{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T17:20:58Z","timestamp":1769016058792,"version":"3.49.0"},"reference-count":34,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2021,11,22]],"date-time":"2021-11-22T00:00:00Z","timestamp":1637539200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antibiotics"],"abstract":"<jats:p>Since 2014, several global and national guidelines have been introduced to address the problem of antimicrobial resistance. We conducted a campaign in a tertiary hospital to promote appropriate quinolone use through educational lectures in 2018. The aim of this retrospective study was to evaluate the changes in the following: prescription characteristics, trend of oral quinolone use, and antibiotic susceptibility of bacteria from 2013 to 2020. Antimicrobial use was assessed as days of therapy per 1000 patient-days. We found a significant reduction in unnecessary antibiotic prescriptions between December 2013 and December 2020. Significant negative trends were detected in the use of quinolones over 8 years (outpatients, coefficient = \u22120.15655, p &lt; 0.001; inpatients, coefficient = \u22120.004825, p = 0.0016). In particular, the monthly mean use of quinolones among outpatients significantly decreased by 11% from 2013 to 2014 (p &lt; 0.05) and reduced further by 31% from 2017 to 2020 (p &lt; 0.001). A significant positive trend was observed in the susceptibility of Pseudomonas aeruginosa to levofloxacin (p &lt; 0.001). These results demonstrate that the use of oral quinolones was further reduced following educational intervention and the bacterial susceptibility improved with optimal quinolone usage compared to that in 2013.<\/jats:p>","DOI":"10.3390\/antibiotics10111426","type":"journal-article","created":{"date-parts":[[2021,11,23]],"date-time":"2021-11-23T02:55:17Z","timestamp":1637636117000},"page":"1426","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Effect of Antimicrobial Stewardship on Oral Quinolone Use and Resistance Patterns over 8 Years (2013\u20132020)"],"prefix":"10.3390","volume":"10","author":[{"given":"Atsushi","family":"Uda","sequence":"first","affiliation":[{"name":"Department of Infection Control and Prevention, Kobe University Hospital, Kobe 650-0017, Japan"},{"name":"Department of Pharmacy, Kobe University Hospital, Kobe 650-0017, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsumi","family":"Shigemura","sequence":"additional","affiliation":[{"name":"Department of Infection Control and Prevention, Kobe University Hospital, Kobe 650-0017, Japan"},{"name":"Division of Infectious Diseases, Department of Public Health, Graduate School of Medicine, Kobe University, Kobe 654-0142, Japan"},{"name":"Division of Urology, Graduate School of Medicine, Kobe University, Kobe 650-0017, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koichi","family":"Kitagawa","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Public Health, Graduate School of Medicine, Kobe University, Kobe 654-0142, Japan"},{"name":"Division of Advanced Medical Science, Graduate School of Medicine, Kobe University, Technology and Innovation, Kobe 657-8501, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4787-4333","authenticated-orcid":false,"given":"Kayo","family":"Osawa","sequence":"additional","affiliation":[{"name":"Department of Medical Technology, Kobe Tokiwa University, Kobe 653-0838, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mari","family":"Kusuki","sequence":"additional","affiliation":[{"name":"Department of Infection Control and Prevention, Kobe University Hospital, Kobe 650-0017, Japan"},{"name":"Department of Clinical Laboratory, Kobe University Hospital, Kobe 650-0017, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yonmin","family":"Yan","sequence":"additional","affiliation":[{"name":"Division of Urology, Graduate School of Medicine, Kobe University, Kobe 650-0017, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ikuko","family":"Yano","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Kobe University Hospital, Kobe 650-0017, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takayuki","family":"Miyara","sequence":"additional","affiliation":[{"name":"Department of Infection Control and Prevention, Kobe University Hospital, Kobe 650-0017, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,11,22]]},"reference":[{"key":"ref_1","unstructured":"(2021, April 06). 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