{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T11:01:46Z","timestamp":1779361306952,"version":"3.51.4"},"reference-count":50,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2021,9,13]],"date-time":"2021-09-13T00:00:00Z","timestamp":1631491200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100006093","name":"Patient-Centered Outcomes Research Institute","doi-asserted-by":"publisher","award":["CER-1402-10800"],"award-info":[{"award-number":["CER-1402-10800"]}],"id":[{"id":"10.13039\/100006093","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antibiotics"],"abstract":"<jats:p>Recurrent skin and soft tissue infections (SSTI) caused by Community-Associated Methicillin-Resistant Staphylococcus aureus (CA-MRSA) or Methicillin-Sensitive Staphylococcus aureus (CA-MSSA) present treatment challenges. This community-based trial examined the effectiveness of an evidence-based intervention (CDC Guidelines, topical decolonization, surface decontamination) to reduce SSTI recurrence, mitigate household contamination\/transmission, and improve patient-reported outcomes. Participants (n = 186) were individuals with confirmed MRSA(+)\/MSSA(+) SSTIs and their household members. During home visits; Community Health Workers\/Promotoras provided hygiene instructions; a five-day supply of nasal mupirocin; chlorhexidine for body cleansing; and household disinfecting wipes (Experimental; EXP) or Usual Care Control (UC CON) pamphlets. Primary outcome was six-month SSTI recurrence from electronic health records (EHR). Home visits (months 0; 3) and telephone assessments (months 0; 1; 6) collected self-report data. Index patients and participating household members provided surveillance culture swabs. Secondary outcomes included household surface contamination; household member colonization and transmission; quality of life; and satisfaction with care. There were no significant differences in SSTI recurrence between EXP and UC in the intent-to-treat cohort (n = 186) or the enrolled cohort (n = 119). EXP participants showed reduced but non-significant colonization rates. EXP and UC did not differ in household member transmission, contaminated surfaces, or patient-reported outcomes. This intervention did not reduce clinician-reported MRSA\/MSSA SSTI recurrence. Taken together with other recent studies that employed more intensive decolonization protocols, it is possible that a promotora-delivered intervention instructing treatment for a longer or repetitive duration may be effective and should be examined by future studies.<\/jats:p>","DOI":"10.3390\/antibiotics10091105","type":"journal-article","created":{"date-parts":[[2021,9,13]],"date-time":"2021-09-13T21:37:12Z","timestamp":1631569032000},"page":"1105","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Comparative Effectiveness Study of Home-Based Interventions to Prevent CA-MRSA Infection Recurrence"],"prefix":"10.3390","volume":"10","author":[{"given":"Jonathan N.","family":"Tobin","sequence":"first","affiliation":[{"name":"Clinical Directors Network, Inc. (CDN), New York, NY 10018, USA"},{"name":"Center for Clinical and Translational Science, The Rockefeller University, New York, NY 10065, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suzanne","family":"Hower","sequence":"additional","affiliation":[{"name":"Clinical Directors Network, Inc. (CDN), New York, NY 10018, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brianna M.","family":"D\u2019Orazio","sequence":"additional","affiliation":[{"name":"Clinical Directors Network, Inc. (CDN), New York, NY 10018, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3273-6392","authenticated-orcid":false,"given":"Mar\u00eda","family":"Pardos de la G\u00e1ndara","sequence":"additional","affiliation":[{"name":"Center for Clinical and Translational Science, The Rockefeller University, New York, NY 10065, USA"},{"name":"Institut Pasteur, 75015 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teresa H.","family":"Evering","sequence":"additional","affiliation":[{"name":"Center for Clinical and Translational Science, The Rockefeller University, New York, NY 10065, USA"},{"name":"Weill Cornell Medicine, New York, NY 10065, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chamanara","family":"Khalida","sequence":"additional","affiliation":[{"name":"Clinical Directors Network, Inc. (CDN), New York, NY 10018, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica","family":"Ramachandran","sequence":"additional","affiliation":[{"name":"Clinical Directors Network, Inc. (CDN), New York, NY 10018, USA"},{"name":"Metropolitan Hospital Center, New York City Health + Hospitals, New York, NY 10029, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leidy Johana","family":"Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Clinical Directors Network, Inc. (CDN), New York, NY 10018, USA"},{"name":"Metropolitan Hospital Center, New York City Health + Hospitals, New York, NY 10029, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rhonda G.","family":"Kost","sequence":"additional","affiliation":[{"name":"Center for Clinical and Translational Science, The Rockefeller University, New York, NY 10065, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kimberly S.","family":"Vasquez","sequence":"additional","affiliation":[{"name":"Center for Clinical and Translational Science, The Rockefeller University, New York, NY 10065, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Herm\u00ednia","family":"de Lencastre","sequence":"additional","affiliation":[{"name":"Laboratory of Microbiology and Infectious Diseases, The Rockefeller University, New York, NY 10065, USA"},{"name":"Instituto de Tecnologia Qu\u00edmica e Biol\u00f3gica (ITQB\/UNL), 2780-157 Oeiras, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Tomasz","sequence":"additional","affiliation":[{"name":"Laboratory of Microbiology and Infectious Diseases, The Rockefeller University, New York, NY 10065, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barry S.","family":"Coller","sequence":"additional","affiliation":[{"name":"Center for Clinical and Translational Science, The Rockefeller University, New York, NY 10065, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roger","family":"Vaughan","sequence":"additional","affiliation":[{"name":"Center for Clinical and Translational Science, The Rockefeller University, New York, NY 10065, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,9,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1086\/666329","article-title":"Trends in hospitalization for community-associated methicillin-resistant Staphylococcus aureus in New York City, 1997\u20132006: Data from New York State\u2019s Statewide Planning and Research Cooperative System","volume":"33","author":"Farr","year":"2012","journal-title":"Infect. 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