{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T22:41:51Z","timestamp":1768689711492,"version":"3.49.0"},"reference-count":70,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2021,11,25]],"date-time":"2021-11-25T00:00:00Z","timestamp":1637798400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antibiotics"],"abstract":"<jats:p>Development of processes using green solvents as supercritical fluids (SCFs) depends on the accuracy of modeling and predicting phase equilibrium which is of considerable importance to exploit the use of SCF process at the level of pharmaceutical industries. Solid-Fluid equilibrium modeling is associated to many drawbacks when compressed gas-based models as cubic equations of states (cEoSs) are used. The unavailability of experimental values of solute\u2019s sublimation pressure presents one of the major obstacles to the solubility modeling with this type of models, and thus, its estimation is essential and inevitable. This work is an attempt to address a question regarding \u201caccurate estimated value\u201d of sublimation pressure of two antibiotics Penicillin G (benzyl penicillin) and Penicillin V (phenoxymethyl penicillin). Toward that, first, cEoSs are provided as the thermodynamics modeling framework and fundamental approach. Second, a discussion and a review of some literature results are given. Third, results are invoked to present a criticism analysis that comes from the use of modified form of Peng-Robinson (PR) equation of states. Finally, considerable improvement of modeling results by using a new sublimation pressure is shown.<\/jats:p>","DOI":"10.3390\/antibiotics10121448","type":"journal-article","created":{"date-parts":[[2021,11,28]],"date-time":"2021-11-28T22:19:16Z","timestamp":1638137956000},"page":"1448","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Penicillins\u2019 Solubility in Supercritical Carbon Dioxide: Modeling by Cubic Equations of States Revisited"],"prefix":"10.3390","volume":"10","author":[{"given":"Loubna","family":"Nasri","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Engineering, Faculty of Process Engineering, University Constantine 3-Salah Boubnider, Constantine 25000, Algeria"},{"name":"Laboratoire ReMeDD, University Constantine 3-Salah Boubnider, Constantine 25000, Algeria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,11,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0378-3812(99)00314-3","article-title":"Representation of solid-supercritical fluid phase equilibria using cubic equations of state","volume":"167","author":"Ashour","year":"2000","journal-title":"Fluid Phase Equilib."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.fluid.2007.03.004","article-title":"Correlation for the solubilities of pharmaceutical compounds in supercritical carbon dioxide","volume":"254","author":"Su","year":"2007","journal-title":"Fluid Phase Equilib."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.supflu.2012.09.006","article-title":"Measurement and correlation solubility of cefixime trihydrate and oxymetholone in supercritical carbon dioxide (CO2)","volume":"73","author":"Khamda","year":"2013","journal-title":"J. Supercrit. Fluids"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"S3967","DOI":"10.1016\/j.arabjc.2014.06.007","article-title":"Supercritical fluid extraction of triterpenes and aliphatic hydrocarbons from olive tree derivatives","volume":"10","author":"Issaoui","year":"2017","journal-title":"Arab. J. Chem."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Chronopoulou, L., Bosco, C., Caprio, F., Prosini, L., Gentili, A., Pagnanelli, F., and Palocci, C. (2019). Extraction of carotenoids and fat-soluble vitamins from Tetradesmus obliquus microalgae: An optimized approach by using supercritical CO2. Molecules, 24.","DOI":"10.3390\/molecules24142581"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"7467","DOI":"10.1007\/s13369-020-04584-6","article-title":"Supercritical Carbon Dioxide Extraction of Sinensetin, Isosinensetin, and Rosmarinic Acid from Orthosiphon stamineus Leaves: Optimization and Modeling","volume":"45","author":"Putra","year":"2020","journal-title":"Arab. J. Sci. Eng."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"115745","DOI":"10.1016\/j.molliq.2021.115745","article-title":"Measuring and modeling the solubility of an antihypertensive drug (losartan potassium, Cozaar) in supercritical carbon dioxide","volume":"331","author":"Sodeifian","year":"2021","journal-title":"J. Mol. Liq."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"6557","DOI":"10.1007\/s11696-021-01822-5","article-title":"Solubility of sinensetin and isosinensetin from Cat\u2019s Whiskers (Orthosiphon stamineus) leaves in ethanol-assisted supercritical carbon dioxide extraction: Experimental and modeling","volume":"75","author":"Putra","year":"2021","journal-title":"Chem. Pap."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-021-87243-6","article-title":"Solubility of Ketoconazole (antifungal drug) in SC-CO2 for binary and ternary systems: Measurements and empirical correlations","volume":"11","author":"Sodeifian","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1885","DOI":"10.1016\/j.compchemeng.2005.04.001","article-title":"Thermodynamic modelling of supercritical fluid\u2014Solid phase equilibrium data","volume":"29","author":"Gordillo","year":"2005","journal-title":"Comput. Chem. Eng."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"112422","DOI":"10.1016\/j.fluid.2019.112422","article-title":"Experimental measurement and thermodynamic modeling of Lansoprazole solubility in supercritical carbon dioxide: Application of SAFT-VR EoS","volume":"507","author":"Sodeifian","year":"2020","journal-title":"Fluid Phase Equilib."},{"key":"ref_12","unstructured":"Wexler, P. (2014). Encyclopedia of Toxicology, Elsevier Inc.. [3rd ed.]."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"101330","DOI":"10.1016\/j.bcab.2019.101330","article-title":"Analysis and evaluation of penicillin production by using soil fungi","volume":"21","author":"Fatima","year":"2019","journal-title":"Biocatal. Agric. Biotechnol."},{"key":"ref_14","unstructured":"Katritzky, A.R., Ramsden, C.A., Scriven, E.F.V., and Taylor, R.J.K. (2008). Comprehensive Heterocyclic Chemistry III, Elsevier Ltd.. [1st ed.]."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1111\/j.1472-765X.1994.tb00988.x","article-title":"Penicillin production by Penicillium nalgiovense","volume":"19","author":"Andersen","year":"1994","journal-title":"Lett. Appl. Microbiol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1093\/jac\/dkl188","article-title":"European surveillance of antimicrobial consumption (ESAC): Outpatient antibiotic use in Europe","volume":"58","author":"Ferech","year":"2006","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"426","DOI":"10.2105\/AJPH.2012.300693","article-title":"Rethinking antibiotic research and development: World War II and the penicillin collaborative","volume":"103","author":"Quinn","year":"2013","journal-title":"Am. J. Public Health"},{"key":"ref_18","unstructured":"Doble, M., and Kruthiventi, A.K. (2007). Green Chemistry and Engineering, Elsevier Inc."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.supflu.2015.05.018","article-title":"Solubilities of four macrolide antibiotics in supercritical carbon dioxide and their correlations using semi-empirical models","volume":"104","author":"Asiabi","year":"2015","journal-title":"J. Supercrit. Fluids"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.cep.2012.06.004","article-title":"Supercritical fluids for pharmaceutical particle engineering: Methods, basic fundamentals and modelling","volume":"60","author":"Tabernero","year":"2012","journal-title":"Chem. Eng. Process. Process. Intensif."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.supflu.2005.03.008","article-title":"A comparison between semi-empirical and molecular-based equations of state for describing the thermodynamic of supercritical micronization processes","volume":"38","author":"Colussi","year":"2006","journal-title":"J. Supercrit. Fluids"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"4718","DOI":"10.1021\/ie960202x","article-title":"Particle Production of Steroid Drugs Using Supercritical Fluid Processing","volume":"35","author":"Alessi","year":"1996","journal-title":"Ind. Eng. Chem. Res."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/S0896-8446(01)00064-X","article-title":"Particle design using supercritical fluids: Literature and patent survey","volume":"20","author":"Jung","year":"2001","journal-title":"J. Supercrit. Fluids"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.cherd.2018.12.020","article-title":"Utilization of ultrasonic-assisted RESOLV(US-RESOLV) with polymeric stabilizers for production of amiodaronehydrochloride nanoparticles: Optimization of the process parameters","volume":"142","author":"Sodeifian","year":"2019","journal-title":"Chem. Eng. Res. Des."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.supflu.2018.11.007","article-title":"Production of Loratadine drug nanoparticles using ultrasonic-assisted Rapid expansion of supercritical solution into aqueous solution (US-RESSAS)","volume":"147","author":"Sodeifian","year":"2019","journal-title":"J. Supercrit. Fluids"},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Franco, P., and de Marco, I. (2020). Supercritical antisolvent process for pharmaceutical applications: A review. Processes, 8.","DOI":"10.3390\/pr8080938"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.supflu.2017.06.014","article-title":"Dependence of SAS particle morphologies on the ternary phase equilibria","volume":"130","author":"Campardelli","year":"2017","journal-title":"J. Supercrit. Fluids"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.supflu.2018.09.010","article-title":"PVP microparticles precipitation from acetone-ethanol mixtures using SAS process: Effect of phase behavior","volume":"143","author":"Campardelli","year":"2019","journal-title":"J. Supercrit. Fluids"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1002\/aic.690350902","article-title":"Phase Equilibria for Supercritical Fluid Process Design","volume":"35","author":"Brennecke","year":"1989","journal-title":"AIChE J."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1021\/ie00092a001","article-title":"Modeling Supercritical Mixtures: How Predictive Is It?","volume":"28","author":"Johnston","year":"1989","journal-title":"Ind. Eng. Chem. Res."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0896-8446(02)00142-0","article-title":"Prediction of solid-gas equilibria with the Peng-Robinson equation of state","volume":"25","author":"Coutsikos","year":"2003","journal-title":"J. Supercrit. Fluids"},{"key":"ref_32","first-page":"1060","article-title":"Equations of state in three centuries. Are we closer to arriving to a single model for all applications?","volume":"7","author":"Kontogeorgis","year":"2020","journal-title":"Chem. Eng. Sci. X"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.fluid.2018.05.018","article-title":"Solubility measurement of an antihistamine drug (Loratadine) in supercritical carbon dioxide: Assessment of qCPA and PCP-SAFT equations of state","volume":"472","author":"Sodeifian","year":"2018","journal-title":"Fluid Phase Equilib."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.jfoodeng.2015.08.004","article-title":"Solubility of virgin coconut oil in supercritical carbon dioxide","volume":"168","author":"Zuknik","year":"2016","journal-title":"J. Food Eng."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.fluid.2016.01.026","article-title":"Semi-Empirical models and a cubic equation of state for correlation of solids solubility in scCO2: Dyes and calix[4]arenes as illustrative examples","volume":"426","author":"Coelho","year":"2016","journal-title":"Fluid Phase Equilib."},{"key":"ref_36","unstructured":"Prausnitz, J.M., Lichtenthaler, R.M., and De Azevedo, A.G. (1999). Molecular Thermodynamics of Fluid Phase Equilibria, Prentice Hall. [3rd ed.]."},{"key":"ref_37","first-page":"131","article-title":"The Solvent-Solute Interaction in Supercritical Solution at Equilibrium: Modeling and Related Industrial Applications","volume":"7","author":"Ksibi","year":"2004","journal-title":"Int. J. Thermodyn."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"3763","DOI":"10.1016\/0009-2509(96)00016-4","article-title":"A comparative study of numerical methods for calculating phase equilibria in fluid mixtures from an equation of state","volume":"51","author":"Fotouh","year":"1996","journal-title":"Chem. Eng. Sci."},{"key":"ref_39","first-page":"37","article-title":"Correlation of the binary interaction factor for polar solutes dissolved in supercritical carbon dioxide","volume":"14","author":"Issaoui","year":"2011","journal-title":"Int. J. Thermodyn."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S0896-8446(99)00008-X","article-title":"Solubility of the antibiotic penicillin G in supercritical carbon dioxide","volume":"15","author":"Gordillo","year":"1999","journal-title":"J. Supercrit. Fluids"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"4087","DOI":"10.1021\/ie00038a051","article-title":"Solubility and Micronization of Griseofulvin in Supercritical CHF3","volume":"34","author":"Reverchon","year":"1995","journal-title":"Ind. Eng. Chem. Res."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1021\/cr60137a013","article-title":"On the Thermodynamics of Solutions. V: An Equation of State. Fugacities of Gaseous Solutions","volume":"44","author":"Redlich","year":"1949","journal-title":"Chem. Rev."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1016\/0009-2509(72)80096-4","article-title":"Equilibrium Constants from a Modified Redlich-Kwong Equation of State","volume":"27","author":"Soave","year":"1972","journal-title":"Chem. Eng. Sci."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1002\/cjce.5450830323","article-title":"Correct Way of Reporting Results when Modeling Supercritical Phase Equilibria using Equations of State","volume":"83","author":"Valderrama","year":"2005","journal-title":"Can. J. Chem. Eng."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1080\/10406638.2016.1200636","article-title":"Modified Wilson\u2019s Model for Correlating Solubilities in Supercritical Fluids of Some Polycyclic Aromatic Solutes","volume":"38","author":"Nasri","year":"2016","journal-title":"Polycycl. Aromat. Compd."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/0896-8446(91)90028-5","article-title":"Solubility of the antibiotic penicillin V in supercritical CO2","volume":"4","author":"Ko","year":"1991","journal-title":"J. Supercrit. Fluids"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1021\/je00009a030","article-title":"Solid Molar Volumes of Interest to Supercritical Extraction at 298 K: Atropine, Berberine Hydrochloride Hydrate, Brucine Dihydrate, Capsaicin, Ergotamine Tartrate Dihydrate, Naphthalene, Penicillin V, Piperine, Quinine, Strychnine, Theobromine, Theophylli","volume":"38","author":"Vafai","year":"1993","journal-title":"J. Chem. Eng. Data"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1021\/je00044a021","article-title":"Solubility of Monofunctional Organic Solids in Chemically diverse Supercritical Fluids","volume":"31","author":"Schmitt","year":"1986","journal-title":"J. Chem. Eng. Data"},{"key":"ref_49","unstructured":"Nasri, L. (2019, January 26\u201328). Modified Equation of State and Sublimation Pressure of Antibiotic Penicillin G. Proceedings of the 2019 10th International Renewable Energy Congress (IREC), Sousse, Tunisia."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.fluid.2019.01.020","article-title":"Estimation of critical point, vapor pressure and heat of sublimation of pharmaceuticals and their solubility in supercritical carbon dioxide","volume":"488","author":"Jahromi","year":"2019","journal-title":"Fluid Phase Equilib."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0896-8446(03)00116-5","article-title":"Solubility of cholesterol and its esters in supercritical carbon dioxide with and without cosolvents","volume":"30","author":"Huang","year":"2004","journal-title":"J. Supercrit. Fluids"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/j.supflu.2007.07.013","article-title":"Calculation of solubility of methimazole, phenazopyridine and propranolol in supercritical carbon dioxide","volume":"43","author":"Housaindokht","year":"2008","journal-title":"J. Supercrit. Fluids"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1351\/pac199365051003","article-title":"Phase equilibria with supercritical components","volume":"65","author":"Wichterle","year":"1993","journal-title":"Pure Appl. Chem."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"104606","DOI":"10.1016\/j.supflu.2019.104606","article-title":"Experimental study and thermodynamic modeling of Esomeprazole (proton-pump inhibitor drug for stomach acid reduction) solubility in supercritical carbon dioxide","volume":"154","author":"Sodeifian","year":"2019","journal-title":"J. Supercrit. Fluids"},{"key":"ref_55","first-page":"1747","article-title":"Prediction of Solubility of Sodium Valproate in Supercritical Carbon Dioxide: Experimental Study and Thermodynamic Modeling","volume":"65","author":"Sodeifian","year":"2020","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.fluid.2017.05.007","article-title":"Peng-Robinson equation of state: 40 years through cubics","volume":"447","year":"2017","journal-title":"Fluid Phase Equilib."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S0896-8446(98)00033-3","article-title":"High-Pressure solubility of 1,4-bis-(n-alkylamino)-9,10-anthraquinones in near- and supercritical carbon dioxide","volume":"13","author":"Kautz","year":"1998","journal-title":"J. Supercrit. Fluids"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/0378-3812(91)85023-N","article-title":"Solubilities of theobromine and caffeine in supercritical carbon dioxide: Correlation with density-based models","volume":"68","author":"Li","year":"1991","journal-title":"Fluid Phase Equilib."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1021\/es00104a004","article-title":"Vapor-Pressure correlations for low-volatility environmental chemicals","volume":"16","author":"Mackay","year":"1982","journal-title":"Environ. Sci. Technol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.dyepig.2004.12.013","article-title":"Solubility Estimations for Disperse Blue14 in Supercritical Carbon Dioxide Dyes","volume":"67","author":"Gordillo","year":"2005","journal-title":"Dye. Pigment."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"100145","DOI":"10.1016\/j.scp.2019.100145","article-title":"About consistency of Solid\u2019s solubility data in supercritical CO2 and some thermodynamic properties estimation","volume":"13","author":"Nasri","year":"2019","journal-title":"Sustain. Chem. Pharm."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1021\/je800418m","article-title":"Solid vapor pressure and enthalpy of sublimation for ammonium perfluorooctanoate","volume":"54","author":"Barton","year":"2009","journal-title":"J. Chem. Eng. Data"},{"key":"ref_63","first-page":"501","article-title":"The solubility of solids in supercritical fluids","volume":"158\u2013160","author":"Teja","year":"1999","journal-title":"Fluid Phase Equilib."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1063\/1.555893","article-title":"Solubilities of solids and liquids of low volatility in supercritical carbon dioxide","volume":"20","author":"Bartle","year":"1991","journal-title":"J. Phys. Chem. Ref. Data"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1021\/je020218w","article-title":"Solubilities of the drugs benzocaine, metronidazole benzoate, and naproxen in supercritical carbon dioxide","volume":"49","author":"Garmroodi","year":"2004","journal-title":"J. Chem. Eng. Data"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S0896-8446(04)00112-3","article-title":"Solubility of some inhaled glucocorticoids in supercritical carbon dioxide","volume":"33","author":"Vatanara","year":"2005","journal-title":"J. Supercrit. Fluids"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.supflu.2019.04.008","article-title":"Solubility measurement and RESOLV-assisted nanonization of gambogic acid in supercritical carbon dioxide for cancer therapy","volume":"150","author":"Xiang","year":"2019","journal-title":"J. Supercrit. Fluids"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"113954","DOI":"10.1016\/j.molliq.2020.113954","article-title":"Measuring solubility of a chemotherapy-anti cancer drug (busulfan) in supercritical carbon dioxide","volume":"317","author":"Pishnamazi","year":"2020","journal-title":"J. Mol. Liq."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"116446","DOI":"10.1016\/j.molliq.2021.116446","article-title":"The solubility of Sulfabenzamide (an antibacterial drug) in supercritical carbon dioxide: Evaluation of a new thermodynamic model","volume":"335","author":"Sodeifian","year":"2021","journal-title":"J. Mol. Liq."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.supflu.2013.02.003","article-title":"Solubility of gabapentin in supercritical carbon dioxide","volume":"78","author":"Shojaee","year":"2013","journal-title":"J. Supercrit. Fluids"}],"container-title":["Antibiotics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2079-6382\/10\/12\/1448\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T07:35:37Z","timestamp":1760168137000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2079-6382\/10\/12\/1448"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,25]]},"references-count":70,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2021,12]]}},"alternative-id":["antibiotics10121448"],"URL":"https:\/\/doi.org\/10.3390\/antibiotics10121448","relation":{},"ISSN":["2079-6382"],"issn-type":[{"value":"2079-6382","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,11,25]]}}}