{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T14:12:57Z","timestamp":1765807977253,"version":"build-2065373602"},"reference-count":40,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2021,11,20]],"date-time":"2021-11-20T00:00:00Z","timestamp":1637366400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antibiotics"],"abstract":"<jats:p>Background: This study explored the antimicrobial prescribing pattern for upper respiratory tract and dental infections in prisoners in Italy, with specific attention paid to the appropriateness of indication and its potential determinants. Methods: This investigation was conducted through the consultation of clinical records of adult male inmates in a prison in the south of Italy. Results: Prescription of antimicrobials for upper respiratory tract infections ranged from 41.9% in influenza diagnoses to 88% in pharyngitis diagnoses, with high prevalence also for bronchitis (73.5%) and common cold (57.7%), and those for dental infections ranged from 82% in pulp necrosis and symptomatic apical periodontitis\/pulp necrosis and localized acute apical abscess diagnoses, to 85.7% in symptomatic irreversible pulpitis with or without symptomatic apical periodontitis diagnoses. The most frequently prescribed antimicrobial was amoxicillin and clavulanic acid (33.8%), followed by amoxicillin (26.5%), macrolides (19.8%) and third-generation cephalosporins (7.9%). The overall antimicrobial overprescription was 69.4%, whereas an antimicrobial prescription was provided in all 52 cases in which it was indicated. The inappropriate antimicrobial prescriptions were significantly less likely for bronchitis, influenza and symptomatic irreversible pulpitis with or without symptomatic apical periodontitis compared to common cold\/pharyngitis\/rhinosinusitis, and when the antimicrobial prescription was provided by medical specialists compared to prison physicians, whereas antimicrobial overprescriptions without indications were significantly more frequent in patients with underlying chronic clinical conditions. Conclusions: A concerning widespread practice of inappropriate antimicrobial prescriptions in prisoners was found. Diagnoses-specific monitoring of antimicrobial use and prison-focused antimicrobial stewardship policies are strongly needed.<\/jats:p>","DOI":"10.3390\/antibiotics10111419","type":"journal-article","created":{"date-parts":[[2021,11,21]],"date-time":"2021-11-21T20:58:21Z","timestamp":1637528301000},"page":"1419","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Pattern and Appropriateness of Antimicrobial Prescriptions for Upper Respiratory Tract and Dental Infections in Male Prisoners in Italy"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4466-6683","authenticated-orcid":false,"given":"Gabriella","family":"Di Giuseppe","sequence":"first","affiliation":[{"name":"Department of Experimental Medicine, University of Campania \u201cLuigi Vanvitelli\u201d, 80138 Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raffaele","family":"Lanzano","sequence":"additional","affiliation":[{"name":"Department of Experimental Medicine, University of Campania \u201cLuigi Vanvitelli\u201d, 80138 Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Armando","family":"Silvestro","sequence":"additional","affiliation":[{"name":"Department of Experimental Medicine, University of Campania \u201cLuigi Vanvitelli\u201d, 80138 Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4694-2418","authenticated-orcid":false,"given":"Francesco","family":"Napolitano","sequence":"additional","affiliation":[{"name":"Department of Experimental Medicine, University of Campania \u201cLuigi Vanvitelli\u201d, 80138 Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3879-1322","authenticated-orcid":false,"given":"Maria","family":"Pavia","sequence":"additional","affiliation":[{"name":"Department of Experimental Medicine, University of Campania \u201cLuigi Vanvitelli\u201d, 80138 Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,11,20]]},"reference":[{"key":"ref_1","unstructured":"WHO (2021, October 13). Ten Threats to Global Health in 2019. Available online: https:\/\/www.who.int\/news-room\/spotlight\/ten-threats-to-global-health-in-2019."},{"key":"ref_2","unstructured":"The Medicines Utilisation Monitoring Centre (2021, October 13). National Report on Antibiotics Use in Italy. Year 2019. Rome: Italian Medicines Agency, Available online: https:\/\/www.aifa.gov.it\/documents\/20142\/1283180\/Rapporto_Antibiotici_2019.pdf."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1093\/jac\/dky447","article-title":"Appropriateness of antibiotic prescribing in the Emergency Department","volume":"74","author":"Denny","year":"2019","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1007\/s00203-020-01818-x","article-title":"Diabetes-associated infections: Development of antimicrobial resistance and possible treatment strategies","volume":"202","author":"Akash","year":"2020","journal-title":"Arch. Microbiol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"e0237868","DOI":"10.1371\/journal.pone.0237868","article-title":"Potentially inappropriate prescribing in older adults with advanced chronic kidney disease","volume":"15","author":"Molnar","year":"2020","journal-title":"PLoS ONE"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1007\/s40266-018-0541-7","article-title":"Inappropriate use of antimicrobials for lower respiratory tract infections in elderly patients: Patient- and community-related implications and possible interventions","volume":"35","author":"Schweitzer","year":"2018","journal-title":"Drugs Aging"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1093\/jac\/dkz008","article-title":"Antibiotic prescribing for residents in long-term-care facilities across the UK","volume":"74","author":"Thornley","year":"2019","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_8","first-page":"738","article-title":"Antibiotic appropriateness and guideline adherence in hospitalized children: Results of a nationwide study","volume":"75","author":"McMullan","year":"2020","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Nobile, C.G., Flotta, D., Nicotera, G., Pileggi, C., and Angelillo, I.F. (2011). Self-reported health status and access to health services in a sample of prisoners in Italy. BMC Public Health, 11.","DOI":"10.1186\/1471-2458-11-529"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1146\/annurev-soc-073014-112326","article-title":"Incarceration and Health","volume":"41","author":"Massoglia","year":"2015","journal-title":"Annu. Rev. Sociol."},{"key":"ref_11","first-page":"52","article-title":"Study of the use of antibiotics in respiratory infections within the prison setting","volume":"7","author":"Alia","year":"2005","journal-title":"Rev. Esp. Sanid. Penit."},{"key":"ref_12","unstructured":"Agenzia Regionale di Sanit\u00e0 della Toscana (2021, October 13). La Salute dei Detenuti in Italia: I Risultati di uno Studio Multicentrico. Available online: https:\/\/www.ars.toscana.it\/files\/pubblicazioni\/Volumi\/2015\/carcere_2015_definitivo.pdf."},{"key":"ref_13","first-page":"956","article-title":"Guidelines for the use of antibiotics in acute upper respiratory tract infections","volume":"74","author":"Wong","year":"2006","journal-title":"Am. Fam. Physician"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"425","DOI":"10.7326\/M15-1840","article-title":"Appropriate antibiotic use for acute respiratory tract infection in adults: Advice for high-value care from the American College of Physicians and the Centers for Disease Control and Prevention","volume":"164","author":"Harris","year":"2016","journal-title":"Ann. Intern. Med."},{"key":"ref_15","unstructured":"Centers for Disease Control and Prevention, National Center for Emerging and Zoonotic Infectious Diseases (NCEZID), Division of Healthcare Quality Promotion (DHQP) (2021, October 13). Adult Outpatient Treatment Recommendations, Available online: https:\/\/www.cdc.gov\/antibiotic-use\/clinicians\/adult-treatment-rec.html."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1016\/j.adaj.2019.08.020","article-title":"Evidence-based clinical practice guideline on antibiotic use for the urgent management of pulpal- and periapical-related dental pain and intraoral swelling: A report from the American Dental Association","volume":"150","author":"Lockhart","year":"2019","journal-title":"J. Am. Dent. Assoc."},{"key":"ref_17","unstructured":"(2021, October 13). Antimicrobial Stewardship Federal Bureau of Prisons Clinical Guidance July, Available online: https:\/\/www.bop.gov\/resources\/pdfs\/antimstewardship2019.pdf2019."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"2199","DOI":"10.2147\/IDR.S170349","article-title":"Antibiotic prescriptions to adults with acute respiratory tract infections by Italian general practitioners","volume":"11","author":"Bianco","year":"2018","journal-title":"Infect. Drug. Resist."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1136\/bmjqs.2010.049049","article-title":"Disease-specific quality indicators for outpatient antibiotic prescribing","volume":"20","author":"Adriaenssens","year":"2011","journal-title":"BMJ Qual. Saf."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Colliers, A., Adriaenssens, N., Anthierens, S., Bartholomeeusen, S., Philips, H., Remmen, R., and Coenen, S. (2019). Antibiotic prescribing quality in out-of-hours primary care and critical appraisal of disease-specific quality indicators. Antibiotics, 8.","DOI":"10.3390\/antibiotics8020079"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"E3463","DOI":"10.1073\/pnas.1717295115","article-title":"Global increase and geographic convergence in antibiotic consumption between 2000 and 2015","volume":"115","author":"Klein","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1016\/j.jiac.2020.02.001","article-title":"Antibiotic prescriptions for Japanese outpatients with acute respiratory tract infections (2013\u20132015): A retrospective observational study","volume":"26","author":"Koyama","year":"2020","journal-title":"J. Infect. Chemother."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/S1473-3099(20)30332-7","article-title":"Assessment of WHO antibiotic consumption and access targets in 76 countries, 2000\u20132015: An analysis of pharmaceutical sales data","volume":"21","author":"Klein","year":"2021","journal-title":"Lancet Infect. Dis."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1093\/jac\/dkm497","article-title":"Rapid identification and antimicrobial susceptibility testing reduce antibiotic use and accelerate pathogen-directed antibiotic use","volume":"61","author":"Kerremans","year":"2008","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Machowska, A., and St\u00e5lsby Lundborg, C. (2018). Drivers of irrational use of antibiotics in Europe. Int. J. Environ. Res. Public Health, 16.","DOI":"10.3390\/ijerph16010027"},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Bianco, A., Licata, F., Nobile, C.G.A., Napolitano, F., and Pavia, M. (2021). Pattern and appropriateness of antibiotic prescriptions for upper respiratory tract infections in primary care pediatric patients. Int. J. Antimicrob. Agents, in press, journal pre-proof.","DOI":"10.1016\/j.ijantimicag.2021.106469"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.japh.2016.11.012","article-title":"Antimicrobial stewardship in the Federal Bureau of Prisons: Approaches from the national and local levels","volume":"57","author":"Long","year":"2017","journal-title":"J. Am. Pharm. Assoc."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1111\/bcpt.12316","article-title":"Compliance with recommendations on outpatient antibiotic prescribing for respiratory tract infections: The case of Spain","volume":"116","author":"Malo","year":"2015","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"106193","DOI":"10.1016\/j.ijantimicag.2020.106193","article-title":"Outpatient antibiotic use associated with acute upper respiratory infections in China: A nationwide cross-sectional study","volume":"56","author":"Zhao","year":"2020","journal-title":"Int. J. Antimicrob. Agents"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1818","DOI":"10.1093\/jac\/dkx048","article-title":"Antibiotic prescribing frequency amongst patients in primary care: A cohort study using electronic health records","volume":"72","author":"Shallcross","year":"2017","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1093\/fampra\/cmm023","article-title":"Is co-morbidity taken into account in the antibiotic management of elderly patients with acute bronchitis and COPD exacerbations?","volume":"24","author":"Bont","year":"2007","journal-title":"Fam. Pract."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"888","DOI":"10.3109\/00365548.2014.954264","article-title":"Antibiotic consumption in relation to socio-demographic factors, co-morbidity, and accessibility of primary health care","volume":"46","author":"Ternhag","year":"2014","journal-title":"Scand. J. Infect. Dis."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1975","DOI":"10.1016\/S0140-6736(12)60319-5","article-title":"Prevalence of risk factors for non-communicable diseases in prison populations worldwide: A systematic review","volume":"379","author":"Herbert","year":"2012","journal-title":"Lancet"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1016\/j.adaj.2017.07.019","article-title":"An evaluation of dental antibiotic prescribing practices in the United States","volume":"148","author":"Durkin","year":"2017","journal-title":"J. Am. Dent. Assoc."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1001\/jama.2021.2900","article-title":"Antimicrobial use in a cohort of US nursing homes, 2017","volume":"325","author":"Thompson","year":"2021","journal-title":"JAMA"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"ii60","DOI":"10.1093\/jac\/dkab178","article-title":"Quality appraisal of antibiotic consumption in the community, European Union\/European Economic Area, 2009 and 2017","volume":"76","author":"Adriaenssens","year":"2021","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1800","DOI":"10.1093\/jac\/dkw054","article-title":"Gender differences in antibiotic prescribing in the community: A systematic review and meta-analysis","volume":"71","author":"Sommer","year":"2016","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_38","unstructured":"(2021, October 13). Decreto del Presidente del Consiglio dei Ministri 1 Aprile 2008. Modalit\u00e0 e Criteri per il Trasferimento al Servizio Sanitario Nazionale delle Funzioni Sanitarie, dei Rapporti di Lavoro, delle Risorse Finanziarie e delle Attrezzature e Beni Strumentali in Materia di Sanit\u00e0 Penitenziaria. Available online: https:\/\/www.gazzettaufficiale.it\/eli\/id\/2008\/05\/30\/08A03777\/sg."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Di Giuseppe, G., Pelullo, C.P., Lanzano, R., Napolitano, F., and Pavia, M. (2021). Knowledge, attitudes, and behavior of prisoners regarding COVID-19 and related vaccination: A survey in Italy. Sci. Rep., submitted for publication.","DOI":"10.1038\/s41598-022-04919-3"},{"key":"ref_40","unstructured":"Stata Corporation (2017). Stata Reference Manual Release 15.1, Stata Corporation."}],"container-title":["Antibiotics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2079-6382\/10\/11\/1419\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T07:33:09Z","timestamp":1760167989000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2079-6382\/10\/11\/1419"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,20]]},"references-count":40,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2021,11]]}},"alternative-id":["antibiotics10111419"],"URL":"https:\/\/doi.org\/10.3390\/antibiotics10111419","relation":{},"ISSN":["2079-6382"],"issn-type":[{"type":"electronic","value":"2079-6382"}],"subject":[],"published":{"date-parts":[[2021,11,20]]}}}