{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T15:04:06Z","timestamp":1790694246633,"version":"4.1.0"},"reference-count":36,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2021,10,4]],"date-time":"2021-10-04T00:00:00Z","timestamp":1633305600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antibiotics"],"abstract":"<jats:p>Antibiotic treatments can participate in the formation of bacterial biofilm in case of under dosage. The interest of indoloquinoline scaffold for drug discovery incited us to study the preparation of new indolo [2,3-b]quinoline derivatives by a domino radical process. We tested the effect of two different \u201cindoloquinoline\u201d molecules (Indol-1 and Indol-2) without antimicrobial activity, in addition to ciprofloxacin, on biofilm formation thanks to crystal violet staining and enumeration of adhered bacteria. This association of ciprofloxacin and Indol-1 or Indol-2 attenuated the formation of biofilm up to almost 80% compared to ciprofloxacin alone, or even prevented the presence of adhered bacteria. In conclusion, these data prove that the association of non-antimicrobial molecules with an antibiotic can be a solution to fight against biofilm and antibiotic resistance emergence.<\/jats:p>","DOI":"10.3390\/antibiotics10101205","type":"journal-article","created":{"date-parts":[[2021,10,4]],"date-time":"2021-10-04T09:24:15Z","timestamp":1633339455000},"page":"1205","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Synergy between Indoloquinolines and Ciprofloxacin: An Antibiofilm Strategy against Pseudomonas aeruginosa"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8470-4432","authenticated-orcid":false,"given":"Emilie","family":"Charpentier","sequence":"first","affiliation":[{"name":"EA 4691 Biomat\u00e9riaux et Inflammation en Site Osseux (BIOS), UFR Pharmacie, Universit\u00e9 de Reims Champagne-Ardenne, SFR Cap Sant\u00e9 (FED 4231), 51097 Reims, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludovic","family":"Doudet","sequence":"additional","affiliation":[{"name":"Institut de Chimie Mol\u00e9culaire de Reims (ICMR-UMR CNRS 7312), UFR Pharmacie, Universit\u00e9 de Reims Champagne-Ardenne, 51097 Reims, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingrid","family":"Allart-Simon","sequence":"additional","affiliation":[{"name":"Institut de Chimie Mol\u00e9culaire de Reims (ICMR-UMR CNRS 7312), UFR Pharmacie, Universit\u00e9 de Reims Champagne-Ardenne, 51097 Reims, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marius","family":"Colin","sequence":"additional","affiliation":[{"name":"EA 4691 Biomat\u00e9riaux et Inflammation en Site Osseux (BIOS), UFR Pharmacie, Universit\u00e9 de Reims Champagne-Ardenne, SFR Cap Sant\u00e9 (FED 4231), 51097 Reims, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2651-9372","authenticated-orcid":false,"given":"Sophie C.","family":"Gangloff","sequence":"additional","affiliation":[{"name":"EA 4691 Biomat\u00e9riaux et Inflammation en Site Osseux (BIOS), UFR Pharmacie, Universit\u00e9 de Reims Champagne-Ardenne, SFR Cap Sant\u00e9 (FED 4231), 51097 Reims, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phane","family":"G\u00e9rard","sequence":"additional","affiliation":[{"name":"Institut de Chimie Mol\u00e9culaire de Reims (ICMR-UMR CNRS 7312), UFR Pharmacie, Universit\u00e9 de Reims Champagne-Ardenne, 51097 Reims, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0753-3761","authenticated-orcid":false,"given":"Fany","family":"Reffuveille","sequence":"additional","affiliation":[{"name":"EA 4691 Biomat\u00e9riaux et Inflammation en Site Osseux (BIOS), UFR Pharmacie, Universit\u00e9 de Reims Champagne-Ardenne, SFR Cap Sant\u00e9 (FED 4231), 51097 Reims, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,10,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1146\/annurev.micro.56.012302.160705","article-title":"Biofilms as Complex Differentiated Communities","volume":"56","author":"Stoodley","year":"2002","journal-title":"Annu. 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