{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T14:24:25Z","timestamp":1781533465217,"version":"3.54.5"},"reference-count":52,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2021,6,3]],"date-time":"2021-06-03T00:00:00Z","timestamp":1622678400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antibiotics"],"abstract":"<jats:p>In this study, we aimed to explore the trends among dentists in the Dominican Republic of providing antibiotic prescriptions to pregnant\/breastfeeding dental patients. A survey was conducted among 98 dentists, using a self-administered questionnaire, about their knowledge and attitudes regarding antibiotic usage in pregnant\/lactating women and the translation of these into practice. The majority of the survey population were female dentists (63.3%) aged 45\u201354 years. A chi-square test showed statistically significant differences in the knowledge sources between older and younger dentists, with a minority having chosen scientific literature as a source (p-value of 0.04). There were statistically significant associations between gender and certain attitudes and practice-based questions, with p-values of 0.04 and 0.01, respectively. The Spearman\u2019s correlation test showed a statistically significant correlation between knowledge and attitude (p-value 0.001), whereas no correlation was found with practice (p-value 0.23). A multiple response analysis showed that the majority of the respondents chose the second and third trimester for antibiotic prescriptions for acute conditions such as cellulitis, periodontal abscess, and pericoronitis. Most dentists had sufficient knowledge about antibiotic usage in pregnant\/lactating women, but it did not translate into practice, and a certain proportion of the participants followed incongruent drug prescription. These findings can be used to focus on judicious antibiotic usage by dentists in the Dominican Republic.<\/jats:p>","DOI":"10.3390\/antibiotics10060668","type":"journal-article","created":{"date-parts":[[2021,6,3]],"date-time":"2021-06-03T10:59:51Z","timestamp":1622717991000},"page":"668","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Knowledge, Attitudes, and Practices among Dental Practitioners Regarding Antibiotic Prescriptions for Pregnant and Breastfeeding Women in the Dominican Republic"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6373-0233","authenticated-orcid":false,"given":"Javier","family":"Aragoneses","sequence":"first","affiliation":[{"name":"Department of Medicine and Medical Specialties, Faculty of Health Sciences, University of Alcal\u00e1, 28801 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2448-6669","authenticated-orcid":false,"given":"Ana","family":"Su\u00e1rez","sequence":"additional","affiliation":[{"name":"Department of Preclinical Dentistry, School of Biomedical Sciences, Universidad Europea de Madrid, Villaviciosa de Od\u00f3n, 28670 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cinthia","family":"Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Department of Dentistry, Universidad Federico Henriquez y Carvajal, 10106 Santo Domingo, Dominican Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3616-3210","authenticated-orcid":false,"given":"Juan","family":"Algar","sequence":"additional","affiliation":[{"name":"Department of Clinical Dentistry, School of Biomedical Sciences, Universidad Europea de Madrid, 28005 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Manuel","family":"Aragoneses","sequence":"additional","affiliation":[{"name":"Dean of The Faculty of Dentistry, Universidad Alfonso X El Sabio, 28691 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,6,3]]},"reference":[{"key":"ref_1","unstructured":"World Health Organization (2012). The Evolving Threat of Antimicrobial Resistance: Options for Action, World Health Organ."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1093\/infdis\/jit293","article-title":"Emergence of colistin-resistance in extremely drug-resistant Acinetobacter baumannii containing a novel pmrCAB operon during colistin therapy of wound infections","volume":"208","author":"Lesho","year":"2013","journal-title":"J. Infect. Dis."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1038\/nrmicro1614","article-title":"The antibiotic resistome: The nexus of chemical and genetic diversity","volume":"5","author":"Wright","year":"2007","journal-title":"Nat. Rev. Genet."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1111\/adj.12643","article-title":"Antibiotic resistance and relevance to general dental practice in Australia","volume":"63","author":"Teoh","year":"2018","journal-title":"Aust. Dent. J."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1111\/adj.12727","article-title":"Think before you prescribe: How dentistry contributes to antibiotic resistance","volume":"65","author":"Sukumar","year":"2019","journal-title":"Aust. Dent. J."},{"key":"ref_6","unstructured":"Oral and Dental Expert Group (2019). Therapeutic Guidelines: Oral and Dental, Therapeutic Guidelines Ltd."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1111\/adj.12622","article-title":"Current prescribing trends of antibiotics by dentists in Australia from 2013 to 2016. Part 1","volume":"63","author":"Teoh","year":"2018","journal-title":"Aust. Dent. J."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1007\/s00404-010-1646-3","article-title":"Antibiotic chemotherapy during pregnancy and lactation period: Aspects for consideration","volume":"283","author":"Mylonas","year":"2011","journal-title":"Arch. Gynecol. Obstet."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"7993","DOI":"10.3390\/ijerph110807993","article-title":"Antibiotic use and misuse during pregnancy and delivery: Benefits and risks","volume":"11","year":"2014","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1002\/pds.1915","article-title":"Prevalence and predictors of anti-infective use during pregnancy","volume":"19","author":"Santos","year":"2010","journal-title":"Pharmacoepidemiol. Drug Saf."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1002\/pds.3492","article-title":"Antibiotics prescribed before, during and after pregnancy in the Netherlands: A drug utilization study","volume":"23","author":"Bos","year":"2014","journal-title":"Pharmacoepidemiol. Drug Saf."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12916-016-0636-0","article-title":"Antibiotic use during pregnancy: How bad is it?","volume":"14","author":"Kuperman","year":"2016","journal-title":"BMC Med."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"e040334","DOI":"10.1136\/bmjopen-2020-040334","article-title":"Containment of Antibiotic REsistance\u2014Measures to improve antibiotic use in pregnancy, childbirth and young children (CAREChild): A protocol of a prospective, quasiexperimental interventional study in Lao PDR","volume":"10","author":"Machowska","year":"2020","journal-title":"BMJ Open"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1002\/phar.1649","article-title":"A Review of Antibiotic Use in Pregnancy","volume":"35","author":"Bookstaver","year":"2015","journal-title":"Pharmacother. J. Hum. Pharmacol. Drug Ther."},{"key":"ref_15","unstructured":"Centers for Disease Control and Prevention (2012, June 08). Breastfeeding Among U.S. Children Born 2000\u20132008, CDC National Immunization Survey, Available online: www.cdc.gov\/breastfeeding\/data\/NIS_data\/index.htm."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.diagmicrobio.2018.09.015","article-title":"How safe is doxycycline for young children or for pregnant or breastfeeding women?","volume":"93","author":"Wormser","year":"2019","journal-title":"Diagn Microbiol. Infect. Dis."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1136\/pgmj.2010.103606","article-title":"Prescribing in pregnancy and during breast feeding: Using principles in clinical practice","volume":"87","author":"Henderson","year":"2011","journal-title":"Postgrad. Med. J."},{"key":"ref_18","unstructured":"Hoover, C., Briggs, G.G., Freeman, R.K., Yaffe, S.J., and Williams, L. (2003). Wilkins Drugs in Pregnancy and Lactation: A Reference Guide to Fetal and Neonatal Risk, Wolters Kluwer\/Lippincott Williams & Wilkins. [6th ed.]."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1159\/000442408","article-title":"Antibiotics and breastfeeding","volume":"61","author":"Lopes","year":"2016","journal-title":"Chemotherapy"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1111\/idj.12146","article-title":"Antibiotics in dental practice: How justified are we","volume":"65","author":"Oberoi","year":"2015","journal-title":"Int. Dent. J."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"6667624","DOI":"10.1155\/2021\/6667624","article-title":"Antibiotic Therapy in Dentistry","volume":"2021","author":"Ahmadi","year":"2021","journal-title":"Int. J. Dent."},{"key":"ref_22","first-page":"CD003811","article-title":"Antibiotics to prevent complications following tooth extractions","volume":"11","author":"Lodi","year":"2012","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.zefq.2017.04.007","article-title":"Quality indicators for the use of systemic antibiotics in dentistry","volume":"122","author":"Hussein","year":"2017","journal-title":"Z. Evid. Fortbild. Qual. Gesundhwes."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1007\/s00228-017-2258-7","article-title":"Rational use of medicine in dentistry: Do dentists prescribe antibiotics in appropriate indications?","volume":"73","author":"Koyuncuoglu","year":"2017","journal-title":"Eur. J. Clin. Pharmacol."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"R\u00f3\u017ca\u0144ska, A., Pac, A., Jachowicz, E., Ja\u015blan, D., Siewierska, M., and W\u00f3jkowska-Mach, J. (2020). Outpatient Antibiotic Prescriptions in Pregnant Women in Ma\u0142opolska Province. Antibiotics, 10.","DOI":"10.3390\/antibiotics10010014"},{"key":"ref_26","unstructured":"(2021, March 03). Antibiotic Resistance: An Ecological Perspective on an Old Problem: This Report Is Based on a Colloquium, Sponsored by the American Academy of Microbiology, Convened October 12\u201314, 2008, at the Conference Center of the Fondation M\u00e9rieux in Annecy, France. Available online: https:\/\/www.asmscience.org\/content\/report\/colloquia\/colloquia.4?crawler=redirect&mimetype=application\/pdf."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1186\/1756-0500-4-266","article-title":"Antibiotics prescribing practices in oral implantology among jordanian dentists. A cross sectional, observational study","volume":"4","author":"AbuKaraky","year":"2011","journal-title":"BMC Res. Notes"},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Chen, C., Gilpin, N., and Walsh, L. (2020). Discrepancy in Therapeutic and Prophylactic Antibiotic Prescribing in General Dentists and Maxillofacial Specialists in Australia. Antibiotics, 9.","DOI":"10.3390\/antibiotics9080492"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1748-5908-7-50","article-title":"Knowledge translation of research findings","volume":"7","author":"Grimshaw","year":"2012","journal-title":"Implement. Sci."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1002\/chp.47","article-title":"Lost in knowledge translation: Time for a map?","volume":"26","author":"Graham","year":"2006","journal-title":"J. Contin. Educ. Health Prof."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Ioannidis, J.P.A. (2006). Evolution and translation of research findings: From bench to where?. PLoS Clin. Trials, 1.","DOI":"10.1371\/journal.pctr.0010036"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.sdentj.2017.02.002","article-title":"From dental science to clinical practice: Knowledge translation and evidence-based dentistry principles","volume":"29","author":"Afrashtehfar","year":"2017","journal-title":"Saudi Dent. J."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"American Academy of Pediatrics Committee on Drugs (2001). Transfer of drugs and other chemicals into human milk. Pediatrics, 108, 776\u2013789.","DOI":"10.1542\/peds.108.3.776"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1177\/154405910508400703","article-title":"Drug-induced Disorders of Teeth","volume":"84","author":"Tredwin","year":"2005","journal-title":"J. Dent. Res."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1080\/0036554021000027010","article-title":"Risk of Infantile Hypertrophic Pyloric Stenosis after Maternal Postnatal Use of Macrolides","volume":"35","author":"Skriver","year":"2003","journal-title":"Scand. J. Infect. Dis."},{"key":"ref_36","first-page":"669","article-title":"Pyloric stenosis associated with erythromycin ingested through breast milk","volume":"69","author":"Stang","year":"1986","journal-title":"Minn Med."},{"key":"ref_37","first-page":"1272","article-title":"Knowledge, practice and attitudes regarding antibiotics use among Lebanese dentists","volume":"16","author":"Mansour","year":"2018","journal-title":"Pharm. Pr."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"2382","DOI":"10.1093\/jac\/dkv115","article-title":"Incidence and nature of adverse reactions to antibiotics used as endocarditis prophylaxis: Figure 1","volume":"70","author":"Thornhill","year":"2015","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1038\/sj.bdj.2016.299","article-title":"Drug therapy during pregnancy: Implications for dental practice","volume":"220","author":"Ouanounou","year":"2016","journal-title":"Br. Dent. J."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Ather, A., Zhong, S., Rosenbaum, A.J., Quinonez, R.B., and Khan, A.A. (2020). Pharmacotherapy during Pregnancy: An Endodontic Perspective. J. Endod., 46.","DOI":"10.1016\/j.joen.2020.05.024"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1007\/s12663-019-01206-z","article-title":"Delay in the Referral of Pregnant Patients with Fascial Spaces Infection: A Cross-Sectional Observational Study from Khartoum Teaching Dental Hospital, Sudan","volume":"19","author":"Ali","year":"2020","journal-title":"J. Maxillofac. Oral Surg."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"3265","DOI":"10.3889\/oamjms.2019.678","article-title":"Awareness of Dental Interns to Treat Pregnant Patients","volume":"7","author":"Swapna","year":"2019","journal-title":"Open Access Maced. J. Med. Sci."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"858","DOI":"10.14219\/jada.archive.2012.0290","article-title":"Pregnancy, breast-feeding and drugs used in dentistry","volume":"143","author":"Donaldson","year":"2012","journal-title":"J. Am. Dent. Assoc."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1590\/S1678-77572008000300006","article-title":"Prenatal dental care: Evaluation of professional knowledge of obstetricians and dentists in the cities of Londrina\/PR and Bauru\/SP, Brazil, 2004","volume":"16","author":"Zanata","year":"2008","journal-title":"J. Appl. Oral Sci."},{"key":"ref_45","first-page":"135","article-title":"Antibiotics in Pregnancy: Are They Safe?","volume":"2","author":"Norwitz","year":"2009","journal-title":"Rev. Obstet. Gynecol."},{"key":"ref_46","first-page":"1169","article-title":"Antibiotics in Endodontics: A review","volume":"50","author":"Gould","year":"2016","journal-title":"Int. Endod. J."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.cden.2016.11.004","article-title":"Odontogenic Infections","volume":"61","author":"Ogle","year":"2017","journal-title":"Dent. Clin. N. Am."},{"key":"ref_48","first-page":"e5592","article-title":"Management of Acute Periodontal Abscess Mimicking Acute Apical Abscess in the Anterior Lingual Region: A Case Report","volume":"11","author":"Alharbi","year":"2019","journal-title":"Cureus"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1258\/0022215041615227","article-title":"How serious are oral infections?","volume":"118","author":"Baqain","year":"2004","journal-title":"J. Laryngol. Otol."},{"key":"ref_50","first-page":"120","article-title":"Third molar infections","volume":"9","year":"2004","journal-title":"Med. Oral Patol. Oral Cir. Bucal."},{"key":"ref_51","first-page":"197","article-title":"Worldwide pattern of antibiotics prescription in endodontic infections","volume":"67","author":"Gallardo","year":"2017","journal-title":"J. Clin. Exp. Dent."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1111\/j.1834-7819.2000.tb00554.x","article-title":"Antibiotic prescribing practices by South Australian general dental practitioners","volume":"45","author":"Jaunay","year":"2000","journal-title":"Aust. Dent. J."}],"container-title":["Antibiotics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2079-6382\/10\/6\/668\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T06:10:36Z","timestamp":1760163036000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2079-6382\/10\/6\/668"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,3]]},"references-count":52,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2021,6]]}},"alternative-id":["antibiotics10060668"],"URL":"https:\/\/doi.org\/10.3390\/antibiotics10060668","relation":{},"ISSN":["2079-6382"],"issn-type":[{"value":"2079-6382","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,3]]}}}