{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T03:11:35Z","timestamp":1784776295956,"version":"3.55.0"},"reference-count":117,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2021,7,28]],"date-time":"2021-07-28T00:00:00Z","timestamp":1627430400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antibiotics"],"abstract":"<jats:p>Dental implants are, nowadays, established surgical devices for the restoration of lost teeth. Considered as an alternative for traditional prosthetic appliances, dental implants surpass them in reliability and patient feedback. Local drug delivery around the implants promotes osseointegration and reduces peri-implantitis. However, there are currently no methods of a multiple, precise topical administration of drugs to the implant area. Engineering coatings on the implants, drug application on carriers during implantation, or gingival pockets do not meet all requirements of dental surgeons. Therefore, there is a need to create porous implants and other medical devices that will allow a multiple drug delivery at a controlled dose and release profile without traumatic treatment. Due to the growing demand for the use of biologically active agents to support dental implant treatment at its various stages (implant placement, long-term use of dental superstructures, treatment of the peri-implant conditions) and due to the proven effectiveness of the topical application of pharmacological biologically active agents to the implant area, the authors would like to present a review and show the methods and devices that can be used by clinicians for local drug administration to facilitate dental implant treatment. Our review concludes that there is a need for research in the field of inventions such as new medical devices or implants with gradient solid\u2013porous structures. These devices, in the future, will enable to perform repeatable, controllable, atraumatic, and repeatable injections of active factors that may affect the improvement of osteointegration and the longer survival of implants, as well as the treatment of peri-implantitis.<\/jats:p>","DOI":"10.3390\/antibiotics10080919","type":"journal-article","created":{"date-parts":[[2021,7,28]],"date-time":"2021-07-28T21:21:04Z","timestamp":1627507264000},"page":"919","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Methods of Topical Administration of Drugs and Biological Active Substances for Dental Implants\u2014A Narrative Review"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6286-5697","authenticated-orcid":false,"given":"Piotr","family":"Wychowa\u0144ski","sequence":"first","affiliation":[{"name":"Department of Oral Surgery, Medical University of Warsaw, 6 St. Binieckiego Street, 02-097 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6900-0429","authenticated-orcid":false,"given":"Anna","family":"Starzy\u0144ska","sequence":"additional","affiliation":[{"name":"Department of Oral Surgery, Medical University of Gda\u0144sk, 7 D\u0119binki Street, 80-211 Gda\u0144sk, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0514-4997","authenticated-orcid":false,"given":"Paulina","family":"Adamska","sequence":"additional","affiliation":[{"name":"Department of Oral Surgery, Medical University of Gda\u0144sk, 7 D\u0119binki Street, 80-211 Gda\u0144sk, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8167-5744","authenticated-orcid":false,"given":"Monika","family":"S\u0142upecka-Ziemilska","sequence":"additional","affiliation":[{"name":"Department of Human Epigenetics, Mossakowski Medical Research Center, Polish Academy of Sciences, 5 Pawi\u0144skiego Street, 02-106 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5074-9701","authenticated-orcid":false,"given":"Bartosz Kamil","family":"Sobocki","sequence":"additional","affiliation":[{"name":"Department of Oral Surgery, Medical University of Gda\u0144sk, 7 D\u0119binki Street, 80-211 Gda\u0144sk, Poland"},{"name":"International Research Agenda 3P\u2014Medicine Laboratory, Medical University of Gda\u0144sk, 3a Marii Sk\u0142odowskiej-Curie Street, 80-210 Gda\u0144sk, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnieszka","family":"Chmielewska","sequence":"additional","affiliation":[{"name":"Faculty of Material Science and Engineering, Warsaw University of Technology, 141 Wo\u0142oska Street, 02-507 Warsaw, Poland"},{"name":"Department of Materials Science and Engineering, The Ohio State University, 140 W 19th Ave, Columbus, OH 43210, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4119-621X","authenticated-orcid":false,"given":"Bart\u0142omiej","family":"Wysocki","sequence":"additional","affiliation":[{"name":"Center of Digital Science and Technology, Cardinal Stefan Wyszy\u0144ski University in Warsaw, Woycickiego 1\/3 Street, 01-938 Warsaw, Poland"},{"name":"Additive Manufacturing Research Center, College of Engineering, Youngstown State University, Youngstown, OH 44555, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Alterio","sequence":"additional","affiliation":[{"name":"Division of Radiotherapy, IEO European Institute of Oncology, IRCCS, 435 Ripamonti Street, 20141 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Marvaso","sequence":"additional","affiliation":[{"name":"Division of Radiotherapy, IEO European Institute of Oncology, IRCCS, 435 Ripamonti Street, 20141 Milan, Italy"},{"name":"Department of Oncology and Hemato-Oncology, University of Milan, 7 Festa del Perdono Street, 20112 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8151-3673","authenticated-orcid":false,"given":"Barbara Alicja","family":"Jereczek-Fossa","sequence":"additional","affiliation":[{"name":"Division of Radiotherapy, IEO European Institute of Oncology, IRCCS, 435 Ripamonti Street, 20141 Milan, Italy"},{"name":"Department of Oncology and Hemato-Oncology, University of Milan, 7 Festa del Perdono Street, 20112 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Kowalski","sequence":"additional","affiliation":[{"name":"Department of Periodontology and Oral Medicine, Medical University of Warsaw, 6 St. Binieckiego Street, 02-097 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,7,28]]},"reference":[{"key":"ref_1","first-page":"81","article-title":"Intra-osseous anchorage of dental prostheses. 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