{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T19:35:28Z","timestamp":1790796928777,"version":"4.1.0"},"reference-count":27,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2021,7,12]],"date-time":"2021-07-12T00:00:00Z","timestamp":1626048000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"USAMVBT","award":["Grant 35PFE"],"award-info":[{"award-number":["Grant 35PFE"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antibiotics"],"abstract":"<jats:p>Treating infections caused by Pseudomonas aeruginosa is increasingly difficult due to high antibiotic resistance, materialized through the presence of multiple resistance strains, as well as due to rapid development of resistance throughout treatment. The present survey was conducted to investigate the antibiotic susceptibility profile of Pseudomonas aeruginosa pathogens in two University Veterinary hospitals from different geographical regions of Romania (i.e., Southwest Timi\u0219oara county and Northeast Ia\u0219i county) involved in superficial canine infections. A total of 142 swab specimens were collected from dogs with superficial infections (superficial skin infections, otitis externa, and perianal abscess) to assess the presence of Pseudomonas\u00a0aeruginosa, based on phenotypic and molecular characterization. According to their confirmed morphological and molecular features, 58 samples (40.84%; 58\/142) were positive for Pseudomonas\u00a0aeruginosa (according to their confirmed morphological and molecular features). Antibiotic susceptibility testing for 12 antibiotics was conducted using the Kirby\u2013Bauer disc diffusion method. Drug resistance was observed in the case of all tested antibiotics. The susceptibility rate of P. aeruginosa strains that were tested in this study was in the following order: ceftazidime (53.44%; 31\/58), followed by aztreonam (51.72%; 30\/58), amikacin (44.82%; 26\/58), azithromycin (41.37%; 24\/58), gentamicin (37.93%; 22\/58), cefepime (36.20%; 21\/58), meropenem (25.86%; 13\/58), piperacillin-tazobactam (25.86%; 13\/58), imipenem (22.41%; 13\/158), ciprofloxacin (17.24%; 10\/58), tobramycin (8.62; 5\/58), and polymyxin B (1.72; 1\/58). The results highlight the importance of antibiotic susceptibility testing in Pseudomonas\u00a0aeruginosa isolates from dogs with superficial infections to use an adequate treatment plan to manage the skin condition and other pathologies (otitis externa and perianal abscesses).<\/jats:p>","DOI":"10.3390\/antibiotics10070846","type":"journal-article","created":{"date-parts":[[2021,7,12]],"date-time":"2021-07-12T21:56:37Z","timestamp":1626126997000},"page":"846","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Antibiotic Susceptibility Profile of Pseudomonas aeruginosa Canine Isolates from a Multicentric Study in Romania"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5859-5057","authenticated-orcid":false,"given":"J\u00e1nos","family":"D\u00e9gi","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases and Preventive Medicine, Faculty of Veterinary Medicine, Banat\u2019s University of Agricultural Sciences and Veterinary Medicine \u201cKing Michael I of Romania\u201d from Timisoara, 300645 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oana-Alexandra","family":"Mo\u021bco","sequence":"additional","affiliation":[{"name":"Dialab Solutions, 011607 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana Maria","family":"D\u00e9gi","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Pharmacy, Faculty of Veterinary Medicine, Banat\u2019s University of Agricultural Sciences and Veterinary Medicine \u201cKing Michael I of Romania\u201d from Timisoara, 300645 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4698-4108","authenticated-orcid":false,"given":"Tiana","family":"Suici","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Faculty of Veterinary Medicine, Banat\u2019s University of Agricultural Sciences and Veterinary Medicine \u201cKing Michael I of Romania\u201d from Timisoara, 300645 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3103-4954","authenticated-orcid":false,"given":"Mihai","family":"Mare\u0219","sequence":"additional","affiliation":[{"name":"Department of Public Health, Faculty of Veterinary Medicine, \u201cIon Ionescu de la Brad\u201d University of Life Sciences, 700489 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kalman","family":"Imre","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Preventive Medicine, Faculty of Veterinary Medicine, Banat\u2019s University of Agricultural Sciences and Veterinary Medicine \u201cKing Michael I of Romania\u201d from Timisoara, 300645 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5420-1516","authenticated-orcid":false,"given":"Romeo Teodor","family":"Cristina","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Pharmacy, Faculty of Veterinary Medicine, Banat\u2019s University of Agricultural Sciences and Veterinary Medicine \u201cKing Michael I of Romania\u201d from Timisoara, 300645 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,7,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.tvjl.2013.11.014","article-title":"Canine superficial bacterial folliculitis: Current understanding of its etiology, diagnosis, and treatment","volume":"199","author":"Bloom","year":"2014","journal-title":"Vet. J."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1111\/j.1365-3164.2006.00550.x","article-title":"Pyoderma caused by Pseudomonas aeruginosa infection in dogs: 20 Cases","volume":"17","author":"Hillier","year":"2006","journal-title":"Vet. Dermatol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/j.cvsm.2003.10.009","article-title":"Medical therapy of otitis externa and otitis media","volume":"34","author":"Morris","year":"2004","journal-title":"Vet. Clin. Small Anim. Pract."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1111\/jam.12707","article-title":"Characterization of antibiotic and disinfectant susceptibility profiles among P seudomonas aeruginosa veterinary isolates recovered during 1994\u20132003","volume":"118","author":"Beier","year":"2015","journal-title":"J. Appl. Microbiol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1136\/vr.101069","article-title":"Suggested guidelines for using systemic antimicrobials in bacterial skin infections: Part 1\u2014Diagnosis based on clinical presentation, cytology and culture","volume":"172","author":"Beco","year":"2013","journal-title":"Vet. Rec."},{"key":"ref_6","first-page":"204","article-title":"Canine superficial pyoderma and therapeutic considerations","volume":"57","author":"Bajwa","year":"2016","journal-title":"Can. Vet. J."},{"key":"ref_7","first-page":"130","article-title":"Salmonella in the feed industry: Problems and potential solutions","volume":"2","year":"2019","journal-title":"J. Agron. Technol. Eng. Manag."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"163-e43","DOI":"10.1111\/vde.12118","article-title":"Guidelines for the diagnosis and antimicrobial therapy of canine superficial bacterial folliculitis (Antimicrobial Guidelines Working Group of the International Society for Companion Animal Infectious Diseases)","volume":"25","author":"Hillier","year":"2014","journal-title":"Vet. Dermatol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.vetmic.2008.02.018","article-title":"Antimicrobial resistance and genetic characterization of fluoroquinolone resistance of Pseudomonas aeruginosa isolated from canine infections","volume":"131","author":"Rubin","year":"2008","journal-title":"Vet. Microbiol."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Valderrama, M.-J., Alfaro, M., Rodr\u00edguez-Avial, I., Baos, E., Rodr\u00edguez-Avial, C., and Culebras, E. (2020). Synergy of linezolid with several antimicrobial agents against linezolid-methicillin-resistant Staphylococcal strains. Antibiotics, 9.","DOI":"10.3390\/antibiotics9080496"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1111\/j.1365-3164.2007.00581.x","article-title":"Variability of laboratory identification and antibiotic susceptibility reporting of Pseudomonas spp. isolates from dogs with chronic otitis externa","volume":"18","author":"Schick","year":"2007","journal-title":"Vet. Dermatol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1292\/jvms1939.52.233","article-title":"Serotypes and antimicrobial susceptibility of Pseudomonas aeruginosa strains isolated from diseased dogs","volume":"52","author":"Ozaki","year":"1990","journal-title":"Jpn. J. Vet. Sci."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Zhen, X., St\u00e5lsby Lundborg, C., Sun, X., Gu, S., and Dong, H. (2020). Clinical and economic burden of carbapenem-resistant infection or colonization caused by Klebsiella pneumoniae, Pseudomonas aeruginosa, Acinetobacter baumannii: A multicenter study in China. Antibiotics, 9.","DOI":"10.3390\/antibiotics9080514"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1046\/j.1439-0450.2000.00336.x","article-title":"Antibacterial susceptibility patterns of Pseudomonas strains isolated from chronic canine otitis externa","volume":"47","year":"2000","journal-title":"J. Vet. Med. Ser. B"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1128\/CMR.00040-09","article-title":"Antibacterial-resistant Pseudomonas aeruginosa: Clinical impact and complex regulation of chromosomally encoded resistance mechanisms","volume":"22","author":"Lister","year":"2009","journal-title":"Clin. Microbiol. Rev."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"301","DOI":"10.5326\/0460301","article-title":"Evaluation of the clinical efficacy of pradofloxacin tablets for the treatment of canine pyoderma","volume":"46","author":"Restrepo","year":"2010","journal-title":"J. Am. Anim. Hosp. Assoc."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/S0378-1135(03)00129-9","article-title":"Mechanisms of fluoroquinolone resistance in Pseudomonas aeruginosa isolates from canine infections","volume":"94","author":"Tejedor","year":"2003","journal-title":"Vet. Microbiol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.vetmic.2010.05.014","article-title":"Topical treatment of Pseudomonas aeruginosa otitis of dogs with a bacteriophage mixture: A before\/after clinical trial","volume":"146","author":"Hawkins","year":"2010","journal-title":"Vet. Microbiol."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Sian-Frosini, M., and Bond, R. (2017). Activity in vitro of clotrimazole against canine methicillin-resistant and susceptible Staphylococcus pseudintermedius. Antibiotics, 6.","DOI":"10.3390\/antibiotics6040029"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Meroni, G., Cardin, E., Rendina, C., Herrera Millar, V.R., Soares Filipe, J.F., and Martino, P.A. (2020). In vitro efficacy of essential oils from Melaleuca Alternifolia and Rosmarinus Officinalis, manuka honey-based gel, and propolis as antibacterial agents against canine Staphylococcus pseudintermedius strains. Antibiotics, 9.","DOI":"10.3390\/antibiotics9060344"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"337","DOI":"10.5326\/0430337","article-title":"Susceptibility of Pseudomonas isolates from the ears and skin of dogs to enrofloxacin, marbofloxacin, and ciprofloxacin","volume":"43","author":"Wildermuth","year":"2007","journal-title":"J. Am. Anim. Hosp. Assoc."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Kakoullis, L., Papachristodoulou, E., Chra, P., and Panos, G. (2021). Mechanisms of antibiotic resistance in important gram-positive and gram-negative pathogens and novel antibiotic solutions. Antibiotics, 10.","DOI":"10.3390\/antibiotics10040415"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Behzadi, P., Bar\u00e1th, Z., and Gajd\u00e1cs, M. (2021). It\u2019s not easy being green: A narrative review on the microbiology, virulence and therapeutic prospects of multidrug-resistant Pseudomonas aeruginosa. Antibiotics, 10.","DOI":"10.3390\/antibiotics10010042"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"245","DOI":"10.3109\/1040841X.2010.481763","article-title":"\u03b2-Lactamases identified in clinical isolates of Pseudomonas aeruginosa","volume":"36","year":"2010","journal-title":"Crit. Rev. Microbiol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"2074","DOI":"10.1128\/JCM.42.5.2074-2079.2004","article-title":"PCR-based assay for differentiation of Pseudomonas aeruginosa from other Pseudomonas species recovered from cystic fibrosis patients","volume":"42","author":"Spilker","year":"2004","journal-title":"J. Clin. Microbiol."},{"key":"ref_26","unstructured":"Weinstein, M.P. (2019). M100: Performance Standards for Antimicrobial Susceptibility Testing, Clinical and Laboratory Standards Institute."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"3341","DOI":"10.1128\/JCM.38.9.3341-3348.2000","article-title":"Use of the National Committee for Clinical Laboratory Standards guidelines for disk diffusion susceptibility testing in New York state laboratories","volume":"38","author":"Kiehlbauch","year":"2000","journal-title":"J. Clin. Microbiol."}],"container-title":["Antibiotics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2079-6382\/10\/7\/846\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T06:29:14Z","timestamp":1760164154000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2079-6382\/10\/7\/846"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,12]]},"references-count":27,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2021,7]]}},"alternative-id":["antibiotics10070846"],"URL":"https:\/\/doi.org\/10.3390\/antibiotics10070846","relation":{"has-preprint":[{"id-type":"doi","id":"10.20944\/preprints202104.0561.v1","asserted-by":"object"}]},"ISSN":["2079-6382"],"issn-type":[{"value":"2079-6382","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7,12]]}}}