{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T21:29:31Z","timestamp":1790285371807,"version":"4.1.0"},"reference-count":35,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2021,6,8]],"date-time":"2021-06-08T00:00:00Z","timestamp":1623110400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Bionorica","award":["2673105"],"award-info":[{"award-number":["2673105"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antibiotics"],"abstract":"<jats:p>Objective: The goal of the present study was to evaluate treatment with Canephron\u00ae compared to standard antibiotic treatment after diagnosis of acute cystitis or urinary tract infection (UTI), with regard to the risk of sporadic recurrent UTIs, frequent recurrent UTIs, UTI-related sick leave, additional antibiotic prescriptions, and renal complications (pyelonephritis). Methods: This retrospective cohort study was based on data from the IMS\u00ae Disease Analyzer database (IQVIA), and included outpatients in Germany with at least one diagnosis of acute cystitis or UTI with a prescription of either Canephron\u00ae or standard antibiotics between January 2016 and June 2019 and treated in general practitioner (GP), gynecologist, or urologist practices, from which the data were obtained. Multivariable regression models were used to investigate the association between Canephron\u00ae prescription and the amount of sporadic or frequent recurrent UTIs, as well as the duration of UTI-related sick leave, the number of additional antibiotic prescriptions, and cases of pyelonephritis. The effects of Canephron\u00ae were adjusted for age, sex, insurance status, and Charlson comorbidity score (CCI). Results: 2320 Canephron\u00ae patients and 158,592 antibiotic patients were available for analysis. Compared to antibiotic prescription, Canephron\u00ae prescription was significantly associated with fewer sporadic recurrences of UTI infections 30\u2013365 days after the index date (odds ratio (OR): 0.66; 95%, confidence interval (CI): 0.58\u20130.72), as well as less frequent recurrences of UTI infections (OR: 0.61; 95% CI: 0.49\u20130.88), and also with reduced additional antibiotic prescription within 31\u2013365 days (OR: 0.57; 95% CI: 0.52\u20130.63). No significant differences were observed between the Canephron\u00ae and antibiotic cohorts with regard to the likelihood of sick leave (OR: 0.99; 95% CI: 0.86\u20131.14), new antibiotic prescription within 1\u201330 days (OR: 1.01; 95% CI: 0.87\u20131.16), or occurrence of pyelonephritis (Hazard Ratio (HR): 1.00; 95% CI: 0.67\u20131.48). Conclusion: These real-world data show that Canephron\u00ae is an effective, safe symptomatic treatment for acute cystitis or UTI. It should be considered as an alternative treatment, particularly to also strengthen antimicrobial stewardship strategies.<\/jats:p>","DOI":"10.3390\/antibiotics10060685","type":"journal-article","created":{"date-parts":[[2021,6,8]],"date-time":"2021-06-08T12:08:55Z","timestamp":1623154135000},"page":"685","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Treatment of Urinary Tract Infections with Canephron\u00ae in Germany: A Retrospective Database Analysis"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3994-4351","authenticated-orcid":false,"given":"Martina","family":"H\u00f6ller","sequence":"first","affiliation":[{"name":"Bionorica SE, Kerschensteinerstr. 11-15, 92318 Neumarkt, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7195-5061","authenticated-orcid":false,"given":"Hubert","family":"Steindl","sequence":"additional","affiliation":[{"name":"Bionorica SE, Kerschensteinerstr. 11-15, 92318 Neumarkt, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitri","family":"Abramov-Sommariva","sequence":"additional","affiliation":[{"name":"Bionorica SE, Kerschensteinerstr. 11-15, 92318 Neumarkt, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2909-0797","authenticated-orcid":false,"given":"Florian","family":"Wagenlehner","sequence":"additional","affiliation":[{"name":"Clinic for Urology, Pediatric Urology and Andrology, Justus-Liebig University, Giessen, Rudolf-Buchheim-Stra\u00dfe 7, 35392 Giessen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1304-5403","authenticated-orcid":false,"given":"Kurt G.","family":"Naber","sequence":"additional","affiliation":[{"name":"Department of Urology, Technical University of Munich, PA: Karl-Bickleder Street 44c, 94315 Straubing, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karel","family":"Kostev","sequence":"additional","affiliation":[{"name":"IQVIA, Epidemiology, Unterscheinstiege 2-14, 60549 Frankfurt, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,6,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1038\/nrmicro3432","article-title":"Urinary tract infections: Epidemiology, mechanisms of infection and treatment options","volume":"13","author":"Walker","year":"2015","journal-title":"Nat. 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