{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T02:33:33Z","timestamp":1760236413670,"version":"build-2065373602"},"reference-count":19,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2021,11,19]],"date-time":"2021-11-19T00:00:00Z","timestamp":1637280000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Clinical Research Fund of the Tokyo Metropolitan Government","award":["2014-2016"],"award-info":[{"award-number":["2014-2016"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antibiotics"],"abstract":"<jats:p>(1) Background: It is critical to administer antibiotics and fluid bolus within 1 h of recognizing sepsis in pediatric patients. This study aimed to identify the predictor of the successful completion of a 1-h sepsis bundle for infants with suspected sepsis. (2) Methods: This is an observational study using a prospective registry including febrile young infants (aged &lt; 90 days) who visited a pediatric emergency department with a core body temperature of 38.0 \u00b0C or higher and 36.0 \u00b0C or lower. Univariate and logistic regression analyses were conducted to determine the predictor (s) of successful sepsis bundle completion. (3) Results: Of the 323 registered patients, 118 patients with suspected sepsis were analyzed, and 38 patients (32.2%) received a bundle-compliant treatment. Among potential variables, such as age, sex, and vital sign parameters, the logistic regression analysis showed that heart rate (odds ratio: OR 1.02; 95% confidence interval: 1.00\u20131.04) is a significant predictor of the completion of a 1-h sepsis bundle. (4) Conclusions: We found that tachycardia facilitated the sepsis recognition and promoted the successful completion of a 1-h sepsis bundle for young infants with suspected septic shock and a possible indicator for improving the quality of the team-based sepsis management.<\/jats:p>","DOI":"10.3390\/antibiotics10111414","type":"journal-article","created":{"date-parts":[[2021,11,19]],"date-time":"2021-11-19T08:29:17Z","timestamp":1637310557000},"page":"1414","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Predictor of Early Administration of Antibiotics and a Volume Resuscitation for Young Infants with Septic Shock"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1296-1768","authenticated-orcid":false,"given":"Osamu","family":"Nomura","sequence":"first","affiliation":[{"name":"Department of Emergency and Disaster Medicine, Hirosaki University, Hirosaki 036-8562, Japan"},{"name":"Division of Pediatric Emergency Medicine, Tokyo Metropolitan Children\u2019s Medical Center, Tokyo 183-8561, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takateru","family":"Ihara","sequence":"additional","affiliation":[{"name":"Division of Pediatric Emergency Medicine, Tokyo Metropolitan Children\u2019s Medical Center, Tokyo 183-8561, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1437-0374","authenticated-orcid":false,"given":"Yoshihiko","family":"Morikawa","sequence":"additional","affiliation":[{"name":"Clinical Research Support Center, Tokyo Metropolitan Children\u2019s Medical Center, Tokyo 183-8561, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Sakakibara","sequence":"additional","affiliation":[{"name":"Division of General Pediatrics, Department of Pediatrics, Tokyo Metropolitan Children\u2019s Medical Center, Tokyo 183-8561, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuho","family":"Horikoshi","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Pediatrics, Tokyo Metropolitan Children\u2019s Medical Center, Tokyo 183-8561, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuaki","family":"Inoue","sequence":"additional","affiliation":[{"name":"Department of Human Resources and Development, National Center for Global Health and Medicine, Tokyo 162-8655, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,11,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e2021052228","DOI":"10.1542\/peds.2021-052228","article-title":"Evaluation and management of well-appearing febrile infants 8 to 60 days old","volume":"148","author":"Pantell","year":"2021","journal-title":"Pediatrics"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1177\/000992289303200703","article-title":"Efficacy of a protocol to distinguish risk of serious bacterial infection in the outpatient evaluation of febrile young infants","volume":"32","author":"Bonadio","year":"1993","journal-title":"Clin. Pediatr."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/S0022-3476(05)81769-X","article-title":"Identifying febrile infants at risk for a serious bacterial infection","volume":"123","author":"Baskin","year":"1993","journal-title":"J. Pediatr."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1542\/peds.92.1.1","article-title":"Practice guideline for the management of infants and children 0 to 36 months of age with fever without source","volume":"92","author":"Baraff","year":"1993","journal-title":"Pediatrics"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"e20194096","DOI":"10.1542\/peds.2019-4096","article-title":"Machine learning to predict serious bacterial infections in young febrile infants","volume":"146","author":"Ramgopal","year":"2020","journal-title":"Pediatrics"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Chiu, I.M., Cheng, C.Y., Zeng, W.H., Huang, Y.H., and Lin, C.H.R. (2021). Using machine learning to predict invasive bacterial infections in young febrile infants visiting the emergency department. J. Clin. Med., 10.","DOI":"10.3390\/jcm10091875"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Tsai, C.-M., Lin, C.-H.R., Zhang, H., Chiu, I.-M., Cheng, C.-Y., Yu, H.-R., and Huang, Y.-H. (2020). Using machine learning to predict bacteremia in febrile children presented to the emergency department. Diagnostics, 10.","DOI":"10.3390\/diagnostics10050307"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"e52","DOI":"10.1097\/PCC.0000000000002198","article-title":"Surviving sepsis campaign international guidelines for the management of septic shock and sepsis-associated organ dysfunction in children","volume":"21","author":"Weiss","year":"2020","journal-title":"Pediatr. Crit. Care Med."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1001\/jama.2018.9071","article-title":"Association between the New York sepsis care mandate and in-hospital mortality for pediatric sepsis","volume":"320","author":"Evans","year":"2018","journal-title":"JAMA"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"e20154153","DOI":"10.1542\/peds.2015-4153","article-title":"High reliability pediatric septic shock quality improvement initiative and decreasing mortality","volume":"138","author":"Lane","year":"2016","journal-title":"Pediatrics"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1097\/JHQ.0000000000000141","article-title":"Decreasing the time to administration of first dose of antibiotics in children with severe sepsis","volume":"41","author":"Mittal","year":"2019","journal-title":"J. Healthc. Qual."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.jpeds.2020.12.035","article-title":"Delayed administration of antibiotics beyond the first hour of recognition is associated with increased mortality rates in children with sepsis\/severe sepsis and septic shock","volume":"233","author":"Sankar","year":"2021","journal-title":"J. Pediatr."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/j.annemergmed.2017.03.019","article-title":"Improving recognition of pediatric severe sepsis in the emergency department: Contributions of a vital sign\u2013based electronic alert and bedside clinician identification","volume":"70","author":"Balamuth","year":"2017","journal-title":"Ann. Emerg. Med."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Nomura, O., Morikawa, Y., Mori, T., Hagiwara, Y., Sakakibara, S., Horikoshi, Y., and Inoie, N. (2021). Limited utility of SIRS criteria in septic young infants. 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Care Med."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1007\/s00134-017-4683-6","article-title":"Surviving sepsis campaign: International guidelines for management of sepsis and septic shock, 2016","volume":"43","author":"Rhodes","year":"2017","journal-title":"Intensive Care Med."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1542\/hpeds.2019-0250","article-title":"Antibiotic timing in pediatric septic shock","volume":"10","author":"Lane","year":"2020","journal-title":"Hosp. 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