{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:07:32Z","timestamp":1787166452730,"version":"build-2736575974"},"reference-count":35,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2020,5,25]],"date-time":"2020-05-25T00:00:00Z","timestamp":1590364800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antibodies"],"abstract":"<jats:p>Aim: Glomerular diseases (GD) associated with malignancies (AM, GDAM) have unique features, which are important to recognize, in the light of the progress made in cancer therapy. We aimed to describe the clinical and histopathological characteristics of patients with GDAM in relation to the presence of circulating autoantibodies, pointing to potential immune pathogenic pathways connecting cancer to GD. Materials and Methods: The included patients were studied retrospectively on the basis of a kidney biopsy proving GD and a related biopsy to establish the diagnosis of AM. We recorded patients\u2019 demographics, serological and laboratory parameters, histopathological findings, and the type of malignancy, GD, and therapy. Results: In total, 41 patients with GDAM, with a mean age of 63.1 (\u00b110.7) years, were studied. In 28 (68.3%) cases, GD was associated with a solid tumor, and in 13 (31.7%) patients with a lymphoid malignancy. The most frequent histopathological pattern was membranous nephropathy (43.9%). Overall, at the time of GD diagnosis, 17% of the patients were positive for antinuclear antibodies (ANA), and 12.2% for antineutrophil cytoplasmic autoantibodies (ANCA), all against myeloperoxidase (MPO). In addition, 93.3% of the patients who had membranous nephropathy were negative for transmembrane glycoprotein M-type phospholipase A2 receptor (PLA2R) antibody. Sixteen patients (39.0%) presented with acute nephritic syndrome, of whom five (31.25%) developed rapidly progressive glomerulonephritis. In a mean follow-up time of 36.1 (\u00b128.3) months, nine (21.95%) patients ended up with end-stage kidney disease, and eight (19.5%) died. Conclusion: We found that 3.2% of patients who underwent a native kidney biopsy in our institution during the past decade, for any reason, were identified as having some type of GD associated with a malignancy. Serology indicated a significant presence of ANA or MPO-ANCA antibodies in patients with nephritic syndrome and the absence of PLA2R antibodies in patients with membranous nephropathy.<\/jats:p>","DOI":"10.3390\/antib9020018","type":"journal-article","created":{"date-parts":[[2020,5,25]],"date-time":"2020-05-25T11:42:02Z","timestamp":1590406922000},"page":"18","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Glomerular Diseases Associated with Malignancies: Histopathological Pattern and Association with Circulating Autoantibodies"],"prefix":"10.3390","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1643-8923","authenticated-orcid":false,"given":"Sophia","family":"Lionaki","sequence":"first","affiliation":[{"name":"Nephrology Department &amp; Transplantation Unit, Faculty of Medicine, Laiko Hospital, National &amp; Kapodistrian University of Athens, 11527 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Smaragdi","family":"Marinaki","sequence":"additional","affiliation":[{"name":"Nephrology Department &amp; Transplantation Unit, Faculty of Medicine, Laiko Hospital, National &amp; Kapodistrian University of Athens, 11527 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantinos","family":"Panagiotellis","sequence":"additional","affiliation":[{"name":"Nephrology Department &amp; Transplantation Unit, Faculty of Medicine, Laiko Hospital, National &amp; Kapodistrian University of Athens, 11527 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioanna","family":"Tsoumbou","sequence":"additional","affiliation":[{"name":"Nephrology Department &amp; Transplantation Unit, Faculty of Medicine, Laiko Hospital, National &amp; Kapodistrian University of Athens, 11527 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Liapis","sequence":"additional","affiliation":[{"name":"Pathology Department, Faculty of Medicine, Laiko Hospital, National &amp; Kapodistrian University of Athens, 11527 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioanna","family":"Vlahadami","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology, Faculty of Medicine, Laiko Hospital, National &amp; Kapodistrian University of Athens, 11527 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Athanasios","family":"Tzioufas","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology, Faculty of Medicine, Laiko Hospital, National &amp; Kapodistrian University of Athens, 11527 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petros","family":"Sfikakis","sequence":"additional","affiliation":[{"name":"1st Department of Propaedeutic and Internal Medicine and Joined Rheumatology Program, Medical School, Laiko Hospital, National and Kapodistrian University of Athens, 11527 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioannis","family":"Boletis","sequence":"additional","affiliation":[{"name":"Nephrology Department &amp; Transplantation Unit, Faculty of Medicine, Laiko Hospital, National &amp; Kapodistrian University of Athens, 11527 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,5,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1038\/ki.2014.29","article-title":"Onconephrology: The need and the emergence of a subspecialty in nephrology","volume":"85","author":"Abudayyeh","year":"2014","journal-title":"Kidney Int."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1038\/nrneph.2010.171","article-title":"Pathogenesis, diagnosis and management of paraneoplastic glomerulonephritis","volume":"7","author":"Lien","year":"2010","journal-title":"Nat. Rev. Nephrol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/j.semnephrol.2010.09.011","article-title":"Membranous Nephropathy and Malignancy","volume":"30","author":"Beck","year":"2010","journal-title":"Semin. Nephrol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.1038\/sj.ki.5001790","article-title":"for the GN-PROGRESS Study Group Membranous nephropathy and cancer: Epidemiologic evidence and determinants of high-risk cancer association","volume":"70","author":"Lefaucheur","year":"2006","journal-title":"Kidney Int."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1007\/s40620-015-0234-9","article-title":"Glomerular diseases and cancer: Evaluation of underlying malignancy","volume":"29","author":"Pani","year":"2015","journal-title":"J. Nephrol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1373\/clinchem.2006.077180","article-title":"Expressing the Modification of Diet in Renal Disease Study Equation for Estimating Glomerular Filtration Rate with Standardized Serum Creatinine Values","volume":"53","author":"Levey","year":"2007","journal-title":"Clin. Chem."},{"key":"ref_7","first-page":"232","article-title":"The nephrotic syndrome in adults aged over 60: Etiology, evolution and treatment of 76 cases","volume":"17","author":"Zech","year":"1982","journal-title":"Clin. Nephrol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1023\/A:1014404006045","article-title":"Characteristics and outcome of membranous nephropathy in older patients","volume":"33","author":"Hicks","year":"2002","journal-title":"Int. Urol. Nephrol."},{"key":"ref_9","first-page":"64","article-title":"Secondary membranous glomerulonephritis","volume":"7","author":"Glassock","year":"1992","journal-title":"Nephrol. Dial. Transplant."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1046\/j.1523-1755.1999.00548.x","article-title":"Paraneoplastic glomerulopathies: New insights into an old entity","volume":"56","author":"Ronco","year":"1999","journal-title":"Kidney Int."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1159\/000364782","article-title":"Prevalence of Cancer in Membranous Nephropathy: A Systematic Review and Meta-Analysis of Observational Studies","volume":"40","author":"Leeaphorn","year":"2014","journal-title":"Am. J. Nephrol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1056\/NEJMoa0810457","article-title":"M-type phospholipase A2 receptor as target antigen in idiopathic membranous nephropathy","volume":"361","author":"Beck","year":"2009","journal-title":"N. Engl. J. Med."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1159\/000166810","article-title":"Crescentic Glomerulonephritis Associated with Nonrenal Malignancies","volume":"4","author":"Biava","year":"1984","journal-title":"Am. J. Nephrol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1002\/1529-0131(199904)42:4<751::AID-ANR19>3.0.CO;2-D","article-title":"Wegener\u2019s granulomatosis associated with renal cell carcinoma","volume":"4","author":"Tatsis","year":"1999","journal-title":"Arthritis Rheum."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1007\/BF02767663","article-title":"A case of severe anti-neutrophil cytoplasmic antibody (ANCA)-positive crescentic glomerulonephritis and asymptomatic gastric cancer","volume":"26","author":"Hruby","year":"1994","journal-title":"Int. Urol. Nephrol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"e24.1","DOI":"10.1053\/ajkd.2000.17727","article-title":"Pauci-immune ANCA-positive crescentic glomerulonephritis associated with metastatic adenocarcinoma of the lung","volume":"36","author":"Baschinsky","year":"2000","journal-title":"Am. J. Kidney Dis."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1191\/0961203305lu2153cr","article-title":"ANCA-associated vasculitis as paraneoplastic syndrome with colon cancer: A case report","volume":"14","author":"Blanco","year":"2005","journal-title":"Lupus"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"3452","DOI":"10.1002\/art.34562","article-title":"Classification of antineutrophil cytoplasmic autoantibody vasculitides: The role of antineutrophil cytoplasmic autoantibody specificity for myeloperoxidase or proteinase 3 in disease recognition and prognosis","volume":"64","author":"Lionaki","year":"2012","journal-title":"Arthritis Rheum."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1345\/aph.1A124","article-title":"Cutaneous and systemic manifestations of drug-induced vasculitis","volume":"36","author":"Holder","year":"2002","journal-title":"Ann. Pharmacother."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"3508","DOI":"10.1093\/ndt\/gfm493","article-title":"Association between thyroid disease and its treatment with ANCA small-vessel vasculitis: A case control study","volume":"22","author":"Lionaki","year":"2007","journal-title":"Nephrol. Dial. Transplant."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"102","DOI":"10.3109\/s10165-009-0238-1","article-title":"Resolution of anti-neutrophil cytoplasmic antibody-associated vasculitis after resection of gastric cancer","volume":"20","author":"Hosoya","year":"2010","journal-title":"Mod. Rheumatol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1716","DOI":"10.1111\/jgs.13584","article-title":"Sixty-Eight-Year-Old Man Presenting with Concurrent Microscopic Polyangiitis and Prostate Cancer","volume":"63","author":"Koklu","year":"2015","journal-title":"J. Am. Geriatr. Soc."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1097\/PAT.0b013e3283468742","article-title":"Concurrent involvement of thyroid gland by Wegener\u2019s granulomatosis and papillary thyroid carcinoma","volume":"43","author":"Lim","year":"2011","journal-title":"Pathology"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1179\/2295333714Y.0000000064","article-title":"pANCA-vasculitis associated with rectal adenocarcinoma","volume":"69","author":"Hommel","year":"2014","journal-title":"Acta Clin. Belg."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/s00296-009-1162-6","article-title":"Microscopic polyangitis complicating double carcinoma of the stomach and duodenum: Improvement after the resection of these carcinomas","volume":"31","author":"Abe","year":"2009","journal-title":"Rheumatol. Int."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1055\/s-2004-818504","article-title":"Bronchioloalveolar carcinoma of the lung associated with a highly positive pANCA-titer and clinical signs of microscopic polyangiitis","volume":"7","author":"Watz","year":"2004","journal-title":"Pneumologie"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1136\/ard.60.3.293","article-title":"Systemic antineutrophil cytoplasmic antibody vasculitis associated with lymphoid neoplasia","volume":"60","author":"Hamidou","year":"2001","journal-title":"Ann. Rheum. Dis."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1136\/pgmj.70.823.373","article-title":"Anti-neutrophil cytoplasmic antibody-associated paraneoplastic vasculitis","volume":"70","author":"Navarro","year":"1994","journal-title":"Postgrad. Med. J."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.2215\/CJN.03770412","article-title":"Onco-Nephrology: Glomerular Diseases with Cancer","volume":"7","author":"Cambier","year":"2012","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1056\/NEJMoa1111097","article-title":"Bevacizumab added to neoadjuvant chemotherapy for breast cancer","volume":"4","author":"Bear","year":"2012","journal-title":"N. Engl. J. Med."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1038\/ki.1994.149","article-title":"Neutrophil activation in vitro and in vivo in Wegener\u2019sgranulomatosis","volume":"45","author":"Brouwer","year":"1994","journal-title":"Kidney Int."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1159\/000442323","article-title":"Overview of the Pathogenesis of ANCA-Associated Vasculitis","volume":"1","author":"Xiao","year":"2015","journal-title":"Kidney Dis."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/S0272-6386(12)80879-1","article-title":"The Pathogenic Role of Antineutrophil Cytoplasmic Autoantibodies","volume":"18","author":"Ewert","year":"1991","journal-title":"Am. J. Kidney Dis."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"2531","DOI":"10.1056\/NEJMoa1707447","article-title":"Axicabtagene Ciloleucel CAR T-Cell Therapy in Refractory Large B-Cell Lymphoma","volume":"377","author":"Neelapu","year":"2017","journal-title":"N. Engl. J. Med."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1007\/s10157-006-0437-4","article-title":"Concurrent FSGS and Hodgkin\u2019s lymphoma: Case report and literature review on the link between nephrotic glomerulopathies and hematological malignancies","volume":"4","author":"Mallouk","year":"2006","journal-title":"Clin. Exp. Nephrol."}],"container-title":["Antibodies"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2073-4468\/9\/2\/18\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T09:32:24Z","timestamp":1760175144000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2073-4468\/9\/2\/18"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5,25]]},"references-count":35,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2020,6]]}},"alternative-id":["antib9020018"],"URL":"https:\/\/doi.org\/10.3390\/antib9020018","relation":{},"ISSN":["2073-4468"],"issn-type":[{"value":"2073-4468","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,5,25]]}}}