{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T18:05:07Z","timestamp":1760551507238,"version":"build-2065373602"},"reference-count":41,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2021,7,31]],"date-time":"2021-07-31T00:00:00Z","timestamp":1627689600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002509","name":"Keimyung University","doi-asserted-by":"publisher","award":["20200341"],"award-info":[{"award-number":["20200341"]}],"id":[{"id":"10.13039\/501100002509","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antibiotics"],"abstract":"<jats:p>Antimicrobial resistance is currently becoming a global threat to human health. We performed a retrospective study on patients who underwent emergency cerclage between January 2016 and December 2018 at the Dongsan Medical Center. Cervical culture was first performed before surgery to confirm that there was no infection and was repeated on days 1, 4, and 7 after surgery. A total of 85 pregnant women underwent emergency cerclage. Among them, six patients had vancomycin-resistant enterococci (VRE) colonization in the cervix after cerclage, and 23 patients developed extended-spectrum \u03b2-lactamase (ESBL)-producing bacterial colonization in the cervix. The average gestational age at delivery was lower in the VRE group. Neonatal death was also significantly higher in the VRE group. The rate of occurrence of early-onset sepsis was also higher in the VRE group, and both VRE and ESBL-producing bacterial colonization cases in which early-onset sepsis occurred resulted in neonatal death. The prognosis of cervical VRE colonization after cervical surgery was poor, whereas the prognosis of ESBL-producing bacterial colonization in the cervix did not differ significantly from that of the control group. However, careful neonatal treatment is required considering that early-onset sepsis is fatal to the newborn.<\/jats:p>","DOI":"10.3390\/antibiotics10080933","type":"journal-article","created":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T21:51:07Z","timestamp":1627854667000},"page":"933","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Vancomycin-Resistant Enterococci and Extended-Spectrum \u03b2-Lactamase-Producing Bacterial Colonization of the Cervix after Emergency Cerclage: Is It Safe?"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9675-7459","authenticated-orcid":false,"given":"Won-Kyu","family":"Jang","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Keimyung University School of Medicine, Dongsan Medical Center, Daegu 42601, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin-Gon","family":"Bae","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Keimyung University School of Medicine, Dongsan Medical Center, Daegu 42601, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,7,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/S0140-6736(08)60136-1","article-title":"An overview of mortality and sequelae of preterm birth from infancy to adulthood","volume":"371","author":"Saigal","year":"2008","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"American College of Obstetricians and Gynecologists (2014). ACOG Practice Bulletin No. 142: Cerclage for the management of cervical insufficiency. Obstet. Gynecol., 123, 372\u2013379.","DOI":"10.1097\/01.AOG.0000443276.68274.cc"},{"key":"ref_3","unstructured":"Cerclage, R.C. (2021, June 01). Green-top Guideline No. 60. Available online: https:\/\/www.rcog.org.uk\/en\/guidelines-research-services\/guidelines\/gtg60."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1097\/01.AOG.0000168435.17200.53","article-title":"Cerclage for short cervix on ultrasonography: Meta-analysis of trials using individual patient-level data","volume":"106","author":"Berghella","year":"2005","journal-title":"Obstet. Gynecol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.siny.2011.08.001","article-title":"Prevention of preterm birth","volume":"17","author":"Flood","year":"2012","journal-title":"Proc. Semin. Fetal Neonatal Med."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1097\/01.AOG.0000275287.08520.4a","article-title":"Prediction and prevention of recurrent spontaneous preterm birth","volume":"110","author":"Spong","year":"2007","journal-title":"Obstet. Gynecol."},{"key":"ref_7","unstructured":"Frieden, T., and US Department of Health & Human Services (2014, February 16). Antibiotic Resistance and the Threat to Public Health, Available online: http:\/\/www.hhs.gov\/asl\/testify\/2010\/04\/t20100428b.html."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1128\/CMR.13.4.686","article-title":"Vancomycin-resistant enterococci","volume":"13","author":"Cetinkaya","year":"2000","journal-title":"Clin. Microbiol. Rev."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1097\/QCO.0b013e3283398dc1","article-title":"Extended-spectrum [beta]-lactamase producing Escherichia coli: Changing epidemiology and clinical impact","volume":"23","author":"Oteo","year":"2010","journal-title":"Curr. Opin. Infect. Dis."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1016\/j.ajog.2015.03.020","article-title":"Extended-spectrum beta-lactamase infections during pregnancy: A growing threat","volume":"213","author":"Eppes","year":"2015","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/j.1469-0691.2007.01857.x","article-title":"Defining an extended-spectrum beta-lactamase","volume":"14","author":"Livermore","year":"2008","journal-title":"Clin. Microbiol. Infect."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1128\/JCM.42.2.855-857.2004","article-title":"Prevalence of vancomycin-resistant enterococcus in prenatal screening cultures","volume":"42","author":"Miller","year":"2004","journal-title":"J. Clin. Microbiol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.ejogrb.2020.01.025","article-title":"Vaginal colonization of extended-spectrum beta-lactamase-producing bacteria during pregnancy: An observational study","volume":"246","author":"Foessleitner","year":"2020","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"ref_14","first-page":"788","article-title":"Global emergence and dissemination of enterococci as nosocomial pathogens: Attack of the clones?","volume":"7","author":"Rogers","year":"2016","journal-title":"Front. Microbiol."},{"key":"ref_15","first-page":"DC06","article-title":"Screening for intestinal colonization with vancomycin resistant enterococci and associated risk factors among patients admitted to an adult intensive care unit of a large teaching hospital","volume":"10","author":"Amberpet","year":"2016","journal-title":"J. Clin. Diagn. Res. JCDR"},{"key":"ref_16","first-page":"768","article-title":"Vancomycin resistant Enterococci: A brief review","volume":"68","author":"Raza","year":"2018","journal-title":"J. Pak. Med. Assoc."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.mib.2013.01.006","article-title":"Genomic transition of enterococci from gut commensals to leading causes of multidrug-resistant hospital infection in the antibiotic era","volume":"16","author":"Gilmore","year":"2013","journal-title":"Curr. Opin. Microbiol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1111\/j.1469-0691.2007.01840.x","article-title":"Risk-factors and predictors of mortality in patients colonised with vancomycin-resistant enterococci","volume":"14","author":"Sakka","year":"2008","journal-title":"Clin. Microbiol. Infect."},{"key":"ref_19","first-page":"1008","article-title":"A Novel Technique of Emergency Cerclage for Mid Trimester Cervical Dilatation","volume":"1","author":"Kilani","year":"2018","journal-title":"Ann. Infert. Rep. Endocrin."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1053\/jhin.2002.1373","article-title":"Extended-spectrum beta-lactamase-producing Klebsiella pneumoniae in a neonatal intensive care unit: Risk factors for infection and colonization","volume":"53","author":"Flannery","year":"2003","journal-title":"J. Hosp. Infect."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.jhin.2007.07.026","article-title":"Risk factors for extended-spectrum beta-lactamase-producing Serratia marcescens and Klebsiella pneumoniae acquisition in a neonatal intensive care unit","volume":"67","author":"Crivaro","year":"2007","journal-title":"J. Hosp. Infect."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1016\/S0002-9378(12)80043-3","article-title":"Infection and labor. VIII. Microbial invasion of the amniotic cavity in patients with suspected cervical incompetence: Prevalence and clinical significance","volume":"167","author":"Romero","year":"1992","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"633.e1","DOI":"10.1016\/j.ajog.2007.11.047","article-title":"The frequency and significance of intraamniotic inflammation in patients with cervical insufficiency","volume":"198","author":"Lee","year":"2008","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1016\/S1701-2163(16)32967-X","article-title":"Bacteriology of amniotic fluid in women with suspected cervical insufficiency","volume":"30","author":"Bujold","year":"2008","journal-title":"J. Obstet. Gynaecol. Can."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1515\/jpm.2010.040","article-title":"Detection of ureaplasmas by the polymerase chain reaction in the amniotic fluid of patients with cervical insufficiency","volume":"38","author":"Oh","year":"2010","journal-title":"J. Perinat. Med."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/S1701-2163(15)30656-3","article-title":"Diagnosis of subclinical amniotic fluid infection prior to rescue cerclage using gram stain and glucose tests: An individual patient meta-analysis","volume":"36","author":"Lisonkova","year":"2014","journal-title":"J. Obstet. Gynaecol. Can."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1097\/AOG.0000000000000443","article-title":"Indomethacin and antibiotics in examination-indicated cerclage: A randomized controlled trial","volume":"124","author":"Burwick","year":"2014","journal-title":"Obstet. Gynecol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"140.e1","DOI":"10.1016\/j.ajog.2019.03.017","article-title":"Evidence that antibiotic administration is effective in the treatment of a subset of patients with intra-amniotic infection\/inflammation presenting with cervical insufficiency","volume":"221","author":"Oh","year":"2019","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Peric, A., Weiss, J., Vulliemoz, N., Baud, D., and Stojanov, M. (2019). Bacterial Colonization of the Female Upper Genital Tract. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20143405"},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"AbdelKhalek, A., Abutaleb, N.S., Mohammad, H., and Seleem, M.N. (2018). Repurposing ebselen for decolonization of vancomycin-resistant enterococci (VRE). PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0199710"},{"key":"ref_31","first-page":"49","article-title":"Limits of fetal viability and its enhancement","volume":"5","author":"Breborowicz","year":"2001","journal-title":"Early Pregnancy"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.siny.2004.04.002","article-title":"Epidemiology of preterm birth and neonatal outcome","volume":"9","author":"Wen","year":"2004","journal-title":"Proc. Semin. Fetal Neonatal Med."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.ijid.2017.08.015","article-title":"Maternal colonization or infection with extended-spectrum beta-lactamase-producing Enterobacteriaceae in Africa: A systematic review and meta-analysis","volume":"64","author":"Bulabula","year":"2017","journal-title":"Int. J. Infect. Dis."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"145","DOI":"10.3233\/NPM-1765","article-title":"Distribution, antimicrobial resistance and predictors of mortality in neonatal sepsis","volume":"11","author":"Bandyopadhyay","year":"2018","journal-title":"J. Neonatal-Perinat. Med."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1053\/j.semperi.2012.06.002","article-title":"Risk assessment in neonatal early onset sepsis","volume":"36","author":"Mukhopadhyay","year":"2012","journal-title":"Proc. Semin. Perinatol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1097\/GRF.0000000000000044","article-title":"Cervical cerclage","volume":"57","author":"Suhag","year":"2014","journal-title":"Clin. Obstet. Gynecol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1111\/1471-0528.15600","article-title":"Prospective observational study of vaginal microbiota pre-and post-rescue cervical cerclage","volume":"126","author":"Brown","year":"2019","journal-title":"BJOG Int. J. Obstet. Gynaecol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1111\/jog.12059","article-title":"Outcomes of pregnancy in women who had rescue cerclage for cervical insufficiency: A single-center retrospective study","volume":"39","author":"Gundabattula","year":"2013","journal-title":"J. Obstet. Gynaecol. Res."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1097\/OGX.0b013e31828737c7","article-title":"Emergency cerclage: Literature review","volume":"68","author":"Namouz","year":"2013","journal-title":"Obstet. Gynecol. Surv."},{"key":"ref_40","first-page":"98","article-title":"M100 Performance standards for antimicrobial susceptibility testing","volume":"240","author":"Patel","year":"2017","journal-title":"United State: Clin. Lab. Stand. Inst."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"6579139","DOI":"10.1155\/2018\/6579139","article-title":"Risk factors for vaginal colonization and relationship between bacterial vaginal colonization and in-hospital outcomes in women with obstructed labor in a Ugandan regional referral hospital","volume":"2018","author":"Ngonzi","year":"2018","journal-title":"Int. J. Microbiol."}],"container-title":["Antibiotics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2079-6382\/10\/8\/933\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T06:38:16Z","timestamp":1760164696000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2079-6382\/10\/8\/933"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,31]]},"references-count":41,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2021,8]]}},"alternative-id":["antibiotics10080933"],"URL":"https:\/\/doi.org\/10.3390\/antibiotics10080933","relation":{},"ISSN":["2079-6382"],"issn-type":[{"type":"electronic","value":"2079-6382"}],"subject":[],"published":{"date-parts":[[2021,7,31]]}}}