{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T00:56:22Z","timestamp":1778633782312,"version":"3.51.4"},"reference-count":89,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2021,10,3]],"date-time":"2021-10-03T00:00:00Z","timestamp":1633219200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antibiotics"],"abstract":"<jats:p>Staphylococcus aureus is a frequent cause of ocular surface infections worldwide. Of these surface infections, those involving the cornea (microbial keratitis) are most sight-threatening. S. aureus can also cause conjunctivitis and contact lens-related non-infectious corneal infiltrative events (niCIE). The aim of this study was to determine the rates of resistance of S. aureus isolates to antibiotics and disinfecting solutions from these different ocular surface conditions. In total, 63 S. aureus strains from the USA and Australia were evaluated; 14 were from niCIE, 26 from conjunctivitis, and 23 from microbial keratitis (MK). The minimum inhibitory (MIC) and minimum bactericidal concentrations (MBC) of all the strains to ciprofloxacin, ceftazidime, oxacillin, gentamicin, vancomycin, chloramphenicol, azithromycin, and polymyxin B were determined. The MIC and MBC of the niCIE strains to contact lens multipurpose disinfectant solutions (MPDSs) was determined. All isolates were susceptible to vancomycin (100%). The susceptibility to other antibiotics decreased in the following order: gentamicin (98%), chloramphenicol (76%), oxacillin (74%), ciprofloxacin (46%), ceftazidime (11%), azithromycin (8%), and polymyxin B (8%). In total, 87% of all the isolates were multidrug resistant and 17% of the isolates from microbial keratitis were extensively drug resistant. The microbial keratitis strains from Australia were usually susceptible to ciprofloxacin (57% vs. 11%; p = 0.04) and oxacillin (93% vs. 11%; p = 0.02) compared to microbial keratitis isolates from the USA. Microbial keratitis isolates from the USA were less susceptible (55%) to chloramphenicol compared to conjunctivitis strains (95%; p = 0.01). Similarly, 75% of conjunctivitis strains from Australia were susceptible to chloramphenicol compared to 14% of microbial keratitis strains (p = 0.04). Most (93%) strains isolated from contact lens wearers were killed in 100% MPDS, except S. aureus 27. OPTI-FREE PureMoist was the most active MPDS against all strains with 35% of strains having an MIC \u2264 11.36%. There was a significant difference in susceptibility between OPTI-FREE PureMoist and Biotrue (p = 0.02). S. aureus non-infectious CIE strains were more susceptible to antibiotics than conjunctivitis strains and conjunctivitis strains were more susceptible than microbial keratitis strains. Microbial keratitis strains from Australia (isolated between 2006 and 2018) were more susceptible to antibiotics in comparison with microbial keratitis strains from the USA (isolated in 2004). Most of the strains were multidrug-resistant. There was variability in the susceptibility of contact lens isolates to MPDSs with one S. aureus strain, S. aureus 27, isolated from niCIE, in Australia in 1997 being highly resistant to all four MPDSs and three different types of antibiotics. Knowledge of the rates of resistance to antibiotics in different conditions and regions could help guide treatment of these diseases.<\/jats:p>","DOI":"10.3390\/antibiotics10101203","type":"journal-article","created":{"date-parts":[[2021,10,4]],"date-time":"2021-10-04T09:24:15Z","timestamp":1633339455000},"page":"1203","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Susceptibility of Ocular Staphylococcus aureus to Antibiotics and Multipurpose Disinfecting Solutions"],"prefix":"10.3390","volume":"10","author":[{"given":"Madeeha","family":"Afzal","sequence":"first","affiliation":[{"name":"School of Optometry and Vision Science, University of New South Wales, Sydney 2052, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8248-6379","authenticated-orcid":false,"given":"Ajay Kumar","family":"Vijay","sequence":"additional","affiliation":[{"name":"School of Optometry and Vision Science, University of New South Wales, Sydney 2052, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fiona","family":"Stapleton","sequence":"additional","affiliation":[{"name":"School of Optometry and Vision Science, University of New South Wales, Sydney 2052, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3842-7563","authenticated-orcid":false,"given":"Mark D. P.","family":"Willcox","sequence":"additional","affiliation":[{"name":"School of Optometry and Vision Science, University of New South Wales, Sydney 2052, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,10,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1370\/afm.526","article-title":"Nasal carriage of Staphylococcus aureus and methicillin-resistant S. aureus in the United States, 2001\u20132002","volume":"4","author":"Mainous","year":"2006","journal-title":"Ann. Fam. Med."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1136\/bjo.85.7.842","article-title":"Bacterial keratitis: A prospective clinical and microbiological study","volume":"85","author":"Schaefer","year":"2001","journal-title":"Br. J. Ophthalmol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1894","DOI":"10.1016\/j.jcrs.2014.09.023","article-title":"Current knowledge about and recommendations for ocular methicillin-resistant Staphylococcus aureus","volume":"40","author":"Mah","year":"2014","journal-title":"J. Cataract Refract. Surg."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1136\/bjophthalmol-2018-312881","article-title":"Queensland microbial keratitis database: 2005\u20132015","volume":"103","author":"Green","year":"2019","journal-title":"Br. J. Ophthalmol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1136\/bjophthalmol-2016-310026","article-title":"Evolving risk factors and antibiotic sensitivity patterns for microbial keratitis at a large county hospital","volume":"101","author":"Jin","year":"2017","journal-title":"Br. J. Ophthalmol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1016\/j.ophtha.2014.11.027","article-title":"Microbial keratitis in los angeles: The doheny eye institute and the los angeles county hospital experience","volume":"122","author":"Sand","year":"2015","journal-title":"Ophthalmology"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1097\/ICO.0b013e31820770f4","article-title":"Pediatric ocular surface infections: A 5-year review of demographics, clinical features, risk factors, microbiological results, and treatment","volume":"30","author":"Wong","year":"2011","journal-title":"Cornea"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1097\/00003226-200307000-00009","article-title":"Clinical characterization of corneal infiltrative events observed with soft contact lens wear","volume":"22","author":"Sweeney","year":"2003","journal-title":"Cornea"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"215","DOI":"10.4103\/0301-4738.40360","article-title":"Medical management approach to infectious keratitis","volume":"56","author":"Gokhale","year":"2008","journal-title":"Indian J. Ophthalmol."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Asbell, P.A., and DeCory, H.H. (2018). Antibiotic resistance among bacterial conjunctival pathogens collected in the Antibiotic Resistance Monitoring in Ocular Microorganisms (ARMOR) surveillance study. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0205814"},{"key":"ref_11","first-page":"735","article-title":"Conjunctivitis","volume":"57","author":"Morrow","year":"1998","journal-title":"Am. Fam. Physician"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Monaco, M., Pimentel de Araujo, F., Cruciani, M., Coccia, E.M., and Pantosti, A. (2016). Worldwide Epidemiology and Antibiotic Resistance of Staphylococcus aureus, Springer Science and Business Media LLC.","DOI":"10.1007\/82_2016_3"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"4-2","DOI":"10.1128\/microbiolspec.VMBF-0016-2015","article-title":"Mechanisms of antibiotic resistance","volume":"4","author":"Munita","year":"2016","journal-title":"Microbiol. Spectr."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.drup.2010.08.003","article-title":"Aminoglycoside modifying enzymes","volume":"13","author":"Ramirez","year":"2010","journal-title":"Drug Resist. Updates"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1007\/s10156-013-0640-7","article-title":"The ABCD\u2019s of \u03b2-lactamase nomenclature","volume":"19","author":"Bush","year":"2013","journal-title":"J. Infect. Chemother."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1038\/nrmicro1994","article-title":"The porin and the permeating antibiotic: A selective diffusion barrier in Gram-negative bacteria","volume":"6","author":"James","year":"2008","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1146\/annurev.micro.56.012302.160310","article-title":"Function of Pseudomonas porins in uptake and efflux","volume":"56","author":"Hancock","year":"2002","journal-title":"Annu. Rev. Microbiol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1093\/jac\/dki171","article-title":"Efflux-mediated antimicrobial resistance","volume":"56","author":"Poole","year":"2005","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1021\/cr030112j","article-title":"Rifamycin-mode of action, resistance, and biosynthesis","volume":"105","author":"Floss","year":"2005","journal-title":"Chem. Rev."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"e02253-16","DOI":"10.1128\/AAC.02253-16","article-title":"Antibiotic effects on methicillin-resistant Staphylococcus aureus cytoplasmic peptidoglycan intermediate levels and evidence for potential metabolite level regulatory loops","volume":"61","author":"Vemula","year":"2017","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.biochi.2015.11.017","article-title":"Cytoplasmic peptidoglycan intermediate levels in Staphylococcus aureus","volume":"121","author":"Vemula","year":"2016","journal-title":"Biochimie"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.jhin.2011.02.018","article-title":"Prevalence of antiseptic-resistance genes in Staphylococcus aureus and coagulase-negative staphylococci colonising nurses and the general population in Hong Kong","volume":"78","author":"Zhang","year":"2011","journal-title":"J. Hosp. Infect."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.jaapos.2012.12.151","article-title":"Trends in ophthalmic manifestations of methicillin-resistant Staphylococcus aureus (MRSA) in a northern California pediatric population","volume":"17","author":"Amato","year":"2013","journal-title":"J. Am. Assoc. Pediatr. Ophthalmol. Strabis."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1016\/j.jcrs.2011.05.006","article-title":"Microbial keratitis trends following refractive surgery: Results of the ASCRS infectious keratitis survey and comparisons with prior ASCRS surveys of infectious keratitis following keratorefractive procedures","volume":"37","author":"Solomon","year":"2011","journal-title":"J. Cataract Refract. Surg."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"565","DOI":"10.2217\/fmb.09.30","article-title":"Genetics of antimicrobial resistance in Staphylococcus aureus","volume":"4","author":"Jensen","year":"2009","journal-title":"Future Microbiol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"323","DOI":"10.2217\/17460913.2.3.323","article-title":"Mechanisms of antibiotic resistance in Staphylococcus aureus","volume":"2","author":"Pantosti","year":"2007","journal-title":"Future Microbiol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"e01755-19","DOI":"10.1128\/mBio.01755-19","article-title":"Transient silencing of antibiotic resistance by mutation represents a significant potential source of unanticipated therapeutic failure","volume":"10","author":"Kime","year":"2019","journal-title":"mBio"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"7-2","DOI":"10.1128\/microbiolspec.GPP3-0057-2018","article-title":"Antibiotic resistance and the MRSA problem","volume":"7","author":"Vestergaard","year":"2019","journal-title":"Microbiol. Spectr."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1111\/cxo.12582","article-title":"Disturbing the balance: Effect of contact lens use on the ocular proteome and microbiome","volume":"100","author":"Boost","year":"2017","journal-title":"Clin. Exp. Optom."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1111\/j.1469-0691.2011.03570.x","article-title":"Multidrug-resistant, extensively drug-resistant and pandrug-resistant bacteria: An international expert proposal for interim standard definitions for acquired resistance","volume":"18","author":"Magiorakos","year":"2012","journal-title":"Clin. Microbiol. Infect."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1167\/tvst.9.5.2","article-title":"Susceptibility of contact lens-related Pseudomonas aeruginosa keratitis isolates to multipurpose disinfecting solutions, disinfectants, and antibiotics","volume":"9","author":"Khan","year":"2020","journal-title":"Transl. Vis. Sci. Technol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1097\/ICO.0000000000002248","article-title":"Contact lenses and infectious keratitis: From a case-control study to a momputation of the risk for wearers","volume":"39","author":"Sauer","year":"2020","journal-title":"Cornea"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1111\/cxo.13082","article-title":"Contact lens-related corneal infection in Australia","volume":"103","author":"Stapleton","year":"2020","journal-title":"Clin. Exp. Optom."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1038\/s41558-018-0161-6","article-title":"Antibiotic resistance increases with local temperature","volume":"8","author":"MacFadden","year":"2018","journal-title":"Nat. Clim. Chang."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1136\/bjo.69.12.920","article-title":"Corneal ulceration at an urban African hospital","volume":"69","author":"Carmichael","year":"1985","journal-title":"Br. J. Ophthalmol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/S0002-9394(14)76903-X","article-title":"Epidemiologic characteristics, predisposing factors, and etiologic diagnosis of corneal ulceration in Nepal","volume":"111","author":"Upadhyay","year":"1991","journal-title":"Am. J. Ophthalmol."},{"key":"ref_37","first-page":"234","article-title":"Infectious keratitis in Baltimore","volume":"23","author":"Wahl","year":"1991","journal-title":"Ann. Ophthalmol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/S0140-6736(05)17907-0","article-title":"Outpatient antibiotic use in Europe and association with resistance: A cross-national database study","volume":"365","author":"Goossens","year":"2005","journal-title":"Lancet"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1007\/s10096-007-0321-5","article-title":"Antimicrobial use in Europe and antimicrobial resistance in Streptococcus pneumoniae","volume":"26","author":"Riedel","year":"2007","journal-title":"Eur. J. Clin. Microbiol. Infect. Dis."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1093\/jac\/43.5.729","article-title":"Reduced susceptibility to vancomycin of nosocomial isolates of methicillin-resistant Staphylococcus aureus","volume":"43","author":"Kantzanou","year":"1999","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1097\/ICO.0000000000000431","article-title":"Antibiotic resistance in the treatment of Staphylococcus aureus keratitis: A 20-year review","volume":"34","author":"Chang","year":"2015","journal-title":"Cornea"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1111\/ceo.13672","article-title":"Antimicrobial resistance trends in bacterial keratitis over 5 years in Sydney, Australia","volume":"48","author":"Khoo","year":"2020","journal-title":"Clin. Exp. Ophthalmol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.ajo.2007.03.032","article-title":"Spectrum of eye disease caused by methicillin-resistant Staphylococcus aureus","volume":"144","author":"Freidlin","year":"2007","journal-title":"Am. J. Ophthalmol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1111\/apm.12295","article-title":"Surface proteins of Staphylococcus aureus play an important role in experimental skin infection","volume":"122","author":"Kwiecinski","year":"2014","journal-title":"Apmis"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1111\/ceo.13364","article-title":"Keratitis antimicrobial resistance surveillance program, Sydney, Australia: 2016 Annual Report","volume":"47","author":"Watson","year":"2019","journal-title":"Clin. Exp. Ophthalmol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1177\/112067210501500104","article-title":"Infectious keratitis in South Australia: Emerging resistance to cephazolin","volume":"15","author":"Leibovitch","year":"2005","journal-title":"Eur. J. Ophthalmol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1071\/HI15014","article-title":"Rising fluoroquinolone resistance rates in corneal isolates: Implications for the wider use of antibiotics within the community","volume":"20","author":"Samarawickrama","year":"2015","journal-title":"Healthc. Infect."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1111\/j.1442-9071.2006.01143.x","article-title":"Bacteria commonly isolated from keratitis specimens retain antibiotic susceptibility to fluoroquinolones and gentamicin plus cephalothin","volume":"34","author":"Ly","year":"2006","journal-title":"Clin. Exp. Ophthalmol."},{"key":"ref_49","first-page":"S121","article-title":"Antibiotic Resistance in Animals","volume":"27","author":"Pratt","year":"2003","journal-title":"Commun. Dis. Intell. Q. Rep."},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Smith, T.C., Gebreyes, W.A., Abley, M.J., Harper, A.L., Forshey, B.M., Male, M.J., Martin, H.W., Molla, B.Z., Sreevatsan, S., and Thakur, S. (2013). Methicillin-resistant Staphylococcus aureus in pigs and farm workers on conventional and antibiotic-free swine farms in the USA. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0063704"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1016\/j.envres.2009.05.005","article-title":"Fate of antimicrobial-resistant enterococci and staphylococci and resistance determinants in stored poultry litter","volume":"109","author":"Graham","year":"2009","journal-title":"Environ. Res."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1289\/ehp.7647","article-title":"Fluoroquinolone-resistant campylobacter isolates from conventional and antibiotic-free chicken products","volume":"113","author":"Price","year":"2005","journal-title":"Environ. Health Perspect."},{"key":"ref_53","first-page":"277","article-title":"The antibiotic resistance crisis: Part 1: Causes and threats","volume":"40","author":"Ventola","year":"2015","journal-title":"Pharm. Ther."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1128\/CMR.00002-11","article-title":"Food Animals and Antimicrobials: Impacts on Human Health","volume":"24","author":"Marshall","year":"2011","journal-title":"Clin. Microbiol. Rev."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"S71","DOI":"10.1093\/cid\/ciu392","article-title":"The future of antibiotics and resistance: A tribute to a career of leadership by John Bartlett","volume":"59","author":"Spellberg","year":"2014","journal-title":"Clin. Infect. Dis."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"218","DOI":"10.4103\/0255-0857.83903","article-title":"Antibiotic resistance in ocular bacterial pathogens","volume":"29","author":"Sharma","year":"2011","journal-title":"Indian J. Med. Microbiol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1016\/j.ophtha.2012.11.005","article-title":"Changes in ocular flora in eyes exposed to ophthalmic antibiotics","volume":"120","author":"Dave","year":"2013","journal-title":"Ophthalmology"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"15","DOI":"10.2147\/OPTO.S189115","article-title":"Antibiotic resistance among ocular pathogens: Current trends from the ARMOR surveillance study (2009\u20132016)","volume":"11","author":"Thomas","year":"2019","journal-title":"Clin. Optom."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.ajo.2003.10.026","article-title":"Ciprofloxacin and levofloxacin resistance among methicillin-sensitive staphylococcus aureus isolates from keratitis and conjunctivitis","volume":"137","author":"Marangon","year":"2004","journal-title":"Am. J. Ophthalmol."},{"key":"ref_60","first-page":"287","article-title":"Clinical resistance of Staphylococcus keratitis to ciprofloxacin monotherapy","volume":"52","author":"Sharma","year":"2004","journal-title":"Indian J. Ophthalmol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1038\/eye.2011.288","article-title":"Contact lens-related microbial keratitis: How have epidemiology and genetics helped us with pathogenesis and prophylaxis","volume":"26","author":"Stapleton","year":"2012","journal-title":"Eye"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S0002-9394(03)00905-X","article-title":"Shifting trends in in vitro antibiotic susceptibilities for common ocular isolates during a period of 15 years","volume":"137","author":"Chalita","year":"2004","journal-title":"Am. J. Ophthalmol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"105","DOI":"10.2165\/00003495-198529020-00002","article-title":"Ceftazidime","volume":"29","author":"Richards","year":"1985","journal-title":"Drugs"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"4900","DOI":"10.1128\/AAC.00594-10","article-title":"A mecA-negative strain of methicillin-resistant Staphylococcus aureus with high-level \u03b2-lactam resistance contains mutations in three genes","volume":"54","author":"Banerjee","year":"2010","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1111\/j.1444-0938.2007.00219.x","article-title":"Staphylococcus aureus ocular isolates from symptomatic adverse events: Antibiotic resistance and similarity of bacteria causing adverse events","volume":"91","author":"Schubert","year":"2008","journal-title":"Clin. Exp. Optom."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1136\/bjo.84.7.687","article-title":"In vitro antibiotic resistance in bacterial keratitis in London","volume":"84","author":"Tuft","year":"2000","journal-title":"Br. J. Ophthalmol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/S0964-8305(03)00044-1","article-title":"Disinfectant resistance mechanisms, cross-resistance, and co-resistance","volume":"51","author":"Chapman","year":"2003","journal-title":"Int. Biodeterior. Biodegrad."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1128\/AAC.41.1.1","article-title":"O-Acetyltransferases for chloramphenicol and other natural products","volume":"41","author":"Murray","year":"1997","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.femsre.2004.04.001","article-title":"Molecular basis of bacterial resistance to chloramphenicol and florfenicol","volume":"28","author":"Schwarz","year":"2004","journal-title":"FEMS Microbiol. Rev."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1016\/j.addr.2005.04.002","article-title":"Bacterial resistance to antibiotics: Enzymatic degradation and modification","volume":"57","author":"Wright","year":"2005","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3109\/10409238309102789","article-title":"Chloramphenicol acetyltransferase: Enzymology and molecular biology","volume":"14","author":"Shaw","year":"1983","journal-title":"Crit. Rev. Biochem."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1083\/jcb.67.1.174","article-title":"Cytoplasmic transfer of chloramphenicol resistance in human tissue culture cells","volume":"67","author":"Wallace","year":"1975","journal-title":"J. Cell Biol."},{"key":"ref_73","doi-asserted-by":"crossref","unstructured":"Chuang, C.-C., Hsiao, C.-H., Tan, H.-Y., Ma, D.H.-K., Lin, K.-K., Chang, C.-J., and Huang, Y.-C. (2012). Staphylococcus aureus ocular infection: Methicillin-resistance, clinical features, and antibiotic susceptibilities. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0042437"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1097\/ICO.0b013e318268d6f4","article-title":"In vitro comparison of combination and monotherapy for the empiric and optimal coverage of bacterial keratitis based on incidence of infection","volume":"32","author":"Kowalski","year":"2013","journal-title":"Cornea"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1086\/345476","article-title":"Comparison of mortality associated with methicillin-resistant and methicillin-susceptible Staphylococcus aureus bacteremia: A meta-analysis","volume":"36","author":"Cosgrove","year":"2003","journal-title":"Clin. Infect. Dis."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1128\/CMR.12.1.147","article-title":"Antiseptics, and disinfectants: Activity, action, and resistance","volume":"12","author":"McDonnell","year":"1999","journal-title":"Clin. Microbiol. Rev."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1097\/ICL.0b013e31826f1004","article-title":"Impact of contact lens materials on multipurpose contact lens solution disinfection activity against Fusarium Solani","volume":"38","author":"Clavet","year":"2012","journal-title":"Eye Contact Lens"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1097\/ICL.0b013e31826f0893","article-title":"The effects of contact lens materials on a multipurpose contact lens solution disinfection activity against Staphylococcus aureus","volume":"38","author":"Shoff","year":"2012","journal-title":"Eye Contact Lens"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1093\/jac\/dkg228","article-title":"Aspects of the antimicrobial mechanisms of action of a polyquaternium and an amidoamine","volume":"51","author":"Codling","year":"2003","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/s12941-014-0041-5","article-title":"Antimicrobial activity of alexidine, chlorhexidine and cetrimide against Streptococcus mutant\u2019s biofilm","volume":"13","author":"Aguado","year":"2014","journal-title":"Ann. Clin. Microbiol. Antimicrob."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.exppara.2017.09.007","article-title":"Status of the effectiveness of contact lens disinfectants in Malaysia against keratitis-causing pathogens","volume":"183","author":"Abjani","year":"2017","journal-title":"Exp. Parasitol."},{"key":"ref_82","first-page":"5916712","article-title":"Comparison of the Antimicrobial Efficacy of Various Contact Lens Solutions to Inhibit the Growth of Pseudomonas aeruginosa and Staphylococcus aureus","volume":"2018","author":"Rao","year":"2018","journal-title":"Int. J. Microbiol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1097\/ICL.0000000000000308","article-title":"Antimicrobial efficacy of multipurpose disinfecting solutions in the presence of contact lenses and lens cases","volume":"44","author":"Gabriel","year":"2018","journal-title":"Eye Contact Lens"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1097\/OPX.0000000000000177","article-title":"Effect of multipurpose solutions against Acinetobacter carrying QAC genes","volume":"91","author":"Boost","year":"2014","journal-title":"Optom. Vis. Sci."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"8475","DOI":"10.1167\/iovs.14-15667","article-title":"Susceptibility of Stenotrophomonas maltophilia clinical isolates to antibiotics and contact lens multipurpose disinfecting solutions","volume":"55","author":"Watanabe","year":"2014","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_86","unstructured":"CLSI (2018). M100 Performance Standards for Antimicrobial Susceptibility Testing, CLSI."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1001\/jamaophthalmol.2015.3888","article-title":"Antibiotic resistance among ocular pathogenis in the United States","volume":"133","author":"Asbell","year":"2015","journal-title":"JAMA Ophthalmol."},{"key":"ref_88","unstructured":"EUCAST (2021, October 02). Clinical Breakpoints and Dosing of Antibiotics. Available online: https:\/\/eucast.org\/ast_of_bacteria."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1128\/AAC.23.1.142","article-title":"Determination of minimum bactericidal concentrations of oxacillin for Staphylococcus aureus: Influence and significance of technical factors","volume":"23","author":"Taylor","year":"1983","journal-title":"Antimicrob. Agents Chemother."}],"container-title":["Antibiotics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2079-6382\/10\/10\/1203\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T07:09:08Z","timestamp":1760166548000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2079-6382\/10\/10\/1203"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,3]]},"references-count":89,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2021,10]]}},"alternative-id":["antibiotics10101203"],"URL":"https:\/\/doi.org\/10.3390\/antibiotics10101203","relation":{},"ISSN":["2079-6382"],"issn-type":[{"value":"2079-6382","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,3]]}}}