{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T17:31:19Z","timestamp":1763141479169,"version":"build-2065373602"},"reference-count":48,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2020,12,23]],"date-time":"2020-12-23T00:00:00Z","timestamp":1608681600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["CM18\/00054"],"award-info":[{"award-number":["CM18\/00054"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010552","name":"Departament de Salut, Generalitat de Catalunya","doi-asserted-by":"publisher","award":["SLT008\/18\/00193"],"award-info":[{"award-number":["SLT008\/18\/00193"]}],"id":[{"id":"10.13039\/501100010552","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antibiotics"],"abstract":"<jats:p>The effectiveness of antimicrobial stewardship programs (ASP) in reducing antimicrobial use (AU) in children has been proved. Many interventions have been described suitable for different institution sizes, priorities, and patients, with surgical wards being one of the areas that may benefit the most. We aimed to describe the results on AU and length of stay (LOS) in a pre-post study during the three years before (2014\u20132016) and the three years after (2017\u20132019) implementation of an ASP based on postprescription review with feedback in children and adolescents admitted for appendix-related intraabdominal infections (AR-IAI) in a European Referral Paediatric University Hospital. In the postintervention period, the quality of prescriptions (QP) was also evaluated. Overall, 2021 AR-IAIs admissions were included. Global AU, measured both as days of therapy\/100 patient days (DOT\/100PD) and length of therapy (LOT), and global LOS remained unchanged in the postintervention period. Phlegmonous appendicitis LOS (p = 0.003) and LOT (p &lt; 0.001) significantly decreased, but not those of other AR-IAI diagnoses. The use of piperacillin\u2013tazobactam decreased by 96% (p = 0.044), with no rebound in the use of other Gram-negative broad-spectrum antimicrobials. A quasisignificant (p = 0.052) increase in QP was observed upon ASP implementation. Readmission and case fatality rates remained stable. ASP interventions were safe, and they reduced LOS and LOT of phlegmonous appendicitis and the use of selected broad-spectrum antimicrobials, while increasing QP in children with AR-IAI.<\/jats:p>","DOI":"10.3390\/antibiotics10010005","type":"journal-article","created":{"date-parts":[[2020,12,23]],"date-time":"2020-12-23T08:38:43Z","timestamp":1608712723000},"page":"5","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Effects of a Paediatric Antimicrobial Stewardship Program on Antimicrobial Use and Quality of Prescriptions in Patients with Appendix-Related Intraabdominal Infections"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2115-1695","authenticated-orcid":false,"given":"S\u00edlvia","family":"Sim\u00f3","sequence":"first","affiliation":[{"name":"Infectious Diseases and Systemic Inflammatory Response in Paediatrics, Infectious Diseases Unit, Department of Paediatrics, Sant Joan de D\u00e9u Hospital Research Foundation, 08950 Barcelona, Spain"},{"name":"Centre for Biomedical Network Research on Epidemiology and Public Health (CIBERESP), 28029 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2400-3033","authenticated-orcid":false,"given":"Eneritz","family":"Velasco-Arnaiz","sequence":"additional","affiliation":[{"name":"Infectious Diseases and Systemic Inflammatory Response in Paediatrics, Infectious Diseases Unit, Department of Paediatrics, Sant Joan de D\u00e9u Hospital Research Foundation, 08950 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda","family":"R\u00edos-Barn\u00e9s","sequence":"additional","affiliation":[{"name":"Infectious Diseases and Systemic Inflammatory Response in Paediatrics, Infectious Diseases Unit, Department of Paediatrics, Sant Joan de D\u00e9u Hospital Research Foundation, 08950 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Goretti","family":"L\u00f3pez-Ramos","sequence":"additional","affiliation":[{"name":"Pharmacy Department, Sant Joan de D\u00e9u Hospital, 08950 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuel","family":"Monson\u00eds","sequence":"additional","affiliation":[{"name":"Clinical Microbiology Department, Sant Joan de D\u00e9u Hospital, 08950 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mireia","family":"Urrea-Ayala","sequence":"additional","affiliation":[{"name":"Patient Safety Area\u2014Infection Control Unit, Sant Joan de D\u00e9u Hospital, 08950 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2041-4425","authenticated-orcid":false,"given":"Iolanda","family":"Jordan","sequence":"additional","affiliation":[{"name":"Centre for Biomedical Network Research on Epidemiology and Public Health (CIBERESP), 28029 Madrid, Spain"},{"name":"Pediatric Intensive Care Unit, Sant Joan de D\u00e9u Hospital, 08950 Barcelona, Spain"},{"name":"Department of Paediatrics, University of Barcelona, 08007 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricard","family":"Casadevall-Llandrich","sequence":"additional","affiliation":[{"name":"Management Department, Sant Joan de D\u00e9u Hospital, 08950 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Ormaz\u00e1bal-Kirchner","sequence":"additional","affiliation":[{"name":"Computing Department, Sant Joan de D\u00e9u Hospital, 08950 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Cuadras-Pallej\u00e0","sequence":"additional","affiliation":[{"name":"Statistics Department, Sant Joan de D\u00e9u Research Foundation, 08950 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8072-7095","authenticated-orcid":false,"given":"Xavier","family":"Tarrado","sequence":"additional","affiliation":[{"name":"Paediatric Surgery Department, Sant Joan de D\u00e9u Hospital, 08950 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8974-0827","authenticated-orcid":false,"given":"Jordi","family":"Prat","sequence":"additional","affiliation":[{"name":"Paediatric Surgery Department, Sant Joan de D\u00e9u Hospital, 08950 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Em\u00edlia","family":"S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Blanquerna School of Health Science, Ramon Llull University, 08022 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7485-0583","authenticated-orcid":false,"given":"Antoni","family":"Noguera-Julian","sequence":"additional","affiliation":[{"name":"Infectious Diseases and Systemic Inflammatory Response in Paediatrics, Infectious Diseases Unit, Department of Paediatrics, Sant Joan de D\u00e9u Hospital Research Foundation, 08950 Barcelona, Spain"},{"name":"Centre for Biomedical Network Research on Epidemiology and Public Health (CIBERESP), 28029 Madrid, Spain"},{"name":"Statistics Department, Sant Joan de D\u00e9u Research Foundation, 08950 Barcelona, Spain"},{"name":"Translational Research Network in Paediatric Infectious Diseases (RITIP), 28009 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cl\u00e0udia","family":"Fortuny","sequence":"additional","affiliation":[{"name":"Infectious Diseases and Systemic Inflammatory Response in Paediatrics, Infectious Diseases Unit, Department of Paediatrics, Sant Joan de D\u00e9u Hospital Research Foundation, 08950 Barcelona, Spain"},{"name":"Centre for Biomedical Network Research on Epidemiology and Public Health (CIBERESP), 28029 Madrid, Spain"},{"name":"Statistics Department, Sant Joan de D\u00e9u Research Foundation, 08950 Barcelona, Spain"},{"name":"Translational Research Network in Paediatric Infectious Diseases (RITIP), 28009 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2020,12,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e127","DOI":"10.1093\/jpids\/piu141","article-title":"Inpatient antimicrobial stewardship in pediatrics: A systematic review","volume":"4","author":"Smith","year":"2015","journal-title":"J. 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