulatory T cells and promote transplantation tolerance","volume":"44","author":"Lee","year":"2014","journal-title":"Eur. J. Immunol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"3900","DOI":"10.1016\/j.transproceed.2018.04.065","article-title":"Identification of the Subsets of IL-10-Producing Regulatory B Cells in the Course of Tolerance Induction and Maintenance in Islet Allotransplantation","volume":"50","author":"Li","year":"2018","journal-title":"Transplant. Proc."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1681\/ASN.2022020210","article-title":"Induction of Long-Lasting Regulatory B Lymphocytes by Modified Immune Cells in Kidney Transplant Recipients","volume":"34","author":"Morath","year":"2023","journal-title":"J. Am. Soc. Nephrol."}],"container-title":["Antibodies"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2073-4468\/14\/4\/95\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,9]],"date-time":"2025-11-09T05:24:38Z","timestamp":1762665878000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2073-4468\/14\/4\/95"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,7]]},"references-count":74,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["antib14040095"],"URL":"https:\/\/doi.org\/10.3390\/antib14040095","relation":{},"ISSN":["2073-4468"],"issn-type":[{"type":"electronic","value":"2073-4468"}],"subject":[],"published":{"date-parts":[[2025,11,7]]}}}